Endonuclease/exonuclease protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease protein-like protein

Species:

Leishmania infantum

UniProt:

A4IDU8_LEIIN

TriTrypDb:

LINF_360062200

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDU8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0033554	cellular response to stress	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0046483	heterocycle metabolic process	3	10
GO:0050896	response to stimulus	1	10
GO:0051716	cellular response to stimulus	2	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:0006284	base-excision repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004527	exonuclease activity	5	7
GO:0005488	binding	1	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	3
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008309	double-stranded DNA exodeoxyribonuclease activity	7	1
GO:0008311	double-stranded DNA 3'-5' DNA exonuclease activity	8	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.245
CLV_C14_Caspase3-7	437	441	PF00656	0.336
CLV_C14_Caspase3-7	705	709	PF00656	0.599
CLV_NRD_NRD_1	129	131	PF00675	0.298
CLV_NRD_NRD_1	194	196	PF00675	0.308
CLV_NRD_NRD_1	222	224	PF00675	0.297
CLV_NRD_NRD_1	482	484	PF00675	0.333
CLV_NRD_NRD_1	65	67	PF00675	0.391
CLV_NRD_NRD_1	82	84	PF00675	0.391
CLV_PCSK_FUR_1	480	484	PF00082	0.298
CLV_PCSK_KEX2_1	222	224	PF00082	0.274
CLV_PCSK_KEX2_1	257	259	PF00082	0.460
CLV_PCSK_KEX2_1	482	484	PF00082	0.274
CLV_PCSK_KEX2_1	65	67	PF00082	0.391
CLV_PCSK_KEX2_1	682	684	PF00082	0.705
CLV_PCSK_KEX2_1	80	82	PF00082	0.391
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.336
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.705
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.282
CLV_PCSK_SKI1_1	131	135	PF00082	0.284
CLV_PCSK_SKI1_1	309	313	PF00082	0.371
DEG_APCC_DBOX_1	222	230	PF00400	0.298
DEG_APCC_DBOX_1	308	316	PF00400	0.336
DEG_Nend_Nbox_1	1	3	PF02207	0.293
DEG_SPOP_SBC_1	285	289	PF00917	0.302
DEG_SPOP_SBC_1	398	402	PF00917	0.302
DOC_CKS1_1	591	596	PF01111	0.327
DOC_CKS1_1	655	660	PF01111	0.531
DOC_CYCLIN_yCln2_LP_2	318	321	PF00134	0.336
DOC_MAPK_gen_1	649	655	PF00069	0.418
DOC_MAPK_MEF2A_6	196	205	PF00069	0.268
DOC_MAPK_MEF2A_6	391	399	PF00069	0.394
DOC_MAPK_MEF2A_6	630	639	PF00069	0.506
DOC_PP1_RVXF_1	129	136	PF00149	0.298
DOC_PP1_RVXF_1	178	184	PF00149	0.407
DOC_PP1_RVXF_1	576	583	PF00149	0.415
DOC_PP2B_LxvP_1	318	321	PF13499	0.336
DOC_PP2B_LxvP_1	395	398	PF13499	0.383
DOC_PP2B_PxIxI_1	200	206	PF00149	0.391
DOC_PP2B_PxIxI_1	449	455	PF00149	0.279
DOC_PP4_FxxP_1	591	594	PF00568	0.320
DOC_USP7_MATH_1	285	289	PF00917	0.385
DOC_USP7_MATH_1	321	325	PF00917	0.428
DOC_USP7_MATH_1	352	356	PF00917	0.302
DOC_USP7_MATH_1	398	402	PF00917	0.302
DOC_USP7_MATH_1	519	523	PF00917	0.675
DOC_USP7_MATH_1	529	533	PF00917	0.621
DOC_USP7_MATH_1	651	655	PF00917	0.532
DOC_USP7_MATH_1	684	688	PF00917	0.716
DOC_USP7_MATH_1	690	694	PF00917	0.672
DOC_USP7_MATH_1	696	700	PF00917	0.632
DOC_USP7_UBL2_3	196	200	PF12436	0.277
DOC_USP7_UBL2_3	253	257	PF12436	0.481
DOC_WW_Pin1_4	333	338	PF00397	0.223
DOC_WW_Pin1_4	358	363	PF00397	0.485
DOC_WW_Pin1_4	409	414	PF00397	0.388
DOC_WW_Pin1_4	446	451	PF00397	0.480
DOC_WW_Pin1_4	49	54	PF00397	0.391
DOC_WW_Pin1_4	590	595	PF00397	0.321
DOC_WW_Pin1_4	654	659	PF00397	0.522
LIG_14-3-3_CanoR_1	130	136	PF00244	0.298
LIG_14-3-3_CanoR_1	152	158	PF00244	0.298
LIG_14-3-3_CanoR_1	176	180	PF00244	0.262
LIG_14-3-3_CanoR_1	314	319	PF00244	0.496
LIG_14-3-3_CanoR_1	350	358	PF00244	0.406
LIG_14-3-3_CanoR_1	396	405	PF00244	0.403
LIG_14-3-3_CanoR_1	407	413	PF00244	0.336
LIG_14-3-3_CanoR_1	521	529	PF00244	0.635
LIG_APCC_ABBA_1	378	383	PF00400	0.298
LIG_BRCT_BRCA1_1	138	142	PF00533	0.315
LIG_BRCT_BRCA1_1	384	388	PF00533	0.298
LIG_CtBP_PxDLS_1	338	342	PF00389	0.336
LIG_CtBP_PxDLS_1	53	57	PF00389	0.374
LIG_deltaCOP1_diTrp_1	106	112	PF00928	0.277
LIG_EVH1_1	560	564	PF00568	0.498
LIG_EVH1_2	561	565	PF00568	0.521
LIG_FHA_1	176	182	PF00498	0.317
LIG_FHA_1	243	249	PF00498	0.310
LIG_FHA_1	289	295	PF00498	0.454
LIG_FHA_1	429	435	PF00498	0.380
LIG_FHA_1	655	661	PF00498	0.551
LIG_FHA_2	232	238	PF00498	0.306
LIG_FHA_2	30	36	PF00498	0.282
LIG_FHA_2	472	478	PF00498	0.274
LIG_FHA_2	487	493	PF00498	0.274
LIG_FHA_2	525	531	PF00498	0.647
LIG_FHA_2	612	618	PF00498	0.480
LIG_FHA_2	703	709	PF00498	0.724
LIG_GBD_Chelix_1	259	267	PF00786	0.302
LIG_LIR_Apic_2	333	337	PF02991	0.317
LIG_LIR_Apic_2	588	594	PF02991	0.319
LIG_LIR_Gen_1	106	114	PF02991	0.298
LIG_LIR_Gen_1	159	169	PF02991	0.264
LIG_LIR_Gen_1	234	243	PF02991	0.280
LIG_LIR_Gen_1	367	378	PF02991	0.336
LIG_LIR_Gen_1	492	501	PF02991	0.274
LIG_LIR_Gen_1	536	547	PF02991	0.404
LIG_LIR_Nem_3	106	111	PF02991	0.277
LIG_LIR_Nem_3	159	164	PF02991	0.264
LIG_LIR_Nem_3	20	25	PF02991	0.274
LIG_LIR_Nem_3	234	238	PF02991	0.280
LIG_LIR_Nem_3	367	373	PF02991	0.322
LIG_LIR_Nem_3	492	496	PF02991	0.274
LIG_LIR_Nem_3	536	542	PF02991	0.433
LIG_LIR_Nem_3	579	585	PF02991	0.459
LIG_MYND_1	463	467	PF01753	0.391
LIG_NRBOX	225	231	PF00104	0.391
LIG_OCRL_FandH_1	21	33	PF00620	0.313
LIG_PCNA_yPIPBox_3	359	373	PF02747	0.333
LIG_PDZ_Class_3	727	732	PF00595	0.567
LIG_Pex14_2	179	183	PF04695	0.298
LIG_Pex14_2	2	6	PF04695	0.310
LIG_PTB_Apo_2	554	561	PF02174	0.484
LIG_PTB_Phospho_1	554	560	PF10480	0.483
LIG_Rb_pABgroove_1	339	347	PF01858	0.336
LIG_SH2_CRK	370	374	PF00017	0.332
LIG_SH2_CRK	633	637	PF00017	0.400
LIG_SH2_NCK_1	334	338	PF00017	0.391
LIG_SH2_NCK_1	370	374	PF00017	0.223
LIG_SH2_NCK_1	442	446	PF00017	0.223
LIG_SH2_PTP2	493	496	PF00017	0.274
LIG_SH2_STAP1	353	357	PF00017	0.391
LIG_SH2_STAT5	167	170	PF00017	0.307
LIG_SH2_STAT5	212	215	PF00017	0.302
LIG_SH2_STAT5	353	356	PF00017	0.257
LIG_SH2_STAT5	468	471	PF00017	0.291
LIG_SH2_STAT5	473	476	PF00017	0.257
LIG_SH2_STAT5	493	496	PF00017	0.274
LIG_SH3_1	464	470	PF00018	0.336
LIG_SH3_3	163	169	PF00018	0.391
LIG_SH3_3	457	463	PF00018	0.328
LIG_SH3_3	464	470	PF00018	0.279
LIG_SH3_3	513	519	PF00018	0.403
LIG_SH3_3	558	564	PF00018	0.410
LIG_SH3_3	589	595	PF00018	0.359
LIG_SH3_3	65	71	PF00018	0.462
LIG_SH3_3	652	658	PF00018	0.616
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.423
LIG_SUMO_SIM_par_1	201	207	PF11976	0.298
LIG_SUMO_SIM_par_1	291	299	PF11976	0.349
LIG_SUMO_SIM_par_1	651	657	PF11976	0.651
LIG_SUMO_SIM_par_1	725	731	PF11976	0.597
LIG_TRAF2_1	76	79	PF00917	0.311
LIG_TRAF2_2	594	599	PF00917	0.330
LIG_TYR_ITIM	491	496	PF00017	0.274
LIG_UBA3_1	36	43	PF00899	0.391
LIG_WRC_WIRS_1	125	130	PF05994	0.325
LIG_WRC_WIRS_1	232	237	PF05994	0.401
LIG_WRC_WIRS_1	639	644	PF05994	0.485
LIG_WRC_WIRS_1	691	696	PF05994	0.544
LIG_WW_3	319	323	PF00397	0.336
MOD_CK1_1	110	116	PF00069	0.337
MOD_CK1_1	12	18	PF00069	0.333
MOD_CK1_1	21	27	PF00069	0.333
MOD_CK1_1	277	283	PF00069	0.410
MOD_CK1_1	288	294	PF00069	0.375
MOD_CK1_1	295	301	PF00069	0.426
MOD_CK1_1	303	309	PF00069	0.466
MOD_CK1_1	324	330	PF00069	0.400
MOD_CK1_1	382	388	PF00069	0.403
MOD_CK1_1	523	529	PF00069	0.627
MOD_CK1_1	654	660	PF00069	0.608
MOD_CK1_1	692	698	PF00069	0.701
MOD_CK1_1	93	99	PF00069	0.395
MOD_CK2_1	231	237	PF00069	0.389
MOD_CK2_1	524	530	PF00069	0.609
MOD_CK2_1	611	617	PF00069	0.481
MOD_CK2_1	706	712	PF00069	0.641
MOD_GlcNHglycan	114	117	PF01048	0.298
MOD_GlcNHglycan	158	161	PF01048	0.264
MOD_GlcNHglycan	279	283	PF01048	0.391
MOD_GlcNHglycan	288	291	PF01048	0.412
MOD_GlcNHglycan	323	326	PF01048	0.403
MOD_GlcNHglycan	383	387	PF01048	0.391
MOD_GlcNHglycan	401	404	PF01048	0.444
MOD_GlcNHglycan	49	52	PF01048	0.476
MOD_GlcNHglycan	497	500	PF01048	0.343
MOD_GlcNHglycan	523	526	PF01048	0.644
MOD_GlcNHglycan	621	624	PF01048	0.609
MOD_GlcNHglycan	694	697	PF01048	0.698
MOD_GlcNHglycan	698	701	PF01048	0.677
MOD_GlcNHglycan	96	99	PF01048	0.305
MOD_GSK3_1	136	143	PF00069	0.366
MOD_GSK3_1	274	281	PF00069	0.413
MOD_GSK3_1	284	291	PF00069	0.324
MOD_GSK3_1	295	302	PF00069	0.389
MOD_GSK3_1	333	340	PF00069	0.470
MOD_GSK3_1	428	435	PF00069	0.430
MOD_GSK3_1	519	526	PF00069	0.621
MOD_GSK3_1	690	697	PF00069	0.720
MOD_GSK3_1	702	709	PF00069	0.722
MOD_GSK3_1	90	97	PF00069	0.395
MOD_N-GLC_1	208	213	PF02516	0.274
MOD_N-GLC_1	300	305	PF02516	0.330
MOD_NEK2_1	2	7	PF00069	0.287
MOD_NEK2_1	208	213	PF00069	0.280
MOD_NEK2_1	262	267	PF00069	0.336
MOD_NEK2_1	278	283	PF00069	0.373
MOD_NEK2_1	357	362	PF00069	0.368
MOD_NEK2_1	428	433	PF00069	0.316
MOD_NEK2_1	495	500	PF00069	0.336
MOD_NEK2_1	565	570	PF00069	0.438
MOD_NEK2_1	619	624	PF00069	0.525
MOD_NEK2_1	694	699	PF00069	0.703
MOD_NEK2_2	175	180	PF00069	0.245
MOD_NEK2_2	217	222	PF00069	0.333
MOD_NEK2_2	638	643	PF00069	0.575
MOD_OFUCOSY	469	475	PF10250	0.335
MOD_PIKK_1	12	18	PF00454	0.370
MOD_PIKK_1	136	142	PF00454	0.329
MOD_PIKK_1	421	427	PF00454	0.308
MOD_PKA_1	195	201	PF00069	0.360
MOD_PKA_2	175	181	PF00069	0.282
MOD_PKA_2	18	24	PF00069	0.328
MOD_PKA_2	321	327	PF00069	0.455
MOD_PKA_2	520	526	PF00069	0.657
MOD_Plk_1	208	214	PF00069	0.274
MOD_Plk_1	303	309	PF00069	0.268
MOD_Plk_1	90	96	PF00069	0.223
MOD_Plk_2-3	708	714	PF00069	0.509
MOD_Plk_4	107	113	PF00069	0.314
MOD_Plk_4	225	231	PF00069	0.280
MOD_Plk_4	314	320	PF00069	0.327
MOD_Plk_4	428	434	PF00069	0.333
MOD_Plk_4	638	644	PF00069	0.489
MOD_ProDKin_1	333	339	PF00069	0.223
MOD_ProDKin_1	358	364	PF00069	0.485
MOD_ProDKin_1	409	415	PF00069	0.388
MOD_ProDKin_1	446	452	PF00069	0.480
MOD_ProDKin_1	49	55	PF00069	0.391
MOD_ProDKin_1	590	596	PF00069	0.325
MOD_ProDKin_1	654	660	PF00069	0.525
MOD_SUMO_rev_2	35	45	PF00179	0.274
MOD_SUMO_rev_2	622	632	PF00179	0.519
MOD_SUMO_rev_2	663	671	PF00179	0.598
TRG_AP2beta_CARGO_1	536	546	PF09066	0.442
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.391
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.336
TRG_ENDOCYTIC_2	370	373	PF00928	0.332
TRG_ENDOCYTIC_2	493	496	PF00928	0.274
TRG_ER_diArg_1	221	223	PF00400	0.275
TRG_ER_diArg_1	462	465	PF00400	0.468
TRG_ER_diArg_1	480	483	PF00400	0.231
TRG_ER_diArg_1	65	67	PF00400	0.391
TRG_ER_diArg_1	81	83	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB73	Leptomonas seymouri	58%	98%
A0A1X0P3V4	Trypanosomatidae	37%	100%
A0A3R7M024	Trypanosoma rangeli	41%	100%
A0A3S7XBT9	Leishmania donovani	100%	100%
D0A8S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIY2	Leishmania braziliensis	79%	100%
E9ATW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0N5	Leishmania major	93%	100%