LeishMANIAdb
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Putative amino acid transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter
Gene product:
amino acid transporter - putative
Species:
Leishmania infantum
UniProt:
A4IDM7_LEIIN
TriTrypDb:
LINF_360054100
Length:
789

Annotations

Annotations by Jardim et al.

Acidocalcisome, amino acid transporter AAT14

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4IDM7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM7

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 1
GO:0006810 transport 3 1
GO:0006865 amino acid transport 5 1
GO:0009987 cellular process 1 1
GO:0015849 organic acid transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0055085 transmembrane transport 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
GO:1903825 organic acid transmembrane transport 3 1
GO:1905039 carboxylic acid transmembrane transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 1
GO:0005342 organic acid transmembrane transporter activity 3 1
GO:0015171 amino acid transmembrane transporter activity 5 1
GO:0015179 L-amino acid transmembrane transporter activity 6 1
GO:0022857 transmembrane transporter activity 2 1
GO:0046943 carboxylic acid transmembrane transporter activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 181 185 PF00656 0.778
CLV_C14_Caspase3-7 309 313 PF00656 0.276
CLV_C14_Caspase3-7 730 734 PF00656 0.612
CLV_NRD_NRD_1 128 130 PF00675 0.433
CLV_NRD_NRD_1 220 222 PF00675 0.517
CLV_NRD_NRD_1 268 270 PF00675 0.348
CLV_NRD_NRD_1 271 273 PF00675 0.333
CLV_NRD_NRD_1 418 420 PF00675 0.292
CLV_NRD_NRD_1 496 498 PF00675 0.292
CLV_NRD_NRD_1 611 613 PF00675 0.330
CLV_NRD_NRD_1 7 9 PF00675 0.420
CLV_PCSK_FUR_1 266 270 PF00082 0.352
CLV_PCSK_KEX2_1 219 221 PF00082 0.521
CLV_PCSK_KEX2_1 266 268 PF00082 0.361
CLV_PCSK_KEX2_1 271 273 PF00082 0.326
CLV_PCSK_KEX2_1 367 369 PF00082 0.553
CLV_PCSK_KEX2_1 418 420 PF00082 0.292
CLV_PCSK_KEX2_1 496 498 PF00082 0.305
CLV_PCSK_KEX2_1 611 613 PF00082 0.330
CLV_PCSK_KEX2_1 7 9 PF00082 0.420
CLV_PCSK_PC1ET2_1 367 369 PF00082 0.530
CLV_PCSK_PC7_1 216 222 PF00082 0.570
CLV_PCSK_PC7_1 262 268 PF00082 0.438
CLV_PCSK_SKI1_1 272 276 PF00082 0.292
CLV_PCSK_SKI1_1 8 12 PF00082 0.396
DEG_APCC_DBOX_1 495 503 PF00400 0.492
DEG_APCC_DBOX_1 746 754 PF00400 0.639
DEG_Nend_UBRbox_3 1 3 PF02207 0.733
DEG_SCF_FBW7_2 580 585 PF00400 0.529
DEG_SPOP_SBC_1 159 163 PF00917 0.751
DOC_CYCLIN_RxL_1 5 14 PF00134 0.591
DOC_CYCLIN_yCln2_LP_2 66 72 PF00134 0.335
DOC_MAPK_gen_1 749 759 PF00069 0.542
DOC_MAPK_MEF2A_6 477 484 PF00069 0.381
DOC_PP2B_LxvP_1 37 40 PF13499 0.591
DOC_PP2B_LxvP_1 66 69 PF13499 0.335
DOC_PP4_FxxP_1 245 248 PF00568 0.748
DOC_USP7_MATH_1 153 157 PF00917 0.715
DOC_USP7_MATH_1 228 232 PF00917 0.709
DOC_USP7_MATH_1 241 245 PF00917 0.661
DOC_USP7_MATH_1 248 252 PF00917 0.549
DOC_USP7_MATH_1 303 307 PF00917 0.292
DOC_USP7_MATH_1 510 514 PF00917 0.495
DOC_USP7_MATH_1 520 524 PF00917 0.525
DOC_USP7_MATH_1 534 538 PF00917 0.441
DOC_USP7_MATH_1 539 543 PF00917 0.392
DOC_USP7_MATH_1 6 10 PF00917 0.667
DOC_USP7_MATH_1 626 630 PF00917 0.615
DOC_USP7_MATH_1 680 684 PF00917 0.374
DOC_USP7_MATH_1 718 722 PF00917 0.576
DOC_USP7_MATH_1 727 731 PF00917 0.623
DOC_USP7_MATH_1 739 743 PF00917 0.469
DOC_WW_Pin1_4 542 547 PF00397 0.471
DOC_WW_Pin1_4 568 573 PF00397 0.492
DOC_WW_Pin1_4 576 581 PF00397 0.492
DOC_WW_Pin1_4 588 593 PF00397 0.463
DOC_WW_Pin1_4 652 657 PF00397 0.480
DOC_WW_Pin1_4 711 716 PF00397 0.537
LIG_14-3-3_CanoR_1 107 116 PF00244 0.519
LIG_14-3-3_CanoR_1 16 23 PF00244 0.628
LIG_14-3-3_CanoR_1 160 165 PF00244 0.719
LIG_14-3-3_CanoR_1 271 281 PF00244 0.492
LIG_14-3-3_CanoR_1 34 38 PF00244 0.638
LIG_14-3-3_CanoR_1 362 371 PF00244 0.292
LIG_14-3-3_CanoR_1 386 390 PF00244 0.325
LIG_14-3-3_CanoR_1 501 505 PF00244 0.502
LIG_14-3-3_CanoR_1 611 620 PF00244 0.487
LIG_14-3-3_CanoR_1 635 639 PF00244 0.566
LIG_14-3-3_CanoR_1 7 11 PF00244 0.654
LIG_BIR_III_4 103 107 PF00653 0.536
LIG_BIR_III_4 627 631 PF00653 0.570
LIG_BRCT_BRCA1_1 316 320 PF00533 0.355
LIG_BRCT_BRCA1_1 715 719 PF00533 0.611
LIG_deltaCOP1_diTrp_1 339 349 PF00928 0.492
LIG_EH1_1 353 361 PF00400 0.328
LIG_eIF4E_1 466 472 PF01652 0.284
LIG_FHA_1 109 115 PF00498 0.498
LIG_FHA_1 322 328 PF00498 0.332
LIG_FHA_1 395 401 PF00498 0.324
LIG_FHA_1 439 445 PF00498 0.453
LIG_FHA_1 44 50 PF00498 0.642
LIG_FHA_1 526 532 PF00498 0.508
LIG_FHA_1 536 542 PF00498 0.536
LIG_FHA_1 568 574 PF00498 0.484
LIG_FHA_1 644 650 PF00498 0.471
LIG_FHA_1 657 663 PF00498 0.478
LIG_FHA_1 672 678 PF00498 0.335
LIG_FHA_1 696 702 PF00498 0.278
LIG_FHA_2 135 141 PF00498 0.658
LIG_FHA_2 179 185 PF00498 0.776
LIG_FHA_2 307 313 PF00498 0.292
LIG_FHA_2 506 512 PF00498 0.492
LIG_GBD_Chelix_1 49 57 PF00786 0.308
LIG_LIR_Apic_2 244 248 PF02991 0.743
LIG_LIR_Apic_2 403 409 PF02991 0.335
LIG_LIR_Apic_2 779 785 PF02991 0.420
LIG_LIR_Gen_1 340 350 PF02991 0.492
LIG_LIR_Gen_1 351 361 PF02991 0.335
LIG_LIR_Gen_1 381 392 PF02991 0.274
LIG_LIR_Gen_1 581 592 PF02991 0.619
LIG_LIR_Gen_1 618 628 PF02991 0.452
LIG_LIR_Gen_1 667 678 PF02991 0.313
LIG_LIR_Gen_1 694 704 PF02991 0.335
LIG_LIR_Gen_1 775 786 PF02991 0.494
LIG_LIR_Gen_1 88 98 PF02991 0.329
LIG_LIR_Nem_3 284 290 PF02991 0.357
LIG_LIR_Nem_3 317 323 PF02991 0.340
LIG_LIR_Nem_3 340 346 PF02991 0.492
LIG_LIR_Nem_3 351 357 PF02991 0.335
LIG_LIR_Nem_3 370 374 PF02991 0.292
LIG_LIR_Nem_3 378 382 PF02991 0.297
LIG_LIR_Nem_3 581 587 PF02991 0.576
LIG_LIR_Nem_3 618 624 PF02991 0.452
LIG_LIR_Nem_3 667 673 PF02991 0.313
LIG_LIR_Nem_3 694 699 PF02991 0.335
LIG_LIR_Nem_3 746 751 PF02991 0.554
LIG_LIR_Nem_3 775 781 PF02991 0.470
LIG_LIR_Nem_3 88 93 PF02991 0.422
LIG_LIR_Nem_3 94 99 PF02991 0.504
LIG_LYPXL_yS_3 371 374 PF13949 0.292
LIG_MLH1_MIPbox_1 316 320 PF16413 0.325
LIG_NRBOX 755 761 PF00104 0.389
LIG_NRBOX 80 86 PF00104 0.335
LIG_Pex14_2 484 488 PF04695 0.335
LIG_SH2_CRK 287 291 PF00017 0.300
LIG_SH2_CRK 293 297 PF00017 0.335
LIG_SH2_CRK 369 373 PF00017 0.336
LIG_SH2_CRK 379 383 PF00017 0.266
LIG_SH2_CRK 406 410 PF00017 0.499
LIG_SH2_CRK 96 100 PF00017 0.453
LIG_SH2_NCK_1 406 410 PF00017 0.492
LIG_SH2_PTP2 354 357 PF00017 0.325
LIG_SH2_SRC 369 372 PF00017 0.376
LIG_SH2_STAP1 293 297 PF00017 0.335
LIG_SH2_STAP1 584 588 PF00017 0.621
LIG_SH2_STAP1 778 782 PF00017 0.403
LIG_SH2_STAT3 119 122 PF00017 0.531
LIG_SH2_STAT3 363 366 PF00017 0.292
LIG_SH2_STAT5 127 130 PF00017 0.582
LIG_SH2_STAT5 319 322 PF00017 0.295
LIG_SH2_STAT5 354 357 PF00017 0.335
LIG_SH2_STAT5 410 413 PF00017 0.492
LIG_SH2_STAT5 421 424 PF00017 0.492
LIG_SH2_STAT5 446 449 PF00017 0.335
LIG_SH2_STAT5 73 76 PF00017 0.488
LIG_SH2_STAT5 96 99 PF00017 0.335
LIG_SH3_3 426 432 PF00018 0.492
LIG_SH3_3 450 456 PF00018 0.376
LIG_SH3_3 650 656 PF00018 0.482
LIG_SH3_3 709 715 PF00018 0.453
LIG_SUMO_SIM_anti_2 659 667 PF11976 0.492
LIG_SUMO_SIM_par_1 489 495 PF11976 0.335
LIG_SUMO_SIM_par_1 503 508 PF11976 0.492
LIG_SUMO_SIM_par_1 645 650 PF11976 0.492
LIG_SUMO_SIM_par_1 82 89 PF11976 0.330
LIG_TRAF2_1 138 141 PF00917 0.692
LIG_TRAF2_1 261 264 PF00917 0.560
LIG_TYR_ITIM 291 296 PF00017 0.335
LIG_TYR_ITIM 352 357 PF00017 0.325
LIG_UBA3_1 750 754 PF00899 0.578
LIG_WRC_WIRS_1 395 400 PF05994 0.335
LIG_WRC_WIRS_1 446 451 PF05994 0.335
LIG_WRC_WIRS_1 696 701 PF05994 0.278
LIG_WRC_WIRS_1 778 783 PF05994 0.408
LIG_WRC_WIRS_1 87 92 PF05994 0.389
MOD_CK1_1 154 160 PF00069 0.718
MOD_CK1_1 168 174 PF00069 0.748
MOD_CK1_1 202 208 PF00069 0.775
MOD_CK1_1 249 255 PF00069 0.578
MOD_CK1_1 306 312 PF00069 0.292
MOD_CK1_1 33 39 PF00069 0.618
MOD_CK1_1 378 384 PF00069 0.262
MOD_CK1_1 492 498 PF00069 0.336
MOD_CK1_1 542 548 PF00069 0.541
MOD_CK2_1 106 112 PF00069 0.525
MOD_CK2_1 134 140 PF00069 0.698
MOD_CK2_1 194 200 PF00069 0.754
MOD_CK2_1 223 229 PF00069 0.779
MOD_CK2_1 626 632 PF00069 0.553
MOD_GlcNHglycan 153 156 PF01048 0.580
MOD_GlcNHglycan 167 170 PF01048 0.580
MOD_GlcNHglycan 248 251 PF01048 0.375
MOD_GlcNHglycan 511 515 PF01048 0.280
MOD_GlcNHglycan 522 525 PF01048 0.325
MOD_GlcNHglycan 613 616 PF01048 0.288
MOD_GlcNHglycan 627 631 PF01048 0.276
MOD_GlcNHglycan 682 685 PF01048 0.576
MOD_GlcNHglycan 715 718 PF01048 0.392
MOD_GlcNHglycan 720 723 PF01048 0.383
MOD_GlcNHglycan 729 732 PF01048 0.395
MOD_GlcNHglycan 736 739 PF01048 0.368
MOD_GSK3_1 102 109 PF00069 0.518
MOD_GSK3_1 15 22 PF00069 0.673
MOD_GSK3_1 154 161 PF00069 0.832
MOD_GSK3_1 230 237 PF00069 0.773
MOD_GSK3_1 45 52 PF00069 0.541
MOD_GSK3_1 535 542 PF00069 0.565
MOD_GSK3_1 544 551 PF00069 0.500
MOD_GSK3_1 634 641 PF00069 0.588
MOD_GSK3_1 652 659 PF00069 0.431
MOD_GSK3_1 691 698 PF00069 0.278
MOD_GSK3_1 739 746 PF00069 0.595
MOD_N-GLC_1 588 593 PF02516 0.302
MOD_NEK2_1 314 319 PF00069 0.318
MOD_NEK2_1 330 335 PF00069 0.393
MOD_NEK2_1 341 346 PF00069 0.492
MOD_NEK2_1 385 390 PF00069 0.341
MOD_NEK2_1 400 405 PF00069 0.435
MOD_NEK2_1 423 428 PF00069 0.492
MOD_NEK2_1 587 592 PF00069 0.572
MOD_NEK2_1 671 676 PF00069 0.424
MOD_NEK2_1 691 696 PF00069 0.183
MOD_NEK2_1 72 77 PF00069 0.363
MOD_NEK2_1 85 90 PF00069 0.335
MOD_NEK2_2 91 96 PF00069 0.493
MOD_PIKK_1 15 21 PF00454 0.645
MOD_PIKK_1 170 176 PF00454 0.687
MOD_PIKK_1 362 368 PF00454 0.292
MOD_PIKK_1 634 640 PF00454 0.475
MOD_PKA_1 611 617 PF00069 0.508
MOD_PKA_2 106 112 PF00069 0.525
MOD_PKA_2 15 21 PF00069 0.572
MOD_PKA_2 159 165 PF00069 0.754
MOD_PKA_2 25 31 PF00069 0.497
MOD_PKA_2 33 39 PF00069 0.642
MOD_PKA_2 385 391 PF00069 0.276
MOD_PKA_2 500 506 PF00069 0.492
MOD_PKA_2 520 526 PF00069 0.576
MOD_PKA_2 6 12 PF00069 0.671
MOD_PKA_2 611 617 PF00069 0.495
MOD_PKA_2 634 640 PF00069 0.586
MOD_PKB_1 209 217 PF00069 0.686
MOD_Plk_1 202 208 PF00069 0.808
MOD_Plk_1 510 516 PF00069 0.498
MOD_Plk_1 656 662 PF00069 0.576
MOD_Plk_2-3 199 205 PF00069 0.769
MOD_Plk_4 241 247 PF00069 0.683
MOD_Plk_4 342 348 PF00069 0.492
MOD_Plk_4 49 55 PF00069 0.505
MOD_Plk_4 500 506 PF00069 0.496
MOD_Plk_4 56 62 PF00069 0.300
MOD_Plk_4 657 663 PF00069 0.572
MOD_Plk_4 672 678 PF00069 0.239
MOD_Plk_4 691 697 PF00069 0.335
MOD_Plk_4 73 79 PF00069 0.335
MOD_Plk_4 772 778 PF00069 0.389
MOD_ProDKin_1 542 548 PF00069 0.471
MOD_ProDKin_1 568 574 PF00069 0.492
MOD_ProDKin_1 576 582 PF00069 0.492
MOD_ProDKin_1 588 594 PF00069 0.463
MOD_ProDKin_1 652 658 PF00069 0.480
MOD_ProDKin_1 711 717 PF00069 0.537
MOD_SUMO_rev_2 335 344 PF00179 0.489
MOD_SUMO_rev_2 730 737 PF00179 0.611
TRG_DiLeu_BaEn_1 667 672 PF01217 0.335
TRG_DiLeu_BaLyEn_6 746 751 PF01217 0.618
TRG_DiLeu_LyEn_5 569 574 PF01217 0.492
TRG_ENDOCYTIC_2 287 290 PF00928 0.300
TRG_ENDOCYTIC_2 293 296 PF00928 0.335
TRG_ENDOCYTIC_2 319 322 PF00928 0.335
TRG_ENDOCYTIC_2 354 357 PF00928 0.335
TRG_ENDOCYTIC_2 371 374 PF00928 0.309
TRG_ENDOCYTIC_2 379 382 PF00928 0.305
TRG_ENDOCYTIC_2 412 415 PF00928 0.495
TRG_ENDOCYTIC_2 421 424 PF00928 0.502
TRG_ENDOCYTIC_2 446 449 PF00928 0.335
TRG_ENDOCYTIC_2 584 587 PF00928 0.621
TRG_ENDOCYTIC_2 778 781 PF00928 0.445
TRG_ENDOCYTIC_2 96 99 PF00928 0.335
TRG_ER_diArg_1 208 211 PF00400 0.739
TRG_ER_diArg_1 219 221 PF00400 0.719
TRG_ER_diArg_1 265 268 PF00400 0.556
TRG_ER_diArg_1 269 272 PF00400 0.541
TRG_ER_diArg_1 418 420 PF00400 0.492

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDJ5 Leptomonas seymouri 55% 99%
A0A3S7XBM8 Leishmania donovani 99% 100%
A4HPW5 Leishmania braziliensis 68% 99%
E9ATN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
Q4Q0W6 Leishmania major 87% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS