Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDL1_LEIIN

TriTrypDb:

LINF_360031100

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDL1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006304	DNA modification	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016757	glycosyltransferase activity	3	1
GO:0016758	hexosyltransferase activity	4	1
GO:0046527	glucosyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.337
CLV_C14_Caspase3-7	356	360	PF00656	0.458
CLV_C14_Caspase3-7	36	40	PF00656	0.719
CLV_C14_Caspase3-7	752	756	PF00656	0.665
CLV_C14_Caspase3-7	894	898	PF00656	0.596
CLV_NRD_NRD_1	259	261	PF00675	0.478
CLV_NRD_NRD_1	361	363	PF00675	0.536
CLV_NRD_NRD_1	607	609	PF00675	0.420
CLV_NRD_NRD_1	702	704	PF00675	0.529
CLV_NRD_NRD_1	770	772	PF00675	0.700
CLV_NRD_NRD_1	793	795	PF00675	0.596
CLV_PCSK_KEX2_1	259	261	PF00082	0.492
CLV_PCSK_KEX2_1	361	363	PF00082	0.536
CLV_PCSK_KEX2_1	607	609	PF00082	0.420
CLV_PCSK_KEX2_1	702	704	PF00082	0.453
CLV_PCSK_KEX2_1	772	774	PF00082	0.635
CLV_PCSK_KEX2_1	793	795	PF00082	0.596
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.635
CLV_PCSK_SKI1_1	126	130	PF00082	0.421
CLV_PCSK_SKI1_1	274	278	PF00082	0.386
CLV_PCSK_SKI1_1	563	567	PF00082	0.515
CLV_PCSK_SKI1_1	682	686	PF00082	0.405
DEG_APCC_DBOX_1	125	133	PF00400	0.413
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SCF_FBW7_1	194	200	PF00400	0.605
DEG_SPOP_SBC_1	163	167	PF00917	0.582
DEG_SPOP_SBC_1	363	367	PF00917	0.586
DEG_SPOP_SBC_1	369	373	PF00917	0.584
DEG_SPOP_SBC_1	403	407	PF00917	0.639
DEG_SPOP_SBC_1	750	754	PF00917	0.665
DEG_SPOP_SBC_1	806	810	PF00917	0.682
DOC_ANK_TNKS_1	596	603	PF00023	0.431
DOC_CKS1_1	194	199	PF01111	0.616
DOC_CKS1_1	494	499	PF01111	0.607
DOC_CKS1_1	72	77	PF01111	0.591
DOC_CKS1_1	727	732	PF01111	0.402
DOC_CYCLIN_RxL_1	202	212	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	685	691	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	712	718	PF00134	0.395
DOC_MAPK_DCC_7	108	116	PF00069	0.359
DOC_MAPK_gen_1	702	708	PF00069	0.419
DOC_MAPK_MEF2A_6	100	107	PF00069	0.485
DOC_MAPK_MEF2A_6	108	116	PF00069	0.349
DOC_MAPK_MEF2A_6	293	301	PF00069	0.432
DOC_MAPK_MEF2A_6	916	923	PF00069	0.435
DOC_PP1_RVXF_1	647	654	PF00149	0.351
DOC_PP1_RVXF_1	705	711	PF00149	0.411
DOC_PP1_RVXF_1	903	909	PF00149	0.504
DOC_PP2B_LxvP_1	392	395	PF13499	0.565
DOC_PP2B_LxvP_1	774	777	PF13499	0.683
DOC_PP4_FxxP_1	494	497	PF00568	0.617
DOC_PP4_FxxP_1	653	656	PF00568	0.370
DOC_PP4_FxxP_1	927	930	PF00568	0.469
DOC_SPAK_OSR1_1	625	629	PF12202	0.373
DOC_USP7_MATH_1	10	14	PF00917	0.578
DOC_USP7_MATH_1	223	227	PF00917	0.502
DOC_USP7_MATH_1	235	239	PF00917	0.588
DOC_USP7_MATH_1	254	258	PF00917	0.550
DOC_USP7_MATH_1	403	407	PF00917	0.620
DOC_USP7_MATH_1	410	414	PF00917	0.568
DOC_USP7_MATH_1	498	502	PF00917	0.616
DOC_USP7_MATH_1	63	67	PF00917	0.662
DOC_USP7_MATH_1	784	788	PF00917	0.675
DOC_USP7_MATH_1	800	804	PF00917	0.489
DOC_USP7_MATH_1	805	809	PF00917	0.614
DOC_USP7_MATH_1	877	881	PF00917	0.617
DOC_USP7_MATH_1	898	902	PF00917	0.549
DOC_USP7_MATH_1	937	941	PF00917	0.475
DOC_WW_Pin1_4	166	171	PF00397	0.601
DOC_WW_Pin1_4	187	192	PF00397	0.652
DOC_WW_Pin1_4	193	198	PF00397	0.599
DOC_WW_Pin1_4	238	243	PF00397	0.767
DOC_WW_Pin1_4	244	249	PF00397	0.720
DOC_WW_Pin1_4	41	46	PF00397	0.623
DOC_WW_Pin1_4	422	427	PF00397	0.548
DOC_WW_Pin1_4	480	485	PF00397	0.496
DOC_WW_Pin1_4	493	498	PF00397	0.585
DOC_WW_Pin1_4	505	510	PF00397	0.536
DOC_WW_Pin1_4	65	70	PF00397	0.812
DOC_WW_Pin1_4	71	76	PF00397	0.541
DOC_WW_Pin1_4	711	716	PF00397	0.427
DOC_WW_Pin1_4	726	731	PF00397	0.427
DOC_WW_Pin1_4	775	780	PF00397	0.626
DOC_WW_Pin1_4	8	13	PF00397	0.581
DOC_WW_Pin1_4	900	905	PF00397	0.508
LIG_14-3-3_CanoR_1	100	104	PF00244	0.382
LIG_14-3-3_CanoR_1	287	292	PF00244	0.392
LIG_14-3-3_CanoR_1	361	370	PF00244	0.567
LIG_14-3-3_CanoR_1	458	465	PF00244	0.407
LIG_14-3-3_CanoR_1	641	647	PF00244	0.348
LIG_14-3-3_CanoR_1	867	871	PF00244	0.498
LIG_14-3-3_CanoR_1	905	915	PF00244	0.492
LIG_APCC_ABBA_1	855	860	PF00400	0.466
LIG_BRCT_BRCA1_1	211	215	PF00533	0.476
LIG_BRCT_BRCA1_1	261	265	PF00533	0.462
LIG_BRCT_BRCA1_1	649	653	PF00533	0.425
LIG_Clathr_ClatBox_1	276	280	PF01394	0.373
LIG_deltaCOP1_diTrp_1	172	176	PF00928	0.534
LIG_eIF4E_1	295	301	PF01652	0.430
LIG_EVH1_2	490	494	PF00568	0.674
LIG_FHA_1	100	106	PF00498	0.558
LIG_FHA_1	194	200	PF00498	0.671
LIG_FHA_1	364	370	PF00498	0.572
LIG_FHA_1	394	400	PF00498	0.539
LIG_FHA_1	423	429	PF00498	0.543
LIG_FHA_1	570	576	PF00498	0.416
LIG_FHA_1	633	639	PF00498	0.340
LIG_FHA_1	849	855	PF00498	0.480
LIG_FHA_1	901	907	PF00498	0.472
LIG_FHA_2	156	162	PF00498	0.604
LIG_FHA_2	167	173	PF00498	0.524
LIG_FHA_2	452	458	PF00498	0.551
LIG_FHA_2	522	528	PF00498	0.468
LIG_FHA_2	566	572	PF00498	0.508
LIG_FHA_2	759	765	PF00498	0.672
LIG_FHA_2	867	873	PF00498	0.435
LIG_FHA_2	923	929	PF00498	0.469
LIG_GBD_Chelix_1	613	621	PF00786	0.458
LIG_LIR_Apic_2	172	177	PF02991	0.494
LIG_LIR_Apic_2	492	497	PF02991	0.725
LIG_LIR_Apic_2	650	656	PF02991	0.367
LIG_LIR_Apic_2	924	930	PF02991	0.398
LIG_LIR_Gen_1	27	38	PF02991	0.606
LIG_LIR_Gen_1	343	349	PF02991	0.595
LIG_LIR_Gen_1	558	569	PF02991	0.399
LIG_LIR_Gen_1	577	585	PF02991	0.358
LIG_LIR_Gen_1	942	952	PF02991	0.490
LIG_LIR_Nem_3	27	33	PF02991	0.608
LIG_LIR_Nem_3	343	348	PF02991	0.515
LIG_LIR_Nem_3	441	447	PF02991	0.353
LIG_LIR_Nem_3	558	564	PF02991	0.371
LIG_LIR_Nem_3	577	581	PF02991	0.378
LIG_LIR_Nem_3	620	626	PF02991	0.383
LIG_LIR_Nem_3	645	651	PF02991	0.346
LIG_LIR_Nem_3	822	827	PF02991	0.529
LIG_MYND_1	732	736	PF01753	0.500
LIG_Pex14_1	815	819	PF04695	0.607
LIG_Pex14_2	433	437	PF04695	0.360
LIG_Pex14_2	683	687	PF04695	0.388
LIG_PTAP_UEV_1	247	252	PF05743	0.598
LIG_PTAP_UEV_1	778	783	PF05743	0.647
LIG_REV1ctd_RIR_1	856	862	PF16727	0.488
LIG_REV1ctd_RIR_1	942	951	PF16727	0.557
LIG_SH2_CRK	578	582	PF00017	0.371
LIG_SH2_CRK	587	591	PF00017	0.361
LIG_SH2_NCK_1	578	582	PF00017	0.371
LIG_SH2_SRC	357	360	PF00017	0.592
LIG_SH2_SRC	59	62	PF00017	0.636
LIG_SH2_SRC	616	619	PF00017	0.569
LIG_SH2_STAP1	632	636	PF00017	0.427
LIG_SH2_STAT3	295	298	PF00017	0.356
LIG_SH2_STAT5	136	139	PF00017	0.550
LIG_SH2_STAT5	219	222	PF00017	0.417
LIG_SH2_STAT5	291	294	PF00017	0.409
LIG_SH2_STAT5	295	298	PF00017	0.391
LIG_SH2_STAT5	357	360	PF00017	0.516
LIG_SH2_STAT5	510	513	PF00017	0.659
LIG_SH2_STAT5	552	555	PF00017	0.385
LIG_SH2_STAT5	598	601	PF00017	0.445
LIG_SH2_STAT5	616	619	PF00017	0.590
LIG_SH2_STAT5	726	729	PF00017	0.423
LIG_SH2_STAT5	819	822	PF00017	0.600
LIG_SH3_1	598	604	PF00018	0.489
LIG_SH3_1	773	779	PF00018	0.629
LIG_SH3_2	72	77	PF14604	0.606
LIG_SH3_3	188	194	PF00018	0.667
LIG_SH3_3	217	223	PF00018	0.426
LIG_SH3_3	237	243	PF00018	0.664
LIG_SH3_3	245	251	PF00018	0.675
LIG_SH3_3	296	302	PF00018	0.391
LIG_SH3_3	478	484	PF00018	0.483
LIG_SH3_3	598	604	PF00018	0.480
LIG_SH3_3	66	72	PF00018	0.618
LIG_SH3_3	773	779	PF00018	0.629
LIG_SH3_3	81	87	PF00018	0.349
LIG_SH3_3	851	857	PF00018	0.482
LIG_SUMO_SIM_anti_2	851	856	PF11976	0.469
LIG_SUMO_SIM_par_1	113	118	PF11976	0.386
LIG_SUMO_SIM_par_1	241	247	PF11976	0.589
LIG_SUMO_SIM_par_1	31	37	PF11976	0.662
LIG_SUMO_SIM_par_1	571	577	PF11976	0.455
LIG_SUMO_SIM_par_1	837	842	PF11976	0.506
LIG_TRAF2_1	828	831	PF00917	0.519
LIG_UBA3_1	1	7	PF00899	0.673
MOD_CDC14_SPxK_1	714	717	PF00782	0.435
MOD_CDK_SPK_2	422	427	PF00069	0.572
MOD_CDK_SPK_2	900	905	PF00069	0.508
MOD_CDK_SPxK_1	71	77	PF00069	0.615
MOD_CDK_SPxK_1	711	717	PF00069	0.424
MOD_CK1_1	11	17	PF00069	0.609
MOD_CK1_1	165	171	PF00069	0.569
MOD_CK1_1	190	196	PF00069	0.717
MOD_CK1_1	238	244	PF00069	0.627
MOD_CK1_1	252	258	PF00069	0.621
MOD_CK1_1	364	370	PF00069	0.651
MOD_CK1_1	373	379	PF00069	0.579
MOD_CK1_1	393	399	PF00069	0.564
MOD_CK1_1	40	46	PF00069	0.622
MOD_CK1_1	405	411	PF00069	0.563
MOD_CK1_1	413	419	PF00069	0.555
MOD_CK1_1	449	455	PF00069	0.550
MOD_CK1_1	501	507	PF00069	0.628
MOD_CK1_1	574	580	PF00069	0.381
MOD_CK1_1	68	74	PF00069	0.751
MOD_CK1_1	740	746	PF00069	0.645
MOD_CK1_1	753	759	PF00069	0.567
MOD_CK1_1	880	886	PF00069	0.602
MOD_CK2_1	155	161	PF00069	0.583
MOD_CK2_1	343	349	PF00069	0.598
MOD_CK2_1	451	457	PF00069	0.559
MOD_CK2_1	521	527	PF00069	0.468
MOD_CK2_1	758	764	PF00069	0.672
MOD_CK2_1	825	831	PF00069	0.538
MOD_CK2_1	866	872	PF00069	0.423
MOD_CK2_1	888	894	PF00069	0.688
MOD_CK2_1	922	928	PF00069	0.473
MOD_Cter_Amidation	791	794	PF01082	0.672
MOD_DYRK1A_RPxSP_1	775	779	PF00069	0.627
MOD_GlcNHglycan	13	16	PF01048	0.637
MOD_GlcNHglycan	211	214	PF01048	0.654
MOD_GlcNHglycan	222	226	PF01048	0.426
MOD_GlcNHglycan	251	254	PF01048	0.626
MOD_GlcNHglycan	256	259	PF01048	0.556
MOD_GlcNHglycan	261	264	PF01048	0.465
MOD_GlcNHglycan	311	315	PF01048	0.469
MOD_GlcNHglycan	331	334	PF01048	0.396
MOD_GlcNHglycan	345	348	PF01048	0.534
MOD_GlcNHglycan	375	378	PF01048	0.603
MOD_GlcNHglycan	385	388	PF01048	0.646
MOD_GlcNHglycan	392	395	PF01048	0.448
MOD_GlcNHglycan	407	410	PF01048	0.550
MOD_GlcNHglycan	416	419	PF01048	0.626
MOD_GlcNHglycan	49	52	PF01048	0.649
MOD_GlcNHglycan	501	504	PF01048	0.632
MOD_GlcNHglycan	535	538	PF01048	0.565
MOD_GlcNHglycan	755	758	PF01048	0.633
MOD_GlcNHglycan	802	805	PF01048	0.680
MOD_GlcNHglycan	883	886	PF01048	0.644
MOD_GlcNHglycan	890	893	PF01048	0.668
MOD_GSK3_1	162	169	PF00069	0.583
MOD_GSK3_1	189	196	PF00069	0.684
MOD_GSK3_1	238	245	PF00069	0.748
MOD_GSK3_1	349	356	PF00069	0.599
MOD_GSK3_1	364	371	PF00069	0.503
MOD_GSK3_1	37	44	PF00069	0.672
MOD_GSK3_1	373	380	PF00069	0.601
MOD_GSK3_1	405	412	PF00069	0.657
MOD_GSK3_1	446	453	PF00069	0.504
MOD_GSK3_1	485	492	PF00069	0.593
MOD_GSK3_1	501	508	PF00069	0.538
MOD_GSK3_1	551	558	PF00069	0.345
MOD_GSK3_1	565	572	PF00069	0.405
MOD_GSK3_1	737	744	PF00069	0.618
MOD_GSK3_1	749	756	PF00069	0.569
MOD_GSK3_1	780	787	PF00069	0.714
MOD_GSK3_1	875	882	PF00069	0.599
MOD_GSK3_1	884	891	PF00069	0.616
MOD_GSK3_1	89	96	PF00069	0.396
MOD_N-GLC_1	238	243	PF02516	0.653
MOD_N-GLC_1	47	52	PF02516	0.685
MOD_N-GLC_1	888	893	PF02516	0.690
MOD_NEK2_1	209	214	PF00069	0.495
MOD_NEK2_1	404	409	PF00069	0.616
MOD_NEK2_1	446	451	PF00069	0.482
MOD_NEK2_1	521	526	PF00069	0.543
MOD_NEK2_1	550	555	PF00069	0.372
MOD_NEK2_1	617	622	PF00069	0.447
MOD_NEK2_1	725	730	PF00069	0.497
MOD_NEK2_1	807	812	PF00069	0.630
MOD_NEK2_1	98	103	PF00069	0.478
MOD_NEK2_2	642	647	PF00069	0.348
MOD_PK_1	647	653	PF00069	0.398
MOD_PKA_1	259	265	PF00069	0.507
MOD_PKA_1	361	367	PF00069	0.627
MOD_PKA_2	209	215	PF00069	0.521
MOD_PKA_2	259	265	PF00069	0.646
MOD_PKA_2	361	367	PF00069	0.560
MOD_PKA_2	410	416	PF00069	0.666
MOD_PKA_2	457	463	PF00069	0.422
MOD_PKA_2	737	743	PF00069	0.657
MOD_PKA_2	866	872	PF00069	0.447
MOD_PKA_2	99	105	PF00069	0.389
MOD_PKB_1	823	831	PF00069	0.560
MOD_Plk_1	617	623	PF00069	0.555
MOD_Plk_1	632	638	PF00069	0.254
MOD_Plk_1	784	790	PF00069	0.572
MOD_Plk_1	98	104	PF00069	0.396
MOD_Plk_2-3	349	355	PF00069	0.547
MOD_Plk_2-3	37	43	PF00069	0.628
MOD_Plk_4	287	293	PF00069	0.419
MOD_Plk_4	353	359	PF00069	0.544
MOD_Plk_4	617	623	PF00069	0.439
MOD_Plk_4	861	867	PF00069	0.445
MOD_ProDKin_1	166	172	PF00069	0.597
MOD_ProDKin_1	187	193	PF00069	0.656
MOD_ProDKin_1	238	244	PF00069	0.769
MOD_ProDKin_1	41	47	PF00069	0.626
MOD_ProDKin_1	422	428	PF00069	0.537
MOD_ProDKin_1	480	486	PF00069	0.501
MOD_ProDKin_1	493	499	PF00069	0.581
MOD_ProDKin_1	505	511	PF00069	0.535
MOD_ProDKin_1	65	71	PF00069	0.809
MOD_ProDKin_1	711	717	PF00069	0.433
MOD_ProDKin_1	726	732	PF00069	0.435
MOD_ProDKin_1	775	781	PF00069	0.624
MOD_ProDKin_1	8	14	PF00069	0.582
MOD_ProDKin_1	900	906	PF00069	0.493
MOD_SUMO_for_1	946	949	PF00179	0.521
MOD_SUMO_rev_2	343	352	PF00179	0.597
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.516
TRG_ENDOCYTIC_2	125	128	PF00928	0.401
TRG_ENDOCYTIC_2	136	139	PF00928	0.508
TRG_ENDOCYTIC_2	345	348	PF00928	0.522
TRG_ENDOCYTIC_2	436	439	PF00928	0.329
TRG_ENDOCYTIC_2	561	564	PF00928	0.485
TRG_ENDOCYTIC_2	578	581	PF00928	0.380
TRG_ENDOCYTIC_2	587	590	PF00928	0.360
TRG_ER_diArg_1	259	261	PF00400	0.478
TRG_ER_diArg_1	470	473	PF00400	0.440
TRG_ER_diArg_1	56	59	PF00400	0.573
TRG_ER_diArg_1	606	608	PF00400	0.407
TRG_ER_diArg_1	706	709	PF00400	0.403
TRG_ER_diArg_1	771	774	PF00400	0.642
TRG_ER_diArg_1	793	795	PF00400	0.672
TRG_NLS_MonoExtC_3	770	775	PF00514	0.634
TRG_NLS_MonoExtN_4	771	776	PF00514	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R8	Leptomonas seymouri	55%	100%
A0A3Q8IKQ0	Leishmania donovani	100%	100%
A4HPA4	Leishmania braziliensis	81%	99%
E9AT14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1I4	Leishmania major	94%	100%