LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
kinesin-like protein - putative
Species:
Leishmania infantum
UniProt:
A4IDT7_LEIIN
TriTrypDb:
LINF_360061000
Length:
625

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 2
Pissara et al. yes yes: 8
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0005871 kinesin complex 3 1
GO:0005874 microtubule 6 2
GO:0005875 microtubule associated complex 2 1
GO:0015630 microtubule cytoskeleton 6 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0099080 supramolecular complex 2 2
GO:0099081 supramolecular polymer 3 2
GO:0099512 supramolecular fiber 4 2
GO:0099513 polymeric cytoskeletal fiber 5 2
GO:0110165 cellular anatomical entity 1 2

Phosphorylation

Amastigote: 523, 604

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDT7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDT7

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 14
GO:0007018 microtubule-based movement 3 14
GO:0009987 cellular process 1 14
GO:0000226 microtubule cytoskeleton organization 3 1
GO:0000902 cell morphogenesis 3 1
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0009653 anatomical structure morphogenesis 2 1
GO:0016043 cellular component organization 3 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0031122 cytoplasmic microtubule organization 4 1
GO:0032502 developmental process 1 1
GO:0043622 cortical microtubule organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003774 cytoskeletal motor activity 1 14
GO:0003777 microtubule motor activity 2 14
GO:0005488 binding 1 14
GO:0005515 protein binding 2 14
GO:0005524 ATP binding 5 14
GO:0008017 microtubule binding 5 14
GO:0008092 cytoskeletal protein binding 3 14
GO:0015631 tubulin binding 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140657 ATP-dependent activity 1 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14
GO:0003824 catalytic activity 1 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 191 195 PF00656 0.271
CLV_NRD_NRD_1 265 267 PF00675 0.326
CLV_NRD_NRD_1 367 369 PF00675 0.527
CLV_NRD_NRD_1 380 382 PF00675 0.545
CLV_NRD_NRD_1 439 441 PF00675 0.536
CLV_NRD_NRD_1 510 512 PF00675 0.614
CLV_NRD_NRD_1 528 530 PF00675 0.626
CLV_NRD_NRD_1 58 60 PF00675 0.404
CLV_NRD_NRD_1 607 609 PF00675 0.481
CLV_PCSK_KEX2_1 234 236 PF00082 0.409
CLV_PCSK_KEX2_1 265 267 PF00082 0.326
CLV_PCSK_KEX2_1 367 369 PF00082 0.551
CLV_PCSK_KEX2_1 450 452 PF00082 0.482
CLV_PCSK_KEX2_1 469 471 PF00082 0.565
CLV_PCSK_KEX2_1 528 530 PF00082 0.584
CLV_PCSK_KEX2_1 58 60 PF00082 0.501
CLV_PCSK_KEX2_1 607 609 PF00082 0.466
CLV_PCSK_KEX2_1 86 88 PF00082 0.531
CLV_PCSK_PC1ET2_1 234 236 PF00082 0.424
CLV_PCSK_PC1ET2_1 450 452 PF00082 0.526
CLV_PCSK_PC1ET2_1 469 471 PF00082 0.410
CLV_PCSK_PC1ET2_1 86 88 PF00082 0.531
CLV_PCSK_PC7_1 230 236 PF00082 0.386
CLV_PCSK_SKI1_1 138 142 PF00082 0.294
CLV_PCSK_SKI1_1 17 21 PF00082 0.412
CLV_PCSK_SKI1_1 349 353 PF00082 0.429
CLV_PCSK_SKI1_1 35 39 PF00082 0.305
CLV_PCSK_SKI1_1 420 424 PF00082 0.492
CLV_PCSK_SKI1_1 528 532 PF00082 0.587
CLV_PCSK_SKI1_1 87 91 PF00082 0.340
DOC_CKS1_1 199 204 PF01111 0.406
DOC_MAPK_gen_1 263 272 PF00069 0.348
DOC_MAPK_gen_1 381 389 PF00069 0.571
DOC_MAPK_MEF2A_6 263 271 PF00069 0.367
DOC_MAPK_RevD_3 219 235 PF00069 0.358
DOC_PP4_FxxP_1 251 254 PF00568 0.437
DOC_PP4_FxxP_1 72 75 PF00568 0.551
DOC_USP7_MATH_1 117 121 PF00917 0.340
DOC_USP7_MATH_1 28 32 PF00917 0.567
DOC_USP7_MATH_1 433 437 PF00917 0.576
DOC_USP7_MATH_1 579 583 PF00917 0.513
DOC_USP7_MATH_1 79 83 PF00917 0.623
DOC_USP7_UBL2_3 81 85 PF12436 0.614
DOC_WW_Pin1_4 198 203 PF00397 0.420
DOC_WW_Pin1_4 215 220 PF00397 0.420
DOC_WW_Pin1_4 326 331 PF00397 0.305
DOC_WW_Pin1_4 520 525 PF00397 0.531
LIG_14-3-3_CanoR_1 124 129 PF00244 0.288
LIG_14-3-3_CanoR_1 17 26 PF00244 0.320
LIG_14-3-3_CanoR_1 235 243 PF00244 0.398
LIG_14-3-3_CanoR_1 244 251 PF00244 0.432
LIG_14-3-3_CanoR_1 381 389 PF00244 0.551
LIG_14-3-3_CanoR_1 511 519 PF00244 0.616
LIG_14-3-3_CanoR_1 552 558 PF00244 0.641
LIG_14-3-3_CanoR_1 87 95 PF00244 0.397
LIG_APCC_ABBA_1 328 333 PF00400 0.356
LIG_BRCT_BRCA1_1 121 125 PF00533 0.351
LIG_BRCT_BRCA1_1 241 245 PF00533 0.434
LIG_CaM_IQ_9 222 237 PF13499 0.382
LIG_CaM_IQ_9 339 354 PF13499 0.513
LIG_deltaCOP1_diTrp_1 67 72 PF00928 0.529
LIG_FHA_1 216 222 PF00498 0.461
LIG_FHA_1 236 242 PF00498 0.270
LIG_FHA_1 410 416 PF00498 0.390
LIG_FHA_1 511 517 PF00498 0.568
LIG_FHA_2 173 179 PF00498 0.323
LIG_FHA_2 18 24 PF00498 0.407
LIG_FHA_2 189 195 PF00498 0.347
LIG_FHA_2 409 415 PF00498 0.500
LIG_FHA_2 552 558 PF00498 0.684
LIG_FHA_2 600 606 PF00498 0.465
LIG_FHA_2 88 94 PF00498 0.314
LIG_KLC1_Yacidic_2 174 178 PF13176 0.347
LIG_LIR_Apic_2 248 254 PF02991 0.416
LIG_LIR_Apic_2 71 75 PF02991 0.503
LIG_LIR_Gen_1 12 21 PF02991 0.422
LIG_LIR_Gen_1 174 181 PF02991 0.274
LIG_LIR_Gen_1 305 316 PF02991 0.351
LIG_LIR_Gen_1 329 339 PF02991 0.457
LIG_LIR_Gen_1 360 370 PF02991 0.582
LIG_LIR_Gen_1 456 464 PF02991 0.648
LIG_LIR_Gen_1 93 103 PF02991 0.288
LIG_LIR_Nem_3 12 16 PF02991 0.382
LIG_LIR_Nem_3 122 128 PF02991 0.358
LIG_LIR_Nem_3 174 179 PF02991 0.274
LIG_LIR_Nem_3 305 311 PF02991 0.373
LIG_LIR_Nem_3 93 98 PF02991 0.293
LIG_NRBOX 269 275 PF00104 0.334
LIG_Pex14_2 245 249 PF04695 0.384
LIG_Pex14_2 308 312 PF04695 0.425
LIG_SH2_CRK 95 99 PF00017 0.293
LIG_SH2_NCK_1 110 114 PF00017 0.299
LIG_SH2_NCK_1 572 576 PF00017 0.508
LIG_SH2_PTP2 176 179 PF00017 0.323
LIG_SH2_SRC 572 575 PF00017 0.456
LIG_SH2_STAP1 499 503 PF00017 0.632
LIG_SH2_STAP1 572 576 PF00017 0.532
LIG_SH2_STAP1 595 599 PF00017 0.515
LIG_SH2_STAT5 126 129 PF00017 0.347
LIG_SH2_STAT5 176 179 PF00017 0.323
LIG_SH2_STAT5 54 57 PF00017 0.403
LIG_SH3_3 199 205 PF00018 0.349
LIG_SH3_3 45 51 PF00018 0.477
LIG_SH3_3 518 524 PF00018 0.501
LIG_SH3_3 95 101 PF00018 0.302
LIG_SUMO_SIM_anti_2 174 182 PF11976 0.309
LIG_SUMO_SIM_anti_2 385 391 PF11976 0.538
LIG_SUMO_SIM_anti_2 398 403 PF11976 0.363
LIG_SUMO_SIM_par_1 44 50 PF11976 0.354
LIG_TRAF2_1 71 74 PF00917 0.512
LIG_TRAF2_1 75 78 PF00917 0.594
LIG_WRC_WIRS_1 149 154 PF05994 0.296
LIG_WRC_WIRS_1 69 74 PF05994 0.367
MOD_CK1_1 160 166 PF00069 0.309
MOD_CK1_1 172 178 PF00069 0.336
MOD_CK1_1 188 194 PF00069 0.356
MOD_CK1_1 200 206 PF00069 0.401
MOD_CK1_1 237 243 PF00069 0.393
MOD_CK1_1 306 312 PF00069 0.401
MOD_CK1_1 326 332 PF00069 0.412
MOD_CK1_1 4 10 PF00069 0.553
MOD_CK2_1 17 23 PF00069 0.381
MOD_CK2_1 214 220 PF00069 0.383
MOD_CK2_1 359 365 PF00069 0.525
MOD_CK2_1 408 414 PF00069 0.508
MOD_CK2_1 520 526 PF00069 0.495
MOD_CK2_1 551 557 PF00069 0.640
MOD_CK2_1 599 605 PF00069 0.604
MOD_CK2_1 68 74 PF00069 0.450
MOD_GlcNHglycan 121 124 PF01048 0.303
MOD_GlcNHglycan 170 174 PF01048 0.348
MOD_GlcNHglycan 191 194 PF01048 0.449
MOD_GlcNHglycan 202 205 PF01048 0.359
MOD_GlcNHglycan 278 281 PF01048 0.479
MOD_GlcNHglycan 29 33 PF01048 0.581
MOD_GlcNHglycan 292 295 PF01048 0.423
MOD_GlcNHglycan 305 308 PF01048 0.410
MOD_GSK3_1 1 8 PF00069 0.655
MOD_GSK3_1 185 192 PF00069 0.356
MOD_GSK3_1 235 242 PF00069 0.373
MOD_GSK3_1 257 264 PF00069 0.513
MOD_GSK3_1 338 345 PF00069 0.495
MOD_GSK3_1 409 416 PF00069 0.439
MOD_GSK3_1 597 604 PF00069 0.385
MOD_N-GLC_1 158 163 PF02516 0.327
MOD_N-GLC_1 235 240 PF02516 0.490
MOD_N-GLC_1 257 262 PF02516 0.548
MOD_N-GLC_1 408 413 PF02516 0.518
MOD_NEK2_1 1 6 PF00069 0.599
MOD_NEK2_1 179 184 PF00069 0.387
MOD_NEK2_1 342 347 PF00069 0.455
MOD_NEK2_1 80 85 PF00069 0.653
MOD_PIKK_1 599 605 PF00454 0.627
MOD_PIKK_1 615 621 PF00454 0.578
MOD_PIKK_1 87 93 PF00454 0.301
MOD_PK_1 512 518 PF00069 0.453
MOD_PKA_1 234 240 PF00069 0.391
MOD_PKA_1 615 621 PF00069 0.615
MOD_PKA_2 234 240 PF00069 0.399
MOD_PKA_2 243 249 PF00069 0.398
MOD_PKA_2 303 309 PF00069 0.307
MOD_PKA_2 380 386 PF00069 0.509
MOD_PKA_2 510 516 PF00069 0.610
MOD_PKA_2 551 557 PF00069 0.620
MOD_PKB_1 15 23 PF00069 0.317
MOD_Plk_1 158 164 PF00069 0.296
MOD_Plk_1 257 263 PF00069 0.540
MOD_Plk_1 28 34 PF00069 0.533
MOD_Plk_1 359 365 PF00069 0.549
MOD_Plk_4 124 130 PF00069 0.271
MOD_Plk_4 172 178 PF00069 0.287
MOD_Plk_4 311 317 PF00069 0.436
MOD_Plk_4 359 365 PF00069 0.531
MOD_Plk_4 385 391 PF00069 0.447
MOD_ProDKin_1 198 204 PF00069 0.420
MOD_ProDKin_1 215 221 PF00069 0.420
MOD_ProDKin_1 326 332 PF00069 0.313
MOD_ProDKin_1 520 526 PF00069 0.531
MOD_SUMO_for_1 402 405 PF00179 0.478
MOD_SUMO_for_1 593 596 PF00179 0.556
MOD_SUMO_rev_2 22 26 PF00179 0.482
MOD_SUMO_rev_2 371 376 PF00179 0.462
MOD_SUMO_rev_2 379 383 PF00179 0.358
MOD_SUMO_rev_2 474 480 PF00179 0.521
MOD_SUMO_rev_2 505 513 PF00179 0.594
MOD_SUMO_rev_2 533 541 PF00179 0.603
MOD_SUMO_rev_2 611 618 PF00179 0.516
TRG_ENDOCYTIC_2 176 179 PF00928 0.288
TRG_ENDOCYTIC_2 229 232 PF00928 0.288
TRG_ENDOCYTIC_2 332 335 PF00928 0.509
TRG_ENDOCYTIC_2 54 57 PF00928 0.403
TRG_ENDOCYTIC_2 95 98 PF00928 0.274
TRG_ER_diArg_1 14 17 PF00400 0.317
TRG_ER_diArg_1 265 267 PF00400 0.326
TRG_ER_diArg_1 366 368 PF00400 0.549
TRG_ER_diArg_1 528 530 PF00400 0.552
TRG_ER_diArg_1 57 59 PF00400 0.513
TRG_ER_diArg_1 606 608 PF00400 0.542
TRG_NES_CRM1_1 385 400 PF08389 0.350
TRG_NES_CRM1_1 453 465 PF08389 0.554
TRG_NLS_MonoExtN_4 347 353 PF00514 0.518
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 367 371 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 529 534 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 607 611 PF00026 0.485

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1K9 Leptomonas seymouri 69% 100%
A0A0S4IR67 Bodo saltans 23% 80%
A0A0S4J0Q2 Bodo saltans 22% 75%
A0A0S4JFN9 Bodo saltans 23% 73%
A0A0S4JPE8 Bodo saltans 33% 69%
A0A0S4JRN9 Bodo saltans 23% 95%
A0A1X0NWZ8 Trypanosomatidae 23% 84%
A0A1X0P435 Trypanosomatidae 43% 100%
A0A3R7KHX7 Trypanosoma rangeli 21% 85%
A0A3S7XBW9 Leishmania donovani 100% 100%
A0A422NMD1 Trypanosoma rangeli 45% 100%
A4HQ31 Leishmania braziliensis 75% 100%
D0A8T5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9ATU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
P46873 Caenorhabditis elegans 22% 89%
Q1MTQ1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 100%
Q4Q0P7 Leishmania major 94% 100%
Q4QEL8 Leishmania major 23% 77%
V5B6Q5 Trypanosoma cruzi 44% 100%
V5D733 Trypanosoma cruzi 23% 83%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS