LeishMANIAdb
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Exocyst complex component Sec8

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Exocyst complex component Sec8
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDS3_LEIIN
TriTrypDb:
LINF_360059500
Length:
352

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 6
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4IDS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDS3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 169 171 PF00675 0.692
CLV_NRD_NRD_1 172 174 PF00675 0.685
CLV_NRD_NRD_1 208 210 PF00675 0.603
CLV_NRD_NRD_1 291 293 PF00675 0.734
CLV_NRD_NRD_1 346 348 PF00675 0.730
CLV_PCSK_FUR_1 344 348 PF00082 0.746
CLV_PCSK_KEX2_1 169 171 PF00082 0.680
CLV_PCSK_KEX2_1 208 210 PF00082 0.603
CLV_PCSK_KEX2_1 291 293 PF00082 0.734
CLV_PCSK_KEX2_1 344 346 PF00082 0.650
CLV_PCSK_PC7_1 341 347 PF00082 0.745
CLV_PCSK_SKI1_1 123 127 PF00082 0.485
CLV_PCSK_SKI1_1 209 213 PF00082 0.567
CLV_PCSK_SKI1_1 249 253 PF00082 0.627
DEG_MDM2_SWIB_1 135 142 PF02201 0.535
DEG_SPOP_SBC_1 301 305 PF00917 0.713
DOC_CDC14_PxL_1 20 28 PF14671 0.508
DOC_CKS1_1 45 50 PF01111 0.526
DOC_CYCLIN_yCln2_LP_2 21 27 PF00134 0.507
DOC_MAPK_FxFP_2 218 221 PF00069 0.474
DOC_MAPK_gen_1 113 121 PF00069 0.456
DOC_MAPK_gen_1 208 214 PF00069 0.533
DOC_MAPK_gen_1 341 351 PF00069 0.732
DOC_MAPK_JIP1_4 247 253 PF00069 0.565
DOC_MAPK_MEF2A_6 12 21 PF00069 0.489
DOC_MAPK_MEF2A_6 243 252 PF00069 0.516
DOC_PP1_RVXF_1 116 122 PF00149 0.487
DOC_PP1_RVXF_1 201 207 PF00149 0.427
DOC_PP2B_LxvP_1 21 24 PF13499 0.498
DOC_PP4_FxxP_1 218 221 PF00568 0.474
DOC_SPAK_OSR1_1 239 243 PF12202 0.484
DOC_USP7_MATH_1 290 294 PF00917 0.588
DOC_USP7_MATH_1 322 326 PF00917 0.723
DOC_USP7_MATH_1 33 37 PF00917 0.606
DOC_WW_Pin1_4 44 49 PF00397 0.533
DOC_WW_Pin1_4 80 85 PF00397 0.657
LIG_14-3-3_CanoR_1 226 230 PF00244 0.524
LIG_14-3-3_CanoR_1 280 289 PF00244 0.748
LIG_APCC_ABBA_1 212 217 PF00400 0.501
LIG_BIR_II_1 1 5 PF00653 0.716
LIG_BIR_III_4 88 92 PF00653 0.567
LIG_EH_1 73 77 PF12763 0.667
LIG_FHA_1 14 20 PF00498 0.568
LIG_FHA_1 153 159 PF00498 0.510
LIG_FHA_1 186 192 PF00498 0.574
LIG_FHA_1 258 264 PF00498 0.566
LIG_FHA_2 45 51 PF00498 0.554
LIG_LIR_Apic_2 217 221 PF02991 0.486
LIG_LIR_Gen_1 40 48 PF02991 0.588
LIG_LIR_LC3C_4 260 263 PF02991 0.548
LIG_LIR_Nem_3 228 233 PF02991 0.487
LIG_LIR_Nem_3 40 46 PF02991 0.582
LIG_PCNA_PIPBox_1 234 243 PF02747 0.596
LIG_PCNA_yPIPBox_3 232 241 PF02747 0.594
LIG_PDZ_Class_2 347 352 PF00595 0.659
LIG_Pex14_2 135 139 PF04695 0.534
LIG_SH2_SRC 184 187 PF00017 0.612
LIG_SH2_STAT5 146 149 PF00017 0.459
LIG_SH2_STAT5 157 160 PF00017 0.307
LIG_SH2_STAT5 241 244 PF00017 0.484
LIG_SH2_STAT5 41 44 PF00017 0.524
LIG_SH3_3 180 186 PF00018 0.697
LIG_SH3_3 275 281 PF00018 0.598
LIG_SUMO_SIM_anti_2 13 19 PF11976 0.581
LIG_SUMO_SIM_anti_2 210 215 PF11976 0.513
LIG_SUMO_SIM_anti_2 63 69 PF11976 0.488
LIG_SUMO_SIM_par_1 16 22 PF11976 0.623
LIG_SUMO_SIM_par_1 23 28 PF11976 0.530
LIG_SUMO_SIM_par_1 259 265 PF11976 0.624
LIG_TRAF2_1 37 40 PF00917 0.582
LIG_ULM_U2AF65_1 344 349 PF00076 0.746
MOD_CK1_1 187 193 PF00069 0.603
MOD_CK1_1 199 205 PF00069 0.528
MOD_CK1_1 302 308 PF00069 0.747
MOD_CK1_1 44 50 PF00069 0.506
MOD_CK2_1 138 144 PF00069 0.480
MOD_Cter_Amidation 167 170 PF01082 0.646
MOD_Cter_Amidation 342 345 PF01082 0.618
MOD_GlcNHglycan 285 288 PF01048 0.767
MOD_GlcNHglycan 292 295 PF01048 0.697
MOD_GlcNHglycan 307 310 PF01048 0.616
MOD_GlcNHglycan 311 314 PF01048 0.601
MOD_GlcNHglycan 317 321 PF01048 0.666
MOD_GlcNHglycan 324 327 PF01048 0.643
MOD_GlcNHglycan 328 331 PF01048 0.627
MOD_GlcNHglycan 34 38 PF01048 0.489
MOD_GSK3_1 158 165 PF00069 0.562
MOD_GSK3_1 281 288 PF00069 0.747
MOD_GSK3_1 297 304 PF00069 0.586
MOD_GSK3_1 305 312 PF00069 0.672
MOD_GSK3_1 322 329 PF00069 0.680
MOD_GSK3_1 6 13 PF00069 0.646
MOD_N-GLC_1 10 15 PF02516 0.616
MOD_N-GLC_2 56 58 PF02516 0.415
MOD_NEK2_1 19 24 PF00069 0.503
MOD_NEK2_1 27 32 PF00069 0.490
MOD_NEK2_1 283 288 PF00069 0.719
MOD_NEK2_1 4 9 PF00069 0.567
MOD_NEK2_2 225 230 PF00069 0.599
MOD_PIKK_1 158 164 PF00454 0.600
MOD_PKA_2 225 231 PF00069 0.562
MOD_PKA_2 257 263 PF00069 0.632
MOD_PKA_2 290 296 PF00069 0.713
MOD_PKA_2 4 10 PF00069 0.659
MOD_Plk_1 10 16 PF00069 0.640
MOD_Plk_1 162 168 PF00069 0.615
MOD_Plk_1 27 33 PF00069 0.317
MOD_Plk_4 106 112 PF00069 0.527
MOD_Plk_4 13 19 PF00069 0.530
MOD_Plk_4 153 159 PF00069 0.465
MOD_Plk_4 196 202 PF00069 0.513
MOD_Plk_4 225 231 PF00069 0.539
MOD_Plk_4 257 263 PF00069 0.518
MOD_ProDKin_1 44 50 PF00069 0.530
MOD_ProDKin_1 80 86 PF00069 0.658
TRG_DiLeu_BaEn_1 196 201 PF01217 0.484
TRG_DiLeu_BaEn_1 63 68 PF01217 0.452
TRG_DiLeu_BaLyEn_6 21 26 PF01217 0.504
TRG_DiLeu_BaLyEn_6 246 251 PF01217 0.615
TRG_ER_diArg_1 207 209 PF00400 0.579
TRG_ER_diArg_1 344 347 PF00400 0.664
TRG_NES_CRM1_1 265 276 PF08389 0.628
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.561

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVC1 Leptomonas seymouri 53% 100%
A0A1X0P309 Trypanosomatidae 28% 100%
A0A3Q8IJW1 Leishmania donovani 99% 100%
A0A3R7KTI3 Trypanosoma rangeli 26% 100%
A4HQ17 Leishmania braziliensis 74% 100%
E9ATT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q0R2 Leishmania major 90% 100%
V5D4Y6 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS