Apolipophorin

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Apolipophorin

Gene product:

Domain of unknown function (DUF4496) - putative

Species:

Leishmania infantum

UniProt:

A4IDT3_LEIIN

TriTrypDb:

LINF_360060600

Length:

264

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IDT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDT3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.406
CLV_C14_Caspase3-7	249	253	PF00656	0.562
CLV_NRD_NRD_1	260	262	PF00675	0.614
CLV_PCSK_KEX2_1	260	262	PF00082	0.648
CLV_PCSK_KEX2_1	61	63	PF00082	0.308
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.308
CLV_PCSK_SKI1_1	107	111	PF00082	0.525
CLV_PCSK_SKI1_1	186	190	PF00082	0.288
CLV_PCSK_SKI1_1	78	82	PF00082	0.318
DEG_APCC_DBOX_1	185	193	PF00400	0.288
DEG_Nend_UBRbox_2	1	3	PF02207	0.746
DOC_CKS1_1	201	206	PF01111	0.538
DOC_MAPK_gen_1	60	69	PF00069	0.400
DOC_MAPK_MEF2A_6	60	69	PF00069	0.400
DOC_MAPK_NFAT4_5	62	70	PF00069	0.400
DOC_SPAK_OSR1_1	138	142	PF12202	0.308
DOC_USP7_UBL2_3	103	107	PF12436	0.390
DOC_WW_Pin1_4	200	205	PF00397	0.480
LIG_14-3-3_CanoR_1	158	168	PF00244	0.344
LIG_14-3-3_CanoR_1	191	197	PF00244	0.385
LIG_14-3-3_CanoR_1	244	250	PF00244	0.547
LIG_BRCT_BRCA1_1	184	188	PF00533	0.344
LIG_FHA_1	161	167	PF00498	0.365
LIG_FHA_2	201	207	PF00498	0.519
LIG_FHA_2	22	28	PF00498	0.373
LIG_LIR_Apic_2	203	208	PF02991	0.433
LIG_LIR_Gen_1	124	134	PF02991	0.312
LIG_LIR_Nem_3	124	130	PF02991	0.289
LIG_Pex14_1	184	188	PF04695	0.284
LIG_Pex14_2	100	104	PF04695	0.308
LIG_SH2_CRK	205	209	PF00017	0.455
LIG_SH2_NCK_1	205	209	PF00017	0.455
LIG_SH2_PTP2	127	130	PF00017	0.312
LIG_SH2_SRC	205	208	PF00017	0.435
LIG_SH2_STAT3	30	33	PF00017	0.284
LIG_SH2_STAT5	127	130	PF00017	0.412
LIG_SH2_STAT5	155	158	PF00017	0.324
LIG_SH3_2	215	220	PF14604	0.538
LIG_SH3_3	198	204	PF00018	0.468
LIG_SH3_3	212	218	PF00018	0.543
LIG_SH3_3	92	98	PF00018	0.263
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.227
LIG_SUMO_SIM_par_1	162	167	PF11976	0.344
LIG_SUMO_SIM_par_1	21	27	PF11976	0.227
LIG_SUMO_SIM_par_1	93	99	PF11976	0.286
LIG_TYR_ITIM	125	130	PF00017	0.308
MOD_CK1_1	123	129	PF00069	0.349
MOD_CK1_1	162	168	PF00069	0.360
MOD_CK1_1	243	249	PF00069	0.619
MOD_CK1_1	5	11	PF00069	0.587
MOD_CK2_1	145	151	PF00069	0.284
MOD_CK2_1	243	249	PF00069	0.576
MOD_GlcNHglycan	245	248	PF01048	0.628
MOD_GlcNHglycan	62	65	PF01048	0.400
MOD_GlcNHglycan	7	10	PF01048	0.649
MOD_GSK3_1	1	8	PF00069	0.736
MOD_GSK3_1	117	124	PF00069	0.522
MOD_GSK3_1	129	136	PF00069	0.335
MOD_GSK3_1	255	262	PF00069	0.520
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	192	197	PF00069	0.360
MOD_NEK2_1	230	235	PF00069	0.432
MOD_NEK2_1	240	245	PF00069	0.495
MOD_NEK2_1	254	259	PF00069	0.476
MOD_NEK2_1	31	36	PF00069	0.342
MOD_NEK2_1	70	75	PF00069	0.284
MOD_NEK2_1	82	87	PF00069	0.284
MOD_PIKK_1	230	236	PF00454	0.533
MOD_PKA_1	60	66	PF00069	0.344
MOD_PKA_2	192	198	PF00069	0.388
MOD_PKA_2	235	241	PF00069	0.497
MOD_PKA_2	243	249	PF00069	0.521
MOD_Plk_1	176	182	PF00069	0.360
MOD_Plk_1	82	88	PF00069	0.399
MOD_Plk_2-3	21	27	PF00069	0.227
MOD_Plk_4	123	129	PF00069	0.360
MOD_Plk_4	21	27	PF00069	0.405
MOD_Plk_4	235	241	PF00069	0.534
MOD_ProDKin_1	200	206	PF00069	0.484
MOD_SUMO_rev_2	83	92	PF00179	0.379
TRG_DiLeu_BaEn_1	21	26	PF01217	0.227
TRG_ENDOCYTIC_2	127	130	PF00928	0.308
TRG_ENDOCYTIC_2	16	19	PF00928	0.324
TRG_ER_diArg_1	259	261	PF00400	0.668
TRG_NES_CRM1_1	21	33	PF08389	0.251
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P360	Leptomonas seymouri	77%	100%
A0A1X0NFH5	Trypanosomatidae	53%	100%
A0A3Q8IJR1	Leishmania donovani	100%	100%
A0A422N6F8	Trypanosoma rangeli	55%	83%
A4HQ27	Leishmania braziliensis	86%	100%
D0A8U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ATU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q0Q1	Leishmania major	95%	100%