LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Vacuolar sorting protein 9 (VPS9) domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IDP4_LEIIN
TriTrypDb:
LINF_360056000
Length:
931

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0030139 endocytic vesicle 7 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDP4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDP4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 7
GO:0016192 vesicle-mediated transport 4 7
GO:0051179 localization 1 7
GO:0051234 establishment of localization 2 7
Molecular functions
Term Name Level Count
GO:0005085 guanyl-nucleotide exchange factor activity 3 7
GO:0030234 enzyme regulator activity 2 7
GO:0030695 GTPase regulator activity 4 7
GO:0060589 nucleoside-triphosphatase regulator activity 3 7
GO:0098772 molecular function regulator activity 1 7
GO:0140677 molecular function activator activity 2 7
GO:0140678 molecular function inhibitor activity 2 7
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0031267 small GTPase binding 5 1
GO:0051020 GTPase binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 116 120 PF00656 0.596
CLV_C14_Caspase3-7 5 9 PF00656 0.521
CLV_C14_Caspase3-7 816 820 PF00656 0.653
CLV_NRD_NRD_1 428 430 PF00675 0.551
CLV_NRD_NRD_1 490 492 PF00675 0.425
CLV_NRD_NRD_1 529 531 PF00675 0.486
CLV_NRD_NRD_1 603 605 PF00675 0.312
CLV_PCSK_FUR_1 601 605 PF00082 0.285
CLV_PCSK_KEX2_1 162 164 PF00082 0.369
CLV_PCSK_KEX2_1 428 430 PF00082 0.551
CLV_PCSK_KEX2_1 490 492 PF00082 0.425
CLV_PCSK_KEX2_1 529 531 PF00082 0.455
CLV_PCSK_KEX2_1 603 605 PF00082 0.312
CLV_PCSK_KEX2_1 607 609 PF00082 0.312
CLV_PCSK_PC1ET2_1 162 164 PF00082 0.369
CLV_PCSK_PC1ET2_1 607 609 PF00082 0.340
CLV_PCSK_PC7_1 603 609 PF00082 0.340
CLV_PCSK_SKI1_1 122 126 PF00082 0.396
CLV_PCSK_SKI1_1 224 228 PF00082 0.384
CLV_PCSK_SKI1_1 349 353 PF00082 0.562
CLV_PCSK_SKI1_1 511 515 PF00082 0.367
CLV_PCSK_SKI1_1 604 608 PF00082 0.291
CLV_PCSK_SKI1_1 718 722 PF00082 0.615
CLV_PCSK_SKI1_1 73 77 PF00082 0.486
CLV_PCSK_SKI1_1 743 747 PF00082 0.558
CLV_PCSK_SKI1_1 898 902 PF00082 0.448
CLV_PCSK_SKI1_1 924 928 PF00082 0.461
DEG_APCC_DBOX_1 223 231 PF00400 0.438
DEG_APCC_DBOX_1 498 506 PF00400 0.358
DEG_SCF_FBW7_1 242 248 PF00400 0.515
DEG_SCF_FBW7_1 489 496 PF00400 0.444
DOC_CDC14_PxL_1 251 259 PF14671 0.572
DOC_CKS1_1 242 247 PF01111 0.556
DOC_CYCLIN_RxL_1 534 543 PF00134 0.448
DOC_CYCLIN_RxL_1 894 903 PF00134 0.422
DOC_MAPK_gen_1 36 44 PF00069 0.423
DOC_MAPK_gen_1 894 902 PF00069 0.522
DOC_MAPK_MEF2A_6 587 596 PF00069 0.312
DOC_PP1_RVXF_1 643 650 PF00149 0.388
DOC_PP2B_LxvP_1 279 282 PF13499 0.672
DOC_PP2B_LxvP_1 42 45 PF13499 0.324
DOC_PP2B_LxvP_1 844 847 PF13499 0.619
DOC_PP2B_LxvP_1 882 885 PF13499 0.586
DOC_PP4_FxxP_1 575 578 PF00568 0.312
DOC_PP4_FxxP_1 659 662 PF00568 0.388
DOC_USP7_MATH_1 181 185 PF00917 0.577
DOC_USP7_MATH_1 392 396 PF00917 0.735
DOC_USP7_MATH_1 406 410 PF00917 0.655
DOC_USP7_MATH_1 471 475 PF00917 0.470
DOC_USP7_MATH_1 663 667 PF00917 0.331
DOC_USP7_MATH_1 773 777 PF00917 0.646
DOC_USP7_MATH_1 802 806 PF00917 0.624
DOC_USP7_MATH_1 813 817 PF00917 0.704
DOC_USP7_MATH_1 822 826 PF00917 0.493
DOC_USP7_UBL2_3 237 241 PF12436 0.524
DOC_WW_Pin1_4 241 246 PF00397 0.559
DOC_WW_Pin1_4 489 494 PF00397 0.402
DOC_WW_Pin1_4 574 579 PF00397 0.312
DOC_WW_Pin1_4 697 702 PF00397 0.559
DOC_WW_Pin1_4 73 78 PF00397 0.511
DOC_WW_Pin1_4 842 847 PF00397 0.732
DOC_WW_Pin1_4 880 885 PF00397 0.659
DOC_WW_Pin1_4 889 894 PF00397 0.559
DOC_WW_Pin1_4 91 96 PF00397 0.832
LIG_14-3-3_CanoR_1 246 252 PF00244 0.574
LIG_14-3-3_CanoR_1 339 346 PF00244 0.592
LIG_14-3-3_CanoR_1 444 449 PF00244 0.404
LIG_14-3-3_CanoR_1 46 51 PF00244 0.374
LIG_14-3-3_CanoR_1 473 481 PF00244 0.391
LIG_14-3-3_CanoR_1 494 502 PF00244 0.579
LIG_14-3-3_CanoR_1 511 518 PF00244 0.270
LIG_14-3-3_CanoR_1 645 650 PF00244 0.312
LIG_BIR_II_1 1 5 PF00653 0.469
LIG_BIR_III_2 551 555 PF00653 0.381
LIG_BRCT_BRCA1_1 678 682 PF00533 0.353
LIG_BRCT_BRCA1_1 78 82 PF00533 0.544
LIG_Clathr_ClatBox_1 133 137 PF01394 0.380
LIG_Clathr_ClatBox_1 539 543 PF01394 0.491
LIG_CtBP_PxDLS_1 724 728 PF00389 0.598
LIG_DLG_GKlike_1 46 53 PF00625 0.388
LIG_FHA_1 124 130 PF00498 0.337
LIG_FHA_1 242 248 PF00498 0.583
LIG_FHA_1 304 310 PF00498 0.608
LIG_FHA_1 490 496 PF00498 0.477
LIG_FHA_1 512 518 PF00498 0.460
LIG_FHA_2 739 745 PF00498 0.605
LIG_FHA_2 785 791 PF00498 0.577
LIG_FHA_2 910 916 PF00498 0.431
LIG_LIR_Apic_2 573 578 PF02991 0.312
LIG_LIR_Apic_2 657 662 PF02991 0.388
LIG_LIR_Gen_1 130 139 PF02991 0.403
LIG_LIR_Gen_1 436 446 PF02991 0.441
LIG_LIR_Gen_1 475 482 PF02991 0.471
LIG_LIR_Gen_1 515 524 PF02991 0.389
LIG_LIR_Gen_1 907 916 PF02991 0.420
LIG_LIR_Nem_3 119 124 PF02991 0.409
LIG_LIR_Nem_3 126 131 PF02991 0.346
LIG_LIR_Nem_3 142 147 PF02991 0.428
LIG_LIR_Nem_3 426 430 PF02991 0.469
LIG_LIR_Nem_3 436 442 PF02991 0.460
LIG_LIR_Nem_3 475 481 PF02991 0.478
LIG_LIR_Nem_3 515 521 PF02991 0.384
LIG_LIR_Nem_3 907 911 PF02991 0.426
LIG_MYND_1 880 884 PF01753 0.544
LIG_PCNA_yPIPBox_3 499 513 PF02747 0.463
LIG_Pex14_2 438 442 PF04695 0.483
LIG_Pex14_2 633 637 PF04695 0.312
LIG_PTB_Apo_2 138 145 PF02174 0.536
LIG_PTB_Apo_2 649 656 PF02174 0.312
LIG_PTB_Phospho_1 649 655 PF10480 0.312
LIG_REV1ctd_RIR_1 572 577 PF16727 0.312
LIG_SH2_CRK 131 135 PF00017 0.353
LIG_SH2_CRK 427 431 PF00017 0.440
LIG_SH2_CRK 518 522 PF00017 0.381
LIG_SH2_NCK_1 331 335 PF00017 0.591
LIG_SH2_STAP1 277 281 PF00017 0.626
LIG_SH2_STAT5 327 330 PF00017 0.608
LIG_SH2_STAT5 331 334 PF00017 0.556
LIG_SH2_STAT5 461 464 PF00017 0.594
LIG_SH2_STAT5 512 515 PF00017 0.364
LIG_SH2_STAT5 58 61 PF00017 0.492
LIG_SH2_STAT5 655 658 PF00017 0.342
LIG_SH2_STAT5 671 674 PF00017 0.312
LIG_SH3_3 108 114 PF00018 0.625
LIG_SH3_3 196 202 PF00018 0.625
LIG_SH3_3 249 255 PF00018 0.649
LIG_SH3_3 316 322 PF00018 0.670
LIG_SH3_3 848 854 PF00018 0.590
LIG_Sin3_3 637 644 PF02671 0.312
LIG_SUMO_SIM_anti_2 49 54 PF11976 0.441
LIG_SUMO_SIM_anti_2 500 507 PF11976 0.415
LIG_SUMO_SIM_anti_2 787 793 PF11976 0.566
LIG_SUMO_SIM_par_1 306 313 PF11976 0.607
LIG_TRAF2_1 666 669 PF00917 0.312
LIG_TRAF2_1 780 783 PF00917 0.593
LIG_TRAF2_2 95 100 PF00917 0.665
LIG_TYR_ITIM 129 134 PF00017 0.346
LIG_UBA3_1 207 212 PF00899 0.399
LIG_UBA3_1 29 36 PF00899 0.393
LIG_WW_3 845 849 PF00397 0.623
MOD_CDC14_SPxK_1 845 848 PF00782 0.673
MOD_CDK_SPK_2 241 246 PF00069 0.517
MOD_CDK_SPK_2 489 494 PF00069 0.451
MOD_CDK_SPK_2 574 579 PF00069 0.312
MOD_CDK_SPK_2 889 894 PF00069 0.457
MOD_CDK_SPxK_1 842 848 PF00069 0.672
MOD_CDK_SPxxK_3 574 581 PF00069 0.312
MOD_CDK_SPxxK_3 889 896 PF00069 0.442
MOD_CK1_1 142 148 PF00069 0.423
MOD_CK1_1 184 190 PF00069 0.656
MOD_CK1_1 233 239 PF00069 0.673
MOD_CK1_1 280 286 PF00069 0.602
MOD_CK1_1 3 9 PF00069 0.442
MOD_CK1_1 342 348 PF00069 0.601
MOD_CK1_1 373 379 PF00069 0.774
MOD_CK1_1 67 73 PF00069 0.684
MOD_CK1_1 827 833 PF00069 0.613
MOD_CK1_1 889 895 PF00069 0.697
MOD_CK2_1 150 156 PF00069 0.501
MOD_CK2_1 233 239 PF00069 0.510
MOD_CK2_1 28 34 PF00069 0.403
MOD_CK2_1 301 307 PF00069 0.611
MOD_CK2_1 344 350 PF00069 0.597
MOD_CK2_1 437 443 PF00069 0.466
MOD_CK2_1 522 528 PF00069 0.468
MOD_CK2_1 574 580 PF00069 0.312
MOD_CK2_1 663 669 PF00069 0.388
MOD_CK2_1 777 783 PF00069 0.798
MOD_CK2_1 853 859 PF00069 0.592
MOD_CK2_1 909 915 PF00069 0.441
MOD_GlcNHglycan 147 150 PF01048 0.493
MOD_GlcNHglycan 183 186 PF01048 0.594
MOD_GlcNHglycan 191 194 PF01048 0.593
MOD_GlcNHglycan 232 235 PF01048 0.536
MOD_GlcNHglycan 279 282 PF01048 0.727
MOD_GlcNHglycan 346 349 PF01048 0.634
MOD_GlcNHglycan 353 356 PF01048 0.784
MOD_GlcNHglycan 375 378 PF01048 0.562
MOD_GlcNHglycan 474 477 PF01048 0.441
MOD_GlcNHglycan 495 498 PF01048 0.370
MOD_GlcNHglycan 617 620 PF01048 0.308
MOD_GlcNHglycan 69 73 PF01048 0.634
MOD_GlcNHglycan 703 706 PF01048 0.744
MOD_GlcNHglycan 713 716 PF01048 0.556
MOD_GlcNHglycan 727 730 PF01048 0.614
MOD_GlcNHglycan 78 81 PF01048 0.519
MOD_GlcNHglycan 819 823 PF01048 0.655
MOD_GlcNHglycan 855 858 PF01048 0.622
MOD_GSK3_1 184 191 PF00069 0.625
MOD_GSK3_1 241 248 PF00069 0.556
MOD_GSK3_1 293 300 PF00069 0.738
MOD_GSK3_1 301 308 PF00069 0.579
MOD_GSK3_1 456 463 PF00069 0.474
MOD_GSK3_1 489 496 PF00069 0.468
MOD_GSK3_1 64 71 PF00069 0.614
MOD_GSK3_1 663 670 PF00069 0.388
MOD_GSK3_1 672 679 PF00069 0.422
MOD_GSK3_1 697 704 PF00069 0.655
MOD_GSK3_1 763 770 PF00069 0.608
MOD_GSK3_1 773 780 PF00069 0.657
MOD_GSK3_1 818 825 PF00069 0.601
MOD_GSK3_1 827 834 PF00069 0.662
MOD_GSK3_1 900 907 PF00069 0.402
MOD_LATS_1 269 275 PF00433 0.553
MOD_N-GLC_1 145 150 PF02516 0.479
MOD_N-GLC_1 392 397 PF02516 0.663
MOD_N-GLC_1 522 527 PF02516 0.441
MOD_N-GLC_1 763 768 PF02516 0.632
MOD_N-GLC_1 889 894 PF02516 0.623
MOD_N-GLC_1 904 909 PF02516 0.382
MOD_N-GLC_2 299 301 PF02516 0.616
MOD_NEK2_1 20 25 PF00069 0.448
MOD_NEK2_1 230 235 PF00069 0.591
MOD_NEK2_1 247 252 PF00069 0.682
MOD_NEK2_1 305 310 PF00069 0.546
MOD_NEK2_1 351 356 PF00069 0.653
MOD_NEK2_1 370 375 PF00069 0.596
MOD_NEK2_1 59 64 PF00069 0.568
MOD_NEK2_1 676 681 PF00069 0.388
MOD_NEK2_1 900 905 PF00069 0.426
MOD_NEK2_2 406 411 PF00069 0.606
MOD_NEK2_2 713 718 PF00069 0.632
MOD_OFUCOSY 584 589 PF10250 0.388
MOD_PIKK_1 465 471 PF00454 0.350
MOD_PIKK_1 763 769 PF00454 0.599
MOD_PIKK_1 900 906 PF00454 0.420
MOD_PK_1 831 837 PF00069 0.619
MOD_PKA_2 150 156 PF00069 0.501
MOD_PKA_2 181 187 PF00069 0.543
MOD_PKA_2 245 251 PF00069 0.691
MOD_PKA_2 472 478 PF00069 0.380
MOD_PKA_2 493 499 PF00069 0.520
MOD_PKA_2 500 506 PF00069 0.407
MOD_PKA_2 64 70 PF00069 0.678
MOD_PKA_2 822 828 PF00069 0.640
MOD_PKA_2 847 853 PF00069 0.682
MOD_PKB_1 337 345 PF00069 0.569
MOD_PKB_1 643 651 PF00069 0.312
MOD_Plk_1 342 348 PF00069 0.698
MOD_Plk_1 667 673 PF00069 0.312
MOD_Plk_1 904 910 PF00069 0.432
MOD_Plk_2-3 777 783 PF00069 0.646
MOD_Plk_2-3 784 790 PF00069 0.563
MOD_Plk_2-3 909 915 PF00069 0.441
MOD_Plk_4 20 26 PF00069 0.470
MOD_Plk_4 247 253 PF00069 0.646
MOD_Plk_4 305 311 PF00069 0.594
MOD_Plk_4 500 506 PF00069 0.520
MOD_Plk_4 645 651 PF00069 0.312
MOD_Plk_4 676 682 PF00069 0.444
MOD_Plk_4 784 790 PF00069 0.637
MOD_ProDKin_1 241 247 PF00069 0.558
MOD_ProDKin_1 489 495 PF00069 0.396
MOD_ProDKin_1 574 580 PF00069 0.312
MOD_ProDKin_1 697 703 PF00069 0.558
MOD_ProDKin_1 73 79 PF00069 0.509
MOD_ProDKin_1 842 848 PF00069 0.679
MOD_ProDKin_1 880 886 PF00069 0.662
MOD_ProDKin_1 889 895 PF00069 0.548
MOD_ProDKin_1 91 97 PF00069 0.835
MOD_SUMO_rev_2 233 242 PF00179 0.565
MOD_SUMO_rev_2 858 867 PF00179 0.559
TRG_DiLeu_BaEn_1 218 223 PF01217 0.347
TRG_DiLeu_BaEn_1 441 446 PF01217 0.472
TRG_DiLeu_BaEn_1 922 927 PF01217 0.516
TRG_DiLeu_BaEn_4 668 674 PF01217 0.340
TRG_ENDOCYTIC_2 131 134 PF00928 0.341
TRG_ENDOCYTIC_2 331 334 PF00928 0.598
TRG_ENDOCYTIC_2 427 430 PF00928 0.485
TRG_ENDOCYTIC_2 439 442 PF00928 0.426
TRG_ENDOCYTIC_2 478 481 PF00928 0.384
TRG_ENDOCYTIC_2 518 521 PF00928 0.460
TRG_ER_diArg_1 179 182 PF00400 0.558
TRG_ER_diArg_1 427 429 PF00400 0.529
TRG_ER_diArg_1 489 491 PF00400 0.415
TRG_ER_diArg_1 600 603 PF00400 0.285
TRG_ER_diArg_1 642 645 PF00400 0.312
TRG_ER_diArg_1 893 896 PF00400 0.531
TRG_Pf-PMV_PEXEL_1 924 929 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7P3 Leptomonas seymouri 43% 92%
A0A3S7XBS1 Leishmania donovani 99% 100%
A4HPY3 Leishmania braziliensis 64% 100%
E9ATQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q0U8 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS