Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4IDP9_LEIIN

TriTrypDb:

LINF_360056500

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Phosphorylation

Promastigote: 553

Expansion

Sequence features

A4IDP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.500
CLV_C14_Caspase3-7	668	672	PF00656	0.766
CLV_NRD_NRD_1	169	171	PF00675	0.738
CLV_NRD_NRD_1	223	225	PF00675	0.503
CLV_NRD_NRD_1	273	275	PF00675	0.480
CLV_NRD_NRD_1	365	367	PF00675	0.598
CLV_NRD_NRD_1	402	404	PF00675	0.632
CLV_NRD_NRD_1	55	57	PF00675	0.521
CLV_NRD_NRD_1	611	613	PF00675	0.704
CLV_NRD_NRD_1	697	699	PF00675	0.578
CLV_NRD_NRD_1	710	712	PF00675	0.609
CLV_PCSK_FUR_1	221	225	PF00082	0.552
CLV_PCSK_FUR_1	708	712	PF00082	0.606
CLV_PCSK_KEX2_1	223	225	PF00082	0.545
CLV_PCSK_KEX2_1	273	275	PF00082	0.516
CLV_PCSK_KEX2_1	365	367	PF00082	0.598
CLV_PCSK_KEX2_1	402	404	PF00082	0.632
CLV_PCSK_KEX2_1	472	474	PF00082	0.598
CLV_PCSK_KEX2_1	545	547	PF00082	0.728
CLV_PCSK_KEX2_1	55	57	PF00082	0.623
CLV_PCSK_KEX2_1	611	613	PF00082	0.704
CLV_PCSK_KEX2_1	632	634	PF00082	0.717
CLV_PCSK_KEX2_1	683	685	PF00082	0.598
CLV_PCSK_KEX2_1	697	699	PF00082	0.578
CLV_PCSK_KEX2_1	707	709	PF00082	0.598
CLV_PCSK_KEX2_1	710	712	PF00082	0.609
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.612
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.728
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.623
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.768
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.598
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.598
CLV_PCSK_SKI1_1	529	533	PF00082	0.523
CLV_PCSK_SKI1_1	535	539	PF00082	0.567
CLV_PCSK_SKI1_1	582	586	PF00082	0.761
CLV_PCSK_SKI1_1	691	695	PF00082	0.581
CLV_Separin_Metazoa	530	534	PF03568	0.566
DEG_APCC_DBOX_1	364	372	PF00400	0.571
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DEG_SPOP_SBC_1	498	502	PF00917	0.695
DOC_MAPK_gen_1	178	188	PF00069	0.605
DOC_MAPK_gen_1	221	228	PF00069	0.546
DOC_MAPK_gen_1	533	541	PF00069	0.615
DOC_MAPK_gen_1	694	703	PF00069	0.580
DOC_MAPK_MEF2A_6	181	188	PF00069	0.558
DOC_PP1_RVXF_1	523	529	PF00149	0.535
DOC_PP1_RVXF_1	697	704	PF00149	0.591
DOC_USP7_MATH_1	176	180	PF00917	0.745
DOC_USP7_MATH_1	499	503	PF00917	0.752
DOC_USP7_MATH_1	573	577	PF00917	0.748
DOC_USP7_MATH_1	659	663	PF00917	0.784
DOC_USP7_MATH_1	666	670	PF00917	0.685
DOC_USP7_MATH_1	98	102	PF00917	0.563
DOC_USP7_UBL2_3	167	171	PF12436	0.686
DOC_USP7_UBL2_3	567	571	PF12436	0.743
DOC_WW_Pin1_4	299	304	PF00397	0.464
DOC_WW_Pin1_4	558	563	PF00397	0.647
LIG_14-3-3_CanoR_1	121	126	PF00244	0.533
LIG_14-3-3_CanoR_1	143	152	PF00244	0.728
LIG_14-3-3_CanoR_1	412	422	PF00244	0.516
LIG_14-3-3_CanoR_1	56	60	PF00244	0.544
LIG_14-3-3_CanoR_1	595	605	PF00244	0.794
LIG_Actin_WH2_2	119	134	PF00022	0.606
LIG_APCC_ABBA_1	226	231	PF00400	0.531
LIG_BRCT_BRCA1_1	103	107	PF00533	0.546
LIG_BRCT_BRCA1_1	338	342	PF00533	0.548
LIG_BRCT_BRCA1_1	72	76	PF00533	0.591
LIG_FHA_1	120	126	PF00498	0.591
LIG_FHA_1	13	19	PF00498	0.692
LIG_FHA_1	183	189	PF00498	0.699
LIG_FHA_1	46	52	PF00498	0.436
LIG_FHA_2	206	212	PF00498	0.401
LIG_FHA_2	457	463	PF00498	0.558
LIG_FHA_2	516	522	PF00498	0.661
LIG_LIR_Apic_2	314	318	PF02991	0.507
LIG_LIR_Gen_1	432	439	PF02991	0.500
LIG_LIR_Nem_3	432	436	PF02991	0.494
LIG_Pex14_1	315	319	PF04695	0.505
LIG_PTB_Apo_2	288	295	PF02174	0.552
LIG_SH2_SRC	227	230	PF00017	0.484
LIG_SH2_STAP1	260	264	PF00017	0.489
LIG_SH2_STAT3	235	238	PF00017	0.457
LIG_SH2_STAT3	89	92	PF00017	0.636
LIG_SH2_STAT5	113	116	PF00017	0.504
LIG_SH2_STAT5	227	230	PF00017	0.526
LIG_SH2_STAT5	235	238	PF00017	0.432
LIG_SH2_STAT5	241	244	PF00017	0.467
LIG_SH2_STAT5	376	379	PF00017	0.678
LIG_SH2_STAT5	399	402	PF00017	0.646
LIG_SH3_1	181	187	PF00018	0.666
LIG_SH3_2	187	192	PF14604	0.548
LIG_SH3_3	15	21	PF00018	0.681
LIG_SH3_3	181	187	PF00018	0.692
LIG_SH3_3	34	40	PF00018	0.471
LIG_SH3_3	60	66	PF00018	0.550
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.546
LIG_SUMO_SIM_par_1	120	127	PF11976	0.614
LIG_SUMO_SIM_par_1	210	219	PF11976	0.469
LIG_SUMO_SIM_par_1	420	425	PF11976	0.489
LIG_TRAF2_1	138	141	PF00917	0.570
LIG_WRC_WIRS_1	332	337	PF05994	0.494
MOD_CDK_SPxxK_3	558	565	PF00069	0.649
MOD_CK1_1	101	107	PF00069	0.455
MOD_CK1_1	165	171	PF00069	0.725
MOD_CK1_1	179	185	PF00069	0.643
MOD_CK1_1	252	258	PF00069	0.436
MOD_CK1_1	287	293	PF00069	0.557
MOD_CK1_1	379	385	PF00069	0.650
MOD_CK1_1	497	503	PF00069	0.756
MOD_CK1_1	506	512	PF00069	0.705
MOD_CK1_1	586	592	PF00069	0.831
MOD_CK1_1	598	604	PF00069	0.592
MOD_CK1_1	607	613	PF00069	0.550
MOD_CK1_1	615	621	PF00069	0.670
MOD_CK1_1	640	646	PF00069	0.825
MOD_CK1_1	669	675	PF00069	0.803
MOD_CK2_1	100	106	PF00069	0.411
MOD_CK2_1	456	462	PF00069	0.554
MOD_CK2_1	55	61	PF00069	0.539
MOD_Cter_Amidation	147	150	PF01082	0.737
MOD_GlcNHglycan	115	118	PF01048	0.411
MOD_GlcNHglycan	164	167	PF01048	0.745
MOD_GlcNHglycan	181	184	PF01048	0.621
MOD_GlcNHglycan	251	254	PF01048	0.395
MOD_GlcNHglycan	26	29	PF01048	0.434
MOD_GlcNHglycan	286	289	PF01048	0.555
MOD_GlcNHglycan	371	374	PF01048	0.569
MOD_GlcNHglycan	389	392	PF01048	0.718
MOD_GlcNHglycan	424	427	PF01048	0.450
MOD_GlcNHglycan	617	620	PF01048	0.716
MOD_GlcNHglycan	638	642	PF01048	0.785
MOD_GlcNHglycan	657	660	PF01048	0.698
MOD_GlcNHglycan	76	79	PF01048	0.644
MOD_GlcNHglycan	98	101	PF01048	0.411
MOD_GSK3_1	115	122	PF00069	0.411
MOD_GSK3_1	12	19	PF00069	0.534
MOD_GSK3_1	162	169	PF00069	0.715
MOD_GSK3_1	248	255	PF00069	0.412
MOD_GSK3_1	283	290	PF00069	0.514
MOD_GSK3_1	374	381	PF00069	0.577
MOD_GSK3_1	493	500	PF00069	0.682
MOD_GSK3_1	502	509	PF00069	0.703
MOD_GSK3_1	511	518	PF00069	0.685
MOD_GSK3_1	586	593	PF00069	0.722
MOD_GSK3_1	642	649	PF00069	0.684
MOD_GSK3_1	651	658	PF00069	0.657
MOD_GSK3_1	70	77	PF00069	0.694
MOD_GSK3_1	96	103	PF00069	0.411
MOD_N-GLC_1	284	289	PF02516	0.525
MOD_N-GLC_1	290	295	PF02516	0.542
MOD_N-GLC_1	385	390	PF02516	0.711
MOD_N-GLC_1	502	507	PF02516	0.647
MOD_N-GLC_1	701	706	PF02516	0.595
MOD_N-GLC_2	199	201	PF02516	0.463
MOD_N-GLC_2	367	369	PF02516	0.557
MOD_NEK2_1	248	253	PF00069	0.395
MOD_NEK2_1	283	288	PF00069	0.506
MOD_NEK2_1	346	351	PF00069	0.409
MOD_NEK2_1	422	427	PF00069	0.458
MOD_NEK2_1	617	622	PF00069	0.661
MOD_NEK2_1	642	647	PF00069	0.711
MOD_NEK2_2	331	336	PF00069	0.591
MOD_PIKK_1	234	240	PF00454	0.444
MOD_PIKK_1	503	509	PF00454	0.686
MOD_PK_1	121	127	PF00069	0.411
MOD_PK_1	268	274	PF00069	0.503
MOD_PK_1	55	61	PF00069	0.641
MOD_PK_1	612	618	PF00069	0.619
MOD_PKA_1	170	176	PF00069	0.694
MOD_PKA_1	55	61	PF00069	0.641
MOD_PKA_1	566	572	PF00069	0.783
MOD_PKA_2	177	183	PF00069	0.828
MOD_PKA_2	413	419	PF00069	0.498
MOD_PKA_2	55	61	PF00069	0.539
MOD_PKA_2	586	592	PF00069	0.780
MOD_Plk_1	119	125	PF00069	0.411
MOD_Plk_1	16	22	PF00069	0.577
MOD_Plk_1	268	274	PF00069	0.503
MOD_Plk_1	290	296	PF00069	0.533
MOD_Plk_1	337	343	PF00069	0.514
MOD_Plk_1	374	380	PF00069	0.581
MOD_Plk_1	493	499	PF00069	0.672
MOD_Plk_1	637	643	PF00069	0.715
MOD_Plk_1	69	75	PF00069	0.577
MOD_Plk_1	701	707	PF00069	0.595
MOD_Plk_2-3	515	521	PF00069	0.680
MOD_Plk_2-3	550	556	PF00069	0.779
MOD_Plk_4	290	296	PF00069	0.533
MOD_Plk_4	379	385	PF00069	0.621
MOD_Plk_4	395	401	PF00069	0.602
MOD_Plk_4	612	618	PF00069	0.694
MOD_Plk_4	642	648	PF00069	0.759
MOD_Plk_4	70	76	PF00069	0.525
MOD_ProDKin_1	299	305	PF00069	0.463
MOD_ProDKin_1	558	564	PF00069	0.647
MOD_SUMO_for_1	516	519	PF00179	0.584
MOD_SUMO_for_1	693	696	PF00179	0.561
MOD_SUMO_rev_2	509	518	PF00179	0.698
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.594
TRG_ENDOCYTIC_2	319	322	PF00928	0.498
TRG_ER_diArg_1	142	145	PF00400	0.530
TRG_ER_diArg_1	223	225	PF00400	0.611
TRG_ER_diArg_1	272	274	PF00400	0.557
TRG_ER_diArg_1	364	366	PF00400	0.595
TRG_ER_diArg_1	401	403	PF00400	0.622
TRG_ER_diArg_1	412	415	PF00400	0.520
TRG_ER_diArg_1	448	451	PF00400	0.572
TRG_ER_diArg_1	532	535	PF00400	0.576
TRG_ER_diArg_1	611	613	PF00400	0.700
TRG_ER_diArg_1	708	711	PF00400	0.605
TRG_NES_CRM1_1	2	14	PF08389	0.545
TRG_NLS_Bipartite_1	157	174	PF00514	0.598
TRG_NLS_Bipartite_1	682	702	PF00514	0.586
TRG_NLS_MonoCore_2	629	634	PF00514	0.724
TRG_NLS_MonoExtC_3	54	60	PF00514	0.551
TRG_NLS_MonoExtC_3	564	570	PF00514	0.703
TRG_NLS_MonoExtN_4	167	174	PF00514	0.625
TRG_NLS_MonoExtN_4	562	569	PF00514	0.752
TRG_NLS_MonoExtN_4	630	635	PF00514	0.747
TRG_NLS_MonoExtN_4	697	702	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Z8	Leptomonas seymouri	75%	100%
A0A3S7XBM3	Leishmania donovani	99%	100%
A4HPY8	Leishmania braziliensis	74%	99%
E9ATQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0U2	Leishmania major	91%	100%