Putative 60S ribosomal protein L22

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L22 - putative

Species:

Leishmania infantum

UniProt:

A4IDM1_LEIIN

TriTrypDb:

LINF_360041100

Length:

138

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L22

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 32

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4IDM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDM1

PDB structure(s): 6az3_U

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	15
GO:0006518	peptide metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009058	biosynthetic process	2	15
GO:0009059	macromolecule biosynthetic process	4	15
GO:0009987	cellular process	1	15
GO:0019538	protein metabolic process	3	15
GO:0034641	cellular nitrogen compound metabolic process	3	15
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	15
GO:0043043	peptide biosynthetic process	5	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043603	amide metabolic process	3	15
GO:0043604	amide biosynthetic process	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0044249	cellular biosynthetic process	3	15
GO:0044260	obsolete cellular macromolecule metabolic process	3	15
GO:0044271	cellular nitrogen compound biosynthetic process	4	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:1901566	organonitrogen compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:0002181	cytoplasmic translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	15
GO:0005198	structural molecule activity	1	15
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.388
CLV_NRD_NRD_1	68	70	PF00675	0.308
CLV_NRD_NRD_1	94	96	PF00675	0.319
CLV_PCSK_SKI1_1	104	108	PF00082	0.329
CLV_PCSK_SKI1_1	32	36	PF00082	0.332
CLV_PCSK_SKI1_1	97	101	PF00082	0.313
DOC_MAPK_gen_1	108	118	PF00069	0.296
DOC_MAPK_gen_1	69	79	PF00069	0.296
DOC_MAPK_HePTP_8	66	81	PF00069	0.296
DOC_MAPK_MEF2A_6	72	81	PF00069	0.296
DOC_USP7_UBL2_3	104	108	PF12436	0.296
DOC_USP7_UBL2_3	26	30	PF12436	0.428
DOC_USP7_UBL2_3	32	36	PF12436	0.284
DOC_USP7_UBL2_3	72	76	PF12436	0.296
DOC_USP7_UBL2_3	96	100	PF12436	0.296
LIG_14-3-3_CanoR_1	78	82	PF00244	0.388
LIG_BIR_II_1	1	5	PF00653	0.386
LIG_FHA_1	123	129	PF00498	0.318
LIG_FHA_1	6	12	PF00498	0.410
LIG_Integrin_isoDGR_2	67	69	PF01839	0.311
LIG_LIR_Gen_1	114	120	PF02991	0.296
LIG_LIR_Nem_3	114	118	PF02991	0.296
LIG_Pex14_2	56	60	PF04695	0.296
LIG_SH2_GRB2like	130	133	PF00017	0.296
LIG_SH2_STAT3	22	25	PF00017	0.555
LIG_SH2_STAT5	130	133	PF00017	0.306
LIG_SH2_STAT5	22	25	PF00017	0.514
LIG_SH2_STAT5	98	101	PF00017	0.296
LIG_SUMO_SIM_par_1	83	91	PF11976	0.299
LIG_TYR_ITIM	128	133	PF00017	0.296
MOD_CK1_1	3	9	PF00069	0.375
MOD_Cter_Amidation	30	33	PF01082	0.419
MOD_Cter_Amidation	67	70	PF01082	0.296
MOD_GlcNHglycan	3	6	PF01048	0.374
MOD_GSK3_1	1	8	PF00069	0.504
MOD_GSK3_1	118	125	PF00069	0.434
MOD_GSK3_1	84	91	PF00069	0.305
MOD_NEK2_1	1	6	PF00069	0.384
MOD_NEK2_1	86	91	PF00069	0.296
MOD_PKA_2	77	83	PF00069	0.388
MOD_Plk_1	37	43	PF00069	0.324
TRG_ENDOCYTIC_2	130	133	PF00928	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE6	Leptomonas seymouri	95%	100%
A0A0S4IZF7	Bodo saltans	80%	100%
A0A1X0P1I5	Trypanosomatidae	84%	100%
A0A381MX11	Leishmania infantum	100%	100%
A0A3Q8IJA8	Leishmania donovani	100%	100%
A0A3Q8ILD5	Leishmania donovani	99%	100%
A0A3R7MXP1	Trypanosoma rangeli	84%	100%
A4FUH0	Bos taurus	44%	100%
A4HPJ4	Leishmania braziliensis	97%	100%
A4HPV9	Leishmania braziliensis	98%	100%
D0A4A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
D0A8M1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	100%
E9ATA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
P05749	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P35268	Homo sapiens	38%	100%
P47198	Rattus norvegicus	41%	100%
P50886	Xenopus laevis	43%	100%
P52819	Caenorhabditis elegans	36%	100%
P52865	Gadus morhua	39%	100%
P56628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P67984	Mus musculus	41%	100%
P67985	Sus scrofa	41%	100%
Q09668	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
Q23BV5	Tetrahymena thermophila (strain SB210)	41%	100%
Q28IL6	Xenopus tropicalis	43%	100%
Q4Q0X2	Leishmania major	100%	100%
Q4R5I3	Macaca fascicularis	41%	100%
Q54GK6	Dictyostelium discoideum	42%	100%
Q54JE3	Dictyostelium discoideum	43%	100%
Q5I0R6	Xenopus tropicalis	45%	100%
Q6P5R6	Homo sapiens	46%	100%
Q8SS49	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q90YU6	Ictalurus punctatus	38%	100%
Q98TF8	Gallus gallus	38%	100%
Q9D7S7	Mus musculus	44%	100%
Q9FE58	Arabidopsis thaliana	39%	100%
Q9M9W1	Arabidopsis thaliana	41%	100%
Q9SRX7	Arabidopsis thaliana	38%	100%