LeishMANIAdb
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Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Similar to
Gene product:
32 kDa ER-associated protein - putative
Species:
Leishmania infantum
UniProt:
A4IDS8_LEIIN
TriTrypDb:
LINF_360060000
Length:
267

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, 32 kDa ER-associated Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 8
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDS8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.384
CLV_NRD_NRD_1 137 139 PF00675 0.527
CLV_NRD_NRD_1 222 224 PF00675 0.552
CLV_NRD_NRD_1 243 245 PF00675 0.680
CLV_NRD_NRD_1 50 52 PF00675 0.654
CLV_PCSK_KEX2_1 137 139 PF00082 0.543
CLV_PCSK_KEX2_1 222 224 PF00082 0.552
CLV_PCSK_KEX2_1 242 244 PF00082 0.482
CLV_PCSK_KEX2_1 52 54 PF00082 0.658
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.655
CLV_PCSK_SKI1_1 243 247 PF00082 0.676
CLV_PCSK_SKI1_1 61 65 PF00082 0.677
CLV_PCSK_SKI1_1 99 103 PF00082 0.564
DEG_APCC_DBOX_1 10 18 PF00400 0.424
DEG_SPOP_SBC_1 22 26 PF00917 0.478
DOC_MAPK_FxFP_2 169 172 PF00069 0.401
DOC_MAPK_gen_1 150 159 PF00069 0.368
DOC_MAPK_gen_1 71 81 PF00069 0.423
DOC_MAPK_HePTP_8 147 159 PF00069 0.390
DOC_MAPK_MEF2A_6 150 159 PF00069 0.364
DOC_MAPK_MEF2A_6 74 83 PF00069 0.391
DOC_MAPK_NFAT4_5 152 160 PF00069 0.402
DOC_PP1_RVXF_1 2 8 PF00149 0.647
DOC_PP2B_LxvP_1 157 160 PF13499 0.409
DOC_PP4_FxxP_1 169 172 PF00568 0.377
DOC_PP4_FxxP_1 64 67 PF00568 0.438
DOC_USP7_MATH_1 160 164 PF00917 0.417
DOC_USP7_MATH_1 22 26 PF00917 0.443
DOC_WW_Pin1_4 209 214 PF00397 0.442
DOC_WW_Pin1_4 63 68 PF00397 0.374
DOC_WW_Pin1_4 85 90 PF00397 0.416
DOC_WW_Pin1_4 94 99 PF00397 0.377
LIG_14-3-3_CanoR_1 4 10 PF00244 0.664
LIG_14-3-3_CanoR_1 51 60 PF00244 0.474
LIG_14-3-3_CterR_2 263 267 PF00244 0.477
LIG_Actin_WH2_2 102 118 PF00022 0.418
LIG_BRCT_BRCA1_1 24 28 PF00533 0.443
LIG_BRCT_BRCA1_1 87 91 PF00533 0.477
LIG_deltaCOP1_diTrp_1 58 64 PF00928 0.472
LIG_FHA_1 174 180 PF00498 0.348
LIG_FHA_1 205 211 PF00498 0.507
LIG_FHA_1 232 238 PF00498 0.448
LIG_FHA_1 91 97 PF00498 0.413
LIG_FHA_2 149 155 PF00498 0.355
LIG_FHA_2 189 195 PF00498 0.370
LIG_LIR_Apic_2 162 167 PF02991 0.423
LIG_LIR_Apic_2 44 48 PF02991 0.450
LIG_LIR_Apic_2 62 67 PF02991 0.424
LIG_LIR_Gen_1 153 164 PF02991 0.383
LIG_LIR_Gen_1 78 86 PF02991 0.422
LIG_LIR_Gen_1 88 98 PF02991 0.357
LIG_LIR_Nem_3 153 159 PF02991 0.384
LIG_LIR_Nem_3 212 217 PF02991 0.400
LIG_LIR_Nem_3 54 59 PF02991 0.447
LIG_LIR_Nem_3 62 68 PF02991 0.435
LIG_LIR_Nem_3 78 83 PF02991 0.377
LIG_LIR_Nem_3 88 94 PF02991 0.451
LIG_PALB2_WD40_1 193 201 PF16756 0.406
LIG_Pex14_1 60 64 PF04695 0.414
LIG_Pex14_2 171 175 PF04695 0.415
LIG_Pex14_2 39 43 PF04695 0.384
LIG_SH2_CRK 164 168 PF00017 0.445
LIG_SH2_CRK 45 49 PF00017 0.368
LIG_SH2_CRK 65 69 PF00017 0.210
LIG_SH2_NCK_1 45 49 PF00017 0.421
LIG_SH2_SRC 156 159 PF00017 0.283
LIG_SH2_STAT5 120 123 PF00017 0.372
LIG_SH2_STAT5 132 135 PF00017 0.306
LIG_SH2_STAT5 156 159 PF00017 0.414
LIG_SH2_STAT5 56 59 PF00017 0.447
LIG_SH3_3 207 213 PF00018 0.502
LIG_SH3_3 83 89 PF00018 0.405
LIG_SUMO_SIM_par_1 82 88 PF11976 0.440
LIG_TRAF2_1 70 73 PF00917 0.406
LIG_UBA3_1 90 99 PF00899 0.412
MOD_CDK_SPK_2 94 99 PF00069 0.416
MOD_CK1_1 204 210 PF00069 0.412
MOD_CK1_1 46 52 PF00069 0.413
MOD_CK2_1 188 194 PF00069 0.373
MOD_CK2_1 235 241 PF00069 0.438
MOD_CK2_1 67 73 PF00069 0.343
MOD_GlcNHglycan 198 201 PF01048 0.652
MOD_GlcNHglycan 30 33 PF01048 0.386
MOD_GlcNHglycan 61 64 PF01048 0.628
MOD_GSK3_1 227 234 PF00069 0.431
MOD_GSK3_1 59 66 PF00069 0.412
MOD_GSK3_1 90 97 PF00069 0.399
MOD_LATS_1 148 154 PF00433 0.313
MOD_NEK2_1 102 107 PF00069 0.292
MOD_NEK2_1 179 184 PF00069 0.417
MOD_NEK2_1 188 193 PF00069 0.383
MOD_NEK2_1 201 206 PF00069 0.344
MOD_NEK2_1 21 26 PF00069 0.292
MOD_NEK2_1 227 232 PF00069 0.374
MOD_NEK2_1 28 33 PF00069 0.360
MOD_NEK2_1 5 10 PF00069 0.637
MOD_NEK2_1 59 64 PF00069 0.417
MOD_NEK2_1 90 95 PF00069 0.413
MOD_PKA_1 235 241 PF00069 0.463
MOD_PKA_1 51 57 PF00069 0.419
MOD_Plk_4 23 29 PF00069 0.380
MOD_Plk_4 79 85 PF00069 0.406
MOD_ProDKin_1 209 215 PF00069 0.433
MOD_ProDKin_1 63 69 PF00069 0.366
MOD_ProDKin_1 85 91 PF00069 0.419
MOD_ProDKin_1 94 100 PF00069 0.371
TRG_DiLeu_BaEn_4 72 78 PF01217 0.390
TRG_ENDOCYTIC_2 156 159 PF00928 0.380
TRG_ENDOCYTIC_2 224 227 PF00928 0.388
TRG_ENDOCYTIC_2 56 59 PF00928 0.420
TRG_ENDOCYTIC_2 65 68 PF00928 0.355
TRG_ER_diArg_1 136 138 PF00400 0.340
TRG_ER_diArg_1 222 224 PF00400 0.354
TRG_ER_diArg_1 242 244 PF00400 0.282
TRG_ER_diArg_1 50 53 PF00400 0.425
TRG_NLS_MonoExtN_4 48 55 PF00514 0.360
TRG_Pf-PMV_PEXEL_1 138 142 PF00026 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZW1 Leptomonas seymouri 67% 100%
A0A0S4JNP4 Bodo saltans 28% 100%
A0A1X0NDW5 Trypanosomatidae 39% 100%
A0A3S7XBV9 Leishmania donovani 97% 100%
A4HQ21 Leishmania braziliensis 85% 100%
D0A8U8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9ATT9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q0Q7 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS