SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain/UBX domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IDV8_LEIIN

TriTrypDb:

LINF_360064100

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IDV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDV8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.667
CLV_C14_Caspase3-7	226	230	PF00656	0.634
CLV_C14_Caspase3-7	465	469	PF00656	0.557
CLV_NRD_NRD_1	281	283	PF00675	0.542
CLV_NRD_NRD_1	413	415	PF00675	0.716
CLV_NRD_NRD_1	45	47	PF00675	0.538
CLV_NRD_NRD_1	505	507	PF00675	0.538
CLV_NRD_NRD_1	56	58	PF00675	0.642
CLV_NRD_NRD_1	6	8	PF00675	0.760
CLV_PCSK_FUR_1	54	58	PF00082	0.708
CLV_PCSK_KEX2_1	281	283	PF00082	0.503
CLV_PCSK_KEX2_1	413	415	PF00082	0.716
CLV_PCSK_KEX2_1	45	47	PF00082	0.537
CLV_PCSK_KEX2_1	5	7	PF00082	0.768
CLV_PCSK_KEX2_1	504	506	PF00082	0.525
CLV_PCSK_KEX2_1	56	58	PF00082	0.644
CLV_PCSK_SKI1_1	159	163	PF00082	0.556
CLV_PCSK_SKI1_1	211	215	PF00082	0.696
CLV_PCSK_SKI1_1	307	311	PF00082	0.512
CLV_PCSK_SKI1_1	447	451	PF00082	0.517
CLV_PCSK_SKI1_1	46	50	PF00082	0.556
CLV_PCSK_SKI1_1	610	614	PF00082	0.616
DEG_APCC_DBOX_1	45	53	PF00400	0.599
DEG_Nend_UBRbox_3	1	3	PF02207	0.765
DOC_AGCK_PIF_2	359	364	PF00069	0.517
DOC_CYCLIN_RxL_1	43	51	PF00134	0.623
DOC_CYCLIN_yClb5_NLxxxL_5	530	539	PF00134	0.563
DOC_MAPK_gen_1	319	328	PF00069	0.452
DOC_MAPK_MEF2A_6	319	328	PF00069	0.414
DOC_MAPK_MEF2A_6	603	611	PF00069	0.529
DOC_PP2B_LxvP_1	276	279	PF13499	0.516
DOC_USP7_MATH_1	174	178	PF00917	0.694
DOC_USP7_MATH_1	200	204	PF00917	0.788
DOC_USP7_MATH_1	207	211	PF00917	0.622
DOC_USP7_MATH_1	272	276	PF00917	0.578
DOC_USP7_MATH_1	526	530	PF00917	0.718
DOC_USP7_MATH_1	568	572	PF00917	0.476
DOC_USP7_MATH_1	58	62	PF00917	0.694
DOC_USP7_MATH_1	66	70	PF00917	0.606
DOC_USP7_UBL2_3	232	236	PF12436	0.791
DOC_USP7_UBL2_3	307	311	PF12436	0.551
DOC_USP7_UBL2_3	447	451	PF12436	0.385
DOC_WW_Pin1_4	11	16	PF00397	0.723
DOC_WW_Pin1_4	18	23	PF00397	0.727
DOC_WW_Pin1_4	183	188	PF00397	0.673
DOC_WW_Pin1_4	198	203	PF00397	0.633
DOC_WW_Pin1_4	251	256	PF00397	0.703
DOC_WW_Pin1_4	33	38	PF00397	0.698
DOC_WW_Pin1_4	422	427	PF00397	0.777
DOC_WW_Pin1_4	438	443	PF00397	0.591
DOC_WW_Pin1_4	515	520	PF00397	0.720
DOC_WW_Pin1_4	56	61	PF00397	0.713
LIG_14-3-3_CanoR_1	281	286	PF00244	0.588
LIG_14-3-3_CanoR_1	298	306	PF00244	0.389
LIG_14-3-3_CanoR_1	428	433	PF00244	0.703
LIG_14-3-3_CanoR_1	594	600	PF00244	0.487
LIG_APCC_ABBA_1	153	158	PF00400	0.479
LIG_BRCT_BRCA1_1	218	222	PF00533	0.631
LIG_BRCT_BRCA1_1	527	531	PF00533	0.679
LIG_deltaCOP1_diTrp_1	588	596	PF00928	0.566
LIG_eIF4E_1	156	162	PF01652	0.610
LIG_FHA_1	148	154	PF00498	0.510
LIG_FHA_1	238	244	PF00498	0.722
LIG_FHA_1	604	610	PF00498	0.428
LIG_FHA_2	152	158	PF00498	0.584
LIG_FHA_2	42	48	PF00498	0.609
LIG_FHA_2	429	435	PF00498	0.685
LIG_FHA_2	74	80	PF00498	0.761
LIG_Integrin_isoDGR_2	3	5	PF01839	0.799
LIG_LIR_Gen_1	595	601	PF02991	0.508
LIG_LIR_Nem_3	357	362	PF02991	0.476
LIG_LIR_Nem_3	571	575	PF02991	0.529
LIG_LIR_Nem_3	595	599	PF02991	0.517
LIG_Pex14_1	306	310	PF04695	0.519
LIG_Pex14_2	218	222	PF04695	0.702
LIG_Rb_pABgroove_1	150	158	PF01858	0.583
LIG_SH2_CRK	131	135	PF00017	0.597
LIG_SH2_CRK	440	444	PF00017	0.560
LIG_SH2_NCK_1	440	444	PF00017	0.619
LIG_SH2_STAT5	303	306	PF00017	0.549
LIG_SH2_STAT5	440	443	PF00017	0.622
LIG_SH3_2	206	211	PF14604	0.770
LIG_SH3_2	419	424	PF14604	0.700
LIG_SH3_3	181	187	PF00018	0.774
LIG_SH3_3	203	209	PF00018	0.758
LIG_SH3_3	336	342	PF00018	0.476
LIG_SH3_3	402	408	PF00018	0.684
LIG_SH3_3	416	422	PF00018	0.766
LIG_SH3_3	60	66	PF00018	0.745
LIG_SUMO_SIM_par_1	149	158	PF11976	0.503
LIG_SUMO_SIM_par_1	372	378	PF11976	0.476
LIG_SUMO_SIM_par_1	441	446	PF11976	0.511
LIG_SUMO_SIM_par_1	462	468	PF11976	0.530
LIG_TYR_ITIM	438	443	PF00017	0.640
LIG_UBA3_1	539	547	PF00899	0.557
LIG_UBA3_1	607	613	PF00899	0.508
LIG_WRPW_2	340	343	PF00400	0.476
MOD_CDC14_SPxK_1	21	24	PF00782	0.727
MOD_CDC14_SPxK_1	254	257	PF00782	0.708
MOD_CDC14_SPxK_1	425	428	PF00782	0.551
MOD_CDK_SPxK_1	18	24	PF00069	0.735
MOD_CDK_SPxK_1	251	257	PF00069	0.715
MOD_CDK_SPxK_1	422	428	PF00069	0.564
MOD_CDK_SPxxK_3	18	25	PF00069	0.733
MOD_CDK_SPxxK_3	183	190	PF00069	0.712
MOD_CK1_1	284	290	PF00069	0.546
MOD_CK1_1	482	488	PF00069	0.714
MOD_CK1_1	518	524	PF00069	0.694
MOD_CK1_1	59	65	PF00069	0.755
MOD_CK1_1	9	15	PF00069	0.706
MOD_CK2_1	41	47	PF00069	0.584
MOD_CK2_1	428	434	PF00069	0.658
MOD_CK2_1	494	500	PF00069	0.468
MOD_CK2_1	557	563	PF00069	0.407
MOD_CK2_1	568	574	PF00069	0.431
MOD_CK2_1	75	81	PF00069	0.715
MOD_Cter_Amidation	3	6	PF01082	0.724
MOD_Cter_Amidation	411	414	PF01082	0.724
MOD_GlcNHglycan	11	14	PF01048	0.799
MOD_GlcNHglycan	176	179	PF01048	0.660
MOD_GlcNHglycan	218	221	PF01048	0.672
MOD_GlcNHglycan	268	271	PF01048	0.721
MOD_GlcNHglycan	459	462	PF01048	0.617
MOD_GlcNHglycan	482	485	PF01048	0.666
MOD_GlcNHglycan	496	499	PF01048	0.362
MOD_GlcNHglycan	515	518	PF01048	0.430
MOD_GlcNHglycan	523	526	PF01048	0.661
MOD_GlcNHglycan	68	71	PF01048	0.702
MOD_GlcNHglycan	92	95	PF01048	0.615
MOD_GSK3_1	147	154	PF00069	0.569
MOD_GSK3_1	198	205	PF00069	0.764
MOD_GSK3_1	216	223	PF00069	0.644
MOD_GSK3_1	29	36	PF00069	0.599
MOD_GSK3_1	476	483	PF00069	0.652
MOD_GSK3_1	5	12	PF00069	0.780
MOD_GSK3_1	521	528	PF00069	0.675
MOD_GSK3_1	86	93	PF00069	0.677
MOD_NEK2_1	242	247	PF00069	0.612
MOD_NEK2_1	29	34	PF00069	0.664
MOD_NEK2_2	151	156	PF00069	0.584
MOD_NEK2_2	489	494	PF00069	0.579
MOD_NEK2_2	526	531	PF00069	0.593
MOD_PIKK_1	112	118	PF00454	0.603
MOD_PIKK_1	195	201	PF00454	0.760
MOD_PIKK_1	396	402	PF00454	0.674
MOD_PK_1	281	287	PF00069	0.571
MOD_PKA_1	281	287	PF00069	0.568
MOD_PKA_1	5	11	PF00069	0.712
MOD_PKA_2	281	287	PF00069	0.617
MOD_PKA_2	5	11	PF00069	0.801
MOD_PKA_2	64	70	PF00069	0.662
MOD_PKB_1	88	96	PF00069	0.652
MOD_Plk_1	554	560	PF00069	0.426
MOD_Plk_4	151	157	PF00069	0.540
MOD_Plk_4	29	35	PF00069	0.471
MOD_Plk_4	526	532	PF00069	0.648
MOD_Plk_4	603	609	PF00069	0.417
MOD_ProDKin_1	11	17	PF00069	0.721
MOD_ProDKin_1	18	24	PF00069	0.726
MOD_ProDKin_1	183	189	PF00069	0.673
MOD_ProDKin_1	198	204	PF00069	0.636
MOD_ProDKin_1	251	257	PF00069	0.706
MOD_ProDKin_1	33	39	PF00069	0.693
MOD_ProDKin_1	422	428	PF00069	0.773
MOD_ProDKin_1	438	444	PF00069	0.582
MOD_ProDKin_1	515	521	PF00069	0.721
MOD_ProDKin_1	56	62	PF00069	0.715
MOD_SUMO_for_1	585	588	PF00179	0.613
MOD_SUMO_rev_2	229	239	PF00179	0.699
MOD_SUMO_rev_2	433	438	PF00179	0.659
TRG_ENDOCYTIC_2	131	134	PF00928	0.601
TRG_ENDOCYTIC_2	440	443	PF00928	0.570
TRG_ER_diArg_1	281	283	PF00400	0.605
TRG_ER_diArg_1	413	415	PF00400	0.736
TRG_ER_diArg_1	5	7	PF00400	0.804
TRG_ER_diArg_1	503	506	PF00400	0.554
TRG_ER_diArg_1	53	56	PF00400	0.612
TRG_ER_diArg_1	87	90	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMT0	Leptomonas seymouri	56%	98%
A0A0S4JTW8	Bodo saltans	32%	100%
A0A1X0P060	Trypanosomatidae	35%	100%
A0A3R7LYT2	Trypanosoma rangeli	32%	100%
A0A3S7XBW1	Leishmania donovani	100%	100%
A4HQ59	Leishmania braziliensis	76%	99%
D0A458	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ATX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4Q0L7	Leishmania major	93%	100%
V5BQB1	Trypanosoma cruzi	34%	100%