Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDW2_LEIIN

TriTrypDb:

LINF_360064500

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.672
CLV_NRD_NRD_1	286	288	PF00675	0.574
CLV_NRD_NRD_1	293	295	PF00675	0.429
CLV_PCSK_FUR_1	284	288	PF00082	0.513
CLV_PCSK_KEX2_1	286	288	PF00082	0.574
CLV_PCSK_KEX2_1	293	295	PF00082	0.429
CLV_PCSK_KEX2_1	301	303	PF00082	0.359
CLV_PCSK_KEX2_1	411	413	PF00082	0.638
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.510
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.525
CLV_PCSK_SKI1_1	391	395	PF00082	0.542
DEG_Nend_UBRbox_2	1	3	PF02207	0.686
DEG_SPOP_SBC_1	595	599	PF00917	0.535
DEG_SPOP_SBC_1	658	662	PF00917	0.514
DOC_MAPK_gen_1	298	305	PF00069	0.511
DOC_MAPK_MEF2A_6	166	173	PF00069	0.456
DOC_PP2B_LxvP_1	569	572	PF13499	0.641
DOC_PP2B_LxvP_1	626	629	PF13499	0.687
DOC_PP4_FxxP_1	21	24	PF00568	0.687
DOC_PP4_FxxP_1	237	240	PF00568	0.647
DOC_PP4_FxxP_1	655	658	PF00568	0.593
DOC_USP7_MATH_1	120	124	PF00917	0.733
DOC_USP7_MATH_1	143	147	PF00917	0.737
DOC_USP7_MATH_1	211	215	PF00917	0.573
DOC_USP7_MATH_1	251	255	PF00917	0.666
DOC_USP7_MATH_1	32	36	PF00917	0.723
DOC_USP7_MATH_1	368	372	PF00917	0.525
DOC_USP7_MATH_1	532	536	PF00917	0.675
DOC_USP7_MATH_1	558	562	PF00917	0.647
DOC_USP7_MATH_1	608	612	PF00917	0.620
DOC_WW_Pin1_4	149	154	PF00397	0.667
DOC_WW_Pin1_4	235	240	PF00397	0.674
DOC_WW_Pin1_4	247	252	PF00397	0.613
DOC_WW_Pin1_4	472	477	PF00397	0.669
DOC_WW_Pin1_4	478	483	PF00397	0.631
DOC_WW_Pin1_4	659	664	PF00397	0.587
DOC_WW_Pin1_4	66	71	PF00397	0.690
DOC_WW_Pin1_4	79	84	PF00397	0.588
LIG_14-3-3_CanoR_1	187	191	PF00244	0.506
LIG_14-3-3_CanoR_1	243	252	PF00244	0.636
LIG_14-3-3_CanoR_1	319	325	PF00244	0.596
LIG_Actin_WH2_2	172	189	PF00022	0.456
LIG_BRCT_BRCA1_1	260	264	PF00533	0.567
LIG_BRCT_BRCA1_1	651	655	PF00533	0.586
LIG_Clathr_ClatBox_1	170	174	PF01394	0.441
LIG_Clathr_ClatBox_1	5	9	PF01394	0.626
LIG_FHA_1	187	193	PF00498	0.488
LIG_FHA_1	225	231	PF00498	0.624
LIG_FHA_1	339	345	PF00498	0.436
LIG_FHA_1	35	41	PF00498	0.842
LIG_FHA_1	388	394	PF00498	0.579
LIG_FHA_1	511	517	PF00498	0.636
LIG_FHA_1	531	537	PF00498	0.572
LIG_FHA_2	111	117	PF00498	0.727
LIG_FHA_2	120	126	PF00498	0.517
LIG_FHA_2	146	152	PF00498	0.618
LIG_FHA_2	199	205	PF00498	0.500
LIG_FHA_2	294	300	PF00498	0.500
LIG_FHA_2	362	368	PF00498	0.504
LIG_FHA_2	634	640	PF00498	0.635
LIG_LIR_Apic_2	20	24	PF02991	0.573
LIG_LIR_Apic_2	234	240	PF02991	0.585
LIG_LIR_Apic_2	652	658	PF02991	0.593
LIG_LIR_Gen_1	400	407	PF02991	0.507
LIG_LIR_Gen_1	636	643	PF02991	0.714
LIG_LIR_Gen_1	645	656	PF02991	0.582
LIG_LIR_Nem_3	373	379	PF02991	0.485
LIG_LIR_Nem_3	400	406	PF02991	0.630
LIG_LIR_Nem_3	589	595	PF02991	0.658
LIG_LIR_Nem_3	636	640	PF02991	0.719
LIG_LIR_Nem_3	645	651	PF02991	0.580
LIG_LIR_Nem_3	652	656	PF02991	0.494
LIG_LYPXL_yS_3	543	546	PF13949	0.679
LIG_LYPXL_yS_3	653	656	PF13949	0.650
LIG_MAD2	243	251	PF02301	0.574
LIG_PCNA_yPIPBox_3	307	318	PF02747	0.429
LIG_Pex14_2	173	177	PF04695	0.458
LIG_RPA_C_Fungi	302	314	PF08784	0.490
LIG_SH2_CRK	403	407	PF00017	0.502
LIG_SH2_CRK	648	652	PF00017	0.633
LIG_SH2_NCK_1	403	407	PF00017	0.502
LIG_SH2_NCK_1	497	501	PF00017	0.689
LIG_SH2_STAP1	403	407	PF00017	0.502
LIG_SH2_STAT3	504	507	PF00017	0.691
LIG_SH2_STAT3	58	61	PF00017	0.717
LIG_SH2_STAT5	200	203	PF00017	0.460
LIG_SH2_STAT5	304	307	PF00017	0.510
LIG_SH2_STAT5	343	346	PF00017	0.594
LIG_SH2_STAT5	461	464	PF00017	0.699
LIG_SH2_STAT5	497	500	PF00017	0.613
LIG_SH2_STAT5	504	507	PF00017	0.691
LIG_SH2_STAT5	594	597	PF00017	0.669
LIG_SH3_3	101	107	PF00018	0.703
LIG_SH3_3	130	136	PF00018	0.660
LIG_SH3_3	428	434	PF00018	0.653
LIG_SH3_3	500	506	PF00018	0.677
LIG_SH3_3	53	59	PF00018	0.642
LIG_SH3_3	538	544	PF00018	0.695
LIG_SH3_3	584	590	PF00018	0.632
LIG_SH3_3	629	635	PF00018	0.649
LIG_SH3_3	648	654	PF00018	0.468
LIG_SUMO_SIM_anti_2	535	540	PF11976	0.656
LIG_SUMO_SIM_par_1	143	148	PF11976	0.564
LIG_SUMO_SIM_par_1	168	174	PF11976	0.531
LIG_SUMO_SIM_par_1	2	9	PF11976	0.701
LIG_SUMO_SIM_par_1	517	523	PF11976	0.672
LIG_TRAF2_1	113	116	PF00917	0.672
LIG_TRFH_1	497	501	PF08558	0.689
LIG_TYR_ITIM	401	406	PF00017	0.621
LIG_TYR_ITIM	541	546	PF00017	0.682
LIG_TYR_ITIM	651	656	PF00017	0.640
MOD_CDC14_SPxK_1	82	85	PF00782	0.698
MOD_CDK_SPK_2	472	477	PF00069	0.531
MOD_CDK_SPxK_1	79	85	PF00069	0.704
MOD_CK1_1	226	232	PF00069	0.589
MOD_CK1_1	456	462	PF00069	0.708
MOD_CK1_1	478	484	PF00069	0.672
MOD_CK1_1	585	591	PF00069	0.548
MOD_CK1_1	659	665	PF00069	0.565
MOD_CK1_1	97	103	PF00069	0.699
MOD_CK2_1	110	116	PF00069	0.730
MOD_CK2_1	145	151	PF00069	0.618
MOD_CK2_1	198	204	PF00069	0.500
MOD_CK2_1	251	257	PF00069	0.613
MOD_CK2_1	633	639	PF00069	0.762
MOD_GlcNHglycan	108	111	PF01048	0.647
MOD_GlcNHglycan	115	120	PF01048	0.579
MOD_GlcNHglycan	122	125	PF01048	0.662
MOD_GlcNHglycan	183	186	PF01048	0.467
MOD_GlcNHglycan	260	263	PF01048	0.592
MOD_GlcNHglycan	276	279	PF01048	0.411
MOD_GlcNHglycan	329	332	PF01048	0.458
MOD_GlcNHglycan	353	356	PF01048	0.505
MOD_GlcNHglycan	413	416	PF01048	0.591
MOD_GlcNHglycan	42	45	PF01048	0.675
MOD_GlcNHglycan	469	472	PF01048	0.682
MOD_GlcNHglycan	584	587	PF01048	0.658
MOD_GlcNHglycan	611	614	PF01048	0.614
MOD_GlcNHglycan	96	99	PF01048	0.782
MOD_GSK3_1	106	113	PF00069	0.685
MOD_GSK3_1	115	122	PF00069	0.676
MOD_GSK3_1	143	150	PF00069	0.671
MOD_GSK3_1	247	254	PF00069	0.658
MOD_GSK3_1	265	272	PF00069	0.447
MOD_GSK3_1	32	39	PF00069	0.763
MOD_GSK3_1	387	394	PF00069	0.589
MOD_GSK3_1	452	459	PF00069	0.640
MOD_GSK3_1	511	518	PF00069	0.787
MOD_GSK3_1	520	527	PF00069	0.695
MOD_GSK3_1	530	537	PF00069	0.538
MOD_GSK3_1	578	585	PF00069	0.625
MOD_GSK3_1	658	665	PF00069	0.599
MOD_GSK3_1	92	99	PF00069	0.648
MOD_LATS_1	409	415	PF00433	0.570
MOD_N-GLC_1	40	45	PF02516	0.703
MOD_N-GLC_1	558	563	PF02516	0.649
MOD_NEK2_1	1	6	PF00069	0.771
MOD_NEK2_1	186	191	PF00069	0.534
MOD_NEK2_1	19	24	PF00069	0.633
MOD_NEK2_1	264	269	PF00069	0.641
MOD_NEK2_1	361	366	PF00069	0.594
MOD_NEK2_1	387	392	PF00069	0.628
MOD_NEK2_1	40	45	PF00069	0.660
MOD_NEK2_1	495	500	PF00069	0.625
MOD_NEK2_2	338	343	PF00069	0.391
MOD_PIKK_1	346	352	PF00454	0.531
MOD_PIKK_1	438	444	PF00454	0.687
MOD_PIKK_1	481	487	PF00454	0.615
MOD_PIKK_1	526	532	PF00454	0.639
MOD_PIKK_1	544	550	PF00454	0.564
MOD_PIKK_1	559	565	PF00454	0.636
MOD_PIKK_1	596	602	PF00454	0.563
MOD_PKA_1	293	299	PF00069	0.499
MOD_PKA_1	411	417	PF00069	0.573
MOD_PKA_2	186	192	PF00069	0.481
MOD_PKA_2	293	299	PF00069	0.499
MOD_PKA_2	411	417	PF00069	0.573
MOD_Plk_1	1	7	PF00069	0.801
MOD_Plk_1	211	217	PF00069	0.487
MOD_Plk_1	32	38	PF00069	0.649
MOD_Plk_4	1	7	PF00069	0.720
MOD_Plk_4	205	211	PF00069	0.449
MOD_Plk_4	212	218	PF00069	0.426
MOD_Plk_4	251	257	PF00069	0.613
MOD_Plk_4	338	344	PF00069	0.430
MOD_Plk_4	361	367	PF00069	0.496
MOD_Plk_4	462	468	PF00069	0.665
MOD_Plk_4	534	540	PF00069	0.706
MOD_Plk_4	616	622	PF00069	0.681
MOD_Plk_4	633	639	PF00069	0.513
MOD_ProDKin_1	149	155	PF00069	0.667
MOD_ProDKin_1	235	241	PF00069	0.671
MOD_ProDKin_1	247	253	PF00069	0.615
MOD_ProDKin_1	472	478	PF00069	0.669
MOD_ProDKin_1	659	665	PF00069	0.592
MOD_ProDKin_1	66	72	PF00069	0.692
MOD_ProDKin_1	79	85	PF00069	0.587
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.566
TRG_ENDOCYTIC_2	403	406	PF00928	0.623
TRG_ENDOCYTIC_2	543	546	PF00928	0.679
TRG_ENDOCYTIC_2	592	595	PF00928	0.659
TRG_ENDOCYTIC_2	648	651	PF00928	0.664
TRG_ENDOCYTIC_2	653	656	PF00928	0.613
TRG_ER_diArg_1	284	287	PF00400	0.576
TRG_ER_diArg_1	292	294	PF00400	0.438
TRG_NES_CRM1_1	388	400	PF08389	0.427
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJZ7	Leishmania donovani	98%	100%
A4HQ65	Leishmania braziliensis	68%	97%
E9ATY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q0L3	Leishmania major	91%	100%