Uncharacterized protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDM5_LEIIN

TriTrypDb:

LINF_360053900

Length:

160

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.534
CLV_PCSK_SKI1_1	33	37	PF00082	0.387
DEG_MDM2_SWIB_1	56	64	PF02201	0.405
DOC_USP7_MATH_1	21	25	PF00917	0.570
DOC_USP7_UBL2_3	136	140	PF12436	0.489
LIG_14-3-3_CanoR_1	3	7	PF00244	0.544
LIG_14-3-3_CanoR_1	85	89	PF00244	0.396
LIG_14-3-3_CanoR_1	90	96	PF00244	0.400
LIG_FHA_1	34	40	PF00498	0.400
LIG_FHA_1	91	97	PF00498	0.466
LIG_FHA_2	20	26	PF00498	0.640
LIG_FHA_2	90	96	PF00498	0.403
LIG_NRBOX	30	36	PF00104	0.497
LIG_Pex14_2	56	60	PF04695	0.384
LIG_SH2_STAP1	67	71	PF00017	0.419
LIG_SH2_STAT5	134	137	PF00017	0.400
LIG_SH2_STAT5	91	94	PF00017	0.413
LIG_SH2_STAT5	99	102	PF00017	0.425
MOD_CK2_1	142	148	PF00069	0.543
MOD_CK2_1	59	65	PF00069	0.466
MOD_CK2_1	74	80	PF00069	0.474
MOD_CK2_1	89	95	PF00069	0.401
MOD_GSK3_1	17	24	PF00069	0.558
MOD_GSK3_1	55	62	PF00069	0.484
MOD_GSK3_1	86	93	PF00069	0.465
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	19	24	PF00069	0.643
MOD_PKA_2	2	8	PF00069	0.549
MOD_PKA_2	84	90	PF00069	0.406
MOD_Plk_1	74	80	PF00069	0.474
MOD_Plk_4	2	8	PF00069	0.641
MOD_SUMO_for_1	135	138	PF00179	0.481
MOD_SUMO_rev_2	132	142	PF00179	0.491
MOD_SUMO_rev_2	145	152	PF00179	0.370
MOD_SUMO_rev_2	23	29	PF00179	0.560
TRG_DiLeu_BaEn_2	147	153	PF01217	0.510
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M0	Leptomonas seymouri	72%	99%
A0A0S4J6P4	Bodo saltans	50%	100%
A0A1X0P0A8	Trypanosomatidae	47%	99%
A0A3Q8IHP5	Leishmania donovani	99%	100%
A0A422P577	Trypanosoma rangeli	52%	100%
A4HPW3	Leishmania braziliensis	78%	100%
D0A4B1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9ATN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0W8	Leishmania major	93%	100%