LeishMANIAdb
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Putative NADH dehydrogenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative NADH dehydrogenase
Gene product:
NADH dehydrogenase - putative
Species:
Leishmania infantum
UniProt:
A4IDV2_LEIIN
TriTrypDb:
LINF_360063500
Length:
527

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), NADH dehydrogenase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0020023 kinetoplast 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDV2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDV2

Function

Biological processes
Term Name Level Count
GO:0006116 NADH oxidation 3 12
GO:0006734 NADH metabolic process 2 12
GO:0008152 metabolic process 1 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0003954 NADH dehydrogenase activity 4 12
GO:0016491 oxidoreductase activity 2 12
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 156 158 PF00675 0.228
CLV_NRD_NRD_1 237 239 PF00675 0.286
CLV_NRD_NRD_1 251 253 PF00675 0.148
CLV_NRD_NRD_1 458 460 PF00675 0.413
CLV_NRD_NRD_1 490 492 PF00675 0.494
CLV_NRD_NRD_1 7 9 PF00675 0.532
CLV_PCSK_KEX2_1 158 160 PF00082 0.223
CLV_PCSK_KEX2_1 178 180 PF00082 0.211
CLV_PCSK_KEX2_1 237 239 PF00082 0.253
CLV_PCSK_KEX2_1 7 9 PF00082 0.575
CLV_PCSK_PC1ET2_1 158 160 PF00082 0.226
CLV_PCSK_PC1ET2_1 178 180 PF00082 0.226
CLV_PCSK_PC7_1 154 160 PF00082 0.211
CLV_PCSK_PC7_1 3 9 PF00082 0.449
CLV_PCSK_SKI1_1 143 147 PF00082 0.407
CLV_PCSK_SKI1_1 178 182 PF00082 0.211
CLV_PCSK_SKI1_1 290 294 PF00082 0.307
CLV_PCSK_SKI1_1 431 435 PF00082 0.350
CLV_PCSK_SKI1_1 486 490 PF00082 0.433
CLV_PCSK_SKI1_1 7 11 PF00082 0.504
CLV_PCSK_SKI1_1 96 100 PF00082 0.287
DEG_APCC_DBOX_1 2 10 PF00400 0.574
DEG_APCC_DBOX_1 413 421 PF00400 0.276
DEG_Nend_Nbox_1 1 3 PF02207 0.480
DEG_SPOP_SBC_1 53 57 PF00917 0.226
DOC_CKS1_1 47 52 PF01111 0.211
DOC_MAPK_gen_1 178 186 PF00069 0.211
DOC_MAPK_gen_1 237 244 PF00069 0.255
DOC_MAPK_gen_1 252 259 PF00069 0.143
DOC_MAPK_gen_1 296 304 PF00069 0.190
DOC_MAPK_gen_1 414 421 PF00069 0.270
DOC_MAPK_gen_1 7 17 PF00069 0.383
DOC_MAPK_gen_1 96 105 PF00069 0.354
DOC_MAPK_MEF2A_6 243 251 PF00069 0.215
DOC_MAPK_MEF2A_6 414 421 PF00069 0.270
DOC_MAPK_MEF2A_6 7 16 PF00069 0.407
DOC_MAPK_MEF2A_6 96 105 PF00069 0.245
DOC_PP4_FxxP_1 117 120 PF00568 0.238
DOC_PP4_FxxP_1 135 138 PF00568 0.211
DOC_USP7_MATH_1 170 174 PF00917 0.339
DOC_USP7_MATH_1 339 343 PF00917 0.211
DOC_USP7_MATH_1 381 385 PF00917 0.382
DOC_USP7_MATH_1 517 521 PF00917 0.648
DOC_WW_Pin1_4 459 464 PF00397 0.483
DOC_WW_Pin1_4 46 51 PF00397 0.211
DOC_WW_Pin1_4 494 499 PF00397 0.585
LIG_14-3-3_CanoR_1 131 136 PF00244 0.204
LIG_14-3-3_CanoR_1 179 185 PF00244 0.301
LIG_14-3-3_CanoR_1 252 259 PF00244 0.335
LIG_14-3-3_CanoR_1 3 7 PF00244 0.574
LIG_14-3-3_CanoR_1 443 450 PF00244 0.380
LIG_14-3-3_CanoR_1 82 88 PF00244 0.305
LIG_BRCT_BRCA1_1 361 365 PF00533 0.417
LIG_BRCT_BRCA1_1 425 429 PF00533 0.290
LIG_EVH1_2 79 83 PF00568 0.214
LIG_FHA_1 114 120 PF00498 0.245
LIG_FHA_1 132 138 PF00498 0.211
LIG_FHA_1 164 170 PF00498 0.243
LIG_FHA_1 181 187 PF00498 0.270
LIG_FHA_1 210 216 PF00498 0.335
LIG_FHA_1 252 258 PF00498 0.426
LIG_FHA_1 272 278 PF00498 0.084
LIG_FHA_1 287 293 PF00498 0.238
LIG_FHA_1 47 53 PF00498 0.211
LIG_FHA_1 474 480 PF00498 0.565
LIG_FHA_1 55 61 PF00498 0.211
LIG_FHA_2 189 195 PF00498 0.216
LIG_FHA_2 219 225 PF00498 0.237
LIG_FHA_2 258 264 PF00498 0.322
LIG_FHA_2 517 523 PF00498 0.530
LIG_LIR_Apic_2 116 120 PF02991 0.314
LIG_LIR_Apic_2 134 138 PF02991 0.211
LIG_LIR_Gen_1 118 128 PF02991 0.245
LIG_LIR_Gen_1 404 413 PF02991 0.292
LIG_LIR_Gen_1 415 424 PF02991 0.266
LIG_LIR_Gen_1 442 453 PF02991 0.423
LIG_LIR_LC3C_4 274 278 PF02991 0.212
LIG_LIR_Nem_3 118 124 PF02991 0.245
LIG_LIR_Nem_3 404 409 PF02991 0.326
LIG_LIR_Nem_3 415 421 PF02991 0.312
LIG_LIR_Nem_3 442 448 PF02991 0.322
LIG_LIR_Nem_3 59 65 PF02991 0.211
LIG_Pex14_1 21 25 PF04695 0.211
LIG_Pex14_1 402 406 PF04695 0.251
LIG_REV1ctd_RIR_1 143 152 PF16727 0.226
LIG_REV1ctd_RIR_1 200 208 PF16727 0.270
LIG_SH2_CRK 121 125 PF00017 0.211
LIG_SH2_CRK 217 221 PF00017 0.282
LIG_SH2_CRK 239 243 PF00017 0.287
LIG_SH2_CRK 25 29 PF00017 0.105
LIG_SH2_CRK 367 371 PF00017 0.348
LIG_SH2_CRK 445 449 PF00017 0.468
LIG_SH2_PTP2 418 421 PF00017 0.273
LIG_SH2_SRC 418 421 PF00017 0.367
LIG_SH2_STAP1 121 125 PF00017 0.211
LIG_SH2_STAP1 445 449 PF00017 0.468
LIG_SH2_STAP1 475 479 PF00017 0.459
LIG_SH2_STAP1 89 93 PF00017 0.305
LIG_SH2_STAT5 123 126 PF00017 0.354
LIG_SH2_STAT5 217 220 PF00017 0.305
LIG_SH2_STAT5 347 350 PF00017 0.278
LIG_SH2_STAT5 406 409 PF00017 0.292
LIG_SH2_STAT5 418 421 PF00017 0.301
LIG_SH2_STAT5 435 438 PF00017 0.301
LIG_SH2_STAT5 475 478 PF00017 0.574
LIG_SH3_3 44 50 PF00018 0.211
LIG_SH3_3 495 501 PF00018 0.565
LIG_SH3_3 62 68 PF00018 0.211
LIG_SUMO_SIM_par_1 13 19 PF11976 0.211
LIG_SUMO_SIM_par_1 380 387 PF11976 0.312
LIG_TRAF2_1 260 263 PF00917 0.344
LIG_TRAF2_1 449 452 PF00917 0.352
LIG_TYR_ITIM 119 124 PF00017 0.211
LIG_TYR_ITIM 215 220 PF00017 0.282
LIG_UBA3_1 409 416 PF00899 0.421
LIG_WRC_WIRS_1 114 119 PF05994 0.226
LIG_WRC_WIRS_1 229 234 PF05994 0.245
MOD_CK1_1 231 237 PF00069 0.181
MOD_CK1_1 369 375 PF00069 0.316
MOD_CK1_1 412 418 PF00069 0.395
MOD_CK1_1 473 479 PF00069 0.507
MOD_CK2_1 170 176 PF00069 0.267
MOD_CK2_1 188 194 PF00069 0.226
MOD_CK2_1 218 224 PF00069 0.211
MOD_CK2_1 257 263 PF00069 0.287
MOD_CK2_1 474 480 PF00069 0.567
MOD_CK2_1 516 522 PF00069 0.653
MOD_CK2_1 61 67 PF00069 0.270
MOD_GlcNHglycan 267 270 PF01048 0.337
MOD_GlcNHglycan 284 287 PF01048 0.305
MOD_GlcNHglycan 379 382 PF01048 0.267
MOD_GlcNHglycan 403 406 PF01048 0.258
MOD_GlcNHglycan 445 448 PF01048 0.428
MOD_GlcNHglycan 519 522 PF01048 0.510
MOD_GSK3_1 278 285 PF00069 0.400
MOD_GSK3_1 377 384 PF00069 0.334
MOD_GSK3_1 401 408 PF00069 0.301
MOD_GSK3_1 451 458 PF00069 0.445
MOD_GSK3_1 470 477 PF00069 0.519
MOD_GSK3_1 52 59 PF00069 0.214
MOD_N-GLC_1 210 215 PF02516 0.323
MOD_N-GLC_1 377 382 PF02516 0.384
MOD_N-GLC_1 473 478 PF02516 0.493
MOD_N-GLC_2 33 35 PF02516 0.270
MOD_N-GLC_2 394 396 PF02516 0.275
MOD_NEK2_1 1 6 PF00069 0.531
MOD_NEK2_1 180 185 PF00069 0.269
MOD_NEK2_1 493 498 PF00069 0.511
MOD_NEK2_1 83 88 PF00069 0.329
MOD_PIKK_1 423 429 PF00454 0.425
MOD_PIKK_1 506 512 PF00454 0.533
MOD_PKA_1 7 13 PF00069 0.482
MOD_PKA_2 2 8 PF00069 0.480
MOD_PKA_2 251 257 PF00069 0.292
MOD_PKA_2 300 306 PF00069 0.269
MOD_Plk_1 210 216 PF00069 0.323
MOD_Plk_1 377 383 PF00069 0.394
MOD_Plk_1 431 437 PF00069 0.295
MOD_Plk_2-3 61 67 PF00069 0.270
MOD_Plk_4 180 186 PF00069 0.270
MOD_Plk_4 210 216 PF00069 0.270
MOD_Plk_4 218 224 PF00069 0.154
MOD_Plk_4 405 411 PF00069 0.292
MOD_ProDKin_1 459 465 PF00069 0.489
MOD_ProDKin_1 46 52 PF00069 0.211
MOD_ProDKin_1 494 500 PF00069 0.589
MOD_SUMO_rev_2 173 180 PF00179 0.226
MOD_SUMO_rev_2 201 210 PF00179 0.305
MOD_SUMO_rev_2 520 527 PF00179 0.616
MOD_SUMO_rev_2 90 98 PF00179 0.305
TRG_DiLeu_BaEn_1 176 181 PF01217 0.211
TRG_DiLeu_BaEn_1 351 356 PF01217 0.411
TRG_DiLeu_BaEn_3 141 147 PF01217 0.331
TRG_DiLeu_BaLyEn_6 47 52 PF01217 0.211
TRG_DiLeu_LyEn_5 176 181 PF01217 0.211
TRG_ENDOCYTIC_2 121 124 PF00928 0.211
TRG_ENDOCYTIC_2 217 220 PF00928 0.305
TRG_ENDOCYTIC_2 239 242 PF00928 0.341
TRG_ENDOCYTIC_2 25 28 PF00928 0.105
TRG_ENDOCYTIC_2 367 370 PF00928 0.330
TRG_ENDOCYTIC_2 406 409 PF00928 0.272
TRG_ENDOCYTIC_2 418 421 PF00928 0.273
TRG_ENDOCYTIC_2 445 448 PF00928 0.467
TRG_ER_diArg_1 156 159 PF00400 0.227
TRG_ER_diArg_1 236 238 PF00400 0.261
TRG_ER_diArg_1 299 302 PF00400 0.222
TRG_ER_diArg_1 6 8 PF00400 0.575
TRG_NLS_MonoExtC_3 458 463 PF00514 0.392
TRG_NLS_MonoExtN_4 154 161 PF00514 0.226
TRG_Pf-PMV_PEXEL_1 309 313 PF00026 0.354
TRG_Pf-PMV_PEXEL_1 491 495 PF00026 0.642

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P920 Leptomonas seymouri 80% 99%
A0A0S4IWQ4 Bodo saltans 59% 100%
A0A1X0P0A4 Trypanosomatidae 61% 100%
A0A3Q8IL33 Leishmania donovani 100% 100%
A0A3R7KGC5 Trypanosoma rangeli 61% 100%
A4HQ53 Leishmania braziliensis 85% 100%
D0A465 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9ATX3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F2Z699 Yarrowia lipolytica (strain CLIB 122 / E 150) 32% 91%
M0ZYF3 Solanum tuberosum 42% 100%
O05267 Bacillus subtilis (strain 168) 31% 100%
O14121 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 96%
O43090 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 31% 96%
O80874 Arabidopsis thaliana 42% 100%
P00393 Escherichia coli (strain K12) 29% 100%
P32340 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
P40215 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 94%
P44856 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 25% 100%
P73735 Synechocystis sp. (strain PCC 6803 / Kazusa) 26% 100%
P80861 Bacillus subtilis (strain 168) 24% 100%
P95160 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 28% 100%
P95200 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 100%
Q07500 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 97%
Q2FID4 Staphylococcus aureus (strain USA300) 26% 100%
Q2FZV7 Staphylococcus aureus (strain NCTC 8325 / PS 47) 26% 100%
Q2YWP9 Staphylococcus aureus (strain bovine RF122 / ET3-1) 26% 100%
Q49W80 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 26% 100%
Q4L4V6 Staphylococcus haemolyticus (strain JCSC1435) 27% 100%
Q4Q0M3 Leishmania major 97% 100%
Q55CD9 Dictyostelium discoideum 39% 100%
Q58065 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 24% 100%
Q5HHE4 Staphylococcus aureus (strain COL) 26% 100%
Q5HQM1 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 25% 100%
Q6GAY5 Staphylococcus aureus (strain MSSA476) 26% 100%
Q6GIE7 Staphylococcus aureus (strain MRSA252) 26% 100%
Q7A6J4 Staphylococcus aureus (strain N315) 26% 100%
Q8CPV5 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 25% 100%
Q8GWA1 Arabidopsis thaliana 41% 100%
Q8GXR9 Arabidopsis thaliana 24% 100%
Q8NXG0 Staphylococcus aureus (strain MW2) 26% 100%
Q99VE0 Staphylococcus aureus (strain Mu50 / ATCC 700699) 26% 100%
Q9SKT7 Arabidopsis thaliana 36% 91%
Q9ST63 Solanum tuberosum 43% 100%
V5DLP7 Trypanosoma cruzi 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS