LeishMANIAdb
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Putative tyrosine specific protein phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative tyrosine specific protein phosphatase
Gene product:
tyrosine specific protein phosphatase - putative
Species:
Leishmania infantum
UniProt:
A4IDV1_LEIIN
TriTrypDb:
LINF_360063400
Length:
493

Annotations

Annotations by Jardim et al.

Phosphatase, tyrosine specific phosphatase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDV1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDV1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 8
GO:0006793 phosphorus metabolic process 3 8
GO:0006796 phosphate-containing compound metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 8
GO:0009987 cellular process 1 8
GO:0016311 dephosphorylation 5 8
GO:0019538 protein metabolic process 3 8
GO:0036211 protein modification process 4 8
GO:0043170 macromolecule metabolic process 3 8
GO:0043412 macromolecule modification 4 8
GO:0044237 cellular metabolic process 2 8
GO:0044238 primary metabolic process 2 8
GO:0071704 organic substance metabolic process 2 8
GO:1901564 organonitrogen compound metabolic process 3 8
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 8
GO:0004721 phosphoprotein phosphatase activity 3 8
GO:0004725 protein tyrosine phosphatase activity 4 8
GO:0016787 hydrolase activity 2 8
GO:0016788 hydrolase activity, acting on ester bonds 3 8
GO:0016791 phosphatase activity 5 8
GO:0042578 phosphoric ester hydrolase activity 4 8
GO:0140096 catalytic activity, acting on a protein 2 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 84 88 PF00656 0.424
CLV_NRD_NRD_1 17 19 PF00675 0.574
CLV_NRD_NRD_1 180 182 PF00675 0.372
CLV_NRD_NRD_1 281 283 PF00675 0.375
CLV_NRD_NRD_1 39 41 PF00675 0.522
CLV_PCSK_FUR_1 484 488 PF00082 0.652
CLV_PCSK_KEX2_1 17 19 PF00082 0.534
CLV_PCSK_KEX2_1 180 182 PF00082 0.372
CLV_PCSK_KEX2_1 39 41 PF00082 0.522
CLV_PCSK_KEX2_1 486 488 PF00082 0.625
CLV_PCSK_PC1ET2_1 486 488 PF00082 0.657
CLV_PCSK_SKI1_1 180 184 PF00082 0.430
CLV_PCSK_SKI1_1 270 274 PF00082 0.410
CLV_PCSK_SKI1_1 299 303 PF00082 0.510
CLV_PCSK_SKI1_1 347 351 PF00082 0.783
CLV_PCSK_SKI1_1 4 8 PF00082 0.468
DEG_APCC_DBOX_1 180 188 PF00400 0.410
DEG_APCC_KENBOX_2 140 144 PF00400 0.387
DEG_SCF_FBW7_1 352 358 PF00400 0.556
DOC_CKS1_1 352 357 PF01111 0.632
DOC_CYCLIN_RxL_1 174 186 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 336 342 PF00134 0.759
DOC_MAPK_DCC_7 99 109 PF00069 0.430
DOC_MAPK_gen_1 282 289 PF00069 0.420
DOC_MAPK_gen_1 7 16 PF00069 0.510
DOC_MAPK_gen_1 99 106 PF00069 0.430
DOC_MAPK_MEF2A_6 101 109 PF00069 0.430
DOC_MAPK_MEF2A_6 242 251 PF00069 0.376
DOC_PP2B_LxvP_1 336 339 PF13499 0.765
DOC_PP2B_LxvP_1 428 431 PF13499 0.749
DOC_PP4_FxxP_1 102 105 PF00568 0.376
DOC_SPAK_OSR1_1 11 15 PF12202 0.506
DOC_USP7_MATH_1 208 212 PF00917 0.387
DOC_USP7_MATH_1 355 359 PF00917 0.692
DOC_USP7_MATH_2 364 370 PF00917 0.705
DOC_USP7_UBL2_3 141 145 PF12436 0.410
DOC_WW_Pin1_4 221 226 PF00397 0.390
DOC_WW_Pin1_4 227 232 PF00397 0.359
DOC_WW_Pin1_4 331 336 PF00397 0.647
DOC_WW_Pin1_4 351 356 PF00397 0.436
DOC_WW_Pin1_4 367 372 PF00397 0.697
DOC_WW_Pin1_4 393 398 PF00397 0.709
DOC_WW_Pin1_4 400 405 PF00397 0.720
DOC_WW_Pin1_4 426 431 PF00397 0.696
DOC_WW_Pin1_4 460 465 PF00397 0.750
DOC_WW_Pin1_4 486 491 PF00397 0.671
LIG_14-3-3_CanoR_1 226 234 PF00244 0.424
LIG_14-3-3_CanoR_1 299 308 PF00244 0.501
LIG_14-3-3_CanoR_1 357 367 PF00244 0.763
LIG_14-3-3_CanoR_1 424 429 PF00244 0.726
LIG_14-3-3_CanoR_1 452 458 PF00244 0.786
LIG_14-3-3_CanoR_1 467 472 PF00244 0.572
LIG_BRCT_BRCA1_1 488 492 PF00533 0.681
LIG_CtBP_PxDLS_1 397 401 PF00389 0.573
LIG_FHA_1 275 281 PF00498 0.410
LIG_FHA_1 460 466 PF00498 0.720
LIG_FHA_1 467 473 PF00498 0.595
LIG_FHA_2 116 122 PF00498 0.346
LIG_FHA_2 211 217 PF00498 0.419
LIG_FHA_2 321 327 PF00498 0.707
LIG_Integrin_RGD_1 188 190 PF01839 0.462
LIG_LIR_Apic_2 100 105 PF02991 0.430
LIG_LIR_Apic_2 148 154 PF02991 0.397
LIG_LIR_Gen_1 130 140 PF02991 0.376
LIG_LIR_Gen_1 284 293 PF02991 0.376
LIG_LIR_Nem_3 121 126 PF02991 0.376
LIG_LIR_Nem_3 243 249 PF02991 0.430
LIG_LIR_Nem_3 284 289 PF02991 0.376
LIG_LIR_Nem_3 442 448 PF02991 0.646
LIG_LYPXL_S_1 23 27 PF13949 0.557
LIG_LYPXL_yS_3 24 27 PF13949 0.559
LIG_OCRL_FandH_1 245 257 PF00620 0.430
LIG_PCNA_yPIPBox_3 294 305 PF02747 0.454
LIG_PDZ_Class_1 488 493 PF00595 0.686
LIG_Pex14_1 123 127 PF04695 0.376
LIG_Pex14_2 102 106 PF04695 0.376
LIG_Pex14_2 488 492 PF04695 0.681
LIG_PTB_Apo_2 89 96 PF02174 0.376
LIG_PTB_Phospho_1 89 95 PF10480 0.346
LIG_SH2_GRB2like 127 130 PF00017 0.430
LIG_SH2_GRB2like 90 93 PF00017 0.376
LIG_SH2_PTP2 286 289 PF00017 0.430
LIG_SH2_SRC 90 93 PF00017 0.357
LIG_SH2_SRC 95 98 PF00017 0.363
LIG_SH2_STAP1 53 57 PF00017 0.455
LIG_SH2_STAT3 195 198 PF00017 0.353
LIG_SH2_STAT3 291 294 PF00017 0.376
LIG_SH2_STAT5 108 111 PF00017 0.376
LIG_SH2_STAT5 199 202 PF00017 0.376
LIG_SH2_STAT5 286 289 PF00017 0.359
LIG_SH2_STAT5 390 393 PF00017 0.650
LIG_SH2_STAT5 44 47 PF00017 0.482
LIG_SH2_STAT5 90 93 PF00017 0.376
LIG_SH2_STAT5 95 98 PF00017 0.376
LIG_SH3_3 197 203 PF00018 0.410
LIG_SH3_3 391 397 PF00018 0.590
LIG_SH3_3 428 434 PF00018 0.741
LIG_SH3_3 435 441 PF00018 0.712
LIG_SUMO_SIM_anti_2 165 171 PF11976 0.410
LIG_SUMO_SIM_anti_2 210 216 PF11976 0.501
LIG_SUMO_SIM_par_1 162 167 PF11976 0.430
LIG_UBA3_1 214 223 PF00899 0.376
LIG_WW_3 152 156 PF00397 0.397
MOD_CDK_SPK_2 221 226 PF00069 0.501
MOD_CDK_SPxK_1 351 357 PF00069 0.554
MOD_CDK_SPxxK_3 460 467 PF00069 0.726
MOD_CK1_1 210 216 PF00069 0.411
MOD_CK1_1 224 230 PF00069 0.309
MOD_CK1_1 351 357 PF00069 0.720
MOD_CK1_1 358 364 PF00069 0.713
MOD_CK1_1 396 402 PF00069 0.716
MOD_CK1_1 415 421 PF00069 0.692
MOD_CK1_1 429 435 PF00069 0.754
MOD_CK1_1 451 457 PF00069 0.738
MOD_CK1_1 459 465 PF00069 0.689
MOD_CK1_1 56 62 PF00069 0.485
MOD_CK2_1 210 216 PF00069 0.430
MOD_CK2_1 320 326 PF00069 0.670
MOD_DYRK1A_RPxSP_1 393 397 PF00069 0.563
MOD_GlcNHglycan 130 133 PF01048 0.501
MOD_GlcNHglycan 236 239 PF01048 0.376
MOD_GlcNHglycan 360 363 PF01048 0.790
MOD_GlcNHglycan 53 56 PF01048 0.547
MOD_GSK3_1 217 224 PF00069 0.411
MOD_GSK3_1 327 334 PF00069 0.697
MOD_GSK3_1 351 358 PF00069 0.647
MOD_GSK3_1 362 369 PF00069 0.785
MOD_GSK3_1 396 403 PF00069 0.771
MOD_GSK3_1 412 419 PF00069 0.617
MOD_GSK3_1 429 436 PF00069 0.706
MOD_GSK3_1 447 454 PF00069 0.706
MOD_GSK3_1 456 463 PF00069 0.800
MOD_GSK3_1 53 60 PF00069 0.465
MOD_N-GLC_1 128 133 PF02516 0.501
MOD_N-GLC_1 261 266 PF02516 0.365
MOD_N-GLC_1 79 84 PF02516 0.365
MOD_NEK2_1 115 120 PF00069 0.341
MOD_NEK2_1 164 169 PF00069 0.426
MOD_NEK2_1 183 188 PF00069 0.212
MOD_NEK2_1 217 222 PF00069 0.430
MOD_NEK2_1 300 305 PF00069 0.502
MOD_NEK2_1 310 315 PF00069 0.634
MOD_NEK2_1 350 355 PF00069 0.710
MOD_NEK2_1 356 361 PF00069 0.738
MOD_NEK2_1 423 428 PF00069 0.750
MOD_NEK2_1 458 463 PF00069 0.738
MOD_NEK2_1 466 471 PF00069 0.701
MOD_NEK2_1 57 62 PF00069 0.486
MOD_NEK2_1 79 84 PF00069 0.501
MOD_PIKK_1 108 114 PF00454 0.376
MOD_PIKK_1 225 231 PF00454 0.424
MOD_PIKK_1 300 306 PF00454 0.611
MOD_PIKK_1 327 333 PF00454 0.739
MOD_PIKK_1 81 87 PF00454 0.424
MOD_PK_1 174 180 PF00069 0.410
MOD_PKA_2 225 231 PF00069 0.501
MOD_PKA_2 356 362 PF00069 0.725
MOD_PKA_2 423 429 PF00069 0.807
MOD_PKA_2 451 457 PF00069 0.792
MOD_PKA_2 466 472 PF00069 0.545
MOD_Plk_1 128 134 PF00069 0.501
MOD_Plk_1 261 267 PF00069 0.365
MOD_Plk_1 410 416 PF00069 0.741
MOD_Plk_2-3 383 389 PF00069 0.685
MOD_Plk_4 115 121 PF00069 0.376
MOD_Plk_4 147 153 PF00069 0.430
MOD_Plk_4 164 170 PF00069 0.430
MOD_Plk_4 210 216 PF00069 0.430
MOD_Plk_4 453 459 PF00069 0.746
MOD_Plk_4 467 473 PF00069 0.520
MOD_Plk_4 72 78 PF00069 0.349
MOD_Plk_4 86 92 PF00069 0.295
MOD_ProDKin_1 221 227 PF00069 0.390
MOD_ProDKin_1 331 337 PF00069 0.644
MOD_ProDKin_1 351 357 PF00069 0.438
MOD_ProDKin_1 367 373 PF00069 0.699
MOD_ProDKin_1 393 399 PF00069 0.711
MOD_ProDKin_1 400 406 PF00069 0.719
MOD_ProDKin_1 426 432 PF00069 0.697
MOD_ProDKin_1 460 466 PF00069 0.749
MOD_ProDKin_1 486 492 PF00069 0.677
MOD_SUMO_for_1 146 149 PF00179 0.430
MOD_SUMO_rev_2 186 194 PF00179 0.421
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.424
TRG_DiLeu_BaLyEn_6 332 337 PF01217 0.696
TRG_DiLeu_BaLyEn_6 461 466 PF01217 0.682
TRG_ENDOCYTIC_2 24 27 PF00928 0.501
TRG_ENDOCYTIC_2 286 289 PF00928 0.376
TRG_ENDOCYTIC_2 290 293 PF00928 0.376
TRG_ER_diArg_1 16 18 PF00400 0.603
TRG_ER_diArg_1 180 182 PF00400 0.372
TRG_ER_diArg_1 314 317 PF00400 0.647
TRG_ER_diArg_1 38 40 PF00400 0.510
TRG_Pf-PMV_PEXEL_1 17 21 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P9E1 Leptomonas seymouri 66% 96%
A0A3Q8ILM2 Leishmania donovani 99% 100%
A4HQ52 Leishmania braziliensis 77% 100%
E9ATX2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q0M4 Leishmania major 95% 100%
V5B554 Trypanosoma cruzi 47% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS