Putative mitochondrial intermediate peptidase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial intermediate peptidase - putative

Species:

Leishmania infantum

UniProt:

A4IDM4_LEIIN

TriTrypDb:

LINF_360053800

Length:

676

Annotations

Annotations by Jardim et al.

Proteases, mitochondrial intermediate peptidase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM4

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004222	metalloendopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.438
CLV_C14_Caspase3-7	95	99	PF00656	0.327
CLV_NRD_NRD_1	144	146	PF00675	0.347
CLV_NRD_NRD_1	159	161	PF00675	0.370
CLV_NRD_NRD_1	175	177	PF00675	0.335
CLV_NRD_NRD_1	277	279	PF00675	0.331
CLV_NRD_NRD_1	3	5	PF00675	0.498
CLV_NRD_NRD_1	303	305	PF00675	0.275
CLV_NRD_NRD_1	426	428	PF00675	0.345
CLV_NRD_NRD_1	624	626	PF00675	0.260

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N6	Leptomonas seymouri	87%	100%
A0A0N1PBM8	Leptomonas seymouri	25%	99%
A0A0N1PDB7	Leptomonas seymouri	23%	100%
A0A0S4JRG5	Bodo saltans	22%	99%
A0A0S4JWM4	Bodo saltans	67%	100%
A0A1X0P0Z5	Trypanosomatidae	75%	98%
A0A3Q8IKU0	Leishmania donovani	100%	100%
A0A3S7WZY5	Leishmania donovani	24%	99%
A0A422MUB5	Trypanosoma rangeli	26%	99%
A0A422P572	Trypanosoma rangeli	73%	99%

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