Outer arm dynein light chain 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDR6_LEIIN

TriTrypDb:

LINF_360058300

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	13
GO:0110165	cellular anatomical entity	1	14
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IDR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDR6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0036158	outer dynein arm assembly	7	13
GO:0036159	inner dynein arm assembly	7	13
GO:0043933	protein-containing complex organization	4	13
GO:0065003	protein-containing complex assembly	5	13
GO:0070286	axonemal dynein complex assembly	6	13
GO:0071840	cellular component organization or biogenesis	2	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0044877	protein-containing complex binding	2	13
GO:0070840	dynein complex binding	3	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.473
CLV_C14_Caspase3-7	5	9	PF00656	0.587
CLV_C14_Caspase3-7	79	83	PF00656	0.517
CLV_C14_Caspase3-7	92	96	PF00656	0.521
CLV_NRD_NRD_1	187	189	PF00675	0.393
CLV_NRD_NRD_1	192	194	PF00675	0.315
CLV_PCSK_KEX2_1	187	189	PF00082	0.427
CLV_PCSK_KEX2_1	194	196	PF00082	0.340
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.454
CLV_PCSK_SKI1_1	176	180	PF00082	0.396
CLV_PCSK_SKI1_1	285	289	PF00082	0.585
DEG_APCC_DBOX_1	132	140	PF00400	0.366
DEG_APCC_DBOX_1	171	179	PF00400	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.674
DOC_CDC14_PxL_1	97	105	PF14671	0.427
DOC_CKS1_1	271	276	PF01111	0.455
DOC_CKS1_1	31	36	PF01111	0.385
DOC_CYCLIN_RxL_1	172	184	PF00134	0.273
DOC_WW_Pin1_4	186	191	PF00397	0.487
DOC_WW_Pin1_4	270	275	PF00397	0.615
DOC_WW_Pin1_4	277	282	PF00397	0.629
DOC_WW_Pin1_4	30	35	PF00397	0.387
LIG_14-3-3_CanoR_1	172	176	PF00244	0.450
LIG_APCC_ABBA_1	60	65	PF00400	0.343
LIG_BRCT_BRCA1_1	18	22	PF00533	0.302
LIG_Clathr_ClatBox_1	148	152	PF01394	0.450
LIG_FHA_1	103	109	PF00498	0.543
LIG_FHA_1	15	21	PF00498	0.371
LIG_FHA_1	175	181	PF00498	0.375
LIG_FHA_1	237	243	PF00498	0.534
LIG_FHA_1	278	284	PF00498	0.649
LIG_FHA_1	31	37	PF00498	0.207
LIG_FHA_1	55	61	PF00498	0.350
LIG_FHA_2	46	52	PF00498	0.267
LIG_FHA_2	77	83	PF00498	0.473
LIG_LIR_Nem_3	207	212	PF02991	0.399
LIG_LIR_Nem_3	247	252	PF02991	0.443
LIG_NRBOX	125	131	PF00104	0.450
LIG_NRBOX	144	150	PF00104	0.450
LIG_NRBOX	174	180	PF00104	0.446
LIG_Pex14_1	196	200	PF04695	0.428
LIG_SH2_NCK_1	31	35	PF00017	0.424
LIG_SH2_SRC	297	300	PF00017	0.655
LIG_SH2_SRC	41	44	PF00017	0.425
LIG_SH2_SRC	63	66	PF00017	0.352
LIG_SH2_STAT5	275	278	PF00017	0.485
LIG_SH2_STAT5	297	300	PF00017	0.547
LIG_SH2_STAT5	41	44	PF00017	0.348
LIG_SH2_STAT5	63	66	PF00017	0.333
LIG_SH2_STAT5	85	88	PF00017	0.450
LIG_SH3_3	95	101	PF00018	0.450
LIG_SUMO_SIM_par_1	146	152	PF11976	0.495
MOD_CDK_SPxxK_3	186	193	PF00069	0.473
MOD_CK2_1	29	35	PF00069	0.412
MOD_GlcNHglycan	145	148	PF01048	0.283
MOD_GlcNHglycan	234	237	PF01048	0.490
MOD_GSK3_1	143	150	PF00069	0.504
MOD_GSK3_1	232	239	PF00069	0.518
MOD_GSK3_1	279	286	PF00069	0.592
MOD_GSK3_1	76	83	PF00069	0.491
MOD_GSK3_1	89	96	PF00069	0.394
MOD_N-GLC_1	283	288	PF02516	0.615
MOD_NEK2_1	151	156	PF00069	0.476
MOD_NEK2_1	16	21	PF00069	0.500
MOD_NEK2_1	45	50	PF00069	0.402
MOD_NEK2_1	84	89	PF00069	0.480
MOD_PIKK_1	267	273	PF00454	0.637
MOD_PIKK_1	45	51	PF00454	0.327
MOD_PKA_2	171	177	PF00069	0.456
MOD_Plk_1	161	167	PF00069	0.330
MOD_Plk_1	283	289	PF00069	0.614
MOD_Plk_4	125	131	PF00069	0.452
MOD_Plk_4	16	22	PF00069	0.394
MOD_Plk_4	283	289	PF00069	0.588
MOD_Plk_4	80	86	PF00069	0.446
MOD_ProDKin_1	186	192	PF00069	0.478
MOD_ProDKin_1	270	276	PF00069	0.616
MOD_ProDKin_1	277	283	PF00069	0.632
MOD_ProDKin_1	30	36	PF00069	0.388
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.442
TRG_ENDOCYTIC_2	209	212	PF00928	0.448
TRG_ENDOCYTIC_2	252	255	PF00928	0.468
TRG_ER_diArg_1	193	196	PF00400	0.354
TRG_NES_CRM1_1	51	65	PF08389	0.245
TRG_NLS_MonoExtN_4	190	197	PF00514	0.262
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJD4	Leptomonas seymouri	60%	96%
A0A0S4JHJ7	Bodo saltans	38%	81%
A0A1X0NUQ9	Trypanosomatidae	35%	72%
A0A1X0P4D9	Trypanosomatidae	45%	100%
A0A3Q8IWC9	Leishmania donovani	99%	100%
A0A3R7KFT3	Trypanosoma rangeli	33%	68%
A0A422NC68	Trypanosoma rangeli	45%	100%
A4HQ05	Leishmania braziliensis	77%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A9U1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	71%
E9ATS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q09JZ4	Chlamydomonas reinhardtii	32%	72%
Q15435	Homo sapiens	24%	87%
Q3T0W4	Bos taurus	24%	87%
Q4Q0S4	Leishmania major	91%	100%
Q5RFS7	Pongo abelii	23%	87%