Putative chaperone protein DNAj

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DNAj - putative

Species:

Leishmania infantum

UniProt:

A4IDM6_LEIIN

TriTrypDb:

LINF_360054000

Length:

275

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, chaperone DNAj

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 224

Expansion

Sequence features

A4IDM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0031072	heat shock protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	258	260	PF00675	0.674
CLV_NRD_NRD_1	268	270	PF00675	0.655
CLV_NRD_NRD_1	28	30	PF00675	0.221
CLV_NRD_NRD_1	61	63	PF00675	0.261
CLV_PCSK_KEX2_1	240	242	PF00082	0.534
CLV_PCSK_KEX2_1	249	251	PF00082	0.553
CLV_PCSK_KEX2_1	266	268	PF00082	0.633
CLV_PCSK_KEX2_1	28	30	PF00082	0.232
CLV_PCSK_KEX2_1	61	63	PF00082	0.259
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.534
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.553
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.688
CLV_PCSK_PC7_1	245	251	PF00082	0.546
CLV_PCSK_SKI1_1	191	195	PF00082	0.554
CLV_PCSK_SKI1_1	236	240	PF00082	0.494
CLV_PCSK_SKI1_1	29	33	PF00082	0.257
CLV_PCSK_SKI1_1	99	103	PF00082	0.520
DEG_SCF_FBW7_2	160	167	PF00400	0.414
DOC_MAPK_gen_1	127	136	PF00069	0.381
DOC_PP2B_LxvP_1	12	15	PF13499	0.323
DOC_USP7_MATH_1	15	19	PF00917	0.260
DOC_USP7_MATH_1	165	169	PF00917	0.557
DOC_USP7_MATH_1	244	248	PF00917	0.639
DOC_USP7_UBL2_3	236	240	PF12436	0.552
DOC_USP7_UBL2_3	266	270	PF12436	0.702
DOC_WW_Pin1_4	158	163	PF00397	0.593
DOC_WW_Pin1_4	168	173	PF00397	0.490
DOC_WW_Pin1_4	74	79	PF00397	0.428
LIG_14-3-3_CanoR_1	149	155	PF00244	0.539
LIG_14-3-3_CanoR_1	221	227	PF00244	0.555
LIG_14-3-3_CanoR_1	87	93	PF00244	0.376
LIG_FHA_1	66	72	PF00498	0.443
LIG_FHA_1	9	15	PF00498	0.310
LIG_FHA_2	151	157	PF00498	0.564
LIG_LIR_Gen_1	132	140	PF02991	0.505
LIG_LIR_Gen_1	224	233	PF02991	0.468
LIG_LIR_Gen_1	50	59	PF02991	0.351
LIG_LIR_Nem_3	132	136	PF02991	0.514
LIG_LIR_Nem_3	26	30	PF02991	0.309
LIG_LIR_Nem_3	44	49	PF02991	0.132
LIG_LIR_Nem_3	50	56	PF02991	0.243
LIG_SH2_CRK	27	31	PF00017	0.191
LIG_SH2_CRK	53	57	PF00017	0.258
LIG_SH2_CRK	9	13	PF00017	0.272
LIG_SH2_STAP1	226	230	PF00017	0.568
LIG_SH2_STAT5	133	136	PF00017	0.541
LIG_SH2_STAT5	237	240	PF00017	0.491
LIG_TRAF2_1	108	111	PF00917	0.370
LIG_UBA3_1	175	180	PF00899	0.495
LIG_UBA3_1	229	236	PF00899	0.432
MOD_CK1_1	168	174	PF00069	0.528
MOD_CK1_1	225	231	PF00069	0.547
MOD_CK1_1	248	254	PF00069	0.583
MOD_CK1_1	74	80	PF00069	0.643
MOD_CK2_1	105	111	PF00069	0.405
MOD_CK2_1	15	21	PF00069	0.327
MOD_CK2_1	150	156	PF00069	0.463
MOD_CK2_1	167	173	PF00069	0.322
MOD_CK2_1	221	227	PF00069	0.572
MOD_CK2_1	228	234	PF00069	0.424
MOD_CK2_1	54	60	PF00069	0.382
MOD_GlcNHglycan	107	110	PF01048	0.407
MOD_GlcNHglycan	198	201	PF01048	0.606
MOD_GlcNHglycan	203	206	PF01048	0.591
MOD_GlcNHglycan	73	76	PF01048	0.554
MOD_GSK3_1	101	108	PF00069	0.393
MOD_GSK3_1	221	228	PF00069	0.506
MOD_GSK3_1	244	251	PF00069	0.628
MOD_GSK3_1	65	72	PF00069	0.504
MOD_N-GLC_1	158	163	PF02516	0.508
MOD_NEK2_1	101	106	PF00069	0.416
MOD_NEK2_1	150	155	PF00069	0.397
MOD_NEK2_1	196	201	PF00069	0.559
MOD_NEK2_1	8	13	PF00069	0.412
MOD_PK_1	45	51	PF00069	0.273
MOD_PKA_1	269	275	PF00069	0.650
MOD_PKA_2	244	250	PF00069	0.590
MOD_PKA_2	262	268	PF00069	0.628
MOD_PKB_1	219	227	PF00069	0.584
MOD_PKB_1	267	275	PF00069	0.519
MOD_Plk_1	16	22	PF00069	0.209
MOD_Plk_1	209	215	PF00069	0.549
MOD_Plk_4	150	156	PF00069	0.487
MOD_Plk_4	225	231	PF00069	0.536
MOD_ProDKin_1	158	164	PF00069	0.597
MOD_ProDKin_1	168	174	PF00069	0.486
MOD_ProDKin_1	74	80	PF00069	0.429
MOD_SUMO_rev_2	120	129	PF00179	0.522
MOD_SUMO_rev_2	228	238	PF00179	0.462
TRG_ENDOCYTIC_2	133	136	PF00928	0.518
TRG_ENDOCYTIC_2	226	229	PF00928	0.528
TRG_ENDOCYTIC_2	27	30	PF00928	0.187
TRG_ENDOCYTIC_2	53	56	PF00928	0.258
TRG_ENDOCYTIC_2	9	12	PF00928	0.257
TRG_ER_diArg_1	218	221	PF00400	0.590
TRG_ER_diArg_1	27	29	PF00400	0.232
TRG_NLS_Bipartite_1	249	270	PF00514	0.617
TRG_NLS_MonoExtC_3	265	270	PF00514	0.642
TRG_NLS_MonoExtN_4	263	270	PF00514	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P699	Leptomonas seymouri	65%	100%
A0A0S4J0E0	Bodo saltans	41%	100%
A0A1X0P0E8	Trypanosomatidae	41%	97%
A0A3Q8IIZ8	Leishmania donovani	100%	100%
A0A3S5ISR2	Trypanosoma rangeli	44%	100%
A4HPW4	Leishmania braziliensis	76%	100%
D0A4B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ATN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0W7	Leishmania major	91%	100%
Q8WXX5	Homo sapiens	30%	100%
Q91WN1	Mus musculus	29%	100%
Q9VGR7	Drosophila melanogaster	25%	92%
V5BL40	Trypanosoma cruzi	31%	90%
V5BUT9	Trypanosoma cruzi	44%	100%