Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDQ7_LEIIN

TriTrypDb:

LINF_360057400

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.755
CLV_C14_Caspase3-7	89	93	PF00656	0.680
CLV_NRD_NRD_1	141	143	PF00675	0.574
CLV_NRD_NRD_1	149	151	PF00675	0.549
CLV_NRD_NRD_1	199	201	PF00675	0.479
CLV_NRD_NRD_1	234	236	PF00675	0.619
CLV_NRD_NRD_1	320	322	PF00675	0.590
CLV_NRD_NRD_1	394	396	PF00675	0.580
CLV_NRD_NRD_1	452	454	PF00675	0.585
CLV_NRD_NRD_1	531	533	PF00675	0.779
CLV_NRD_NRD_1	549	551	PF00675	0.569
CLV_NRD_NRD_1	580	582	PF00675	0.719
CLV_NRD_NRD_1	606	608	PF00675	0.533
CLV_NRD_NRD_1	614	616	PF00675	0.547
CLV_NRD_NRD_1	672	674	PF00675	0.538
CLV_NRD_NRD_1	714	716	PF00675	0.751
CLV_NRD_NRD_1	728	730	PF00675	0.615
CLV_NRD_NRD_1	754	756	PF00675	0.722
CLV_NRD_NRD_1	886	888	PF00675	0.726
CLV_NRD_NRD_1	909	911	PF00675	0.674
CLV_PCSK_FUR_1	547	551	PF00082	0.755
CLV_PCSK_FUR_1	884	888	PF00082	0.704
CLV_PCSK_KEX2_1	140	142	PF00082	0.572
CLV_PCSK_KEX2_1	148	150	PF00082	0.530
CLV_PCSK_KEX2_1	234	236	PF00082	0.567
CLV_PCSK_KEX2_1	320	322	PF00082	0.588
CLV_PCSK_KEX2_1	394	396	PF00082	0.532
CLV_PCSK_KEX2_1	403	405	PF00082	0.550
CLV_PCSK_KEX2_1	451	453	PF00082	0.576
CLV_PCSK_KEX2_1	488	490	PF00082	0.600
CLV_PCSK_KEX2_1	547	549	PF00082	0.755
CLV_PCSK_KEX2_1	614	616	PF00082	0.659
CLV_PCSK_KEX2_1	714	716	PF00082	0.751
CLV_PCSK_KEX2_1	728	730	PF00082	0.807
CLV_PCSK_KEX2_1	754	756	PF00082	0.693
CLV_PCSK_KEX2_1	883	885	PF00082	0.741
CLV_PCSK_KEX2_1	886	888	PF00082	0.717
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.627
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.586
CLV_PCSK_PC1ET2_1	883	885	PF00082	0.753
CLV_PCSK_PC7_1	144	150	PF00082	0.593
CLV_PCSK_SKI1_1	124	128	PF00082	0.609
CLV_PCSK_SKI1_1	157	161	PF00082	0.577
CLV_PCSK_SKI1_1	395	399	PF00082	0.547
CLV_PCSK_SKI1_1	453	457	PF00082	0.596
CLV_PCSK_SKI1_1	473	477	PF00082	0.643
CLV_PCSK_SKI1_1	488	492	PF00082	0.542
CLV_PCSK_SKI1_1	50	54	PF00082	0.493
CLV_PCSK_SKI1_1	586	590	PF00082	0.627
CLV_Separin_Metazoa	679	683	PF03568	0.681
DEG_APCC_DBOX_1	824	832	PF00400	0.736
DEG_Nend_Nbox_1	1	3	PF02207	0.700
DEG_SPOP_SBC_1	290	294	PF00917	0.620
DEG_SPOP_SBC_1	33	37	PF00917	0.629
DOC_CYCLIN_RxL_1	581	594	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.738
DOC_MAPK_gen_1	883	893	PF00069	0.728
DOC_MAPK_HePTP_8	299	311	PF00069	0.613
DOC_MAPK_MEF2A_6	302	311	PF00069	0.622
DOC_PP1_RVXF_1	887	894	PF00149	0.733
DOC_PP2B_LxvP_1	106	109	PF13499	0.589
DOC_PP2B_LxvP_1	510	513	PF13499	0.735
DOC_PP4_FxxP_1	766	769	PF00568	0.737
DOC_PP4_FxxP_1	913	916	PF00568	0.623
DOC_USP7_MATH_1	109	113	PF00917	0.806
DOC_USP7_MATH_1	212	216	PF00917	0.605
DOC_USP7_MATH_1	223	227	PF00917	0.697
DOC_USP7_MATH_1	250	254	PF00917	0.566
DOC_USP7_MATH_1	26	30	PF00917	0.817
DOC_USP7_MATH_1	33	37	PF00917	0.670
DOC_USP7_MATH_1	455	459	PF00917	0.680
DOC_USP7_MATH_1	567	571	PF00917	0.770
DOC_USP7_MATH_1	722	726	PF00917	0.690
DOC_USP7_MATH_1	757	761	PF00917	0.701
DOC_USP7_MATH_1	772	776	PF00917	0.719
DOC_USP7_MATH_1	788	792	PF00917	0.692
DOC_USP7_MATH_1	846	850	PF00917	0.764
DOC_USP7_MATH_1	866	870	PF00917	0.472
DOC_USP7_UBL2_3	201	205	PF12436	0.563
DOC_USP7_UBL2_3	428	432	PF12436	0.645
DOC_USP7_UBL2_3	533	537	PF12436	0.795
DOC_WW_Pin1_4	116	121	PF00397	0.679
DOC_WW_Pin1_4	466	471	PF00397	0.638
DOC_WW_Pin1_4	524	529	PF00397	0.744
DOC_WW_Pin1_4	554	559	PF00397	0.757
DOC_WW_Pin1_4	702	707	PF00397	0.716
DOC_WW_Pin1_4	718	723	PF00397	0.686
DOC_WW_Pin1_4	82	87	PF00397	0.676
DOC_WW_Pin1_4	830	835	PF00397	0.741
DOC_WW_Pin1_4	852	857	PF00397	0.760
DOC_WW_Pin1_4	864	869	PF00397	0.655
DOC_WW_Pin1_4	897	902	PF00397	0.649
DOC_WW_Pin1_4	99	104	PF00397	0.716
LIG_14-3-3_CanoR_1	320	328	PF00244	0.601
LIG_14-3-3_CanoR_1	410	417	PF00244	0.643
LIG_14-3-3_CanoR_1	548	554	PF00244	0.767
LIG_14-3-3_CanoR_1	586	591	PF00244	0.700
LIG_14-3-3_CanoR_1	631	640	PF00244	0.715
LIG_14-3-3_CanoR_1	700	707	PF00244	0.700
LIG_14-3-3_CanoR_1	74	78	PF00244	0.645
LIG_14-3-3_CanoR_1	877	883	PF00244	0.810
LIG_14-3-3_CanoR_1	886	892	PF00244	0.719
LIG_14-3-3_CanoR_1	908	914	PF00244	0.672
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.629
LIG_BIR_III_2	305	309	PF00653	0.485
LIG_BRCT_BRCA1_1	75	79	PF00533	0.680
LIG_BRCT_BRCA1_1	889	893	PF00533	0.738
LIG_Clathr_ClatBox_1	180	184	PF01394	0.513
LIG_eIF4E_1	823	829	PF01652	0.740
LIG_FHA_1	165	171	PF00498	0.674
LIG_FHA_1	291	297	PF00498	0.540
LIG_FHA_1	349	355	PF00498	0.699
LIG_FHA_1	470	476	PF00498	0.550
LIG_FHA_1	681	687	PF00498	0.675
LIG_FHA_1	699	705	PF00498	0.657
LIG_FHA_1	7	13	PF00498	0.781
LIG_FHA_1	734	740	PF00498	0.566
LIG_FHA_1	796	802	PF00498	0.822
LIG_FHA_1	877	883	PF00498	0.739
LIG_FHA_2	29	35	PF00498	0.680
LIG_FHA_2	442	448	PF00498	0.575
LIG_FHA_2	630	636	PF00498	0.638
LIG_FHA_2	738	744	PF00498	0.623
LIG_FHA_2	87	93	PF00498	0.771
LIG_FHA_2	9	15	PF00498	0.666
LIG_HCF-1_HBM_1	594	597	PF13415	0.535
LIG_Integrin_RGD_1	813	815	PF01839	0.643
LIG_IRF3_LxIS_1	307	312	PF10401	0.643
LIG_LIR_Apic_2	912	916	PF02991	0.706
LIG_LIR_Gen_1	827	837	PF02991	0.687
LIG_LIR_Gen_1	85	94	PF02991	0.557
LIG_LIR_Nem_3	827	832	PF02991	0.676
LIG_LIR_Nem_3	85	90	PF02991	0.552
LIG_MYND_1	466	470	PF01753	0.559
LIG_NRBOX	295	301	PF00104	0.605
LIG_Pex14_2	388	392	PF04695	0.514
LIG_PTB_Apo_2	505	512	PF02174	0.692
LIG_PTB_Phospho_1	505	511	PF10480	0.694
LIG_RPA_C_Fungi	441	453	PF08784	0.584
LIG_SH2_CRK	823	827	PF00017	0.745
LIG_SH2_NCK_1	511	515	PF00017	0.737
LIG_SH2_NCK_1	823	827	PF00017	0.667
LIG_SH2_SRC	399	402	PF00017	0.636
LIG_SH2_SRC	511	514	PF00017	0.738
LIG_SH2_STAP1	171	175	PF00017	0.678
LIG_SH2_STAP1	326	330	PF00017	0.581
LIG_SH2_STAT3	474	477	PF00017	0.579
LIG_SH2_STAT3	597	600	PF00017	0.536
LIG_SH2_STAT5	10	13	PF00017	0.668
LIG_SH2_STAT5	474	477	PF00017	0.526
LIG_SH3_1	460	466	PF00018	0.592
LIG_SH3_3	20	26	PF00018	0.607
LIG_SH3_3	225	231	PF00018	0.540
LIG_SH3_3	301	307	PF00018	0.609
LIG_SH3_3	357	363	PF00018	0.775
LIG_SH3_3	411	417	PF00018	0.508
LIG_SH3_3	460	466	PF00018	0.614
LIG_SH3_3	681	687	PF00018	0.730
LIG_SH3_3	716	722	PF00018	0.788
LIG_SH3_3	72	78	PF00018	0.576
LIG_SH3_3	761	767	PF00018	0.727
LIG_SH3_3	791	797	PF00018	0.634
LIG_SUMO_SIM_par_1	307	312	PF11976	0.604
LIG_SUMO_SIM_par_1	586	591	PF11976	0.626
LIG_TRAF2_1	182	185	PF00917	0.469
LIG_TRAF2_1	413	416	PF00917	0.667
LIG_TRAF2_1	619	622	PF00917	0.568
MOD_CDC14_SPxK_1	102	105	PF00782	0.623
MOD_CDC14_SPxK_1	705	708	PF00782	0.660
MOD_CDK_SPK_2	554	559	PF00069	0.757
MOD_CDK_SPxK_1	702	708	PF00069	0.704
MOD_CDK_SPxK_1	99	105	PF00069	0.622
MOD_CDK_SPxxK_3	466	473	PF00069	0.692
MOD_CDK_SPxxK_3	852	859	PF00069	0.735
MOD_CK1_1	116	122	PF00069	0.779
MOD_CK1_1	274	280	PF00069	0.627
MOD_CK1_1	312	318	PF00069	0.699
MOD_CK1_1	344	350	PF00069	0.713
MOD_CK1_1	441	447	PF00069	0.579
MOD_CK1_1	469	475	PF00069	0.634
MOD_CK1_1	496	502	PF00069	0.709
MOD_CK1_1	5	11	PF00069	0.683
MOD_CK1_1	552	558	PF00069	0.784
MOD_CK1_1	691	697	PF00069	0.732
MOD_CK1_1	698	704	PF00069	0.731
MOD_CK1_1	804	810	PF00069	0.791
MOD_CK1_1	827	833	PF00069	0.673
MOD_CK1_1	838	844	PF00069	0.725
MOD_CK2_1	26	32	PF00069	0.733
MOD_CK2_1	289	295	PF00069	0.587
MOD_CK2_1	441	447	PF00069	0.589
MOD_CK2_1	455	461	PF00069	0.665
MOD_CK2_1	567	573	PF00069	0.744
MOD_CK2_1	718	724	PF00069	0.748
MOD_CK2_1	737	743	PF00069	0.629
MOD_CK2_1	8	14	PF00069	0.739
MOD_CK2_1	889	895	PF00069	0.791
MOD_Cter_Amidation	318	321	PF01082	0.580
MOD_Cter_Amidation	908	911	PF01082	0.654
MOD_GlcNHglycan	111	114	PF01048	0.795
MOD_GlcNHglycan	120	123	PF01048	0.542
MOD_GlcNHglycan	273	276	PF01048	0.649
MOD_GlcNHglycan	314	317	PF01048	0.755
MOD_GlcNHglycan	346	349	PF01048	0.750
MOD_GlcNHglycan	374	377	PF01048	0.531
MOD_GlcNHglycan	420	423	PF01048	0.746
MOD_GlcNHglycan	440	443	PF01048	0.358
MOD_GlcNHglycan	457	460	PF01048	0.665
MOD_GlcNHglycan	495	498	PF01048	0.750
MOD_GlcNHglycan	568	572	PF01048	0.736
MOD_GlcNHglycan	641	644	PF01048	0.769
MOD_GlcNHglycan	660	663	PF01048	0.534
MOD_GlcNHglycan	690	693	PF01048	0.737
MOD_GlcNHglycan	837	840	PF01048	0.725
MOD_GlcNHglycan	843	846	PF01048	0.771
MOD_GlcNHglycan	848	851	PF01048	0.791
MOD_GlcNHglycan	868	871	PF01048	0.641
MOD_GlcNHglycan	922	925	PF01048	0.613
MOD_GSK3_1	109	116	PF00069	0.728
MOD_GSK3_1	2	9	PF00069	0.765
MOD_GSK3_1	212	219	PF00069	0.657
MOD_GSK3_1	28	35	PF00069	0.767
MOD_GSK3_1	307	314	PF00069	0.684
MOD_GSK3_1	344	351	PF00069	0.753
MOD_GSK3_1	368	375	PF00069	0.611
MOD_GSK3_1	489	496	PF00069	0.643
MOD_GSK3_1	522	529	PF00069	0.774
MOD_GSK3_1	548	555	PF00069	0.814
MOD_GSK3_1	691	698	PF00069	0.706
MOD_GSK3_1	718	725	PF00069	0.680
MOD_GSK3_1	733	740	PF00069	0.628
MOD_GSK3_1	801	808	PF00069	0.806
MOD_GSK3_1	82	89	PF00069	0.655
MOD_GSK3_1	860	867	PF00069	0.770
MOD_LATS_1	524	530	PF00433	0.758
MOD_LATS_1	584	590	PF00433	0.654
MOD_N-GLC_1	164	169	PF02516	0.718
MOD_N-GLC_1	300	305	PF02516	0.647
MOD_N-GLC_1	342	347	PF02516	0.672
MOD_N-GLC_1	537	542	PF02516	0.678
MOD_N-GLC_1	694	699	PF02516	0.686
MOD_N-GLC_1	887	892	PF02516	0.784
MOD_NEK2_1	309	314	PF00069	0.681
MOD_NEK2_1	409	414	PF00069	0.687
MOD_NEK2_1	438	443	PF00069	0.606
MOD_NEK2_1	680	685	PF00069	0.692
MOD_NEK2_1	73	78	PF00069	0.615
MOD_NEK2_1	871	876	PF00069	0.779
MOD_NEK2_1	878	883	PF00069	0.721
MOD_PIKK_1	213	219	PF00454	0.659
MOD_PIKK_1	223	229	PF00454	0.604
MOD_PIKK_1	26	32	PF00454	0.822
MOD_PIKK_1	489	495	PF00454	0.687
MOD_PIKK_1	526	532	PF00454	0.786
MOD_PIKK_1	758	764	PF00454	0.776
MOD_PK_1	887	893	PF00069	0.709
MOD_PKA_1	488	494	PF00069	0.660
MOD_PKA_1	548	554	PF00069	0.829
MOD_PKA_2	319	325	PF00069	0.615
MOD_PKA_2	409	415	PF00069	0.642
MOD_PKA_2	488	494	PF00069	0.660
MOD_PKA_2	531	537	PF00069	0.807
MOD_PKA_2	548	554	PF00069	0.664
MOD_PKA_2	699	705	PF00069	0.764
MOD_PKA_2	73	79	PF00069	0.647
MOD_PKA_2	824	830	PF00069	0.733
MOD_PKA_2	876	882	PF00069	0.732
MOD_PKA_2	909	915	PF00069	0.619
MOD_PKB_1	547	555	PF00069	0.754
MOD_PKB_1	629	637	PF00069	0.694
MOD_PKB_1	715	723	PF00069	0.653
MOD_PKB_1	887	895	PF00069	0.709
MOD_Plk_1	207	213	PF00069	0.608
MOD_Plk_1	300	306	PF00069	0.634
MOD_Plk_1	5	11	PF00069	0.752
MOD_Plk_1	624	630	PF00069	0.700
MOD_Plk_1	887	893	PF00069	0.769
MOD_Plk_2-3	28	34	PF00069	0.595
MOD_Plk_4	216	222	PF00069	0.684
MOD_Plk_4	824	830	PF00069	0.679
MOD_Plk_4	889	895	PF00069	0.694
MOD_ProDKin_1	116	122	PF00069	0.697
MOD_ProDKin_1	466	472	PF00069	0.636
MOD_ProDKin_1	524	530	PF00069	0.743
MOD_ProDKin_1	554	560	PF00069	0.755
MOD_ProDKin_1	702	708	PF00069	0.717
MOD_ProDKin_1	718	724	PF00069	0.688
MOD_ProDKin_1	82	88	PF00069	0.678
MOD_ProDKin_1	830	836	PF00069	0.742
MOD_ProDKin_1	852	858	PF00069	0.763
MOD_ProDKin_1	864	870	PF00069	0.656
MOD_ProDKin_1	897	903	PF00069	0.648
MOD_ProDKin_1	99	105	PF00069	0.717
MOD_SUMO_for_1	402	405	PF00179	0.546
MOD_SUMO_rev_2	197	207	PF00179	0.526
MOD_SUMO_rev_2	529	539	PF00179	0.795
MOD_SUMO_rev_2	613	620	PF00179	0.610
TRG_DiLeu_BaEn_1	295	300	PF01217	0.600
TRG_DiLeu_BaEn_1	676	681	PF01217	0.662
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.492
TRG_ENDOCYTIC_2	190	193	PF00928	0.622
TRG_ENDOCYTIC_2	399	402	PF00928	0.500
TRG_ENDOCYTIC_2	42	45	PF00928	0.615
TRG_ER_diArg_1	139	142	PF00400	0.600
TRG_ER_diArg_1	148	150	PF00400	0.584
TRG_ER_diArg_1	334	337	PF00400	0.520
TRG_ER_diArg_1	393	395	PF00400	0.587
TRG_ER_diArg_1	451	453	PF00400	0.628
TRG_ER_diArg_1	547	550	PF00400	0.758
TRG_ER_diArg_1	628	631	PF00400	0.664
TRG_ER_diArg_1	713	715	PF00400	0.745
TRG_ER_diArg_1	884	887	PF00400	0.767
TRG_ER_diArg_1	907	910	PF00400	0.739
TRG_NES_CRM1_1	173	185	PF08389	0.606
TRG_NLS_MonoExtC_3	882	887	PF00514	0.724
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	586	591	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	744	748	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T1	Leptomonas seymouri	43%	97%
A0A3S7XBQ9	Leishmania donovani	100%	100%
A4HPZ6	Leishmania braziliensis	69%	99%
D0A4F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0T4	Leishmania major	89%	100%
V5BQ47	Trypanosoma cruzi	27%	100%