Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

VHS domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IDT6_LEIIN

TriTrypDb:

LINF_360060900

Length:

518

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Phosphorylation

Promastigote/Amastigote: 419

Expansion

Sequence features

A4IDT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDT6

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0007034	vacuolar transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0016192	vesicle-mediated transport	4	10
GO:0016197	endosomal transport	4	10
GO:0032509	endosome transport via multivesicular body sorting pathway	5	10
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	10

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0005543	phospholipid binding	3	10
GO:0008289	lipid binding	2	10
GO:0032182	ubiquitin-like protein binding	3	10
GO:0035091	phosphatidylinositol binding	4	10
GO:0043130	ubiquitin binding	4	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.489
CLV_C14_Caspase3-7	291	295	PF00656	0.463
CLV_C14_Caspase3-7	432	436	PF00656	0.592
CLV_C14_Caspase3-7	463	467	PF00656	0.591
CLV_NRD_NRD_1	187	189	PF00675	0.683
CLV_NRD_NRD_1	65	67	PF00675	0.332
CLV_PCSK_FUR_1	185	189	PF00082	0.749
CLV_PCSK_FUR_1	210	214	PF00082	0.643
CLV_PCSK_KEX2_1	187	189	PF00082	0.740
CLV_PCSK_KEX2_1	212	214	PF00082	0.689

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB53	Leptomonas seymouri	58%	96%
A0A0S4JSH6	Bodo saltans	34%	100%
A0A3Q8IJX3	Leishmania donovani	100%	100%
A0A3R7M014	Trypanosoma rangeli	41%	100%
A4HQ30	Leishmania braziliensis	65%	99%
E9ATU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4Q0P8	Leishmania major	87%	100%
V5BM99	Trypanosoma cruzi	40%	100%

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