Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDR1_LEIIN

TriTrypDb:

LINF_360057800

Length:

472

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.639
CLV_NRD_NRD_1	182	184	PF00675	0.738
CLV_NRD_NRD_1	223	225	PF00675	0.525
CLV_NRD_NRD_1	330	332	PF00675	0.660
CLV_NRD_NRD_1	342	344	PF00675	0.449
CLV_NRD_NRD_1	37	39	PF00675	0.453
CLV_PCSK_KEX2_1	182	184	PF00082	0.660
CLV_PCSK_KEX2_1	223	225	PF00082	0.525
CLV_PCSK_KEX2_1	330	332	PF00082	0.632
CLV_PCSK_KEX2_1	342	344	PF00082	0.520
CLV_PCSK_KEX2_1	37	39	PF00082	0.453
CLV_PCSK_KEX2_1	89	91	PF00082	0.528
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.528
CLV_PCSK_SKI1_1	206	210	PF00082	0.639
CLV_PCSK_SKI1_1	224	228	PF00082	0.413
CLV_PCSK_SKI1_1	240	244	PF00082	0.496
CLV_PCSK_SKI1_1	259	263	PF00082	0.710
CLV_PCSK_SKI1_1	269	273	PF00082	0.455
CLV_PCSK_SKI1_1	32	36	PF00082	0.453
CLV_PCSK_SKI1_1	334	338	PF00082	0.571
DEG_APCC_DBOX_1	205	213	PF00400	0.527
DEG_APCC_DBOX_1	333	341	PF00400	0.567
DEG_SCF_FBW7_1	106	112	PF00400	0.681
DEG_SCF_FBW7_1	138	145	PF00400	0.662
DEG_SPOP_SBC_1	142	146	PF00917	0.659
DOC_CKS1_1	106	111	PF01111	0.749
DOC_CKS1_1	139	144	PF01111	0.662
DOC_CYCLIN_yClb5_NLxxxL_5	309	318	PF00134	0.722
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.543
DOC_MAPK_MEF2A_6	76	85	PF00069	0.501
DOC_MAPK_RevD_3	316	331	PF00069	0.675
DOC_PP1_RVXF_1	340	347	PF00149	0.590
DOC_PP4_FxxP_1	169	172	PF00568	0.610
DOC_USP7_MATH_1	260	264	PF00917	0.717
DOC_USP7_MATH_1	377	381	PF00917	0.588
DOC_USP7_MATH_1	61	65	PF00917	0.716
DOC_USP7_MATH_1	9	13	PF00917	0.664
DOC_WW_Pin1_4	105	110	PF00397	0.747
DOC_WW_Pin1_4	138	143	PF00397	0.664
DOC_WW_Pin1_4	176	181	PF00397	0.720
DOC_WW_Pin1_4	243	248	PF00397	0.623
DOC_WW_Pin1_4	320	325	PF00397	0.656
DOC_WW_Pin1_4	57	62	PF00397	0.734
LIG_14-3-3_CanoR_1	117	121	PF00244	0.743
LIG_14-3-3_CanoR_1	182	187	PF00244	0.613
LIG_14-3-3_CanoR_1	223	232	PF00244	0.509
LIG_14-3-3_CanoR_1	237	243	PF00244	0.483
LIG_14-3-3_CanoR_1	419	425	PF00244	0.632
LIG_14-3-3_CanoR_1	90	95	PF00244	0.520
LIG_APCC_ABBA_1	406	411	PF00400	0.553
LIG_BRCT_BRCA1_1	354	358	PF00533	0.448
LIG_deltaCOP1_diTrp_1	234	238	PF00928	0.481
LIG_EH1_1	398	406	PF00400	0.635
LIG_FHA_1	18	24	PF00498	0.458
LIG_FHA_1	225	231	PF00498	0.511
LIG_FHA_1	31	37	PF00498	0.440
LIG_FHA_1	50	56	PF00498	0.703
LIG_FHA_1	78	84	PF00498	0.598
LIG_FHA_1	89	95	PF00498	0.534
LIG_FHA_1	96	102	PF00498	0.595
LIG_FHA_2	106	112	PF00498	0.483
LIG_FHA_2	290	296	PF00498	0.598
LIG_FHA_2	306	312	PF00498	0.623
LIG_FHA_2	421	427	PF00498	0.467
LIG_FHA_2	48	54	PF00498	0.679
LIG_FHA_2	91	97	PF00498	0.703
LIG_LIR_Apic_2	116	121	PF02991	0.600
LIG_LIR_Apic_2	167	172	PF02991	0.604
LIG_LIR_Gen_1	384	393	PF02991	0.513
LIG_LIR_LC3C_4	20	25	PF02991	0.474
LIG_LIR_Nem_3	189	195	PF02991	0.510
LIG_LIR_Nem_3	198	204	PF02991	0.569
LIG_LIR_Nem_3	2	8	PF02991	0.717
LIG_LIR_Nem_3	234	239	PF02991	0.458
LIG_LIR_Nem_3	355	361	PF02991	0.463
LIG_LIR_Nem_3	384	389	PF02991	0.519
LIG_MAD2	339	347	PF02301	0.533
LIG_PTB_Apo_2	208	215	PF02174	0.508
LIG_PTB_Phospho_1	208	214	PF10480	0.513
LIG_SH2_CRK	118	122	PF00017	0.817
LIG_SH2_CRK	139	143	PF00017	0.691
LIG_SH2_CRK	214	218	PF00017	0.454
LIG_SH2_NCK_1	110	114	PF00017	0.794
LIG_SH2_NCK_1	118	122	PF00017	0.816
LIG_SH2_NCK_1	8	12	PF00017	0.580
LIG_SH2_SRC	409	412	PF00017	0.598
LIG_SH2_STAP1	110	114	PF00017	0.665
LIG_SH2_STAT3	157	160	PF00017	0.704
LIG_SH2_STAT3	62	65	PF00017	0.707
LIG_SH2_STAT5	118	121	PF00017	0.818
LIG_SH2_STAT5	231	234	PF00017	0.492
LIG_SH2_STAT5	399	402	PF00017	0.560
LIG_SH2_STAT5	5	8	PF00017	0.701
LIG_SH3_3	351	357	PF00018	0.521
LIG_SH3_3	52	58	PF00018	0.721
LIG_SH3_3	96	102	PF00018	0.683
LIG_SUMO_SIM_anti_2	20	27	PF11976	0.497
LIG_SUMO_SIM_par_1	20	27	PF11976	0.497
LIG_TRAF2_1	408	411	PF00917	0.587
LIG_TRAF2_1	423	426	PF00917	0.561
LIG_TYR_ITIM	212	217	PF00017	0.476
LIG_Vh1_VBS_1	282	300	PF01044	0.559
LIG_WW_3	179	183	PF00397	0.634
MOD_CDC14_SPxK_1	179	182	PF00782	0.637
MOD_CDK_SPxK_1	176	182	PF00069	0.722
MOD_CDK_SPxxK_3	176	183	PF00069	0.648
MOD_CK1_1	165	171	PF00069	0.777
MOD_CK1_1	225	231	PF00069	0.599
MOD_CK1_1	241	247	PF00069	0.392
MOD_CK1_1	263	269	PF00069	0.672
MOD_CK1_1	305	311	PF00069	0.703
MOD_CK1_1	323	329	PF00069	0.492
MOD_CK1_1	444	450	PF00069	0.568
MOD_CK1_1	48	54	PF00069	0.666
MOD_CK1_1	7	13	PF00069	0.743
MOD_CK2_1	11	17	PF00069	0.673
MOD_CK2_1	289	295	PF00069	0.557
MOD_CK2_1	420	426	PF00069	0.475
MOD_CK2_1	48	54	PF00069	0.684
MOD_CMANNOS	235	238	PF00535	0.473
MOD_GlcNHglycan	126	129	PF01048	0.747
MOD_GlcNHglycan	13	16	PF01048	0.616
MOD_GlcNHglycan	145	148	PF01048	0.550
MOD_GlcNHglycan	176	179	PF01048	0.705
MOD_GlcNHglycan	2	5	PF01048	0.717
MOD_GlcNHglycan	243	246	PF01048	0.512
MOD_GlcNHglycan	53	58	PF01048	0.748
MOD_GlcNHglycan	65	68	PF01048	0.657
MOD_GlcNHglycan	9	12	PF01048	0.683
MOD_GSK3_1	105	112	PF00069	0.764
MOD_GSK3_1	116	123	PF00069	0.640
MOD_GSK3_1	138	145	PF00069	0.744
MOD_GSK3_1	182	189	PF00069	0.589
MOD_GSK3_1	222	229	PF00069	0.485
MOD_GSK3_1	26	33	PF00069	0.611
MOD_GSK3_1	289	296	PF00069	0.708
MOD_GSK3_1	44	51	PF00069	0.465
MOD_GSK3_1	444	451	PF00069	0.553
MOD_GSK3_1	53	60	PF00069	0.716
MOD_GSK3_1	7	14	PF00069	0.712
MOD_LATS_1	222	228	PF00433	0.514
MOD_N-GLC_1	165	170	PF02516	0.776
MOD_N-GLC_1	444	449	PF02516	0.642
MOD_NEK2_1	162	167	PF00069	0.693
MOD_NEK2_1	174	179	PF00069	0.761
MOD_NEK2_1	195	200	PF00069	0.497
MOD_NEK2_1	226	231	PF00069	0.511
MOD_NEK2_1	272	277	PF00069	0.494
MOD_NEK2_1	289	294	PF00069	0.634
MOD_NEK2_1	359	364	PF00069	0.570
MOD_NEK2_1	415	420	PF00069	0.584
MOD_NEK2_1	432	437	PF00069	0.489
MOD_NEK2_1	44	49	PF00069	0.622
MOD_NEK2_1	88	93	PF00069	0.550
MOD_NEK2_1	95	100	PF00069	0.674
MOD_PIKK_1	272	278	PF00454	0.610
MOD_PIKK_1	325	331	PF00454	0.760
MOD_PIKK_1	432	438	PF00454	0.586
MOD_PIKK_1	61	67	PF00454	0.761
MOD_PKA_1	182	188	PF00069	0.622
MOD_PKA_1	89	95	PF00069	0.581
MOD_PKA_2	116	122	PF00069	0.743
MOD_PKA_2	17	23	PF00069	0.529
MOD_PKA_2	182	188	PF00069	0.598
MOD_PKA_2	222	228	PF00069	0.616
MOD_PKA_2	89	95	PF00069	0.577
MOD_Plk_1	165	171	PF00069	0.777
MOD_Plk_1	26	32	PF00069	0.622
MOD_Plk_1	305	311	PF00069	0.675
MOD_Plk_1	444	450	PF00069	0.584
MOD_Plk_1	45	51	PF00069	0.455
MOD_Plk_1	95	101	PF00069	0.687
MOD_Plk_4	150	156	PF00069	0.611
MOD_Plk_4	182	188	PF00069	0.700
MOD_Plk_4	226	232	PF00069	0.503
MOD_Plk_4	30	36	PF00069	0.490
MOD_Plk_4	305	311	PF00069	0.717
MOD_Plk_4	90	96	PF00069	0.553
MOD_ProDKin_1	105	111	PF00069	0.747
MOD_ProDKin_1	138	144	PF00069	0.662
MOD_ProDKin_1	176	182	PF00069	0.719
MOD_ProDKin_1	243	249	PF00069	0.636
MOD_ProDKin_1	320	326	PF00069	0.657
MOD_ProDKin_1	57	63	PF00069	0.734
MOD_SUMO_for_1	428	431	PF00179	0.636
MOD_SUMO_rev_2	311	318	PF00179	0.622
TRG_ENDOCYTIC_2	201	204	PF00928	0.556
TRG_ENDOCYTIC_2	214	217	PF00928	0.457
TRG_ENDOCYTIC_2	236	239	PF00928	0.451
TRG_ER_diArg_1	181	183	PF00400	0.666
TRG_ER_diArg_1	341	343	PF00400	0.609
TRG_ER_diArg_1	36	38	PF00400	0.455
TRG_ER_diArg_1	371	374	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I895	Leptomonas seymouri	57%	95%
A0A3Q8IRK5	Leishmania donovani	99%	100%
A4HQ00	Leishmania braziliensis	70%	100%
E9ATR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q0T0	Leishmania major	90%	100%