EF-hand domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDL4_LEIIN

TriTrypDb:

LINF_360031400

Length:

338

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDL4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005509	calcium ion binding	5	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.545
CLV_NRD_NRD_1	293	295	PF00675	0.541
CLV_PCSK_KEX2_1	144	146	PF00082	0.545
CLV_PCSK_KEX2_1	32	34	PF00082	0.553
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.396
CLV_PCSK_SKI1_1	119	123	PF00082	0.436
CLV_PCSK_SKI1_1	172	176	PF00082	0.394
CLV_PCSK_SKI1_1	179	183	PF00082	0.341
DEG_APCC_DBOX_1	239	247	PF00400	0.396
DEG_Nend_Nbox_1	1	3	PF02207	0.414
DOC_MAPK_FxFP_2	195	198	PF00069	0.313
DOC_PP2B_LxvP_1	324	327	PF13499	0.492
DOC_PP4_FxxP_1	195	198	PF00568	0.313
DOC_USP7_MATH_1	13	17	PF00917	0.362
DOC_USP7_MATH_1	154	158	PF00917	0.593
DOC_USP7_MATH_1	327	331	PF00917	0.579
DOC_USP7_UBL2_3	319	323	PF12436	0.531
DOC_WW_Pin1_4	147	152	PF00397	0.624
LIG_14-3-3_CanoR_1	263	268	PF00244	0.450
LIG_BIR_III_2	148	152	PF00653	0.516
LIG_BRCT_BRCA1_1	69	73	PF00533	0.373
LIG_Clathr_ClatBox_1	139	143	PF01394	0.415
LIG_CtBP_PxDLS_1	198	202	PF00389	0.389
LIG_FHA_1	20	26	PF00498	0.473
LIG_FHA_2	181	187	PF00498	0.339
LIG_FHA_2	237	243	PF00498	0.373
LIG_FHA_2	70	76	PF00498	0.473
LIG_Integrin_RGD_1	184	186	PF01839	0.345
LIG_LIR_Apic_2	207	211	PF02991	0.481
LIG_LIR_Gen_1	70	79	PF02991	0.473
LIG_LIR_Nem_3	129	134	PF02991	0.336
LIG_LIR_Nem_3	227	233	PF02991	0.350
LIG_LIR_Nem_3	70	76	PF02991	0.473
LIG_PTB_Apo_2	272	279	PF02174	0.441
LIG_PTB_Phospho_1	272	278	PF10480	0.439
LIG_SH2_CRK	313	317	PF00017	0.511
LIG_SH2_PTP2	208	211	PF00017	0.414
LIG_SH2_SRC	88	91	PF00017	0.463
LIG_SH2_STAP1	132	136	PF00017	0.351
LIG_SH2_STAP1	219	223	PF00017	0.410
LIG_SH2_STAP1	88	92	PF00017	0.530
LIG_SH2_STAT3	309	312	PF00017	0.550
LIG_SH2_STAT5	194	197	PF00017	0.428
LIG_SH2_STAT5	208	211	PF00017	0.482
LIG_SH2_STAT5	230	233	PF00017	0.404
LIG_SH2_STAT5	320	323	PF00017	0.616
LIG_SH2_STAT5	34	37	PF00017	0.456
LIG_SH3_3	109	115	PF00018	0.426
LIG_SH3_3	117	123	PF00018	0.397
LIG_SH3_3	174	180	PF00018	0.296
LIG_SUMO_SIM_par_1	22	29	PF11976	0.462
LIG_UBA3_1	168	175	PF00899	0.444
LIG_UBA3_1	273	280	PF00899	0.409
LIG_WRC_WIRS_1	301	306	PF05994	0.541
MOD_CK1_1	150	156	PF00069	0.600
MOD_CK1_1	157	163	PF00069	0.540
MOD_CK1_1	262	268	PF00069	0.522
MOD_CK2_1	69	75	PF00069	0.450
MOD_GlcNHglycan	152	155	PF01048	0.727
MOD_GlcNHglycan	159	162	PF01048	0.632
MOD_GlcNHglycan	199	204	PF01048	0.362
MOD_GlcNHglycan	282	285	PF01048	0.499
MOD_GlcNHglycan	329	332	PF01048	0.475
MOD_GlcNHglycan	49	52	PF01048	0.419
MOD_GSK3_1	122	129	PF00069	0.356
MOD_GSK3_1	150	157	PF00069	0.669
MOD_GSK3_1	219	226	PF00069	0.321
MOD_GSK3_1	259	266	PF00069	0.402
MOD_GSK3_1	327	334	PF00069	0.490
MOD_GSK3_1	43	50	PF00069	0.551
MOD_LATS_1	298	304	PF00433	0.465
MOD_N-GLC_1	19	24	PF02516	0.413
MOD_PIKK_1	122	128	PF00454	0.358
MOD_PKA_1	279	285	PF00069	0.475
MOD_PKA_2	211	217	PF00069	0.453
MOD_PKA_2	262	268	PF00069	0.427
MOD_PKA_2	52	58	PF00069	0.474
MOD_Plk_1	219	225	PF00069	0.355
MOD_Plk_1	99	105	PF00069	0.413
MOD_Plk_4	132	138	PF00069	0.340
MOD_Plk_4	263	269	PF00069	0.483
MOD_Plk_4	99	105	PF00069	0.440
MOD_ProDKin_1	147	153	PF00069	0.629
TRG_ENDOCYTIC_2	230	233	PF00928	0.321
TRG_ENDOCYTIC_2	313	316	PF00928	0.505
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ0	Leptomonas seymouri	72%	98%
A0A1X0NFQ9	Trypanosomatidae	43%	100%
A0A3Q8IH99	Leishmania donovani	99%	100%
A0A3R7N4F8	Trypanosoma rangeli	43%	100%
A4HPA6	Leishmania braziliensis	82%	100%
D0A3B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1I1	Leishmania major	96%	100%