LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IDR3_LEIIN
TriTrypDb:
LINF_360058000
Length:
610

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDR3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDR3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 293 297 PF00656 0.606
CLV_NRD_NRD_1 397 399 PF00675 0.426
CLV_NRD_NRD_1 436 438 PF00675 0.381
CLV_NRD_NRD_1 441 443 PF00675 0.387
CLV_NRD_NRD_1 445 447 PF00675 0.440
CLV_NRD_NRD_1 550 552 PF00675 0.440
CLV_PCSK_KEX2_1 397 399 PF00082 0.397
CLV_PCSK_KEX2_1 435 437 PF00082 0.395
CLV_PCSK_KEX2_1 441 443 PF00082 0.388
CLV_PCSK_KEX2_1 445 447 PF00082 0.442
CLV_PCSK_KEX2_1 550 552 PF00082 0.455
CLV_PCSK_PC7_1 437 443 PF00082 0.380
CLV_PCSK_SKI1_1 222 226 PF00082 0.547
CLV_PCSK_SKI1_1 227 231 PF00082 0.400
CLV_PCSK_SKI1_1 323 327 PF00082 0.459
CLV_PCSK_SKI1_1 381 385 PF00082 0.413
CLV_PCSK_SKI1_1 437 441 PF00082 0.353
CLV_PCSK_SKI1_1 446 450 PF00082 0.483
CLV_PCSK_SKI1_1 533 537 PF00082 0.584
DEG_APCC_DBOX_1 415 423 PF00400 0.492
DEG_APCC_DBOX_1 484 492 PF00400 0.444
DOC_AGCK_PIF_2 119 124 PF00069 0.452
DOC_CKS1_1 264 269 PF01111 0.598
DOC_CYCLIN_RxL_1 216 228 PF00134 0.515
DOC_CYCLIN_RxL_1 326 338 PF00134 0.490
DOC_CYCLIN_yCln2_LP_2 209 215 PF00134 0.458
DOC_CYCLIN_yCln2_LP_2 303 309 PF00134 0.452
DOC_MAPK_gen_1 402 409 PF00069 0.380
DOC_MAPK_gen_1 441 451 PF00069 0.440
DOC_MAPK_JIP1_4 211 217 PF00069 0.458
DOC_MAPK_MEF2A_6 211 219 PF00069 0.462
DOC_PP1_RVXF_1 477 483 PF00149 0.410
DOC_PP2B_LxvP_1 303 306 PF13499 0.464
DOC_PP2B_LxvP_1 484 487 PF13499 0.420
DOC_PP2B_LxvP_1 582 585 PF13499 0.583
DOC_PP4_FxxP_1 113 116 PF00568 0.599
DOC_USP7_MATH_1 316 320 PF00917 0.408
DOC_USP7_MATH_1 344 348 PF00917 0.416
DOC_USP7_MATH_1 487 491 PF00917 0.434
DOC_USP7_MATH_1 555 559 PF00917 0.527
DOC_USP7_UBL2_3 326 330 PF12436 0.416
DOC_WW_Pin1_4 103 108 PF00397 0.722
DOC_WW_Pin1_4 263 268 PF00397 0.607
DOC_WW_Pin1_4 27 32 PF00397 0.642
DOC_WW_Pin1_4 57 62 PF00397 0.669
DOC_WW_Pin1_4 580 585 PF00397 0.716
LIG_14-3-3_CanoR_1 175 184 PF00244 0.602
LIG_14-3-3_CanoR_1 272 277 PF00244 0.552
LIG_14-3-3_CanoR_1 339 345 PF00244 0.500
LIG_14-3-3_CanoR_1 416 426 PF00244 0.454
LIG_14-3-3_CanoR_1 522 531 PF00244 0.575
LIG_14-3-3_CanoR_1 556 562 PF00244 0.598
LIG_BIR_II_1 1 5 PF00653 0.497
LIG_Clathr_ClatBox_1 279 283 PF01394 0.452
LIG_Clathr_ClatBox_1 542 546 PF01394 0.468
LIG_FHA_1 106 112 PF00498 0.637
LIG_FHA_1 149 155 PF00498 0.562
LIG_FHA_1 264 270 PF00498 0.560
LIG_FHA_1 3 9 PF00498 0.369
LIG_FHA_1 378 384 PF00498 0.446
LIG_FHA_1 452 458 PF00498 0.505
LIG_FHA_1 524 530 PF00498 0.506
LIG_FHA_1 537 543 PF00498 0.489
LIG_FHA_1 62 68 PF00498 0.585
LIG_FHA_2 192 198 PF00498 0.457
LIG_FHA_2 359 365 PF00498 0.497
LIG_FHA_2 498 504 PF00498 0.446
LIG_GBD_Chelix_1 409 417 PF00786 0.459
LIG_GBD_Chelix_1 498 506 PF00786 0.448
LIG_LIR_Gen_1 123 130 PF02991 0.465
LIG_LIR_Gen_1 161 169 PF02991 0.566
LIG_LIR_Gen_1 453 463 PF02991 0.391
LIG_LIR_Nem_3 123 127 PF02991 0.405
LIG_LIR_Nem_3 161 165 PF02991 0.513
LIG_LIR_Nem_3 275 279 PF02991 0.426
LIG_LIR_Nem_3 453 459 PF02991 0.417
LIG_MYND_1 489 493 PF01753 0.565
LIG_MYND_1 61 65 PF01753 0.613
LIG_Pex14_1 162 166 PF04695 0.514
LIG_Rb_pABgroove_1 116 124 PF01858 0.436
LIG_SH2_NCK_1 576 580 PF00017 0.575
LIG_SH2_STAT3 392 395 PF00017 0.448
LIG_SH2_STAT5 19 22 PF00017 0.472
LIG_SH2_STAT5 357 360 PF00017 0.511
LIG_SH2_STAT5 392 395 PF00017 0.448
LIG_SH2_STAT5 483 486 PF00017 0.399
LIG_SH3_3 104 110 PF00018 0.641
LIG_SH3_3 261 267 PF00018 0.556
LIG_SH3_3 62 68 PF00018 0.602
LIG_SUMO_SIM_anti_2 138 145 PF11976 0.377
LIG_SUMO_SIM_par_1 141 147 PF11976 0.440
LIG_SUMO_SIM_par_1 275 281 PF11976 0.457
LIG_SUMO_SIM_par_1 304 311 PF11976 0.436
LIG_SUMO_SIM_par_1 447 455 PF11976 0.534
LIG_TRAF2_1 194 197 PF00917 0.447
LIG_TRAF2_1 340 343 PF00917 0.448
LIG_TRAF2_1 606 609 PF00917 0.603
LIG_TYR_ITIM 17 22 PF00017 0.326
LIG_UBA3_1 77 83 PF00899 0.477
LIG_WRC_WIRS_1 41 46 PF05994 0.513
LIG_WRC_WIRS_1 463 468 PF05994 0.479
MOD_CDC14_SPxK_1 30 33 PF00782 0.655
MOD_CDK_SPxK_1 27 33 PF00069 0.655
MOD_CK1_1 178 184 PF00069 0.671
MOD_CK1_1 2 8 PF00069 0.454
MOD_CK1_1 218 224 PF00069 0.426
MOD_CK1_1 285 291 PF00069 0.727
MOD_CK1_1 40 46 PF00069 0.597
MOD_CK1_1 415 421 PF00069 0.489
MOD_CK1_1 56 62 PF00069 0.625
MOD_CK1_1 594 600 PF00069 0.676
MOD_CK2_1 177 183 PF00069 0.637
MOD_CK2_1 191 197 PF00069 0.520
MOD_CK2_1 363 369 PF00069 0.504
MOD_CK2_1 561 567 PF00069 0.494
MOD_CK2_1 603 609 PF00069 0.639
MOD_GlcNHglycan 1 4 PF01048 0.611
MOD_GlcNHglycan 101 104 PF01048 0.614
MOD_GlcNHglycan 131 135 PF01048 0.528
MOD_GlcNHglycan 166 169 PF01048 0.524
MOD_GlcNHglycan 177 180 PF01048 0.636
MOD_GlcNHglycan 23 26 PF01048 0.514
MOD_GlcNHglycan 292 295 PF01048 0.657
MOD_GlcNHglycan 346 349 PF01048 0.485
MOD_GlcNHglycan 364 368 PF01048 0.387
MOD_GlcNHglycan 55 58 PF01048 0.626
MOD_GlcNHglycan 557 560 PF01048 0.585
MOD_GSK3_1 173 180 PF00069 0.631
MOD_GSK3_1 223 230 PF00069 0.525
MOD_GSK3_1 23 30 PF00069 0.567
MOD_GSK3_1 334 341 PF00069 0.524
MOD_GSK3_1 344 351 PF00069 0.482
MOD_GSK3_1 53 60 PF00069 0.635
MOD_GSK3_1 587 594 PF00069 0.685
MOD_GSK3_1 66 73 PF00069 0.548
MOD_GSK3_1 97 104 PF00069 0.710
MOD_LATS_1 173 179 PF00433 0.655
MOD_N-GLC_1 348 353 PF02516 0.443
MOD_N-GLC_1 37 42 PF02516 0.632
MOD_NEK2_1 12 17 PF00069 0.364
MOD_NEK2_1 130 135 PF00069 0.444
MOD_NEK2_1 21 26 PF00069 0.477
MOD_NEK2_1 215 220 PF00069 0.445
MOD_NEK2_1 412 417 PF00069 0.464
MOD_NEK2_1 587 592 PF00069 0.775
MOD_PIKK_1 391 397 PF00454 0.448
MOD_PIKK_1 464 470 PF00454 0.418
MOD_PKA_2 338 344 PF00069 0.553
MOD_PKA_2 415 421 PF00069 0.413
MOD_PKA_2 555 561 PF00069 0.509
MOD_Plk_1 227 233 PF00069 0.468
MOD_Plk_1 295 301 PF00069 0.523
MOD_Plk_1 37 43 PF00069 0.595
MOD_Plk_1 518 524 PF00069 0.593
MOD_Plk_2-3 123 129 PF00069 0.429
MOD_Plk_2-3 338 344 PF00069 0.498
MOD_Plk_4 215 221 PF00069 0.550
MOD_Plk_4 316 322 PF00069 0.387
MOD_Plk_4 37 43 PF00069 0.546
MOD_Plk_4 487 493 PF00069 0.475
MOD_Plk_4 497 503 PF00069 0.442
MOD_Plk_4 587 593 PF00069 0.614
MOD_ProDKin_1 103 109 PF00069 0.720
MOD_ProDKin_1 263 269 PF00069 0.607
MOD_ProDKin_1 27 33 PF00069 0.644
MOD_ProDKin_1 57 63 PF00069 0.669
MOD_ProDKin_1 580 586 PF00069 0.719
MOD_SUMO_for_1 403 406 PF00179 0.404
TRG_DiLeu_BaEn_1 139 144 PF01217 0.372
TRG_DiLeu_BaEn_1 429 434 PF01217 0.457
TRG_DiLeu_BaEn_1 513 518 PF01217 0.471
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.436
TRG_ENDOCYTIC_2 124 127 PF00928 0.402
TRG_ENDOCYTIC_2 19 22 PF00928 0.339
TRG_ER_diArg_1 396 398 PF00400 0.395
TRG_ER_diArg_1 422 425 PF00400 0.509
TRG_ER_diArg_1 434 437 PF00400 0.385
TRG_ER_diArg_1 440 442 PF00400 0.391
TRG_ER_diArg_1 550 552 PF00400 0.444
TRG_NES_CRM1_1 207 223 PF08389 0.461
TRG_NES_CRM1_1 462 473 PF08389 0.439
TRG_Pf-PMV_PEXEL_1 474 478 PF00026 0.521
TRG_Pf-PMV_PEXEL_1 550 554 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7N7 Leptomonas seymouri 49% 98%
A0A3Q8IJM8 Leishmania donovani 100% 100%
A4HQ02 Leishmania braziliensis 78% 100%
E9ATR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q0S8 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS