DUF2040 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDV0_LEIIN

TriTrypDb:

LINF_360062400

Length:

195

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.534
CLV_NRD_NRD_1	174	176	PF00675	0.498
CLV_NRD_NRD_1	64	66	PF00675	0.498
CLV_PCSK_KEX2_1	112	114	PF00082	0.560
CLV_PCSK_KEX2_1	174	176	PF00082	0.468
CLV_PCSK_KEX2_1	52	54	PF00082	0.518
CLV_PCSK_KEX2_1	64	66	PF00082	0.484
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.560
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.477
CLV_PCSK_SKI1_1	12	16	PF00082	0.528
CLV_PCSK_SKI1_1	47	51	PF00082	0.459
CLV_PCSK_SKI1_1	82	86	PF00082	0.662
DEG_Nend_Nbox_1	1	3	PF02207	0.698
DEG_SCF_FBW7_2	91	96	PF00400	0.412
DOC_MAPK_gen_1	152	160	PF00069	0.460
DOC_MAPK_gen_1	25	34	PF00069	0.569
DOC_MAPK_gen_1	81	88	PF00069	0.629
DOC_MAPK_MEF2A_6	28	36	PF00069	0.563
DOC_MAPK_RevD_3	98	112	PF00069	0.546
DOC_USP7_UBL2_3	132	136	PF12436	0.570
DOC_WW_Pin1_4	89	94	PF00397	0.610
LIG_14-3-3_CanoR_1	174	180	PF00244	0.546
LIG_14-3-3_CanoR_1	31	35	PF00244	0.498
LIG_FHA_1	128	134	PF00498	0.533
LIG_FHA_1	31	37	PF00498	0.560
LIG_FHA_1	83	89	PF00498	0.604
LIG_FHA_2	1	7	PF00498	0.687
LIG_FHA_2	13	19	PF00498	0.449
LIG_FHA_2	174	180	PF00498	0.484
LIG_FHA_2	186	192	PF00498	0.576
LIG_Rb_pABgroove_1	52	60	PF01858	0.521
LIG_Rb_pABgroove_1	98	106	PF01858	0.484
LIG_SH2_SRC	58	61	PF00017	0.447
LIG_SH2_STAP1	104	108	PF00017	0.426
LIG_SH2_STAP1	161	165	PF00017	0.519
LIG_SH2_STAP1	58	62	PF00017	0.451
LIG_SH2_STAT5	164	167	PF00017	0.495
LIG_SH2_STAT5	2	5	PF00017	0.577
LIG_SH3_2	170	175	PF14604	0.410
LIG_SH3_3	167	173	PF00018	0.401
LIG_SH3_3	35	41	PF00018	0.521
LIG_SUMO_SIM_par_1	83	89	PF11976	0.526
LIG_TRAF2_1	15	18	PF00917	0.520
LIG_TRAF2_1	93	96	PF00917	0.499
LIG_WW_3	171	175	PF00397	0.411
MOD_CK1_1	43	49	PF00069	0.582
MOD_CK2_1	12	18	PF00069	0.491
MOD_CK2_1	121	127	PF00069	0.638
MOD_CK2_1	173	179	PF00069	0.456
MOD_CK2_1	185	191	PF00069	0.533
MOD_GlcNHglycan	182	185	PF01048	0.505
MOD_GSK3_1	127	134	PF00069	0.528
MOD_GSK3_1	26	33	PF00069	0.606
MOD_GSK3_1	4	11	PF00069	0.555
MOD_GSK3_1	82	89	PF00069	0.550
MOD_NEK2_1	26	31	PF00069	0.561
MOD_PKA_2	127	133	PF00069	0.510
MOD_PKA_2	173	179	PF00069	0.538
MOD_PKA_2	24	30	PF00069	0.485
MOD_PKA_2	4	10	PF00069	0.678
MOD_Plk_1	104	110	PF00069	0.389
MOD_Plk_1	58	64	PF00069	0.489
MOD_Plk_1	82	88	PF00069	0.590
MOD_ProDKin_1	89	95	PF00069	0.605
MOD_SUMO_rev_2	29	39	PF00179	0.514
TRG_ER_diArg_1	173	175	PF00400	0.594
TRG_ER_diArg_1	64	67	PF00400	0.575
TRG_NLS_MonoExtC_3	110	116	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAU2	Leptomonas seymouri	66%	100%
A0A0S4ITG8	Bodo saltans	31%	94%
A0A0S4ITU7	Bodo saltans	29%	100%
A0A0S4IZ88	Bodo saltans	25%	100%
A0A0S4KH12	Bodo saltans	33%	98%
A0A1X0P384	Trypanosomatidae	39%	100%
A0A1X0P828	Trypanosomatidae	27%	100%
A0A3Q8IJ52	Leishmania donovani	100%	100%
A0A422NMA5	Trypanosoma rangeli	40%	100%
A4HQ43	Leishmania braziliensis	78%	100%
D0A8S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AIX6	Leishmania braziliensis	27%	100%
E9ATW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0N3	Leishmania major	93%	100%