LeishMANIAdb
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Putative ABC1 protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ABC1 protein
Gene product:
ABC1 protein - putative
Species:
Leishmania infantum
UniProt:
A4IDN2_LEIIN
TriTrypDb:
LINF_360054600
Length:
533

Annotations

Annotations by Jardim et al.

Transporters, ABC1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDN2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDN2

Function

Biological processes
Term Name Level Count
GO:0006743 ubiquinone metabolic process 5 1
GO:0006744 ubiquinone biosynthetic process 6 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0042180 cellular ketone metabolic process 3 1
GO:0042181 ketone biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901661 quinone metabolic process 4 1
GO:1901663 quinone biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 2
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 444 448 PF00656 0.411
CLV_NRD_NRD_1 281 283 PF00675 0.380
CLV_NRD_NRD_1 502 504 PF00675 0.344
CLV_NRD_NRD_1 531 533 PF00675 0.458
CLV_PCSK_KEX2_1 345 347 PF00082 0.398
CLV_PCSK_KEX2_1 391 393 PF00082 0.387
CLV_PCSK_KEX2_1 502 504 PF00082 0.344
CLV_PCSK_KEX2_1 92 94 PF00082 0.567
CLV_PCSK_PC1ET2_1 345 347 PF00082 0.398
CLV_PCSK_PC1ET2_1 391 393 PF00082 0.387
CLV_PCSK_PC1ET2_1 92 94 PF00082 0.376
CLV_PCSK_SKI1_1 336 340 PF00082 0.367
CLV_PCSK_SKI1_1 367 371 PF00082 0.319
CLV_PCSK_SKI1_1 430 434 PF00082 0.333
DOC_CKS1_1 83 88 PF01111 0.553
DOC_CYCLIN_yCln2_LP_2 70 76 PF00134 0.504
DOC_MAPK_gen_1 141 149 PF00069 0.343
DOC_MAPK_gen_1 389 398 PF00069 0.318
DOC_MAPK_gen_1 502 510 PF00069 0.342
DOC_PP1_RVXF_1 520 526 PF00149 0.358
DOC_PP2B_LxvP_1 490 493 PF13499 0.406
DOC_PP2B_LxvP_1 70 73 PF13499 0.495
DOC_PP4_FxxP_1 177 180 PF00568 0.398
DOC_PP4_FxxP_1 315 318 PF00568 0.272
DOC_USP7_MATH_1 211 215 PF00917 0.291
DOC_USP7_MATH_1 310 314 PF00917 0.321
DOC_USP7_MATH_1 470 474 PF00917 0.339
DOC_USP7_MATH_1 53 57 PF00917 0.674
DOC_WW_Pin1_4 205 210 PF00397 0.448
DOC_WW_Pin1_4 492 497 PF00397 0.378
DOC_WW_Pin1_4 82 87 PF00397 0.540
LIG_14-3-3_CanoR_1 220 224 PF00244 0.327
LIG_14-3-3_CanoR_1 290 294 PF00244 0.403
LIG_14-3-3_CanoR_1 3 7 PF00244 0.708
LIG_14-3-3_CanoR_1 373 379 PF00244 0.291
LIG_14-3-3_CanoR_1 64 74 PF00244 0.570
LIG_Actin_WH2_2 132 150 PF00022 0.381
LIG_Actin_WH2_2 211 226 PF00022 0.398
LIG_BRCT_BRCA1_1 311 315 PF00533 0.398
LIG_BRCT_BRCA1_1 404 408 PF00533 0.316
LIG_EVH1_2 269 273 PF00568 0.272
LIG_FHA_1 324 330 PF00498 0.276
LIG_FHA_1 69 75 PF00498 0.534
LIG_FHA_2 363 369 PF00498 0.291
LIG_FHA_2 436 442 PF00498 0.371
LIG_FHA_2 83 89 PF00498 0.545
LIG_GSK3_LRP6_1 492 497 PF00069 0.363
LIG_LIR_Apic_2 174 180 PF02991 0.291
LIG_LIR_Apic_2 312 318 PF02991 0.295
LIG_LIR_Gen_1 107 117 PF02991 0.431
LIG_LIR_Gen_1 199 210 PF02991 0.293
LIG_LIR_Gen_1 359 369 PF02991 0.449
LIG_LIR_Gen_1 378 388 PF02991 0.133
LIG_LIR_Gen_1 410 420 PF02991 0.277
LIG_LIR_Nem_3 107 112 PF02991 0.293
LIG_LIR_Nem_3 199 205 PF02991 0.300
LIG_LIR_Nem_3 264 268 PF02991 0.237
LIG_LIR_Nem_3 359 364 PF02991 0.449
LIG_LIR_Nem_3 378 384 PF02991 0.133
LIG_LIR_Nem_3 410 415 PF02991 0.277
LIG_LIR_Nem_3 88 94 PF02991 0.498
LIG_LYPXL_yS_3 245 248 PF13949 0.272
LIG_PCNA_yPIPBox_3 328 336 PF02747 0.327
LIG_Pex14_2 105 109 PF04695 0.380
LIG_Pex14_2 370 374 PF04695 0.272
LIG_PTB_Apo_2 380 387 PF02174 0.272
LIG_PTB_Phospho_1 380 386 PF10480 0.398
LIG_SH2_CRK 321 325 PF00017 0.327
LIG_SH2_CRK 91 95 PF00017 0.386
LIG_SH2_SRC 412 415 PF00017 0.291
LIG_SH2_STAP1 291 295 PF00017 0.303
LIG_SH2_STAP1 404 408 PF00017 0.291
LIG_SH2_STAT5 291 294 PF00017 0.350
LIG_SH2_STAT5 316 319 PF00017 0.361
LIG_SH2_STAT5 334 337 PF00017 0.281
LIG_SH2_STAT5 356 359 PF00017 0.291
LIG_SH2_STAT5 394 397 PF00017 0.382
LIG_SH2_STAT5 412 415 PF00017 0.159
LIG_SH2_STAT5 65 68 PF00017 0.410
LIG_SH3_3 229 235 PF00018 0.398
LIG_SH3_3 240 246 PF00018 0.272
LIG_SH3_3 264 270 PF00018 0.364
LIG_SH3_3 344 350 PF00018 0.321
LIG_SH3_3 490 496 PF00018 0.413
LIG_SH3_3 80 86 PF00018 0.564
LIG_SUMO_SIM_anti_2 410 417 PF11976 0.296
LIG_SUMO_SIM_anti_2 452 457 PF11976 0.324
LIG_SUMO_SIM_par_1 151 160 PF11976 0.438
LIG_SUMO_SIM_par_1 71 79 PF11976 0.498
LIG_TRAF2_1 438 441 PF00917 0.473
LIG_TYR_ITIM 243 248 PF00017 0.280
LIG_UBA3_1 108 116 PF00899 0.534
LIG_UBA3_1 277 283 PF00899 0.316
LIG_WRC_WIRS_1 262 267 PF05994 0.221
MOD_CDK_SPK_2 82 87 PF00069 0.540
MOD_CK1_1 251 257 PF00069 0.272
MOD_CK1_1 44 50 PF00069 0.638
MOD_CK1_1 68 74 PF00069 0.504
MOD_CK1_1 81 87 PF00069 0.592
MOD_CK2_1 362 368 PF00069 0.265
MOD_CK2_1 435 441 PF00069 0.364
MOD_Cter_Amidation 343 346 PF01082 0.387
MOD_GlcNHglycan 123 126 PF01048 0.626
MOD_GlcNHglycan 24 27 PF01048 0.641
MOD_GlcNHglycan 284 288 PF01048 0.387
MOD_GlcNHglycan 39 42 PF01048 0.602
MOD_GlcNHglycan 43 46 PF01048 0.552
MOD_GlcNHglycan 504 507 PF01048 0.340
MOD_GlcNHglycan 51 54 PF01048 0.565
MOD_GlcNHglycan 519 522 PF01048 0.324
MOD_GSK3_1 117 124 PF00069 0.625
MOD_GSK3_1 27 34 PF00069 0.551
MOD_GSK3_1 289 296 PF00069 0.394
MOD_GSK3_1 37 44 PF00069 0.636
MOD_GSK3_1 398 405 PF00069 0.434
MOD_GSK3_1 414 421 PF00069 0.174
MOD_GSK3_1 49 56 PF00069 0.574
MOD_GSK3_1 492 499 PF00069 0.371
MOD_GSK3_1 64 71 PF00069 0.576
MOD_GSK3_1 78 85 PF00069 0.570
MOD_N-GLC_1 379 384 PF02516 0.291
MOD_NEK2_1 117 122 PF00069 0.621
MOD_NEK2_1 184 189 PF00069 0.284
MOD_NEK2_1 2 7 PF00069 0.611
MOD_NEK2_1 261 266 PF00069 0.316
MOD_NEK2_1 27 32 PF00069 0.659
MOD_NEK2_1 293 298 PF00069 0.347
MOD_NEK2_1 362 367 PF00069 0.285
MOD_NEK2_1 509 514 PF00069 0.323
MOD_NEK2_2 104 109 PF00069 0.375
MOD_NEK2_2 310 315 PF00069 0.321
MOD_NEK2_2 496 501 PF00069 0.358
MOD_PIKK_1 2 8 PF00454 0.720
MOD_PIKK_1 78 84 PF00454 0.486
MOD_PKA_1 502 508 PF00069 0.325
MOD_PKA_2 2 8 PF00069 0.663
MOD_PKA_2 219 225 PF00069 0.327
MOD_PKA_2 289 295 PF00069 0.350
MOD_PKA_2 31 37 PF00069 0.535
MOD_PKA_2 502 508 PF00069 0.325
MOD_PKA_2 63 69 PF00069 0.572
MOD_Plk_1 156 162 PF00069 0.528
MOD_Plk_4 104 110 PF00069 0.364
MOD_Plk_4 310 316 PF00069 0.442
MOD_Plk_4 423 429 PF00069 0.275
MOD_Plk_4 449 455 PF00069 0.339
MOD_Plk_4 481 487 PF00069 0.363
MOD_ProDKin_1 205 211 PF00069 0.448
MOD_ProDKin_1 492 498 PF00069 0.378
MOD_ProDKin_1 82 88 PF00069 0.546
TRG_ENDOCYTIC_2 245 248 PF00928 0.280
TRG_ENDOCYTIC_2 301 304 PF00928 0.272
TRG_ENDOCYTIC_2 321 324 PF00928 0.311
TRG_ENDOCYTIC_2 412 415 PF00928 0.272
TRG_ENDOCYTIC_2 91 94 PF00928 0.453
TRG_ER_diArg_1 488 491 PF00400 0.394
TRG_ER_diArg_1 502 504 PF00400 0.382
TRG_Pf-PMV_PEXEL_1 276 280 PF00026 0.398

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6U2 Leptomonas seymouri 70% 100%
A0A1X0P0M1 Trypanosomatidae 56% 95%
A0A1X0P192 Trypanosomatidae 25% 84%
A0A3Q8IPG5 Leishmania donovani 100% 100%
A0A3R7RTW5 Trypanosoma rangeli 59% 100%
A0A3S5H636 Leishmania donovani 25% 100%
A1TTA2 Acidovorax citrulli (strain AAC00-1) 24% 100%
A3QJU3 Danio rerio 40% 85%
A4H590 Leishmania braziliensis 26% 100%
A4HPX0 Leishmania braziliensis 85% 100%
A4HTH4 Leishmania infantum 25% 100%
A9BP42 Delftia acidovorans (strain DSM 14801 / SPH-1) 26% 100%
D0A4C0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 95%
O04212 Arabidopsis thaliana 24% 99%
P27697 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P73121 Synechocystis sp. (strain PCC 6803 / Kazusa) 23% 94%
Q18486 Caenorhabditis elegans 45% 71%
Q29RI0 Bos taurus 43% 82%
Q4Q0W1 Leishmania major 94% 100%
Q4QIE6 Leishmania major 25% 100%
Q54IH6 Dictyostelium discoideum 38% 94%
Q55680 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 78%
Q566J8 Mus musculus 43% 100%
Q5BJQ0 Rattus norvegicus 43% 82%
Q5RGU1 Danio rerio 41% 86%
Q60936 Mus musculus 43% 83%
Q6AY19 Rattus norvegicus 43% 100%
Q8NI60 Homo sapiens 42% 82%
Q92338 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 41% 87%
Q94BU1 Arabidopsis thaliana 26% 77%
Q96D53 Homo sapiens 43% 98%
Q9SBB2 Arabidopsis thaliana 40% 86%
Q9W133 Drosophila melanogaster 24% 100%
V5BQ67 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS