LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family - putative
Species:
Leishmania infantum
UniProt:
A4IDP8_LEIIN
TriTrypDb:
LINF_360056400
Length:
992

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDP8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDP8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 584 588 PF00656 0.564
CLV_C14_Caspase3-7 770 774 PF00656 0.543
CLV_NRD_NRD_1 188 190 PF00675 0.457
CLV_NRD_NRD_1 342 344 PF00675 0.495
CLV_NRD_NRD_1 383 385 PF00675 0.475
CLV_NRD_NRD_1 394 396 PF00675 0.386
CLV_NRD_NRD_1 566 568 PF00675 0.755
CLV_NRD_NRD_1 59 61 PF00675 0.492
CLV_NRD_NRD_1 741 743 PF00675 0.650
CLV_NRD_NRD_1 789 791 PF00675 0.683
CLV_NRD_NRD_1 876 878 PF00675 0.451
CLV_PCSK_FUR_1 381 385 PF00082 0.500
CLV_PCSK_KEX2_1 188 190 PF00082 0.457
CLV_PCSK_KEX2_1 342 344 PF00082 0.495
CLV_PCSK_KEX2_1 371 373 PF00082 0.478
CLV_PCSK_KEX2_1 381 383 PF00082 0.470
CLV_PCSK_KEX2_1 396 398 PF00082 0.375
CLV_PCSK_KEX2_1 552 554 PF00082 0.648
CLV_PCSK_KEX2_1 61 63 PF00082 0.489
CLV_PCSK_KEX2_1 740 742 PF00082 0.661
CLV_PCSK_KEX2_1 876 878 PF00082 0.451
CLV_PCSK_KEX2_1 928 930 PF00082 0.434
CLV_PCSK_PC1ET2_1 371 373 PF00082 0.466
CLV_PCSK_PC1ET2_1 396 398 PF00082 0.391
CLV_PCSK_PC1ET2_1 552 554 PF00082 0.648
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.489
CLV_PCSK_PC1ET2_1 740 742 PF00082 0.661
CLV_PCSK_PC1ET2_1 928 930 PF00082 0.434
CLV_PCSK_PC7_1 548 554 PF00082 0.648
CLV_PCSK_SKI1_1 100 104 PF00082 0.571
CLV_PCSK_SKI1_1 216 220 PF00082 0.304
CLV_PCSK_SKI1_1 396 400 PF00082 0.347
CLV_PCSK_SKI1_1 469 473 PF00082 0.696
CLV_PCSK_SKI1_1 516 520 PF00082 0.621
CLV_PCSK_SKI1_1 741 745 PF00082 0.625
CLV_PCSK_SKI1_1 929 933 PF00082 0.346
DEG_APCC_DBOX_1 394 402 PF00400 0.565
DEG_Nend_UBRbox_3 1 3 PF02207 0.569
DEG_SCF_FBW7_2 441 448 PF00400 0.442
DEG_SPOP_SBC_1 311 315 PF00917 0.669
DEG_SPOP_SBC_1 727 731 PF00917 0.521
DOC_ANK_TNKS_1 61 68 PF00023 0.572
DOC_CDC14_PxL_1 349 357 PF14671 0.692
DOC_CDC14_PxL_1 517 525 PF14671 0.457
DOC_CKS1_1 365 370 PF01111 0.687
DOC_CKS1_1 442 447 PF01111 0.441
DOC_CKS1_1 879 884 PF01111 0.669
DOC_CKS1_1 986 991 PF01111 0.636
DOC_CYCLIN_yCln2_LP_2 472 478 PF00134 0.575
DOC_CYCLIN_yCln2_LP_2 916 922 PF00134 0.592
DOC_MAPK_DCC_7 911 920 PF00069 0.522
DOC_MAPK_gen_1 395 402 PF00069 0.513
DOC_MAPK_HePTP_8 908 920 PF00069 0.563
DOC_MAPK_MEF2A_6 395 402 PF00069 0.491
DOC_MAPK_MEF2A_6 469 476 PF00069 0.486
DOC_MAPK_MEF2A_6 911 920 PF00069 0.544
DOC_MAPK_NFAT4_5 469 477 PF00069 0.526
DOC_PIKK_1 51 59 PF02985 0.650
DOC_PP1_RVXF_1 701 708 PF00149 0.488
DOC_PP1_RVXF_1 926 933 PF00149 0.628
DOC_PP2B_LxvP_1 412 415 PF13499 0.431
DOC_PP2B_LxvP_1 472 475 PF13499 0.572
DOC_PP2B_LxvP_1 916 919 PF13499 0.599
DOC_PP4_FxxP_1 130 133 PF00568 0.727
DOC_USP7_MATH_1 111 115 PF00917 0.742
DOC_USP7_MATH_1 183 187 PF00917 0.663
DOC_USP7_MATH_1 265 269 PF00917 0.691
DOC_USP7_MATH_1 297 301 PF00917 0.662
DOC_USP7_MATH_1 427 431 PF00917 0.426
DOC_USP7_MATH_1 487 491 PF00917 0.570
DOC_USP7_MATH_1 605 609 PF00917 0.540
DOC_USP7_MATH_1 665 669 PF00917 0.523
DOC_USP7_MATH_1 752 756 PF00917 0.532
DOC_USP7_MATH_1 757 761 PF00917 0.558
DOC_USP7_MATH_1 808 812 PF00917 0.486
DOC_USP7_MATH_1 828 832 PF00917 0.284
DOC_USP7_MATH_1 851 855 PF00917 0.696
DOC_USP7_MATH_1 87 91 PF00917 0.761
DOC_USP7_MATH_1 880 884 PF00917 0.672
DOC_USP7_MATH_1 886 890 PF00917 0.672
DOC_USP7_UBL2_3 968 972 PF12436 0.553
DOC_WW_Pin1_4 122 127 PF00397 0.758
DOC_WW_Pin1_4 174 179 PF00397 0.663
DOC_WW_Pin1_4 271 276 PF00397 0.744
DOC_WW_Pin1_4 278 283 PF00397 0.699
DOC_WW_Pin1_4 344 349 PF00397 0.662
DOC_WW_Pin1_4 364 369 PF00397 0.711
DOC_WW_Pin1_4 441 446 PF00397 0.445
DOC_WW_Pin1_4 483 488 PF00397 0.594
DOC_WW_Pin1_4 793 798 PF00397 0.532
DOC_WW_Pin1_4 804 809 PF00397 0.413
DOC_WW_Pin1_4 878 883 PF00397 0.664
DOC_WW_Pin1_4 94 99 PF00397 0.711
DOC_WW_Pin1_4 985 990 PF00397 0.571
LIG_14-3-3_CanoR_1 100 109 PF00244 0.773
LIG_14-3-3_CanoR_1 143 147 PF00244 0.631
LIG_14-3-3_CanoR_1 342 348 PF00244 0.695
LIG_14-3-3_CanoR_1 432 438 PF00244 0.545
LIG_14-3-3_CanoR_1 607 613 PF00244 0.495
LIG_14-3-3_CanoR_1 776 780 PF00244 0.486
LIG_14-3-3_CanoR_1 782 786 PF00244 0.487
LIG_14-3-3_CanoR_1 861 867 PF00244 0.672
LIG_Actin_WH2_2 812 827 PF00022 0.330
LIG_APCC_ABBA_1 519 524 PF00400 0.410
LIG_APCC_ABBAyCdc20_2 577 583 PF00400 0.514
LIG_BIR_III_2 350 354 PF00653 0.688
LIG_BIR_III_4 64 68 PF00653 0.576
LIG_BRCT_BRCA1_1 761 765 PF00533 0.561
LIG_eIF4E_1 214 220 PF01652 0.521
LIG_FHA_1 21 27 PF00498 0.537
LIG_FHA_1 213 219 PF00498 0.638
LIG_FHA_1 335 341 PF00498 0.731
LIG_FHA_1 344 350 PF00498 0.671
LIG_FHA_1 444 450 PF00498 0.433
LIG_FHA_1 644 650 PF00498 0.547
LIG_FHA_1 722 728 PF00498 0.500
LIG_FHA_1 793 799 PF00498 0.466
LIG_FHA_1 819 825 PF00498 0.453
LIG_FHA_1 879 885 PF00498 0.671
LIG_FHA_2 154 160 PF00498 0.539
LIG_FHA_2 162 168 PF00498 0.471
LIG_FHA_2 272 278 PF00498 0.638
LIG_FHA_2 608 614 PF00498 0.521
LIG_FHA_2 986 992 PF00498 0.643
LIG_GBD_Chelix_1 974 982 PF00786 0.331
LIG_Integrin_isoDGR_2 546 548 PF01839 0.715
LIG_Integrin_RGD_1 62 64 PF01839 0.424
LIG_LIR_Apic_2 213 217 PF02991 0.555
LIG_LIR_Apic_2 909 915 PF02991 0.599
LIG_LIR_Gen_1 150 158 PF02991 0.545
LIG_LIR_Gen_1 664 674 PF02991 0.535
LIG_LIR_Gen_1 811 822 PF02991 0.370
LIG_LIR_Nem_3 150 154 PF02991 0.552
LIG_LIR_Nem_3 223 227 PF02991 0.514
LIG_LIR_Nem_3 37 42 PF02991 0.535
LIG_LIR_Nem_3 637 642 PF02991 0.595
LIG_LIR_Nem_3 664 669 PF02991 0.546
LIG_LIR_Nem_3 763 769 PF02991 0.462
LIG_LIR_Nem_3 811 817 PF02991 0.370
LIG_LIR_Nem_3 872 878 PF02991 0.689
LIG_LIR_Nem_3 935 940 PF02991 0.538
LIG_NRBOX 153 159 PF00104 0.621
LIG_PDZ_Class_2 987 992 PF00595 0.610
LIG_Pex14_1 818 822 PF04695 0.342
LIG_Pex14_2 142 146 PF04695 0.627
LIG_Pex14_2 16 20 PF04695 0.542
LIG_REV1ctd_RIR_1 456 462 PF16727 0.484
LIG_REV1ctd_RIR_1 962 973 PF16727 0.544
LIG_SH2_CRK 214 218 PF00017 0.634
LIG_SH2_CRK 39 43 PF00017 0.519
LIG_SH2_CRK 666 670 PF00017 0.603
LIG_SH2_CRK 745 749 PF00017 0.385
LIG_SH2_CRK 875 879 PF00017 0.701
LIG_SH2_CRK 944 948 PF00017 0.532
LIG_SH2_STAP1 230 234 PF00017 0.517
LIG_SH2_STAT3 437 440 PF00017 0.437
LIG_SH2_STAT3 940 943 PF00017 0.526
LIG_SH2_STAT5 171 174 PF00017 0.638
LIG_SH2_STAT5 214 217 PF00017 0.557
LIG_SH2_STAT5 251 254 PF00017 0.592
LIG_SH2_STAT5 501 504 PF00017 0.493
LIG_SH2_STAT5 522 525 PF00017 0.426
LIG_SH2_STAT5 666 669 PF00017 0.464
LIG_SH2_STAT5 814 817 PF00017 0.335
LIG_SH2_STAT5 912 915 PF00017 0.574
LIG_SH2_STAT5 940 943 PF00017 0.542
LIG_SH3_1 362 368 PF00018 0.675
LIG_SH3_1 794 800 PF00018 0.501
LIG_SH3_1 876 882 PF00018 0.658
LIG_SH3_3 172 178 PF00018 0.724
LIG_SH3_3 362 368 PF00018 0.675
LIG_SH3_3 41 47 PF00018 0.607
LIG_SH3_3 439 445 PF00018 0.448
LIG_SH3_3 745 751 PF00018 0.418
LIG_SH3_3 794 800 PF00018 0.498
LIG_SH3_3 876 882 PF00018 0.658
LIG_SH3_3 895 901 PF00018 0.664
LIG_SH3_3 911 917 PF00018 0.546
LIG_SH3_3 983 989 PF00018 0.615
LIG_SH3_4 837 844 PF00018 0.629
LIG_SUMO_SIM_anti_2 153 159 PF11976 0.619
LIG_SUMO_SIM_anti_2 337 342 PF11976 0.755
LIG_SUMO_SIM_par_1 153 159 PF11976 0.619
LIG_SUMO_SIM_par_1 241 247 PF11976 0.507
LIG_SUMO_SIM_par_1 462 467 PF11976 0.465
LIG_SUMO_SIM_par_1 679 686 PF11976 0.485
LIG_SUMO_SIM_par_1 825 831 PF11976 0.389
LIG_TYR_ITIM 228 233 PF00017 0.359
LIG_TYR_ITIM 743 748 PF00017 0.468
LIG_TYR_ITSM 35 42 PF00017 0.366
LIG_UBA3_1 517 525 PF00899 0.631
LIG_UBA3_1 920 928 PF00899 0.366
LIG_WRC_WIRS_1 819 824 PF05994 0.278
LIG_WW_1 211 214 PF00397 0.509
MOD_CDC14_SPxK_1 796 799 PF00782 0.629
MOD_CDC14_SPxK_1 97 100 PF00782 0.576
MOD_CDK_SPxK_1 793 799 PF00069 0.627
MOD_CDK_SPxK_1 94 100 PF00069 0.566
MOD_CDK_SPxxK_3 364 371 PF00069 0.579
MOD_CK1_1 10 16 PF00069 0.385
MOD_CK1_1 177 183 PF00069 0.517
MOD_CK1_1 195 201 PF00069 0.668
MOD_CK1_1 300 306 PF00069 0.630
MOD_CK1_1 363 369 PF00069 0.669
MOD_CK1_1 486 492 PF00069 0.703
MOD_CK1_1 534 540 PF00069 0.676
MOD_CK1_1 569 575 PF00069 0.666
MOD_CK1_1 585 591 PF00069 0.550
MOD_CK1_1 608 614 PF00069 0.656
MOD_CK1_1 728 734 PF00069 0.627
MOD_CK1_1 755 761 PF00069 0.584
MOD_CK1_1 774 780 PF00069 0.767
MOD_CK1_1 79 85 PF00069 0.567
MOD_CK1_1 792 798 PF00069 0.565
MOD_CK1_1 853 859 PF00069 0.612
MOD_CK1_1 860 866 PF00069 0.582
MOD_CK1_1 94 100 PF00069 0.576
MOD_CK2_1 153 159 PF00069 0.399
MOD_CK2_1 161 167 PF00069 0.257
MOD_CK2_1 300 306 PF00069 0.781
MOD_CK2_1 656 662 PF00069 0.759
MOD_CK2_1 687 693 PF00069 0.628
MOD_CK2_1 985 991 PF00069 0.536
MOD_CMANNOS 809 812 PF00535 0.483
MOD_GlcNHglycan 103 106 PF01048 0.721
MOD_GlcNHglycan 179 182 PF01048 0.534
MOD_GlcNHglycan 185 188 PF01048 0.569
MOD_GlcNHglycan 189 192 PF01048 0.609
MOD_GlcNHglycan 267 270 PF01048 0.695
MOD_GlcNHglycan 300 303 PF01048 0.780
MOD_GlcNHglycan 362 365 PF01048 0.632
MOD_GlcNHglycan 429 432 PF01048 0.469
MOD_GlcNHglycan 489 492 PF01048 0.719
MOD_GlcNHglycan 5 8 PF01048 0.413
MOD_GlcNHglycan 533 536 PF01048 0.643
MOD_GlcNHglycan 571 574 PF01048 0.684
MOD_GlcNHglycan 607 610 PF01048 0.666
MOD_GlcNHglycan 654 657 PF01048 0.628
MOD_GlcNHglycan 659 662 PF01048 0.633
MOD_GlcNHglycan 78 81 PF01048 0.550
MOD_GlcNHglycan 853 856 PF01048 0.674
MOD_GSK3_1 161 168 PF00069 0.418
MOD_GSK3_1 183 190 PF00069 0.641
MOD_GSK3_1 195 202 PF00069 0.684
MOD_GSK3_1 3 10 PF00069 0.418
MOD_GSK3_1 310 317 PF00069 0.615
MOD_GSK3_1 360 367 PF00069 0.711
MOD_GSK3_1 427 434 PF00069 0.446
MOD_GSK3_1 483 490 PF00069 0.667
MOD_GSK3_1 562 569 PF00069 0.632
MOD_GSK3_1 581 588 PF00069 0.661
MOD_GSK3_1 652 659 PF00069 0.598
MOD_GSK3_1 683 690 PF00069 0.630
MOD_GSK3_1 691 698 PF00069 0.625
MOD_GSK3_1 699 706 PF00069 0.588
MOD_GSK3_1 717 724 PF00069 0.504
MOD_GSK3_1 755 762 PF00069 0.576
MOD_GSK3_1 76 83 PF00069 0.575
MOD_GSK3_1 771 778 PF00069 0.511
MOD_GSK3_1 780 787 PF00069 0.601
MOD_GSK3_1 789 796 PF00069 0.606
MOD_GSK3_1 804 811 PF00069 0.518
MOD_GSK3_1 836 843 PF00069 0.658
MOD_GSK3_1 853 860 PF00069 0.516
MOD_GSK3_1 861 868 PF00069 0.589
MOD_GSK3_1 87 94 PF00069 0.618
MOD_N-GLC_1 111 116 PF02516 0.578
MOD_N-GLC_1 298 303 PF02516 0.707
MOD_N-GLC_1 450 455 PF02516 0.511
MOD_N-GLC_1 7 12 PF02516 0.429
MOD_N-GLC_1 792 797 PF02516 0.654
MOD_N-GLC_2 170 172 PF02516 0.507
MOD_NEK2_1 101 106 PF00069 0.655
MOD_NEK2_1 142 147 PF00069 0.594
MOD_NEK2_1 450 455 PF00069 0.511
MOD_NEK2_1 526 531 PF00069 0.618
MOD_NEK2_1 683 688 PF00069 0.615
MOD_NEK2_1 691 696 PF00069 0.623
MOD_NEK2_1 725 730 PF00069 0.666
MOD_NEK2_1 789 794 PF00069 0.591
MOD_NEK2_1 850 855 PF00069 0.640
MOD_NEK2_2 665 670 PF00069 0.501
MOD_NEK2_2 870 875 PF00069 0.514
MOD_PIKK_1 906 912 PF00454 0.643
MOD_PKA_1 342 348 PF00069 0.602
MOD_PKA_1 567 573 PF00069 0.674
MOD_PKA_2 142 148 PF00069 0.534
MOD_PKA_2 187 193 PF00069 0.703
MOD_PKA_2 342 348 PF00069 0.672
MOD_PKA_2 431 437 PF00069 0.536
MOD_PKA_2 531 537 PF00069 0.683
MOD_PKA_2 566 572 PF00069 0.618
MOD_PKA_2 695 701 PF00069 0.654
MOD_PKA_2 775 781 PF00069 0.615
MOD_PKA_2 789 795 PF00069 0.583
MOD_PKA_2 860 866 PF00069 0.602
MOD_PKB_1 236 244 PF00069 0.356
MOD_Plk_1 450 456 PF00069 0.511
MOD_Plk_1 703 709 PF00069 0.643
MOD_Plk_1 774 780 PF00069 0.626
MOD_Plk_1 886 892 PF00069 0.709
MOD_Plk_2-3 153 159 PF00069 0.399
MOD_Plk_4 10 16 PF00069 0.514
MOD_Plk_4 153 159 PF00069 0.415
MOD_Plk_4 336 342 PF00069 0.655
MOD_Plk_4 687 693 PF00069 0.717
MOD_Plk_4 703 709 PF00069 0.516
MOD_Plk_4 761 767 PF00069 0.570
MOD_Plk_4 781 787 PF00069 0.594
MOD_Plk_4 808 814 PF00069 0.576
MOD_Plk_4 818 824 PF00069 0.335
MOD_Plk_4 828 834 PF00069 0.183
MOD_Plk_4 870 876 PF00069 0.521
MOD_Plk_4 88 94 PF00069 0.543
MOD_Plk_4 936 942 PF00069 0.510
MOD_ProDKin_1 122 128 PF00069 0.707
MOD_ProDKin_1 174 180 PF00069 0.571
MOD_ProDKin_1 271 277 PF00069 0.691
MOD_ProDKin_1 278 284 PF00069 0.621
MOD_ProDKin_1 344 350 PF00069 0.572
MOD_ProDKin_1 364 370 PF00069 0.640
MOD_ProDKin_1 441 447 PF00069 0.546
MOD_ProDKin_1 483 489 PF00069 0.757
MOD_ProDKin_1 793 799 PF00069 0.674
MOD_ProDKin_1 804 810 PF00069 0.494
MOD_ProDKin_1 878 884 PF00069 0.582
MOD_ProDKin_1 94 100 PF00069 0.647
MOD_ProDKin_1 985 991 PF00069 0.460
MOD_SUMO_rev_2 481 486 PF00179 0.591
MOD_SUMO_rev_2 608 617 PF00179 0.669
MOD_SUMO_rev_2 633 642 PF00179 0.540
TRG_ENDOCYTIC_2 230 233 PF00928 0.361
TRG_ENDOCYTIC_2 39 42 PF00928 0.375
TRG_ENDOCYTIC_2 403 406 PF00928 0.335
TRG_ENDOCYTIC_2 666 669 PF00928 0.768
TRG_ENDOCYTIC_2 745 748 PF00928 0.487
TRG_ENDOCYTIC_2 766 769 PF00928 0.573
TRG_ENDOCYTIC_2 814 817 PF00928 0.453
TRG_ENDOCYTIC_2 875 878 PF00928 0.625
TRG_ER_diArg_1 236 239 PF00400 0.382
TRG_ER_diArg_1 325 328 PF00400 0.560
TRG_ER_diArg_1 341 343 PF00400 0.523
TRG_ER_diArg_1 380 383 PF00400 0.558
TRG_ER_diArg_1 395 398 PF00400 0.494
TRG_ER_diArg_1 577 580 PF00400 0.624
TRG_ER_diArg_1 59 62 PF00400 0.616
TRG_ER_diArg_1 741 743 PF00400 0.670
TRG_ER_diArg_1 875 877 PF00400 0.546
TRG_NLS_Bipartite_1 381 399 PF00514 0.514
TRG_Pf-PMV_PEXEL_1 372 377 PF00026 0.557
TRG_Pf-PMV_PEXEL_1 647 651 PF00026 0.631
TRG_Pf-PMV_PEXEL_1 741 746 PF00026 0.636

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8A1 Leptomonas seymouri 46% 92%
A0A3Q8IPH9 Leishmania donovani 99% 100%
A4HPY7 Leishmania braziliensis 68% 100%
E9ATQ4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 99%
Q4Q0U4 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS