LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Probable eukaryotic initiation factor 4A

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable eukaryotic initiation factor 4A
Gene product:
ATP-dependent DEAD/H RNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4IDL9_LEIIN
TriTrypDb:
LINF_360053300
Length:
965

Annotations

Annotations by Jardim et al.

Helicases, ATP-dependent RNA helicase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IDL9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDL9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003676 nucleic acid binding 3 7
GO:0003724 RNA helicase activity 3 7
GO:0003743 translation initiation factor activity 4 7
GO:0003824 catalytic activity 1 7
GO:0004386 helicase activity 2 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0008135 translation factor activity, RNA binding 3 7
GO:0008186 ATP-dependent activity, acting on RNA 2 7
GO:0016787 hydrolase activity 2 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0045182 translation regulator activity 1 7
GO:0090079 translation regulator activity, nucleic acid binding 2 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140098 catalytic activity, acting on RNA 3 7
GO:0140640 catalytic activity, acting on a nucleic acid 2 7
GO:0140657 ATP-dependent activity 1 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 590 594 PF00656 0.647
CLV_C14_Caspase3-7 888 892 PF00656 0.565
CLV_NRD_NRD_1 119 121 PF00675 0.693
CLV_NRD_NRD_1 12 14 PF00675 0.605
CLV_NRD_NRD_1 27 29 PF00675 0.647
CLV_NRD_NRD_1 35 37 PF00675 0.661
CLV_NRD_NRD_1 412 414 PF00675 0.346
CLV_NRD_NRD_1 550 552 PF00675 0.854
CLV_NRD_NRD_1 633 635 PF00675 0.606
CLV_NRD_NRD_1 638 640 PF00675 0.675
CLV_NRD_NRD_1 719 721 PF00675 0.304
CLV_NRD_NRD_1 817 819 PF00675 0.504
CLV_NRD_NRD_1 825 827 PF00675 0.558
CLV_NRD_NRD_1 912 914 PF00675 0.671
CLV_PCSK_FUR_1 328 332 PF00082 0.330
CLV_PCSK_KEX2_1 119 121 PF00082 0.801
CLV_PCSK_KEX2_1 249 251 PF00082 0.782
CLV_PCSK_KEX2_1 29 31 PF00082 0.619
CLV_PCSK_KEX2_1 327 329 PF00082 0.347
CLV_PCSK_KEX2_1 330 332 PF00082 0.345
CLV_PCSK_KEX2_1 35 37 PF00082 0.656
CLV_PCSK_KEX2_1 412 414 PF00082 0.346
CLV_PCSK_KEX2_1 515 517 PF00082 0.732
CLV_PCSK_KEX2_1 633 635 PF00082 0.606
CLV_PCSK_KEX2_1 719 721 PF00082 0.304
CLV_PCSK_PC1ET2_1 119 121 PF00082 0.762
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.782
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.598
CLV_PCSK_PC1ET2_1 327 329 PF00082 0.353
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.339
CLV_PCSK_PC1ET2_1 515 517 PF00082 0.736
CLV_PCSK_SKI1_1 307 311 PF00082 0.375
CLV_PCSK_SKI1_1 353 357 PF00082 0.346
CLV_PCSK_SKI1_1 536 540 PF00082 0.805
CLV_PCSK_SKI1_1 552 556 PF00082 0.560
CLV_PCSK_SKI1_1 6 10 PF00082 0.725
CLV_PCSK_SKI1_1 615 619 PF00082 0.460
CLV_PCSK_SKI1_1 720 724 PF00082 0.314
CLV_PCSK_SKI1_1 74 78 PF00082 0.637
CLV_PCSK_SKI1_1 913 917 PF00082 0.577
CLV_PCSK_SKI1_1 922 926 PF00082 0.675
DEG_APCC_DBOX_1 741 749 PF00400 0.546
DEG_SCF_FBW7_1 545 550 PF00400 0.753
DEG_SCF_FBW7_2 214 219 PF00400 0.521
DEG_SCF_SKP2-CKS1_1 542 549 PF00560 0.751
DEG_SPOP_SBC_1 529 533 PF00917 0.746
DEG_SPOP_SBC_1 99 103 PF00917 0.724
DOC_CKS1_1 388 393 PF01111 0.546
DOC_CYCLIN_RxL_1 204 215 PF00134 0.536
DOC_CYCLIN_RxL_1 339 349 PF00134 0.539
DOC_MAPK_DCC_7 597 606 PF00069 0.634
DOC_MAPK_gen_1 327 338 PF00069 0.547
DOC_MAPK_gen_1 412 419 PF00069 0.546
DOC_MAPK_gen_1 719 730 PF00069 0.504
DOC_MAPK_gen_1 750 758 PF00069 0.546
DOC_MAPK_gen_1 895 903 PF00069 0.532
DOC_MAPK_gen_1 944 952 PF00069 0.631
DOC_MAPK_HePTP_8 650 662 PF00069 0.568
DOC_MAPK_MEF2A_6 138 145 PF00069 0.765
DOC_MAPK_MEF2A_6 357 364 PF00069 0.520
DOC_MAPK_MEF2A_6 653 662 PF00069 0.581
DOC_MAPK_MEF2A_6 723 732 PF00069 0.546
DOC_MAPK_MEF2A_6 752 760 PF00069 0.546
DOC_PP1_RVXF_1 205 212 PF00149 0.529
DOC_PP1_RVXF_1 270 277 PF00149 0.546
DOC_PP1_RVXF_1 705 712 PF00149 0.546
DOC_PP1_RVXF_1 742 748 PF00149 0.546
DOC_PP1_RVXF_1 847 853 PF00149 0.577
DOC_PP2B_LxvP_1 151 154 PF13499 0.736
DOC_PP2B_PxIxI_1 383 389 PF00149 0.546
DOC_PP4_FxxP_1 211 214 PF00568 0.483
DOC_PP4_FxxP_1 276 279 PF00568 0.546
DOC_USP7_MATH_1 100 104 PF00917 0.690
DOC_USP7_MATH_1 105 109 PF00917 0.700
DOC_USP7_MATH_1 517 521 PF00917 0.748
DOC_USP7_MATH_1 527 531 PF00917 0.601
DOC_USP7_MATH_1 547 551 PF00917 0.844
DOC_USP7_MATH_1 554 558 PF00917 0.713
DOC_USP7_MATH_1 63 67 PF00917 0.779
DOC_USP7_MATH_1 638 642 PF00917 0.656
DOC_USP7_MATH_1 688 692 PF00917 0.459
DOC_USP7_MATH_1 83 87 PF00917 0.454
DOC_USP7_MATH_1 93 97 PF00917 0.680
DOC_USP7_UBL2_3 14 18 PF12436 0.607
DOC_USP7_UBL2_3 489 493 PF12436 0.748
DOC_USP7_UBL2_3 5 9 PF12436 0.628
DOC_USP7_UBL2_3 511 515 PF12436 0.684
DOC_USP7_UBL2_3 536 540 PF12436 0.759
DOC_USP7_UBL2_3 555 559 PF12436 0.733
DOC_USP7_UBL2_3 746 750 PF12436 0.546
DOC_USP7_UBL2_3 859 863 PF12436 0.522
DOC_WW_Pin1_4 212 217 PF00397 0.534
DOC_WW_Pin1_4 294 299 PF00397 0.591
DOC_WW_Pin1_4 336 341 PF00397 0.546
DOC_WW_Pin1_4 387 392 PF00397 0.546
DOC_WW_Pin1_4 543 548 PF00397 0.748
LIG_14-3-3_CanoR_1 120 128 PF00244 0.670
LIG_14-3-3_CanoR_1 292 301 PF00244 0.534
LIG_14-3-3_CanoR_1 331 337 PF00244 0.546
LIG_14-3-3_CanoR_1 615 620 PF00244 0.508
LIG_14-3-3_CanoR_1 74 83 PF00244 0.647
LIG_14-3-3_CanoR_1 784 790 PF00244 0.546
LIG_14-3-3_CanoR_1 926 932 PF00244 0.666
LIG_Actin_WH2_2 732 748 PF00022 0.546
LIG_Actin_WH2_2 833 851 PF00022 0.606
LIG_AP2alpha_1 747 751 PF02296 0.546
LIG_BIR_II_1 1 5 PF00653 0.639
LIG_BRCT_BRCA1_1 427 431 PF00533 0.546
LIG_FHA_1 288 294 PF00498 0.491
LIG_FHA_1 339 345 PF00498 0.546
LIG_FHA_1 622 628 PF00498 0.535
LIG_FHA_1 75 81 PF00498 0.638
LIG_FHA_1 947 953 PF00498 0.637
LIG_FHA_2 434 440 PF00498 0.530
LIG_FHA_2 497 503 PF00498 0.836
LIG_FHA_2 583 589 PF00498 0.734
LIG_FHA_2 627 633 PF00498 0.567
LIG_FHA_2 700 706 PF00498 0.530
LIG_GBD_Chelix_1 840 848 PF00786 0.486
LIG_IRF3_LxIS_1 332 339 PF10401 0.619
LIG_LIR_Apic_2 208 214 PF02991 0.462
LIG_LIR_Apic_2 273 279 PF02991 0.546
LIG_LIR_Gen_1 428 438 PF02991 0.546
LIG_LIR_Nem_3 428 434 PF02991 0.546
LIG_LIR_Nem_3 474 480 PF02991 0.656
LIG_LIR_Nem_3 693 698 PF02991 0.546
LIG_LIR_Nem_3 816 820 PF02991 0.436
LIG_NRBOX 280 286 PF00104 0.546
LIG_NRBOX 433 439 PF00104 0.504
LIG_NRBOX 720 726 PF00104 0.546
LIG_NRBOX 75 81 PF00104 0.638
LIG_NRBOX 803 809 PF00104 0.462
LIG_PCNA_yPIPBox_3 357 368 PF02747 0.542
LIG_Pex14_2 747 751 PF04695 0.504
LIG_SH2_CRK 780 784 PF00017 0.619
LIG_SH2_NCK_1 41 45 PF00017 0.806
LIG_SH2_PTP2 416 419 PF00017 0.530
LIG_SH2_STAT5 190 193 PF00017 0.521
LIG_SH2_STAT5 405 408 PF00017 0.546
LIG_SH2_STAT5 416 419 PF00017 0.546
LIG_SH2_STAT5 619 622 PF00017 0.481
LIG_SH2_STAT5 684 687 PF00017 0.454
LIG_SH2_STAT5 695 698 PF00017 0.504
LIG_SH2_STAT5 776 779 PF00017 0.546
LIG_SH2_STAT5 789 792 PF00017 0.546
LIG_SH3_1 138 144 PF00018 0.658
LIG_SH3_3 138 144 PF00018 0.667
LIG_SH3_3 295 301 PF00018 0.513
LIG_SH3_3 602 608 PF00018 0.626
LIG_SH3_3 67 73 PF00018 0.729
LIG_SH3_4 489 496 PF00018 0.748
LIG_SUMO_SIM_anti_2 802 808 PF11976 0.480
LIG_SUMO_SIM_par_1 148 156 PF11976 0.632
LIG_SUMO_SIM_par_1 621 629 PF11976 0.536
LIG_SxIP_EBH_1 109 122 PF03271 0.578
LIG_TRAF2_1 216 219 PF00917 0.529
LIG_TRAF2_1 573 576 PF00917 0.813
LIG_TRAF2_1 65 68 PF00917 0.693
LIG_TYR_ITIM 414 419 PF00017 0.530
LIG_UBA3_1 717 723 PF00899 0.522
LIG_UBA3_1 820 827 PF00899 0.628
LIG_WRC_WIRS_1 831 836 PF05994 0.531
MOD_CDC14_SPxK_1 339 342 PF00782 0.546
MOD_CDK_SPxK_1 336 342 PF00069 0.546
MOD_CDK_SPxK_1 387 393 PF00069 0.546
MOD_CDK_SPxK_1 543 549 PF00069 0.752
MOD_CK1_1 122 128 PF00069 0.689
MOD_CK1_1 254 260 PF00069 0.541
MOD_CK1_1 265 271 PF00069 0.503
MOD_CK1_1 464 470 PF00069 0.642
MOD_CK1_1 530 536 PF00069 0.824
MOD_CK1_1 550 556 PF00069 0.765
MOD_CK1_1 626 632 PF00069 0.534
MOD_CK1_1 86 92 PF00069 0.700
MOD_CK2_1 225 231 PF00069 0.592
MOD_CK2_1 297 303 PF00069 0.563
MOD_CK2_1 433 439 PF00069 0.530
MOD_CK2_1 496 502 PF00069 0.833
MOD_CK2_1 582 588 PF00069 0.731
MOD_CK2_1 626 632 PF00069 0.561
MOD_CK2_1 666 672 PF00069 0.522
MOD_CK2_1 826 832 PF00069 0.550
MOD_Cter_Amidation 512 515 PF01082 0.849
MOD_Cter_Amidation 824 827 PF01082 0.544
MOD_Cter_Amidation 911 914 PF01082 0.655
MOD_Cter_Amidation 962 965 PF01082 0.671
MOD_GlcNHglycan 113 116 PF01048 0.579
MOD_GlcNHglycan 125 128 PF01048 0.660
MOD_GlcNHglycan 185 188 PF01048 0.709
MOD_GlcNHglycan 227 230 PF01048 0.661
MOD_GlcNHglycan 24 27 PF01048 0.512
MOD_GlcNHglycan 253 256 PF01048 0.361
MOD_GlcNHglycan 264 267 PF01048 0.303
MOD_GlcNHglycan 269 272 PF01048 0.277
MOD_GlcNHglycan 427 430 PF01048 0.307
MOD_GlcNHglycan 466 469 PF01048 0.671
MOD_GlcNHglycan 556 559 PF01048 0.742
MOD_GlcNHglycan 621 624 PF01048 0.462
MOD_GlcNHglycan 635 639 PF01048 0.654
MOD_GlcNHglycan 672 675 PF01048 0.557
MOD_GlcNHglycan 927 930 PF01048 0.638
MOD_GlcNHglycan 93 96 PF01048 0.787
MOD_GSK3_1 107 114 PF00069 0.661
MOD_GSK3_1 119 126 PF00069 0.624
MOD_GSK3_1 283 290 PF00069 0.536
MOD_GSK3_1 297 304 PF00069 0.411
MOD_GSK3_1 332 339 PF00069 0.511
MOD_GSK3_1 543 550 PF00069 0.717
MOD_GSK3_1 582 589 PF00069 0.686
MOD_GSK3_1 59 66 PF00069 0.753
MOD_GSK3_1 615 622 PF00069 0.490
MOD_GSK3_1 634 641 PF00069 0.458
MOD_GSK3_1 666 673 PF00069 0.542
MOD_GSK3_1 759 766 PF00069 0.546
MOD_GSK3_1 826 833 PF00069 0.549
MOD_GSK3_1 951 958 PF00069 0.516
MOD_N-GLC_1 680 685 PF02516 0.494
MOD_N-GLC_2 111 113 PF02516 0.711
MOD_NEK2_1 128 133 PF00069 0.711
MOD_NEK2_1 209 214 PF00069 0.542
MOD_NEK2_1 284 289 PF00069 0.466
MOD_NEK2_1 406 411 PF00069 0.546
MOD_NEK2_1 425 430 PF00069 0.546
MOD_NEK2_1 670 675 PF00069 0.557
MOD_NEK2_1 699 704 PF00069 0.546
MOD_NEK2_1 735 740 PF00069 0.546
MOD_NEK2_1 820 825 PF00069 0.512
MOD_NEK2_1 836 841 PF00069 0.390
MOD_NEK2_1 925 930 PF00069 0.667
MOD_NEK2_2 301 306 PF00069 0.466
MOD_PIKK_1 236 242 PF00454 0.645
MOD_PIKK_1 63 69 PF00454 0.782
MOD_PK_1 40 46 PF00069 0.803
MOD_PKA_1 119 125 PF00069 0.718
MOD_PKA_1 307 313 PF00069 0.466
MOD_PKA_1 4 10 PF00069 0.622
MOD_PKA_1 826 832 PF00069 0.550
MOD_PKA_1 913 919 PF00069 0.588
MOD_PKA_1 955 961 PF00069 0.496
MOD_PKA_2 119 125 PF00069 0.794
MOD_PKA_2 183 189 PF00069 0.702
MOD_PKA_2 236 242 PF00069 0.662
MOD_PKA_2 291 297 PF00069 0.563
MOD_PKA_2 517 523 PF00069 0.715
MOD_PKA_2 550 556 PF00069 0.793
MOD_PKA_2 638 644 PF00069 0.647
MOD_PKA_2 783 789 PF00069 0.546
MOD_PKA_2 872 878 PF00069 0.500
MOD_PKA_2 925 931 PF00069 0.663
MOD_PKA_2 946 952 PF00069 0.633
MOD_PKB_1 38 46 PF00069 0.683
MOD_Plk_1 461 467 PF00069 0.678
MOD_Plk_1 680 686 PF00069 0.468
MOD_Plk_2-3 433 439 PF00069 0.530
MOD_Plk_2-3 72 78 PF00069 0.619
MOD_Plk_2-3 879 885 PF00069 0.620
MOD_Plk_4 270 276 PF00069 0.546
MOD_Plk_4 332 338 PF00069 0.504
MOD_Plk_4 433 439 PF00069 0.619
MOD_Plk_4 473 479 PF00069 0.745
MOD_Plk_4 638 644 PF00069 0.588
MOD_Plk_4 680 686 PF00069 0.443
MOD_Plk_4 802 808 PF00069 0.422
MOD_Plk_4 83 89 PF00069 0.570
MOD_Plk_4 836 842 PF00069 0.531
MOD_ProDKin_1 212 218 PF00069 0.529
MOD_ProDKin_1 294 300 PF00069 0.591
MOD_ProDKin_1 336 342 PF00069 0.546
MOD_ProDKin_1 387 393 PF00069 0.546
MOD_ProDKin_1 543 549 PF00069 0.752
MOD_SUMO_rev_2 238 245 PF00179 0.722
TRG_DiLeu_BaEn_1 433 438 PF01217 0.509
TRG_ENDOCYTIC_2 41 44 PF00928 0.807
TRG_ENDOCYTIC_2 416 419 PF00928 0.530
TRG_ENDOCYTIC_2 697 700 PF00928 0.546
TRG_ER_diArg_1 27 30 PF00400 0.615
TRG_ER_diArg_1 35 38 PF00400 0.666
TRG_ER_diArg_1 412 414 PF00400 0.506
TRG_ER_diArg_1 718 720 PF00400 0.504
TRG_ER_diArg_1 742 745 PF00400 0.546
TRG_NLS_Bipartite_1 13 32 PF00514 0.586
TRG_NLS_Bipartite_1 493 515 PF00514 0.661
TRG_NLS_MonoExtC_3 326 331 PF00514 0.563
TRG_NLS_MonoExtC_3 510 515 PF00514 0.822
TRG_NLS_MonoExtC_3 535 540 PF00514 0.705
TRG_NLS_MonoExtN_4 117 123 PF00514 0.655
TRG_NLS_MonoExtN_4 325 331 PF00514 0.534
TRG_NLS_MonoExtN_4 511 518 PF00514 0.760
TRG_NLS_MonoExtN_4 534 540 PF00514 0.738
TRG_Pf-PMV_PEXEL_1 342 347 PF00026 0.346
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.637
TRG_Pf-PMV_PEXEL_1 767 772 PF00026 0.346
TRG_Pf-PMV_PEXEL_1 818 822 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 902 907 PF00026 0.516

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ87 Leptomonas seymouri 69% 100%
A0A3S7XBG9 Leishmania donovani 100% 100%
A4HPV7 Leishmania braziliensis 79% 100%
E9ATM4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q0X4 Leishmania major 93% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS