PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IDN8_LEIIN

TriTrypDb:

LINF_360055300

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDN8

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.579
CLV_C14_Caspase3-7	278	282	PF00656	0.596
CLV_C14_Caspase3-7	417	421	PF00656	0.574
CLV_C14_Caspase3-7	484	488	PF00656	0.553
CLV_NRD_NRD_1	250	252	PF00675	0.398
CLV_NRD_NRD_1	329	331	PF00675	0.305
CLV_NRD_NRD_1	346	348	PF00675	0.283
CLV_NRD_NRD_1	406	408	PF00675	0.521
CLV_NRD_NRD_1	449	451	PF00675	0.446
CLV_NRD_NRD_1	494	496	PF00675	0.670
CLV_NRD_NRD_1	527	529	PF00675	0.483
CLV_NRD_NRD_1	531	533	PF00675	0.518
CLV_NRD_NRD_1	603	605	PF00675	0.532
CLV_NRD_NRD_1	610	612	PF00675	0.531
CLV_NRD_NRD_1	646	648	PF00675	0.460
CLV_PCSK_FUR_1	644	648	PF00082	0.543
CLV_PCSK_KEX2_1	146	148	PF00082	0.534
CLV_PCSK_KEX2_1	191	193	PF00082	0.737
CLV_PCSK_KEX2_1	252	254	PF00082	0.407
CLV_PCSK_KEX2_1	329	331	PF00082	0.277
CLV_PCSK_KEX2_1	346	348	PF00082	0.172
CLV_PCSK_KEX2_1	406	408	PF00082	0.521
CLV_PCSK_KEX2_1	496	498	PF00082	0.683
CLV_PCSK_KEX2_1	527	529	PF00082	0.367
CLV_PCSK_KEX2_1	531	533	PF00082	0.419
CLV_PCSK_KEX2_1	610	612	PF00082	0.644
CLV_PCSK_KEX2_1	646	648	PF00082	0.456
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.534
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.554
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.498
CLV_PCSK_PC1ET2_1	496	498	PF00082	0.696
CLV_PCSK_PC7_1	527	533	PF00082	0.483
CLV_PCSK_SKI1_1	191	195	PF00082	0.671
CLV_PCSK_SKI1_1	29	33	PF00082	0.405
CLV_PCSK_SKI1_1	44	48	PF00082	0.458
CLV_PCSK_SKI1_1	49	53	PF00082	0.446
CLV_PCSK_SKI1_1	6	10	PF00082	0.455
DEG_APCC_DBOX_1	329	337	PF00400	0.487
DEG_APCC_DBOX_1	5	13	PF00400	0.355
DEG_Nend_UBRbox_2	1	3	PF02207	0.416
DEG_SCF_FBW7_1	50	56	PF00400	0.700
DEG_SPOP_SBC_1	157	161	PF00917	0.587
DOC_ANK_TNKS_1	544	551	PF00023	0.420
DOC_CKS1_1	288	293	PF01111	0.519
DOC_CKS1_1	50	55	PF01111	0.609
DOC_CYCLIN_yCln2_LP_2	288	294	PF00134	0.450
DOC_MAPK_gen_1	565	574	PF00069	0.574
DOC_PP2B_LxvP_1	186	189	PF13499	0.625
DOC_PP2B_LxvP_1	314	317	PF13499	0.487
DOC_PP2B_LxvP_1	590	593	PF13499	0.512
DOC_PP4_FxxP_1	229	232	PF00568	0.454
DOC_USP7_MATH_1	116	120	PF00917	0.494
DOC_USP7_MATH_1	157	161	PF00917	0.707
DOC_USP7_MATH_1	181	185	PF00917	0.575
DOC_USP7_MATH_1	202	206	PF00917	0.544
DOC_USP7_MATH_1	270	274	PF00917	0.366
DOC_USP7_MATH_1	37	41	PF00917	0.469
DOC_USP7_MATH_1	53	57	PF00917	0.585
DOC_USP7_MATH_1	60	64	PF00917	0.640
DOC_USP7_MATH_1	87	91	PF00917	0.783
DOC_WW_Pin1_4	158	163	PF00397	0.629
DOC_WW_Pin1_4	200	205	PF00397	0.512
DOC_WW_Pin1_4	287	292	PF00397	0.742
DOC_WW_Pin1_4	401	406	PF00397	0.708
DOC_WW_Pin1_4	431	436	PF00397	0.632
DOC_WW_Pin1_4	44	49	PF00397	0.645
DOC_WW_Pin1_4	443	448	PF00397	0.543
DOC_WW_Pin1_4	488	493	PF00397	0.654
DOC_WW_Pin1_4	78	83	PF00397	0.758
LIG_14-3-3_CanoR_1	176	181	PF00244	0.699
LIG_14-3-3_CanoR_1	214	221	PF00244	0.561
LIG_14-3-3_CanoR_1	251	260	PF00244	0.519
LIG_14-3-3_CanoR_1	29	34	PF00244	0.425
LIG_14-3-3_CanoR_1	296	304	PF00244	0.470
LIG_14-3-3_CanoR_1	567	575	PF00244	0.566
LIG_14-3-3_CanoR_1	646	651	PF00244	0.537
LIG_Actin_WH2_2	331	348	PF00022	0.487
LIG_CtBP_PxDLS_1	425	429	PF00389	0.565
LIG_deltaCOP1_diTrp_1	577	580	PF00928	0.522
LIG_FHA_1	421	427	PF00498	0.608
LIG_FHA_1	45	51	PF00498	0.653
LIG_FHA_1	478	484	PF00498	0.537
LIG_FHA_1	488	494	PF00498	0.676
LIG_FHA_1	613	619	PF00498	0.513
LIG_FHA_2	30	36	PF00498	0.363
LIG_FHA_2	482	488	PF00498	0.565
LIG_FHA_2	50	56	PF00498	0.525
LIG_GBD_Chelix_1	475	483	PF00786	0.528
LIG_LIR_Gen_1	569	576	PF02991	0.520
LIG_LIR_Gen_1	577	586	PF02991	0.444
LIG_LIR_Gen_1	594	603	PF02991	0.436
LIG_LIR_Gen_1	617	627	PF02991	0.510
LIG_LIR_Nem_3	569	574	PF02991	0.529
LIG_LIR_Nem_3	577	583	PF02991	0.436
LIG_LIR_Nem_3	594	600	PF02991	0.431
LIG_NRBOX	478	484	PF00104	0.537
LIG_SH2_NCK_1	597	601	PF00017	0.501
LIG_SH2_PTP2	341	344	PF00017	0.398
LIG_SH2_SRC	247	250	PF00017	0.414
LIG_SH2_SRC	341	344	PF00017	0.470
LIG_SH2_SRC	597	600	PF00017	0.512
LIG_SH2_STAP1	38	42	PF00017	0.416
LIG_SH2_STAT5	271	274	PF00017	0.464
LIG_SH2_STAT5	33	36	PF00017	0.503
LIG_SH2_STAT5	341	344	PF00017	0.533
LIG_SH2_STAT5	448	451	PF00017	0.368
LIG_SH2_STAT5	7	10	PF00017	0.377
LIG_SH3_3	230	236	PF00018	0.546
LIG_SH3_3	264	270	PF00018	0.322
LIG_SH3_3	394	400	PF00018	0.552
LIG_SH3_3	47	53	PF00018	0.628
LIG_SH3_3	486	492	PF00018	0.680
LIG_SUMO_SIM_par_1	581	587	PF11976	0.562
LIG_TRAF2_1	593	596	PF00917	0.546
MOD_CDC14_SPxK_1	404	407	PF00782	0.568
MOD_CDK_SPK_2	401	406	PF00069	0.527
MOD_CDK_SPK_2	44	49	PF00069	0.553
MOD_CDK_SPxK_1	401	407	PF00069	0.572
MOD_CDK_SPxxK_3	158	165	PF00069	0.587
MOD_CDK_SPxxK_3	443	450	PF00069	0.423
MOD_CDK_SPxxK_3	488	495	PF00069	0.679
MOD_CK1_1	160	166	PF00069	0.586
MOD_CK1_1	287	293	PF00069	0.660
MOD_CK1_1	431	437	PF00069	0.699
MOD_CK1_1	456	462	PF00069	0.587
MOD_CK1_1	612	618	PF00069	0.572
MOD_CK1_1	76	82	PF00069	0.745
MOD_CK2_1	29	35	PF00069	0.369
MOD_CK2_1	312	318	PF00069	0.555
MOD_CK2_1	581	587	PF00069	0.420
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.514
MOD_DYRK1A_RPxSP_1	49	53	PF00069	0.556
MOD_GlcNHglycan	105	108	PF01048	0.623
MOD_GlcNHglycan	130	133	PF01048	0.734
MOD_GlcNHglycan	178	181	PF01048	0.717
MOD_GlcNHglycan	183	186	PF01048	0.703
MOD_GlcNHglycan	196	200	PF01048	0.662
MOD_GlcNHglycan	253	256	PF01048	0.505
MOD_GlcNHglycan	273	276	PF01048	0.428
MOD_GlcNHglycan	298	301	PF01048	0.531
MOD_GlcNHglycan	408	411	PF01048	0.728
MOD_GlcNHglycan	462	465	PF01048	0.514
MOD_GlcNHglycan	533	537	PF01048	0.530
MOD_GlcNHglycan	54	58	PF01048	0.649
MOD_GlcNHglycan	561	564	PF01048	0.544
MOD_GlcNHglycan	611	614	PF01048	0.646
MOD_GlcNHglycan	660	663	PF01048	0.596
MOD_GlcNHglycan	89	92	PF01048	0.795
MOD_GlcNHglycan	95	98	PF01048	0.716
MOD_GSK3_1	124	131	PF00069	0.641
MOD_GSK3_1	156	163	PF00069	0.695
MOD_GSK3_1	401	408	PF00069	0.712
MOD_GSK3_1	415	422	PF00069	0.719
MOD_GSK3_1	424	431	PF00069	0.632
MOD_GSK3_1	436	443	PF00069	0.670
MOD_GSK3_1	453	460	PF00069	0.513
MOD_GSK3_1	477	484	PF00069	0.488
MOD_GSK3_1	49	56	PF00069	0.710
MOD_GSK3_1	566	573	PF00069	0.575
MOD_GSK3_1	73	80	PF00069	0.751
MOD_GSK3_1	87	94	PF00069	0.674
MOD_LATS_1	174	180	PF00433	0.608
MOD_LATS_1	249	255	PF00433	0.426
MOD_LATS_1	294	300	PF00433	0.512
MOD_N-GLC_1	440	445	PF02516	0.515
MOD_NEK2_1	124	129	PF00069	0.498
MOD_NEK2_1	303	308	PF00069	0.459
MOD_NEK2_1	379	384	PF00069	0.534
MOD_NEK2_1	419	424	PF00069	0.543
MOD_NEK2_1	428	433	PF00069	0.550
MOD_NEK2_1	436	441	PF00069	0.571
MOD_NEK2_1	477	482	PF00069	0.496
MOD_NEK2_1	581	586	PF00069	0.465
MOD_NEK2_2	550	555	PF00069	0.495
MOD_PIKK_1	124	130	PF00454	0.655
MOD_PIKK_1	420	426	PF00454	0.563
MOD_PIKK_1	74	80	PF00454	0.510
MOD_PK_1	646	652	PF00069	0.470
MOD_PKA_1	251	257	PF00069	0.451
MOD_PKA_1	406	412	PF00069	0.516
MOD_PKA_1	531	537	PF00069	0.526
MOD_PKA_1	646	652	PF00069	0.535
MOD_PKA_2	135	141	PF00069	0.573
MOD_PKA_2	175	181	PF00069	0.682
MOD_PKA_2	213	219	PF00069	0.374
MOD_PKA_2	295	301	PF00069	0.499
MOD_PKA_2	405	411	PF00069	0.741
MOD_PKA_2	531	537	PF00069	0.517
MOD_PKA_2	566	572	PF00069	0.575
MOD_PKA_2	609	615	PF00069	0.598
MOD_PKA_2	646	652	PF00069	0.536
MOD_PKA_2	91	97	PF00069	0.671
MOD_PKB_1	644	652	PF00069	0.538
MOD_Plk_1	550	556	PF00069	0.568
MOD_Plk_2-3	386	392	PF00069	0.533
MOD_Plk_4	242	248	PF00069	0.377
MOD_Plk_4	29	35	PF00069	0.414
MOD_Plk_4	323	329	PF00069	0.457
MOD_Plk_4	38	44	PF00069	0.443
MOD_Plk_4	570	576	PF00069	0.549
MOD_Plk_4	581	587	PF00069	0.562
MOD_Plk_4	60	66	PF00069	0.753
MOD_ProDKin_1	158	164	PF00069	0.628
MOD_ProDKin_1	200	206	PF00069	0.508
MOD_ProDKin_1	287	293	PF00069	0.743
MOD_ProDKin_1	401	407	PF00069	0.711
MOD_ProDKin_1	431	437	PF00069	0.630
MOD_ProDKin_1	44	50	PF00069	0.656
MOD_ProDKin_1	443	449	PF00069	0.539
MOD_ProDKin_1	488	494	PF00069	0.655
MOD_ProDKin_1	78	84	PF00069	0.761
TRG_DiLeu_BaEn_1	577	582	PF01217	0.298
TRG_ENDOCYTIC_2	597	600	PF00928	0.498
TRG_ENDOCYTIC_2	619	622	PF00928	0.506
TRG_ER_diArg_1	328	330	PF00400	0.499
TRG_ER_diArg_1	345	347	PF00400	0.533
TRG_ER_diArg_1	405	407	PF00400	0.515
TRG_ER_diArg_1	494	497	PF00400	0.678
TRG_ER_diArg_1	499	502	PF00400	0.648
TRG_ER_diArg_1	545	548	PF00400	0.670
TRG_ER_diArg_1	644	647	PF00400	0.468
TRG_NLS_MonoExtC_3	494	499	PF00514	0.694
TRG_NLS_MonoExtN_4	492	499	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	616	620	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA05	Leptomonas seymouri	55%	79%
A0A1X0P0C1	Trypanosomatidae	31%	100%
A0A3Q8IHQ6	Leishmania donovani	98%	81%
A0A422P586	Trypanosoma rangeli	32%	100%
A4HPX7	Leishmania braziliensis	71%	100%
D0A4C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0V5	Leishmania major	91%	100%
V5BKJ9	Trypanosoma cruzi	34%	100%