LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDR9_LEIIN
TriTrypDb:
LINF_360058600
Length:
360

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0032991 protein-containing complex 1 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDR9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDR9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 149 151 PF00675 0.544
CLV_NRD_NRD_1 15 17 PF00675 0.451
CLV_NRD_NRD_1 157 159 PF00675 0.468
CLV_NRD_NRD_1 188 190 PF00675 0.539
CLV_NRD_NRD_1 220 222 PF00675 0.441
CLV_NRD_NRD_1 274 276 PF00675 0.420
CLV_NRD_NRD_1 295 297 PF00675 0.541
CLV_NRD_NRD_1 33 35 PF00675 0.472
CLV_NRD_NRD_1 332 334 PF00675 0.428
CLV_NRD_NRD_1 336 338 PF00675 0.435
CLV_NRD_NRD_1 63 65 PF00675 0.644
CLV_PCSK_KEX2_1 113 115 PF00082 0.507
CLV_PCSK_KEX2_1 15 17 PF00082 0.451
CLV_PCSK_KEX2_1 183 185 PF00082 0.489
CLV_PCSK_KEX2_1 220 222 PF00082 0.423
CLV_PCSK_KEX2_1 295 297 PF00082 0.619
CLV_PCSK_KEX2_1 332 334 PF00082 0.470
CLV_PCSK_KEX2_1 52 54 PF00082 0.563
CLV_PCSK_KEX2_1 63 65 PF00082 0.624
CLV_PCSK_PC1ET2_1 113 115 PF00082 0.507
CLV_PCSK_PC1ET2_1 183 185 PF00082 0.482
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.497
CLV_PCSK_PC7_1 48 54 PF00082 0.551
CLV_PCSK_SKI1_1 131 135 PF00082 0.550
CLV_PCSK_SKI1_1 16 20 PF00082 0.443
CLV_PCSK_SKI1_1 220 224 PF00082 0.456
CLV_PCSK_SKI1_1 263 267 PF00082 0.479
CLV_PCSK_SKI1_1 319 323 PF00082 0.523
CLV_PCSK_SKI1_1 43 47 PF00082 0.524
CLV_PCSK_SKI1_1 52 56 PF00082 0.342
DEG_APCC_DBOX_1 15 23 PF00400 0.558
DOC_CYCLIN_RxL_1 221 234 PF00134 0.459
DOC_USP7_MATH_1 314 318 PF00917 0.427
DOC_USP7_MATH_1 5 9 PF00917 0.588
DOC_USP7_MATH_1 66 70 PF00917 0.676
DOC_USP7_UBL2_3 179 183 PF12436 0.591
LIG_14-3-3_CanoR_1 131 136 PF00244 0.520
LIG_14-3-3_CanoR_1 24 32 PF00244 0.559
LIG_14-3-3_CanoR_1 295 303 PF00244 0.514
LIG_FHA_1 224 230 PF00498 0.605
LIG_FHA_1 99 105 PF00498 0.607
LIG_FHA_2 264 270 PF00498 0.479
LIG_FHA_2 351 357 PF00498 0.586
LIG_LIR_Apic_2 297 303 PF02991 0.452
LIG_LIR_Gen_1 115 124 PF02991 0.536
LIG_LIR_Nem_3 115 119 PF02991 0.545
LIG_LIR_Nem_3 317 321 PF02991 0.538
LIG_Pex14_2 280 284 PF04695 0.441
LIG_PTB_Apo_2 230 237 PF02174 0.478
LIG_SH2_CRK 116 120 PF00017 0.554
LIG_SH2_CRK 318 322 PF00017 0.468
LIG_SH2_NCK_1 252 256 PF00017 0.479
LIG_SH2_NCK_1 70 74 PF00017 0.575
LIG_SH2_SRC 252 255 PF00017 0.482
LIG_SH2_SRC 300 303 PF00017 0.471
LIG_SH2_STAP1 120 124 PF00017 0.536
LIG_SH2_STAP1 252 256 PF00017 0.577
LIG_TRAF2_1 167 170 PF00917 0.547
LIG_TRAF2_1 257 260 PF00917 0.464
LIG_TRAF2_1 266 269 PF00917 0.474
LIG_UBA3_1 340 347 PF00899 0.397
MOD_CK2_1 263 269 PF00069 0.477
MOD_GlcNHglycan 7 10 PF01048 0.613
MOD_GlcNHglycan 76 79 PF01048 0.740
MOD_GlcNHglycan 91 94 PF01048 0.587
MOD_GSK3_1 346 353 PF00069 0.556
MOD_GSK3_1 81 88 PF00069 0.752
MOD_N-GLC_1 223 228 PF02516 0.488
MOD_NEK2_1 178 183 PF00069 0.460
MOD_NEK2_1 25 30 PF00069 0.559
MOD_NEK2_1 294 299 PF00069 0.457
MOD_NEK2_1 304 309 PF00069 0.556
MOD_NEK2_1 89 94 PF00069 0.685
MOD_PIKK_1 25 31 PF00454 0.503
MOD_PKA_1 244 250 PF00069 0.407
MOD_PKA_2 25 31 PF00069 0.559
MOD_PKA_2 294 300 PF00069 0.554
MOD_PKA_2 350 356 PF00069 0.503
MOD_PKA_2 89 95 PF00069 0.607
MOD_PKB_1 261 269 PF00069 0.605
MOD_Plk_1 223 229 PF00069 0.486
MOD_Plk_1 98 104 PF00069 0.669
MOD_SUMO_rev_2 154 161 PF00179 0.521
TRG_DiLeu_BaEn_1 260 265 PF01217 0.342
TRG_DiLeu_LyEn_5 260 265 PF01217 0.342
TRG_ENDOCYTIC_2 116 119 PF00928 0.554
TRG_ENDOCYTIC_2 252 255 PF00928 0.482
TRG_ENDOCYTIC_2 318 321 PF00928 0.474
TRG_ER_diArg_1 220 222 PF00400 0.464
TRG_ER_diArg_1 24 27 PF00400 0.471
TRG_ER_diArg_1 261 264 PF00400 0.534
TRG_ER_diArg_1 294 296 PF00400 0.521
TRG_Pf-PMV_PEXEL_1 201 205 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 227 232 PF00026 0.542
TRG_Pf-PMV_PEXEL_1 263 268 PF00026 0.537
TRG_Pf-PMV_PEXEL_1 35 39 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBM7 Leptomonas seymouri 68% 100%
A0A1X0P2Z9 Trypanosomatidae 40% 100%
A0A3Q8ILH7 Leishmania donovani 100% 100%
A0A3R7KX10 Trypanosoma rangeli 38% 100%
A4HQ08 Leishmania braziliensis 82% 100%
D0A8W4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9ATS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q0S1 Leishmania major 98% 100%
V5B8Z3 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS