Mitochondrial chaperone BCS1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone BCS1 - putative

Species:

Leishmania infantum

UniProt:

A4IDV4_LEIIN

TriTrypDb:

LINF_360063700

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4IDV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	60	64	PF00656	0.702
CLV_NRD_NRD_1	270	272	PF00675	0.390
CLV_NRD_NRD_1	29	31	PF00675	0.673
CLV_NRD_NRD_1	313	315	PF00675	0.313
CLV_NRD_NRD_1	350	352	PF00675	0.376
CLV_NRD_NRD_1	402	404	PF00675	0.544
CLV_NRD_NRD_1	506	508	PF00675	0.436
CLV_NRD_NRD_1	70	72	PF00675	0.653
CLV_NRD_NRD_1	76	78	PF00675	0.626
CLV_PCSK_FUR_1	311	315	PF00082	0.351
CLV_PCSK_KEX2_1	269	271	PF00082	0.388
CLV_PCSK_KEX2_1	28	30	PF00082	0.677
CLV_PCSK_KEX2_1	313	315	PF00082	0.318
CLV_PCSK_KEX2_1	350	352	PF00082	0.376
CLV_PCSK_KEX2_1	402	404	PF00082	0.544
CLV_PCSK_KEX2_1	506	508	PF00082	0.436
CLV_PCSK_KEX2_1	70	72	PF00082	0.648
CLV_PCSK_KEX2_1	75	77	PF00082	0.628
CLV_PCSK_PC7_1	25	31	PF00082	0.483
CLV_PCSK_PC7_1	71	77	PF00082	0.643
CLV_PCSK_SKI1_1	116	120	PF00082	0.474
CLV_PCSK_SKI1_1	185	189	PF00082	0.420
CLV_PCSK_SKI1_1	333	337	PF00082	0.387
CLV_PCSK_SKI1_1	403	407	PF00082	0.375
CLV_PCSK_SKI1_1	423	427	PF00082	0.404
CLV_PCSK_SKI1_1	480	484	PF00082	0.488
CLV_PCSK_SKI1_1	554	558	PF00082	0.442
DEG_APCC_DBOX_1	312	320	PF00400	0.351
DEG_MDM2_SWIB_1	231	238	PF02201	0.420
DEG_Nend_UBRbox_3	1	3	PF02207	0.547
DEG_SPOP_SBC_1	108	112	PF00917	0.490
DEG_SPOP_SBC_1	156	160	PF00917	0.403
DEG_SPOP_SBC_1	425	429	PF00917	0.667
DOC_CKS1_1	39	44	PF01111	0.474
DOC_CKS1_1	415	420	PF01111	0.593
DOC_CYCLIN_RxL_1	175	188	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.351
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.578
DOC_MAPK_DCC_7	180	189	PF00069	0.328
DOC_MAPK_gen_1	175	184	PF00069	0.388
DOC_MAPK_gen_1	254	264	PF00069	0.351
DOC_MAPK_gen_1	311	321	PF00069	0.297
DOC_MAPK_gen_1	402	408	PF00069	0.513
DOC_MAPK_gen_1	500	510	PF00069	0.418
DOC_MAPK_MEF2A_6	116	125	PF00069	0.419
DOC_MAPK_MEF2A_6	230	238	PF00069	0.282
DOC_MAPK_MEF2A_6	257	266	PF00069	0.328
DOC_MAPK_MEF2A_6	290	297	PF00069	0.330
DOC_PP1_RVXF_1	137	144	PF00149	0.239
DOC_PP1_RVXF_1	504	511	PF00149	0.433
DOC_PP2B_LxvP_1	319	322	PF13499	0.424
DOC_PP2B_LxvP_1	345	348	PF13499	0.413
DOC_PP2B_LxvP_1	374	377	PF13499	0.351
DOC_PP2B_LxvP_1	40	43	PF13499	0.626
DOC_PP2B_LxvP_1	540	543	PF13499	0.527
DOC_PP4_FxxP_1	31	34	PF00568	0.664
DOC_USP7_MATH_1	106	110	PF00917	0.754
DOC_USP7_MATH_1	137	141	PF00917	0.402
DOC_USP7_MATH_1	18	22	PF00917	0.627
DOC_USP7_MATH_1	34	38	PF00917	0.643
DOC_USP7_MATH_1	401	405	PF00917	0.496
DOC_USP7_MATH_1	425	429	PF00917	0.646
DOC_USP7_MATH_1	439	443	PF00917	0.677
DOC_USP7_MATH_1	543	547	PF00917	0.573
DOC_WW_Pin1_4	197	202	PF00397	0.372
DOC_WW_Pin1_4	38	43	PF00397	0.521
DOC_WW_Pin1_4	414	419	PF00397	0.566
DOC_WW_Pin1_4	442	447	PF00397	0.680
DOC_WW_Pin1_4	529	534	PF00397	0.523
DOC_WW_Pin1_4	556	561	PF00397	0.468
LIG_14-3-3_CanoR_1	157	166	PF00244	0.418
LIG_14-3-3_CanoR_1	217	221	PF00244	0.355
LIG_14-3-3_CanoR_1	290	294	PF00244	0.318
LIG_14-3-3_CanoR_1	313	322	PF00244	0.317
LIG_14-3-3_CanoR_1	459	465	PF00244	0.572
LIG_14-3-3_CanoR_1	554	563	PF00244	0.392
LIG_Actin_WH2_2	214	232	PF00022	0.414
LIG_BIR_III_2	66	70	PF00653	0.526
LIG_BRCT_BRCA1_1	109	113	PF00533	0.522
LIG_BRCT_BRCA1_1	159	163	PF00533	0.403
LIG_FHA_1	118	124	PF00498	0.352
LIG_FHA_1	151	157	PF00498	0.323
LIG_FHA_1	290	296	PF00498	0.330
LIG_FHA_1	316	322	PF00498	0.411
LIG_FHA_1	323	329	PF00498	0.405
LIG_FHA_1	362	368	PF00498	0.351
LIG_FHA_1	395	401	PF00498	0.540
LIG_FHA_1	431	437	PF00498	0.696
LIG_FHA_1	487	493	PF00498	0.474
LIG_FHA_1	52	58	PF00498	0.514
LIG_FHA_2	150	156	PF00498	0.377
LIG_FHA_2	186	192	PF00498	0.390
LIG_FHA_2	237	243	PF00498	0.420
LIG_FHA_2	325	331	PF00498	0.432
LIG_FHA_2	415	421	PF00498	0.467
LIG_FHA_2	483	489	PF00498	0.402
LIG_GBD_Chelix_1	123	131	PF00786	0.478
LIG_LIR_Gen_1	129	137	PF02991	0.326
LIG_LIR_Gen_1	140	151	PF02991	0.251
LIG_LIR_Gen_1	160	170	PF02991	0.333
LIG_LIR_Gen_1	233	241	PF02991	0.416
LIG_LIR_Gen_1	340	348	PF02991	0.403
LIG_LIR_Nem_3	129	135	PF02991	0.274
LIG_LIR_Nem_3	140	146	PF02991	0.242
LIG_LIR_Nem_3	160	166	PF02991	0.333
LIG_LIR_Nem_3	233	238	PF02991	0.416
LIG_LIR_Nem_3	340	345	PF02991	0.398
LIG_LIR_Nem_3	569	575	PF02991	0.538
LIG_NRBOX	45	51	PF00104	0.479
LIG_NRBOX	463	469	PF00104	0.430
LIG_PCNA_yPIPBox_3	565	578	PF02747	0.459
LIG_Pex14_1	349	353	PF04695	0.369
LIG_Pex14_2	231	235	PF04695	0.370
LIG_REV1ctd_RIR_1	264	275	PF16727	0.351
LIG_SH2_CRK	342	346	PF00017	0.421
LIG_SH2_CRK	572	576	PF00017	0.512
LIG_SH2_SRC	320	323	PF00017	0.524
LIG_SH2_STAP1	450	454	PF00017	0.718
LIG_SH2_STAT5	237	240	PF00017	0.420
LIG_SH2_STAT5	296	299	PF00017	0.328
LIG_SH2_STAT5	320	323	PF00017	0.468
LIG_SH2_STAT5	353	356	PF00017	0.319
LIG_SH3_3	12	18	PF00018	0.480
LIG_SH3_3	443	449	PF00018	0.759
LIG_SUMO_SIM_anti_2	404	410	PF11976	0.384
LIG_SUMO_SIM_par_1	152	160	PF11976	0.323
LIG_SUMO_SIM_par_1	185	192	PF11976	0.328
LIG_SUMO_SIM_par_1	379	386	PF11976	0.339
LIG_SUMO_SIM_par_1	389	399	PF11976	0.419
LIG_SUMO_SIM_par_1	404	410	PF11976	0.285
LIG_SUMO_SIM_par_1	480	486	PF11976	0.392
LIG_TRAF2_1	159	162	PF00917	0.323
LIG_TRAF2_1	94	97	PF00917	0.554
LIG_UBA3_1	334	339	PF00899	0.496
LIG_UBA3_1	407	416	PF00899	0.554
MOD_CK1_1	109	115	PF00069	0.598
MOD_CK1_1	202	208	PF00069	0.453
MOD_CK1_1	382	388	PF00069	0.361
MOD_CK1_1	395	401	PF00069	0.418
MOD_CK1_1	424	430	PF00069	0.645
MOD_CK1_1	442	448	PF00069	0.627
MOD_CK1_1	460	466	PF00069	0.335
MOD_CK1_1	532	538	PF00069	0.540
MOD_CK1_1	574	580	PF00069	0.609
MOD_CK2_1	149	155	PF00069	0.349
MOD_CK2_1	156	162	PF00069	0.282
MOD_CK2_1	236	242	PF00069	0.420
MOD_CK2_1	324	330	PF00069	0.446
MOD_CK2_1	414	420	PF00069	0.580
MOD_CK2_1	472	478	PF00069	0.535
MOD_CK2_1	532	538	PF00069	0.537
MOD_CK2_1	545	551	PF00069	0.584
MOD_CK2_1	91	97	PF00069	0.725
MOD_GlcNHglycan	210	213	PF01048	0.400
MOD_GlcNHglycan	423	426	PF01048	0.671
MOD_GlcNHglycan	428	431	PF01048	0.656
MOD_GlcNHglycan	440	444	PF01048	0.559
MOD_GlcNHglycan	459	462	PF01048	0.428
MOD_GlcNHglycan	464	467	PF01048	0.436
MOD_GlcNHglycan	534	537	PF01048	0.540
MOD_GlcNHglycan	543	546	PF01048	0.608
MOD_GlcNHglycan	547	550	PF01048	0.607
MOD_GlcNHglycan	99	102	PF01048	0.676
MOD_GSK3_1	108	115	PF00069	0.628
MOD_GSK3_1	133	140	PF00069	0.403
MOD_GSK3_1	146	153	PF00069	0.438
MOD_GSK3_1	34	41	PF00069	0.695
MOD_GSK3_1	358	365	PF00069	0.309
MOD_GSK3_1	392	399	PF00069	0.564
MOD_GSK3_1	421	428	PF00069	0.653
MOD_GSK3_1	438	445	PF00069	0.623
MOD_GSK3_1	482	489	PF00069	0.409
MOD_GSK3_1	541	548	PF00069	0.593
MOD_GSK3_1	552	559	PF00069	0.494
MOD_GSK3_1	576	583	PF00069	0.645
MOD_GSK3_1	86	93	PF00069	0.653
MOD_N-GLC_1	486	491	PF02516	0.485
MOD_NEK2_1	126	131	PF00069	0.377
MOD_NEK2_1	262	267	PF00069	0.361
MOD_NEK2_1	338	343	PF00069	0.424
MOD_NEK2_1	394	399	PF00069	0.466
MOD_NEK2_1	426	431	PF00069	0.686
MOD_NEK2_1	462	467	PF00069	0.542
MOD_NEK2_1	482	487	PF00069	0.364
MOD_NEK2_1	521	526	PF00069	0.433
MOD_NEK2_2	315	320	PF00069	0.351
MOD_PIKK_1	157	163	PF00454	0.403
MOD_PKA_2	156	162	PF00069	0.320
MOD_PKA_2	216	222	PF00069	0.356
MOD_PKA_2	289	295	PF00069	0.326
MOD_PKA_2	401	407	PF00069	0.522
MOD_PKA_2	51	57	PF00069	0.628
MOD_PKA_2	97	103	PF00069	0.729
MOD_Plk_1	487	493	PF00069	0.464
MOD_Plk_1	521	527	PF00069	0.517
MOD_Plk_1	552	558	PF00069	0.673
MOD_Plk_2-3	324	330	PF00069	0.329
MOD_Plk_2-3	91	97	PF00069	0.555
MOD_Plk_4	126	132	PF00069	0.467
MOD_Plk_4	137	143	PF00069	0.383
MOD_Plk_4	146	152	PF00069	0.419
MOD_Plk_4	192	198	PF00069	0.366
MOD_Plk_4	216	222	PF00069	0.383
MOD_Plk_4	230	236	PF00069	0.449
MOD_Plk_4	262	268	PF00069	0.420
MOD_Plk_4	315	321	PF00069	0.338
MOD_Plk_4	324	330	PF00069	0.402
MOD_Plk_4	362	368	PF00069	0.309
MOD_ProDKin_1	197	203	PF00069	0.372
MOD_ProDKin_1	38	44	PF00069	0.518
MOD_ProDKin_1	414	420	PF00069	0.574
MOD_ProDKin_1	442	448	PF00069	0.679
MOD_ProDKin_1	529	535	PF00069	0.527
MOD_ProDKin_1	556	562	PF00069	0.466
MOD_SUMO_rev_2	191	196	PF00179	0.407
MOD_SUMO_rev_2	97	106	PF00179	0.669
TRG_DiLeu_BaEn_1	478	483	PF01217	0.390
TRG_DiLeu_BaEn_3	330	336	PF01217	0.450
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.442
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.466
TRG_ENDOCYTIC_2	342	345	PF00928	0.397
TRG_ENDOCYTIC_2	572	575	PF00928	0.585
TRG_ER_diArg_1	269	271	PF00400	0.392
TRG_ER_diArg_1	28	30	PF00400	0.490
TRG_ER_diArg_1	311	314	PF00400	0.331
TRG_ER_diArg_1	349	351	PF00400	0.387
TRG_ER_diArg_1	401	403	PF00400	0.568
TRG_ER_diArg_1	506	509	PF00400	0.445
TRG_ER_diArg_1	578	581	PF00400	0.466
TRG_ER_diArg_1	69	71	PF00400	0.641
TRG_ER_diArg_1	75	77	PF00400	0.617
TRG_ER_FFAT_2	129	140	PF00635	0.278
TRG_NES_CRM1_1	310	324	PF08389	0.420
TRG_NES_CRM1_1	373	386	PF08389	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFP5	Leptomonas seymouri	70%	100%
A0A0S4IXD9	Bodo saltans	31%	100%
A0A1X0P1R2	Trypanosomatidae	41%	100%
A0A3Q8IUI9	Leishmania donovani	29%	100%
A0A3S7XBS4	Leishmania donovani	100%	100%
A4HAQ0	Leishmania braziliensis	27%	100%
A4HQ55	Leishmania braziliensis	85%	100%
C9ZVE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ATX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P32839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4Q0M1	Leishmania major	94%	99%
Q54DY9	Dictyostelium discoideum	30%	100%
Q54HY8	Dictyostelium discoideum	27%	100%
Q5E9H5	Bos taurus	28%	100%
Q7ZV60	Danio rerio	27%	100%
Q9CZP5	Mus musculus	27%	100%
Q9Y276	Homo sapiens	27%	100%
V5BUW7	Trypanosoma cruzi	41%	100%