LeishMANIAdb
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Asparaginase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Asparaginase-like protein
Gene product:
asparaginase-like protein
Species:
Leishmania infantum
UniProt:
A4IDM2_LEIIN
TriTrypDb:
LINF_360053600
Length:
369

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Asparaginase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDM2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM2

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006520 amino acid metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009066 aspartate family amino acid metabolic process 5 12
GO:0009987 cellular process 1 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004067 asparaginase activity 5 12
GO:0016787 hydrolase activity 2 12
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 3 12
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 114 118 PF00656 0.367
CLV_NRD_NRD_1 10 12 PF00675 0.477
CLV_NRD_NRD_1 215 217 PF00675 0.263
CLV_NRD_NRD_1 277 279 PF00675 0.240
CLV_NRD_NRD_1 350 352 PF00675 0.258
CLV_NRD_NRD_1 53 55 PF00675 0.469
CLV_PCSK_KEX2_1 277 279 PF00082 0.266
CLV_PCSK_KEX2_1 282 284 PF00082 0.253
CLV_PCSK_KEX2_1 52 54 PF00082 0.456
CLV_PCSK_PC1ET2_1 282 284 PF00082 0.316
CLV_PCSK_PC7_1 278 284 PF00082 0.210
CLV_PCSK_SKI1_1 185 189 PF00082 0.233
CLV_PCSK_SKI1_1 216 220 PF00082 0.314
CLV_PCSK_SKI1_1 237 241 PF00082 0.457
CLV_PCSK_SKI1_1 28 32 PF00082 0.445
CLV_PCSK_SKI1_1 282 286 PF00082 0.278
CLV_PCSK_SKI1_1 338 342 PF00082 0.235
CLV_PCSK_SKI1_1 53 57 PF00082 0.365
DEG_APCC_DBOX_1 53 61 PF00400 0.449
DEG_Nend_Nbox_1 1 3 PF02207 0.533
DEG_SPOP_SBC_1 120 124 PF00917 0.310
DOC_CDC14_PxL_1 258 266 PF14671 0.210
DOC_CYCLIN_yCln2_LP_2 133 139 PF00134 0.233
DOC_MAPK_gen_1 289 297 PF00069 0.294
DOC_MAPK_gen_1 52 59 PF00069 0.435
DOC_MAPK_MEF2A_6 155 163 PF00069 0.221
DOC_MAPK_MEF2A_6 289 297 PF00069 0.341
DOC_MAPK_RevD_3 203 217 PF00069 0.186
DOC_PP1_RVXF_1 133 140 PF00149 0.220
DOC_PP4_FxxP_1 197 200 PF00568 0.220
DOC_USP7_MATH_1 162 166 PF00917 0.260
DOC_USP7_MATH_1 204 208 PF00917 0.367
DOC_USP7_MATH_1 45 49 PF00917 0.477
DOC_USP7_MATH_2 20 26 PF00917 0.450
DOC_WW_Pin1_4 16 21 PF00397 0.542
DOC_WW_Pin1_4 196 201 PF00397 0.225
DOC_WW_Pin1_4 343 348 PF00397 0.333
DOC_WW_Pin1_4 361 366 PF00397 0.327
LIG_14-3-3_CanoR_1 148 157 PF00244 0.239
LIG_14-3-3_CanoR_1 191 195 PF00244 0.267
LIG_Actin_WH2_2 70 85 PF00022 0.275
LIG_BRCT_BRCA1_1 198 202 PF00533 0.233
LIG_DCNL_PONY_1 1 4 PF03556 0.503
LIG_eIF4E_1 3 9 PF01652 0.470
LIG_FHA_1 138 144 PF00498 0.275
LIG_FHA_1 152 158 PF00498 0.275
LIG_FHA_1 223 229 PF00498 0.398
LIG_FHA_1 234 240 PF00498 0.216
LIG_FHA_1 288 294 PF00498 0.216
LIG_FHA_2 274 280 PF00498 0.242
LIG_FHA_2 87 93 PF00498 0.284
LIG_LIR_Gen_1 73 82 PF02991 0.463
LIG_LIR_Gen_1 91 100 PF02991 0.272
LIG_LIR_LC3C_4 290 295 PF02991 0.372
LIG_LIR_Nem_3 103 107 PF02991 0.297
LIG_LIR_Nem_3 199 205 PF02991 0.233
LIG_LIR_Nem_3 91 96 PF02991 0.279
LIG_MAD2 237 245 PF02301 0.367
LIG_Rb_LxCxE_1 58 75 PF01857 0.316
LIG_Rb_pABgroove_1 170 178 PF01858 0.251
LIG_REV1ctd_RIR_1 249 257 PF16727 0.226
LIG_SH2_CRK 303 307 PF00017 0.367
LIG_SH2_NCK_1 258 262 PF00017 0.210
LIG_SH2_STAT5 150 153 PF00017 0.235
LIG_SH2_STAT5 258 261 PF00017 0.210
LIG_SH2_STAT5 3 6 PF00017 0.591
LIG_SH2_STAT5 339 342 PF00017 0.233
LIG_SH2_STAT5 353 356 PF00017 0.324
LIG_SH3_3 197 203 PF00018 0.233
LIG_SH3_3 242 248 PF00018 0.365
LIG_SH3_3 359 365 PF00018 0.386
LIG_SH3_3 66 72 PF00018 0.409
LIG_SUMO_SIM_anti_2 292 299 PF11976 0.367
LIG_SUMO_SIM_par_1 235 242 PF11976 0.337
LIG_SUMO_SIM_par_1 292 299 PF11976 0.254
LIG_SUMO_SIM_par_1 304 310 PF11976 0.244
LIG_SxIP_EBH_1 137 148 PF03271 0.226
LIG_TRAF2_1 19 22 PF00917 0.585
LIG_UBA3_1 129 135 PF00899 0.220
LIG_UBA3_1 284 289 PF00899 0.226
LIG_WRC_WIRS_1 71 76 PF05994 0.226
MOD_CDK_SPxxK_3 361 368 PF00069 0.409
MOD_CK1_1 190 196 PF00069 0.315
MOD_CK1_1 36 42 PF00069 0.423
MOD_CK1_1 363 369 PF00069 0.639
MOD_CK2_1 16 22 PF00069 0.573
MOD_CK2_1 306 312 PF00069 0.346
MOD_Cter_Amidation 9 12 PF01082 0.704
MOD_GlcNHglycan 113 116 PF01048 0.367
MOD_GlcNHglycan 14 17 PF01048 0.565
MOD_GlcNHglycan 21 27 PF01048 0.415
MOD_GlcNHglycan 259 262 PF01048 0.317
MOD_GlcNHglycan 270 273 PF01048 0.278
MOD_GlcNHglycan 323 326 PF01048 0.252
MOD_GlcNHglycan 365 368 PF01048 0.492
MOD_GlcNHglycan 5 8 PF01048 0.607
MOD_GlcNHglycan 84 87 PF01048 0.213
MOD_GSK3_1 12 19 PF00069 0.566
MOD_GSK3_1 120 127 PF00069 0.253
MOD_GSK3_1 183 190 PF00069 0.206
MOD_GSK3_1 233 240 PF00069 0.340
MOD_GSK3_1 82 89 PF00069 0.275
MOD_N-GLC_1 183 188 PF02516 0.214
MOD_NEK2_1 119 124 PF00069 0.233
MOD_NEK2_1 139 144 PF00069 0.123
MOD_NEK2_1 2 7 PF00069 0.563
MOD_NEK2_2 183 188 PF00069 0.198
MOD_NEK2_2 204 209 PF00069 0.251
MOD_PIKK_1 164 170 PF00454 0.251
MOD_PKA_2 190 196 PF00069 0.297
MOD_Plk_1 183 189 PF00069 0.201
MOD_Plk_4 124 130 PF00069 0.230
MOD_Plk_4 139 145 PF00069 0.262
MOD_ProDKin_1 16 22 PF00069 0.538
MOD_ProDKin_1 196 202 PF00069 0.225
MOD_ProDKin_1 343 349 PF00069 0.333
MOD_ProDKin_1 361 367 PF00069 0.341
MOD_SUMO_for_1 100 103 PF00179 0.258
TRG_DiLeu_BaEn_1 95 100 PF01217 0.367
TRG_DiLeu_BaLyEn_6 280 285 PF01217 0.242
TRG_ENDOCYTIC_2 107 110 PF00928 0.302
TRG_ENDOCYTIC_2 150 153 PF00928 0.251
TRG_ENDOCYTIC_2 303 306 PF00928 0.220
TRG_ENDOCYTIC_2 353 356 PF00928 0.301
TRG_ER_diArg_1 227 230 PF00400 0.305
TRG_ER_diArg_1 52 54 PF00400 0.523
TRG_PTS1 366 369 PF00515 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVX8 Leptomonas seymouri 31% 94%
A0A0N1PEN4 Leptomonas seymouri 73% 98%
A0A0S4J4T5 Bodo saltans 48% 91%
A0A0S4J8X9 Bodo saltans 45% 100%
A0A0S4JTX6 Bodo saltans 36% 91%
A0A1X0P1U7 Trypanosomatidae 51% 99%
A0A3Q8IA09 Leishmania donovani 30% 93%
A0A3R7KPG5 Trypanosoma rangeli 50% 100%
A0A3S7XBI7 Leishmania donovani 100% 100%
A0A422N3G9 Trypanosoma rangeli 30% 82%
A1RX40 Thermofilum pendens (strain DSM 2475 / Hrk 5) 26% 82%
A4FWR5 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 26% 88%
A4H811 Leishmania braziliensis 28% 100%
A4HPW0 Leishmania braziliensis 85% 100%
A4HWE1 Leishmania infantum 30% 100%
A4YHH3 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 25% 84%
A5UK11 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 27% 85%
A6UPR4 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 25% 87%
A6VGK5 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 27% 88%
A9AA46 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 26% 88%
B0R6H4 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 26% 86%
C3MPS1 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 25% 83%
C3MYR5 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 25% 83%
C3N5E7 Sulfolobus islandicus (strain M.16.27) 25% 83%
C3NE01 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 25% 83%
C3NHQ2 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 25% 83%
C4KH13 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 25% 83%
E9AQ41 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9ATM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O26802 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 26% 85%
O29380 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 27% 88%
O59132 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 28% 84%
P0A962 Escherichia coli (strain K12) 37% 100%
P0A963 Escherichia coli O157:H7 37% 100%
P26900 Bacillus subtilis (strain 168) 32% 100%
P61400 Methanococcus maripaludis (strain S2 / LL) 26% 88%
P61401 Nanoarchaeum equitans (strain Kin4-M) 27% 94%
Q12X65 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 25% 89%
Q2NEH1 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 24% 84%
Q46GJ6 Methanosarcina barkeri (strain Fusaro / DSM 804) 26% 87%
Q4J955 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 22% 83%
Q4Q0X1 Leishmania major 95% 100%
Q4QFE1 Leishmania major 29% 100%
Q5JI77 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 28% 84%
Q60331 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 27% 88%
Q8PUM7 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 25% 87%
Q8TR66 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 24% 87%
Q8TV84 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 25% 81%
Q8TZE8 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 32% 100%
Q8U0X0 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 27% 84%
Q8ZY04 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 24% 88%
Q971W5 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 26% 82%
Q979L8 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 29% 91%
Q97ZH5 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 25% 83%
Q9HJJ5 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 28% 90%
Q9HP20 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 26% 86%
Q9RRX9 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 26% 100%
Q9V0T9 Pyrococcus abyssi (strain GE5 / Orsay) 28% 84%
Q9Y9T8 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 31% 86%
V5BUU3 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS