Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial N(5)-glutamine methyltransferase MTQ1 - putative

Species:

Leishmania infantum

UniProt:

A4IDM8_LEIIN

TriTrypDb:

LINF_360054200

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IDM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM8

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0032259	methylation	2	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008276	protein methyltransferase activity	3	4
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	4

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.725
CLV_C14_Caspase3-7	390	394	PF00656	0.544
CLV_NRD_NRD_1	229	231	PF00675	0.457
CLV_NRD_NRD_1	29	31	PF00675	0.627
CLV_NRD_NRD_1	290	292	PF00675	0.570
CLV_NRD_NRD_1	460	462	PF00675	0.483
CLV_NRD_NRD_1	80	82	PF00675	0.776
CLV_PCSK_FUR_1	458	462	PF00082	0.515
CLV_PCSK_KEX2_1	229	231	PF00082	0.441
CLV_PCSK_KEX2_1	233	235	PF00082	0.420

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT0	Leptomonas seymouri	56%	100%
A0A0S4K087	Bodo saltans	47%	100%
A0A1X0P0C0	Trypanosomatidae	47%	100%
A0A3R7N4Z4	Trypanosoma rangeli	53%	100%
A0A3S7XBK9	Leishmania donovani	100%	100%
A4HPW6	Leishmania braziliensis	72%	97%
D0A4B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ATN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0W5	Leishmania major	93%	100%
V5DLL0	Trypanosoma cruzi	51%	100%

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