Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDT5_LEIIN

TriTrypDb:

LINF_360060800

Length:

278

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.328
CLV_C14_Caspase3-7	272	276	PF00656	0.409
CLV_MEL_PAP_1	133	139	PF00089	0.306
CLV_NRD_NRD_1	207	209	PF00675	0.460
CLV_PCSK_KEX2_1	152	154	PF00082	0.525
CLV_PCSK_KEX2_1	206	208	PF00082	0.487
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.525
CLV_PCSK_SKI1_1	157	161	PF00082	0.441
CLV_PCSK_SKI1_1	222	226	PF00082	0.447
DEG_APCC_DBOX_1	77	85	PF00400	0.453
DOC_MAPK_MEF2A_6	183	192	PF00069	0.408
DOC_PP4_FxxP_1	45	48	PF00568	0.345
DOC_USP7_MATH_1	102	106	PF00917	0.333
DOC_USP7_MATH_1	143	147	PF00917	0.341
DOC_USP7_MATH_1	151	155	PF00917	0.316
DOC_USP7_MATH_1	227	231	PF00917	0.489
DOC_USP7_MATH_1	255	259	PF00917	0.463
DOC_USP7_MATH_1	73	77	PF00917	0.456
DOC_USP7_UBL2_3	107	111	PF12436	0.470
DOC_WW_Pin1_4	119	124	PF00397	0.505
DOC_WW_Pin1_4	214	219	PF00397	0.367
DOC_WW_Pin1_4	44	49	PF00397	0.505
LIG_14-3-3_CanoR_1	136	142	PF00244	0.343
LIG_14-3-3_CanoR_1	183	189	PF00244	0.420
LIG_14-3-3_CanoR_1	240	248	PF00244	0.463
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_BIR_III_4	23	27	PF00653	0.302
LIG_BRCT_BRCA1_1	70	74	PF00533	0.479
LIG_FHA_1	132	138	PF00498	0.363
LIG_FHA_2	194	200	PF00498	0.493
LIG_FHA_2	270	276	PF00498	0.400
LIG_FHA_2	91	97	PF00498	0.493
LIG_HCF-1_HBM_1	139	142	PF13415	0.263
LIG_LIR_Apic_2	56	60	PF02991	0.341
LIG_LIR_Gen_1	158	167	PF02991	0.345
LIG_LIR_Gen_1	38	48	PF02991	0.351
LIG_LIR_Gen_1	6	14	PF02991	0.317
LIG_LIR_Nem_3	158	162	PF02991	0.372
LIG_LIR_Nem_3	38	43	PF02991	0.371
LIG_LIR_Nem_3	6	10	PF02991	0.323
LIG_LIR_Nem_3	75	80	PF02991	0.337
LIG_SH2_CRK	166	170	PF00017	0.431
LIG_SH2_CRK	7	11	PF00017	0.324
LIG_SH2_GRB2like	7	10	PF00017	0.249
LIG_SH2_NCK_1	57	61	PF00017	0.401
LIG_SH2_SRC	197	200	PF00017	0.435
LIG_SH2_STAP1	234	238	PF00017	0.507
LIG_SH2_STAP1	7	11	PF00017	0.410
LIG_SH2_STAT5	17	20	PF00017	0.406
LIG_SH2_STAT5	197	200	PF00017	0.340
LIG_SH2_STAT5	234	237	PF00017	0.429
LIG_SH2_STAT5	7	10	PF00017	0.396
LIG_SH2_STAT5	80	83	PF00017	0.442
LIG_WW_1	4	7	PF00397	0.440
MOD_CK1_1	118	124	PF00069	0.369
MOD_CK1_1	230	236	PF00069	0.431
MOD_CK1_1	61	67	PF00069	0.490
MOD_CK1_1	68	74	PF00069	0.452
MOD_CK2_1	73	79	PF00069	0.482
MOD_CK2_1	90	96	PF00069	0.395
MOD_GlcNHglycan	1	4	PF01048	0.530
MOD_GlcNHglycan	153	156	PF01048	0.361
MOD_GlcNHglycan	257	260	PF01048	0.472
MOD_GlcNHglycan	70	73	PF01048	0.401
MOD_GSK3_1	102	109	PF00069	0.415
MOD_GSK3_1	115	122	PF00069	0.414
MOD_GSK3_1	131	138	PF00069	0.247
MOD_GSK3_1	230	237	PF00069	0.384
MOD_GSK3_1	246	253	PF00069	0.253
MOD_GSK3_1	58	65	PF00069	0.355
MOD_GSK3_1	68	75	PF00069	0.318
MOD_N-GLC_1	115	120	PF02516	0.436
MOD_N-GLC_1	131	136	PF02516	0.334
MOD_N-GLC_1	227	232	PF02516	0.439
MOD_N-GLC_1	240	245	PF02516	0.343
MOD_N-GLC_1	90	95	PF02516	0.362
MOD_NEK2_1	115	120	PF00069	0.388
MOD_NEK2_1	248	253	PF00069	0.367
MOD_NEK2_1	269	274	PF00069	0.463
MOD_NEK2_2	102	107	PF00069	0.457
MOD_NEK2_2	178	183	PF00069	0.452
MOD_NEK2_2	62	67	PF00069	0.469
MOD_OFUCOSY	113	119	PF10250	0.240
MOD_PKA_2	135	141	PF00069	0.346
MOD_Plk_1	157	163	PF00069	0.354
MOD_Plk_4	193	199	PF00069	0.472
MOD_Plk_4	80	86	PF00069	0.386
MOD_ProDKin_1	119	125	PF00069	0.511
MOD_ProDKin_1	214	220	PF00069	0.370
MOD_ProDKin_1	44	50	PF00069	0.500
MOD_SUMO_rev_2	146	154	PF00179	0.476
TRG_DiLeu_BaEn_2	204	210	PF01217	0.408
TRG_ENDOCYTIC_2	7	10	PF00928	0.412
TRG_ER_diArg_1	206	208	PF00400	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P495	Leptomonas seymouri	61%	100%
A0A0S4JKK5	Bodo saltans	24%	98%
A0A1X0P327	Trypanosomatidae	35%	96%
A0A3Q8IPM4	Leishmania donovani	99%	100%
A0A422NMF9	Trypanosoma rangeli	35%	100%
A4HQ29	Leishmania braziliensis	77%	100%
D0A8T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ATU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0P9	Leishmania major	90%	100%
V5BWK1	Trypanosoma cruzi	35%	100%