LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
L-2-hydroxyglutarate dehydrogenase - mitochondrial - putative
Species:
Leishmania infantum
UniProt:
A4IDW0_LEIIN
TriTrypDb:
LINF_360064300
Length:
522

Annotations

Annotations by Jardim et al.

Oxidoreductase, L-2-hydroxyglutarate dehydrogenase, mitochondrial Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDW0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDW0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0016491 oxidoreductase activity 2 11
GO:0003973 (S)-2-hydroxy-acid oxidase activity 5 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 2
GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor 4 1
GO:0047545 2-hydroxyglutarate dehydrogenase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 424 428 PF00656 0.264
CLV_C14_Caspase3-7 482 486 PF00656 0.397
CLV_NRD_NRD_1 28 30 PF00675 0.501
CLV_NRD_NRD_1 315 317 PF00675 0.284
CLV_NRD_NRD_1 329 331 PF00675 0.387
CLV_NRD_NRD_1 346 348 PF00675 0.256
CLV_NRD_NRD_1 53 55 PF00675 0.429
CLV_NRD_NRD_1 80 82 PF00675 0.310
CLV_PCSK_KEX2_1 28 30 PF00082 0.501
CLV_PCSK_KEX2_1 296 298 PF00082 0.366
CLV_PCSK_KEX2_1 315 317 PF00082 0.422
CLV_PCSK_KEX2_1 346 348 PF00082 0.256
CLV_PCSK_KEX2_1 406 408 PF00082 0.332
CLV_PCSK_KEX2_1 53 55 PF00082 0.429
CLV_PCSK_KEX2_1 82 84 PF00082 0.275
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.339
CLV_PCSK_PC1ET2_1 406 408 PF00082 0.332
CLV_PCSK_PC1ET2_1 82 84 PF00082 0.275
CLV_PCSK_SKI1_1 209 213 PF00082 0.275
CLV_PCSK_SKI1_1 265 269 PF00082 0.388
CLV_PCSK_SKI1_1 407 411 PF00082 0.279
CLV_PCSK_SKI1_1 464 468 PF00082 0.570
CLV_PCSK_SKI1_1 83 87 PF00082 0.275
DEG_APCC_DBOX_1 208 216 PF00400 0.275
DOC_CKS1_1 310 315 PF01111 0.332
DOC_MAPK_gen_1 315 323 PF00069 0.284
DOC_MAPK_gen_1 330 337 PF00069 0.388
DOC_MAPK_gen_1 346 353 PF00069 0.256
DOC_MAPK_gen_1 53 61 PF00069 0.386
DOC_MAPK_gen_1 78 87 PF00069 0.369
DOC_MAPK_JIP1_4 488 494 PF00069 0.360
DOC_MAPK_MEF2A_6 330 339 PF00069 0.278
DOC_MAPK_RevD_3 333 347 PF00069 0.256
DOC_PP4_FxxP_1 110 113 PF00568 0.388
DOC_PP4_FxxP_1 451 454 PF00568 0.371
DOC_USP7_MATH_1 284 288 PF00917 0.286
DOC_USP7_MATH_1 483 487 PF00917 0.595
DOC_USP7_MATH_1 502 506 PF00917 0.245
DOC_USP7_MATH_1 515 519 PF00917 0.316
DOC_USP7_UBL2_3 78 82 PF12436 0.335
DOC_WW_Pin1_4 193 198 PF00397 0.256
DOC_WW_Pin1_4 309 314 PF00397 0.332
DOC_WW_Pin1_4 337 342 PF00397 0.268
DOC_WW_Pin1_4 364 369 PF00397 0.275
DOC_WW_Pin1_4 496 501 PF00397 0.320
LIG_14-3-3_CanoR_1 123 128 PF00244 0.284
LIG_14-3-3_CanoR_1 297 303 PF00244 0.384
LIG_14-3-3_CanoR_1 330 336 PF00244 0.337
LIG_14-3-3_CanoR_1 453 459 PF00244 0.375
LIG_BIR_II_1 1 5 PF00653 0.524
LIG_BRCT_BRCA1_1 516 520 PF00533 0.417
LIG_CSL_BTD_1 194 197 PF09270 0.335
LIG_FHA_1 338 344 PF00498 0.306
LIG_FHA_2 69 75 PF00498 0.300
LIG_LIR_Apic_2 450 454 PF02991 0.334
LIG_LIR_Gen_1 203 212 PF02991 0.257
LIG_LIR_Gen_1 391 401 PF02991 0.326
LIG_LIR_Nem_3 192 198 PF02991 0.341
LIG_LIR_Nem_3 203 207 PF02991 0.202
LIG_LIR_Nem_3 233 237 PF02991 0.269
LIG_LIR_Nem_3 391 396 PF02991 0.298
LIG_LIR_Nem_3 399 404 PF02991 0.287
LIG_LIR_Nem_3 427 432 PF02991 0.288
LIG_Pex14_2 223 227 PF04695 0.256
LIG_Pex14_2 377 381 PF04695 0.353
LIG_Pex14_2 393 397 PF04695 0.206
LIG_Rb_pABgroove_1 155 163 PF01858 0.388
LIG_SH2_CRK 429 433 PF00017 0.356
LIG_SH2_STAP1 369 373 PF00017 0.388
LIG_SH2_STAP1 57 61 PF00017 0.315
LIG_SH2_STAT5 131 134 PF00017 0.275
LIG_SH2_STAT5 366 369 PF00017 0.270
LIG_SH2_STAT5 375 378 PF00017 0.256
LIG_SH2_STAT5 429 432 PF00017 0.356
LIG_SH3_3 453 459 PF00018 0.421
LIG_SUMO_SIM_anti_2 13 19 PF11976 0.408
LIG_SUMO_SIM_anti_2 58 63 PF11976 0.296
LIG_SUMO_SIM_par_1 83 88 PF11976 0.275
LIG_TRFH_1 309 313 PF08558 0.296
LIG_TYR_ITSM 397 404 PF00017 0.284
LIG_UBA3_1 211 220 PF00899 0.312
LIG_UBA3_1 416 423 PF00899 0.383
LIG_UBA3_1 467 472 PF00899 0.377
LIG_Vh1_VBS_1 1 19 PF01044 0.455
LIG_WRC_WIRS_1 45 50 PF05994 0.470
MOD_CDK_SPxK_1 309 315 PF00069 0.332
MOD_CDK_SPxxK_3 309 316 PF00069 0.284
MOD_CK1_1 10 16 PF00069 0.520
MOD_CK1_1 196 202 PF00069 0.256
MOD_CK1_1 205 211 PF00069 0.256
MOD_CK1_1 388 394 PF00069 0.324
MOD_CK1_1 44 50 PF00069 0.321
MOD_CK1_1 484 490 PF00069 0.512
MOD_CK2_1 68 74 PF00069 0.333
MOD_Cter_Amidation 294 297 PF01082 0.275
MOD_GlcNHglycan 101 104 PF01048 0.260
MOD_GlcNHglycan 114 117 PF01048 0.320
MOD_GlcNHglycan 191 194 PF01048 0.347
MOD_GlcNHglycan 198 201 PF01048 0.273
MOD_GlcNHglycan 286 289 PF01048 0.280
MOD_GlcNHglycan 356 359 PF01048 0.299
MOD_GlcNHglycan 476 479 PF01048 0.591
MOD_GlcNHglycan 9 12 PF01048 0.483
MOD_GlcNHglycan 97 100 PF01048 0.289
MOD_GSK3_1 149 156 PF00069 0.308
MOD_GSK3_1 189 196 PF00069 0.335
MOD_GSK3_1 235 242 PF00069 0.333
MOD_GSK3_1 33 40 PF00069 0.474
MOD_GSK3_1 454 461 PF00069 0.383
MOD_GSK3_1 496 503 PF00069 0.306
MOD_GSK3_1 95 102 PF00069 0.256
MOD_NEK2_1 402 407 PF00069 0.325
MOD_PIKK_1 10 16 PF00454 0.538
MOD_PIKK_1 149 155 PF00454 0.388
MOD_PIKK_1 222 228 PF00454 0.312
MOD_PK_1 331 337 PF00069 0.275
MOD_PKA_2 153 159 PF00069 0.347
MOD_PKA_2 454 460 PF00069 0.442
MOD_Plk_1 263 269 PF00069 0.300
MOD_Plk_4 123 129 PF00069 0.370
MOD_Plk_4 263 269 PF00069 0.335
MOD_Plk_4 385 391 PF00069 0.318
MOD_Plk_4 396 402 PF00069 0.383
MOD_Plk_4 41 47 PF00069 0.430
MOD_ProDKin_1 193 199 PF00069 0.256
MOD_ProDKin_1 309 315 PF00069 0.332
MOD_ProDKin_1 337 343 PF00069 0.268
MOD_ProDKin_1 364 370 PF00069 0.275
MOD_ProDKin_1 496 502 PF00069 0.319
MOD_SUMO_rev_2 419 425 PF00179 0.383
TRG_DiLeu_BaEn_1 248 253 PF01217 0.371
TRG_DiLeu_BaEn_1 412 417 PF01217 0.251
TRG_DiLeu_BaLyEn_6 486 491 PF01217 0.371
TRG_ENDOCYTIC_2 308 311 PF00928 0.296
TRG_ENDOCYTIC_2 31 34 PF00928 0.361
TRG_ENDOCYTIC_2 401 404 PF00928 0.388
TRG_ENDOCYTIC_2 429 432 PF00928 0.356
TRG_ER_diArg_1 253 256 PF00400 0.282
TRG_ER_diArg_1 27 29 PF00400 0.492
TRG_ER_diArg_1 304 307 PF00400 0.256
TRG_ER_diArg_1 345 347 PF00400 0.327
TRG_ER_diArg_1 453 456 PF00400 0.387
TRG_ER_diArg_1 80 83 PF00400 0.369
TRG_NLS_MonoExtN_4 78 85 PF00514 0.383
TRG_Pf-PMV_PEXEL_1 465 469 PF00026 0.407
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.526
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.162

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1P3 Leptomonas seymouri 23% 100%
A0A0N1PEN9 Leptomonas seymouri 78% 100%
A0A0S4JUB7 Bodo saltans 45% 100%
A0A1X0P066 Trypanosomatidae 58% 100%
A0A3Q8IJT1 Leishmania donovani 100% 100%
A0A5Y6MCT2 Salmonella houtenae 30% 100%
A4HQ61 Leishmania braziliensis 86% 100%
A7MBI3 Bos taurus 32% 100%
A7SMW7 Nematostella vectensis 35% 100%
A8X2R1 Caenorhabditis briggsae 32% 100%
B7N6P4 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 30% 100%
D0A456 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9ATY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P37339 Escherichia coli (strain K12) 30% 100%
Q4Q0L5 Leishmania major 96% 100%
Q55GI5 Dictyostelium discoideum 31% 100%
Q91YP0 Mus musculus 33% 100%
Q9H9P8 Homo sapiens 31% 100%
Q9LES4 Arabidopsis thaliana 25% 100%
Q9N4Z0 Caenorhabditis elegans 33% 100%
S2DJ52 Indibacter alkaliphilus (strain CCUG 57479 / KCTC 22604 / LW1) 30% 100%
V5DK53 Trypanosoma cruzi 56% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS