LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDS1_LEIIN
TriTrypDb:
LINF_360059300
Length:
331

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDS1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDS1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 171 177 PF00089 0.363
CLV_NRD_NRD_1 256 258 PF00675 0.534
CLV_NRD_NRD_1 266 268 PF00675 0.360
CLV_NRD_NRD_1 69 71 PF00675 0.772
CLV_NRD_NRD_1 74 76 PF00675 0.736
CLV_PCSK_KEX2_1 256 258 PF00082 0.485
CLV_PCSK_KEX2_1 74 76 PF00082 0.795
CLV_PCSK_PC7_1 70 76 PF00082 0.669
CLV_PCSK_SKI1_1 130 134 PF00082 0.654
CLV_PCSK_SKI1_1 185 189 PF00082 0.473
CLV_PCSK_SKI1_1 214 218 PF00082 0.402
CLV_PCSK_SKI1_1 75 79 PF00082 0.574
DEG_APCC_DBOX_1 256 264 PF00400 0.429
DEG_Nend_UBRbox_2 1 3 PF02207 0.617
DEG_SPOP_SBC_1 149 153 PF00917 0.580
DOC_CDC14_PxL_1 234 242 PF14671 0.415
DOC_MAPK_FxFP_2 321 324 PF00069 0.419
DOC_PP1_RVXF_1 212 219 PF00149 0.408
DOC_PP4_FxxP_1 180 183 PF00568 0.353
DOC_PP4_FxxP_1 321 324 PF00568 0.419
DOC_USP7_MATH_1 108 112 PF00917 0.787
DOC_USP7_MATH_1 149 153 PF00917 0.622
DOC_USP7_MATH_1 161 165 PF00917 0.515
DOC_USP7_MATH_1 324 328 PF00917 0.474
DOC_USP7_MATH_1 45 49 PF00917 0.495
DOC_USP7_UBL2_3 81 85 PF12436 0.665
DOC_WW_Pin1_4 227 232 PF00397 0.477
DOC_WW_Pin1_4 6 11 PF00397 0.578
DOC_WW_Pin1_4 62 67 PF00397 0.685
LIG_14-3-3_CanoR_1 167 172 PF00244 0.348
LIG_BRCT_BRCA1_1 169 173 PF00533 0.347
LIG_BRCT_BRCA1_1 176 180 PF00533 0.355
LIG_EVH1_1 63 67 PF00568 0.569
LIG_FHA_1 153 159 PF00498 0.512
LIG_FHA_1 290 296 PF00498 0.354
LIG_FHA_1 320 326 PF00498 0.435
LIG_FHA_2 118 124 PF00498 0.593
LIG_FHA_2 249 255 PF00498 0.601
LIG_GBD_Chelix_1 303 311 PF00786 0.388
LIG_IBAR_NPY_1 30 32 PF08397 0.538
LIG_LIR_Apic_2 177 183 PF02991 0.356
LIG_LIR_Apic_2 225 231 PF02991 0.443
LIG_LIR_Apic_2 318 324 PF02991 0.407
LIG_LIR_Nem_3 47 52 PF02991 0.547
LIG_PCNA_PIPBox_1 95 104 PF02747 0.574
LIG_Pex14_2 175 179 PF04695 0.367
LIG_Pex14_2 180 184 PF04695 0.356
LIG_SH2_CRK 168 172 PF00017 0.339
LIG_SH2_CRK 53 57 PF00017 0.497
LIG_SH2_NCK_1 168 172 PF00017 0.339
LIG_SH2_SRC 51 54 PF00017 0.571
LIG_SH2_STAP1 128 132 PF00017 0.636
LIG_SH2_STAP1 32 36 PF00017 0.535
LIG_SH2_STAT5 219 222 PF00017 0.459
LIG_SH2_STAT5 228 231 PF00017 0.430
LIG_SH2_STAT5 51 54 PF00017 0.571
LIG_SH3_1 61 67 PF00018 0.646
LIG_SH3_3 191 197 PF00018 0.383
LIG_SH3_3 61 67 PF00018 0.646
LIG_SUMO_SIM_par_1 283 289 PF11976 0.352
LIG_TRAF2_1 230 233 PF00917 0.436
LIG_TRAF2_1 312 315 PF00917 0.417
LIG_TRAF2_2 276 281 PF00917 0.401
LIG_TYR_ITIM 166 171 PF00017 0.353
LIG_WRC_WIRS_1 184 189 PF05994 0.391
LIG_WRC_WIRS_1 46 51 PF05994 0.454
MOD_CK1_1 100 106 PF00069 0.634
MOD_CK1_1 118 124 PF00069 0.664
MOD_CK1_1 141 147 PF00069 0.781
MOD_CK1_1 152 158 PF00069 0.577
MOD_CK1_1 208 214 PF00069 0.391
MOD_CK1_1 289 295 PF00069 0.333
MOD_CK1_1 54 60 PF00069 0.604
MOD_CK2_1 227 233 PF00069 0.439
MOD_GlcNHglycan 10 13 PF01048 0.700
MOD_GlcNHglycan 104 107 PF01048 0.632
MOD_GlcNHglycan 15 18 PF01048 0.624
MOD_GlcNHglycan 152 155 PF01048 0.621
MOD_GlcNHglycan 176 179 PF01048 0.384
MOD_GlcNHglycan 207 210 PF01048 0.553
MOD_GlcNHglycan 22 25 PF01048 0.514
MOD_GlcNHglycan 287 291 PF01048 0.357
MOD_GlcNHglycan 326 329 PF01048 0.521
MOD_GSK3_1 115 122 PF00069 0.588
MOD_GSK3_1 138 145 PF00069 0.630
MOD_GSK3_1 148 155 PF00069 0.626
MOD_GSK3_1 18 25 PF00069 0.489
MOD_GSK3_1 205 212 PF00069 0.389
MOD_GSK3_1 319 326 PF00069 0.426
MOD_GSK3_1 4 11 PF00069 0.612
MOD_GSK3_1 81 88 PF00069 0.641
MOD_N-GLC_1 198 203 PF02516 0.403
MOD_NEK2_1 102 107 PF00069 0.736
MOD_NEK2_1 13 18 PF00069 0.563
MOD_NEK2_1 140 145 PF00069 0.617
MOD_NEK2_1 22 27 PF00069 0.538
MOD_NEK2_1 286 291 PF00069 0.352
MOD_NEK2_1 298 303 PF00069 0.397
MOD_NEK2_1 4 9 PF00069 0.565
MOD_NEK2_2 198 203 PF00069 0.447
MOD_NEK2_2 86 91 PF00069 0.637
MOD_PIKK_1 142 148 PF00454 0.627
MOD_PK_1 167 173 PF00069 0.349
MOD_Plk_1 198 204 PF00069 0.396
MOD_Plk_1 258 264 PF00069 0.468
MOD_Plk_1 286 292 PF00069 0.347
MOD_Plk_4 161 167 PF00069 0.495
MOD_Plk_4 289 295 PF00069 0.352
MOD_Plk_4 32 38 PF00069 0.473
MOD_Plk_4 51 57 PF00069 0.574
MOD_Plk_4 97 103 PF00069 0.584
MOD_ProDKin_1 227 233 PF00069 0.472
MOD_ProDKin_1 6 12 PF00069 0.578
MOD_ProDKin_1 62 68 PF00069 0.687
MOD_SUMO_rev_2 246 253 PF00179 0.450
TRG_DiLeu_BaLyEn_6 236 241 PF01217 0.405
TRG_ENDOCYTIC_2 168 171 PF00928 0.337
TRG_ENDOCYTIC_2 53 56 PF00928 0.529
TRG_ER_diArg_1 255 257 PF00400 0.481
TRG_NLS_MonoExtC_3 69 74 PF00514 0.666
TRG_NLS_MonoExtN_4 67 74 PF00514 0.660
TRG_Pf-PMV_PEXEL_1 267 272 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBG8 Leptomonas seymouri 60% 99%
A0A3Q8IJQ3 Leishmania donovani 99% 100%
A4HQ15 Leishmania braziliensis 77% 100%
E9ATT2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q0R4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS