LeishMANIAdb
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Mitochondrial ribosomal protein L23

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial ribosomal protein L23
Gene product:
mitochondrial RNA binding complex 1 subunit
Species:
Leishmania infantum
UniProt:
A4IDK5_LEIIN
TriTrypDb:
LINF_360030200
Length:
325

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Mitochondrial ribosomal S18

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000314 organellar small ribosomal subunit 5 1
GO:0005737 cytoplasm 2 1
GO:0005763 mitochondrial small ribosomal subunit 3 1
GO:0015935 small ribosomal subunit 4 1
GO:0032991 protein-containing complex 1 1
GO:0044391 ribosomal subunit 3 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4IDK5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDK5

PDB structure(s): 7ane_m

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009892 negative regulation of metabolic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009894 regulation of catabolic process 4 1
GO:0009895 negative regulation of catabolic process 5 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010605 negative regulation of macromolecule metabolic process 5 1
GO:0010608 post-transcriptional regulation of gene expression 6 1
GO:0010628 positive regulation of gene expression 6 1
GO:0016070 RNA metabolic process 5 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031324 negative regulation of cellular metabolic process 5 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0031330 negative regulation of cellular catabolic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043487 regulation of RNA stability 3 1
GO:0043488 regulation of mRNA stability 4 1
GO:0043489 RNA stabilization 4 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 6 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048255 mRNA stabilization 5 1
GO:0048518 positive regulation of biological process 3 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051172 negative regulation of nitrogen compound metabolic process 5 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0051253 negative regulation of RNA metabolic process 6 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0061013 regulation of mRNA catabolic process 6 1
GO:0065007 biological regulation 1 1
GO:0065008 regulation of biological quality 2 1
GO:0071704 organic substance metabolic process 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1902369 negative regulation of RNA catabolic process 7 1
GO:1902373 negative regulation of mRNA catabolic process 7 1
GO:1903311 regulation of mRNA metabolic process 6 1
GO:1903312 negative regulation of mRNA metabolic process 7 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 175 181 PF00089 0.394
CLV_NRD_NRD_1 237 239 PF00675 0.603
CLV_NRD_NRD_1 55 57 PF00675 0.472
CLV_PCSK_KEX2_1 237 239 PF00082 0.603
CLV_PCSK_KEX2_1 311 313 PF00082 0.461
CLV_PCSK_KEX2_1 57 59 PF00082 0.481
CLV_PCSK_PC1ET2_1 311 313 PF00082 0.461
CLV_PCSK_PC1ET2_1 57 59 PF00082 0.481
CLV_PCSK_SKI1_1 139 143 PF00082 0.380
CLV_PCSK_SKI1_1 164 168 PF00082 0.396
CLV_PCSK_SKI1_1 237 241 PF00082 0.639
CLV_PCSK_SKI1_1 281 285 PF00082 0.505
CLV_PCSK_SKI1_1 295 299 PF00082 0.483
DEG_Nend_UBRbox_3 1 3 PF02207 0.706
DOC_MAPK_gen_1 164 173 PF00069 0.378
DOC_MAPK_MEF2A_6 120 127 PF00069 0.460
DOC_MAPK_MEF2A_6 167 175 PF00069 0.382
DOC_PP4_FxxP_1 118 121 PF00568 0.502
DOC_PP4_FxxP_1 179 182 PF00568 0.376
DOC_PP4_FxxP_1 315 318 PF00568 0.448
DOC_USP7_MATH_1 239 243 PF00917 0.585
DOC_USP7_UBL2_3 128 132 PF12436 0.396
DOC_USP7_UBL2_3 295 299 PF12436 0.483
DOC_WW_Pin1_4 43 48 PF00397 0.508
LIG_14-3-3_CanoR_1 238 248 PF00244 0.678
LIG_BIR_III_2 39 43 PF00653 0.572
LIG_BRCT_BRCA1_1 186 190 PF00533 0.401
LIG_deltaCOP1_diTrp_1 61 65 PF00928 0.400
LIG_EH_1 180 184 PF12763 0.364
LIG_FHA_1 218 224 PF00498 0.407
LIG_FHA_1 317 323 PF00498 0.467
LIG_FHA_2 34 40 PF00498 0.464
LIG_FHA_2 44 50 PF00498 0.484
LIG_FHA_2 91 97 PF00498 0.407
LIG_LIR_Gen_1 124 134 PF02991 0.398
LIG_LIR_Gen_1 30 35 PF02991 0.450
LIG_LIR_Gen_1 79 90 PF02991 0.483
LIG_LIR_Nem_3 124 129 PF02991 0.405
LIG_LIR_Nem_3 30 34 PF02991 0.437
LIG_LIR_Nem_3 79 85 PF02991 0.483
LIG_LYPXL_S_1 175 179 PF13949 0.384
LIG_Pex14_2 179 183 PF04695 0.375
LIG_Pex14_2 213 217 PF04695 0.411
LIG_SH2_CRK 126 130 PF00017 0.400
LIG_SH2_CRK 131 135 PF00017 0.390
LIG_SH2_PTP2 31 34 PF00017 0.414
LIG_SH2_STAP1 14 18 PF00017 0.451
LIG_SH2_STAT5 226 229 PF00017 0.421
LIG_SH2_STAT5 31 34 PF00017 0.418
LIG_SH3_3 151 157 PF00018 0.400
LIG_SH3_3 283 289 PF00018 0.475
LIG_SUMO_SIM_anti_2 30 36 PF11976 0.507
LIG_TRAF2_1 194 197 PF00917 0.483
LIG_TRAF2_1 46 49 PF00917 0.587
MOD_CDK_SPxxK_3 43 50 PF00069 0.591
MOD_CK1_1 306 312 PF00069 0.469
MOD_CK1_1 316 322 PF00069 0.495
MOD_CK1_1 33 39 PF00069 0.524
MOD_CK2_1 43 49 PF00069 0.588
MOD_Cter_Amidation 54 57 PF01082 0.467
MOD_GlcNHglycan 242 245 PF01048 0.586
MOD_GSK3_1 135 142 PF00069 0.363
MOD_GSK3_1 199 206 PF00069 0.438
MOD_GSK3_1 233 240 PF00069 0.559
MOD_GSK3_1 303 310 PF00069 0.468
MOD_N-GLC_1 262 267 PF02516 0.523
MOD_N-GLC_1 83 88 PF02516 0.427
MOD_NEK2_1 13 18 PF00069 0.521
MOD_NEK2_1 141 146 PF00069 0.392
MOD_NEK2_1 233 238 PF00069 0.593
MOD_NEK2_1 291 296 PF00069 0.468
MOD_NEK2_1 304 309 PF00069 0.462
MOD_NEK2_1 313 318 PF00069 0.454
MOD_NEK2_1 90 95 PF00069 0.537
MOD_PIKK_1 16 22 PF00454 0.527
MOD_PIKK_1 184 190 PF00454 0.397
MOD_PIKK_1 253 259 PF00454 0.581
MOD_PKA_1 237 243 PF00069 0.628
MOD_PKA_2 237 243 PF00069 0.616
MOD_Plk_1 262 268 PF00069 0.494
MOD_Plk_1 279 285 PF00069 0.603
MOD_Plk_1 83 89 PF00069 0.422
MOD_Plk_2-3 262 268 PF00069 0.587
MOD_ProDKin_1 43 49 PF00069 0.507
MOD_SUMO_rev_2 109 115 PF00179 0.441
TRG_AP2beta_CARGO_1 79 89 PF09066 0.481
TRG_DiLeu_BaEn_1 30 35 PF01217 0.437
TRG_ENDOCYTIC_2 126 129 PF00928 0.402
TRG_ENDOCYTIC_2 176 179 PF00928 0.383
TRG_ENDOCYTIC_2 215 218 PF00928 0.446
TRG_ENDOCYTIC_2 31 34 PF00928 0.438
TRG_ENDOCYTIC_2 73 76 PF00928 0.404
TRG_ER_diArg_1 53 56 PF00400 0.449
TRG_NES_CRM1_1 257 267 PF08389 0.581
TRG_NLS_MonoExtC_3 55 60 PF00514 0.484
TRG_NLS_MonoExtN_4 295 302 PF00514 0.482
TRG_NLS_MonoExtN_4 54 60 PF00514 0.484
TRG_Pf-PMV_PEXEL_1 228 232 PF00026 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD70 Leptomonas seymouri 90% 100%
A0A0S4JTC8 Bodo saltans 67% 100%
A0A3S5H825 Leishmania donovani 100% 100%
A0A422NIU3 Trypanosoma rangeli 84% 100%
A4HP99 Leishmania braziliensis 94% 100%
D0A3A4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 83% 100%
E9AT08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
Q4Q1J0 Leishmania major 98% 100%
V5BKY9 Trypanosoma cruzi 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS