Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDK4_LEIIN

TriTrypDb:

LINF_360030100

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4IDK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.619
CLV_PCSK_KEX2_1	257	259	PF00082	0.619
CLV_PCSK_SKI1_1	257	261	PF00082	0.605
CLV_PCSK_SKI1_1	472	476	PF00082	0.527
DEG_Nend_UBRbox_2	1	3	PF02207	0.500
DOC_CKS1_1	350	355	PF01111	0.637
DOC_CYCLIN_RxL_1	95	105	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.455
DOC_MAPK_gen_1	120	128	PF00069	0.637
DOC_MAPK_gen_1	257	265	PF00069	0.375
DOC_MAPK_MEF2A_6	46	53	PF00069	0.379
DOC_PP1_RVXF_1	250	256	PF00149	0.383
DOC_PP2B_LxvP_1	224	227	PF13499	0.486
DOC_PP4_FxxP_1	147	150	PF00568	0.620
DOC_USP7_MATH_1	167	171	PF00917	0.296
DOC_USP7_MATH_1	380	384	PF00917	0.661
DOC_USP7_MATH_1	439	443	PF00917	0.614
DOC_USP7_MATH_1	450	454	PF00917	0.739
DOC_USP7_MATH_1	85	89	PF00917	0.498
DOC_USP7_MATH_1	9	13	PF00917	0.466
DOC_WW_Pin1_4	215	220	PF00397	0.441
DOC_WW_Pin1_4	349	354	PF00397	0.662
DOC_WW_Pin1_4	422	427	PF00397	0.692
DOC_WW_Pin1_4	454	459	PF00397	0.719
DOC_WW_Pin1_4	476	481	PF00397	0.734
LIG_14-3-3_CanoR_1	114	119	PF00244	0.626
LIG_14-3-3_CanoR_1	257	266	PF00244	0.507
LIG_14-3-3_CanoR_1	289	295	PF00244	0.519
LIG_14-3-3_CanoR_1	343	349	PF00244	0.644
LIG_14-3-3_CanoR_1	37	44	PF00244	0.481
LIG_14-3-3_CanoR_1	71	79	PF00244	0.449
LIG_Actin_RPEL_3	91	110	PF02755	0.369
LIG_Actin_WH2_2	17	34	PF00022	0.405
LIG_Actin_WH2_2	186	204	PF00022	0.328
LIG_Actin_WH2_2	242	259	PF00022	0.380
LIG_APCC_ABBA_1	126	131	PF00400	0.564
LIG_BRCT_BRCA1_1	246	250	PF00533	0.407
LIG_BRCT_BRCA1_1	368	372	PF00533	0.651
LIG_BRCT_BRCA1_2	246	252	PF00533	0.391
LIG_FHA_1	103	109	PF00498	0.284
LIG_FHA_1	158	164	PF00498	0.498
LIG_FHA_1	179	185	PF00498	0.422
LIG_FHA_1	196	202	PF00498	0.459
LIG_FHA_1	234	240	PF00498	0.410
LIG_FHA_1	258	264	PF00498	0.405
LIG_FHA_1	398	404	PF00498	0.678
LIG_FHA_1	8	14	PF00498	0.440
LIG_FHA_2	37	43	PF00498	0.426
LIG_FHA_2	442	448	PF00498	0.684
LIG_GBD_Chelix_1	100	108	PF00786	0.331
LIG_GBD_Chelix_1	171	179	PF00786	0.304
LIG_GBD_Chelix_1	241	249	PF00786	0.587
LIG_LIR_Apic_2	145	150	PF02991	0.630
LIG_LIR_Apic_2	210	215	PF02991	0.384
LIG_LIR_Gen_1	105	115	PF02991	0.402
LIG_LIR_Gen_1	16	24	PF02991	0.368
LIG_LIR_Gen_1	236	245	PF02991	0.417
LIG_LIR_Gen_1	247	256	PF02991	0.362
LIG_LIR_Gen_1	59	69	PF02991	0.439
LIG_LIR_Nem_3	105	110	PF02991	0.271
LIG_LIR_Nem_3	16	20	PF02991	0.390
LIG_LIR_Nem_3	236	241	PF02991	0.476
LIG_LIR_Nem_3	247	253	PF02991	0.348
LIG_LIR_Nem_3	59	65	PF02991	0.502
LIG_NRBOX	189	195	PF00104	0.485
LIG_NRBOX	95	101	PF00104	0.304
LIG_Pex14_1	282	286	PF04695	0.304
LIG_RPA_C_Fungi	53	65	PF08784	0.443
LIG_SH2_STAP1	17	21	PF00017	0.503
LIG_SH2_STAP1	234	238	PF00017	0.568
LIG_SH2_STAP1	286	290	PF00017	0.543
LIG_SH2_STAP1	62	66	PF00017	0.565
LIG_SH2_STAT5	267	270	PF00017	0.310
LIG_SH2_STAT5	300	303	PF00017	0.562
LIG_SH2_STAT5	359	362	PF00017	0.547
LIG_SH3_3	224	230	PF00018	0.513
LIG_SH3_3	347	353	PF00018	0.533
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.562
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.494
LIG_SUMO_SIM_par_1	159	164	PF11976	0.426
LIG_SUMO_SIM_par_1	99	105	PF11976	0.460
LIG_TRAF2_1	433	436	PF00917	0.521
LIG_WW_1	14	17	PF00397	0.498
MOD_CDC14_SPxK_1	425	428	PF00782	0.513
MOD_CDK_SPK_2	349	354	PF00069	0.536
MOD_CDK_SPK_2	476	481	PF00069	0.576
MOD_CDK_SPxK_1	422	428	PF00069	0.529
MOD_CDK_SPxxK_3	349	356	PF00069	0.539
MOD_CK1_1	16	22	PF00069	0.572
MOD_CK1_1	237	243	PF00069	0.515
MOD_CK1_1	248	254	PF00069	0.388
MOD_CK1_1	383	389	PF00069	0.572
MOD_CK1_1	422	428	PF00069	0.584
MOD_CK1_1	453	459	PF00069	0.696
MOD_CK2_1	441	447	PF00069	0.594
MOD_GlcNHglycan	165	168	PF01048	0.353
MOD_GlcNHglycan	242	245	PF01048	0.613
MOD_GlcNHglycan	409	412	PF01048	0.648
MOD_GlcNHglycan	421	424	PF01048	0.704
MOD_GlcNHglycan	441	444	PF01048	0.475
MOD_GlcNHglycan	85	88	PF01048	0.544
MOD_GSK3_1	157	164	PF00069	0.471
MOD_GSK3_1	233	240	PF00069	0.522
MOD_GSK3_1	244	251	PF00069	0.537
MOD_GSK3_1	290	297	PF00069	0.454
MOD_GSK3_1	379	386	PF00069	0.628
MOD_GSK3_1	450	457	PF00069	0.666
MOD_GSK3_1	79	86	PF00069	0.538
MOD_GSK3_1	9	16	PF00069	0.577
MOD_N-GLC_1	157	162	PF02516	0.484
MOD_N-GLC_1	245	250	PF02516	0.481
MOD_N-GLC_1	294	299	PF02516	0.492
MOD_N-GLC_1	7	12	PF02516	0.641
MOD_NEK2_1	102	107	PF00069	0.393
MOD_NEK2_1	134	139	PF00069	0.493
MOD_NEK2_1	161	166	PF00069	0.369
MOD_NEK2_1	23	28	PF00069	0.604
MOD_NEK2_1	245	250	PF00069	0.490
MOD_NEK2_1	284	289	PF00069	0.514
MOD_NEK2_1	290	295	PF00069	0.480
MOD_NEK2_1	330	335	PF00069	0.489
MOD_NEK2_1	344	349	PF00069	0.438
MOD_NEK2_1	65	70	PF00069	0.703
MOD_NEK2_2	178	183	PF00069	0.314
MOD_PIKK_1	257	263	PF00454	0.493
MOD_PIKK_1	330	336	PF00454	0.457
MOD_PKA_1	257	263	PF00069	0.514
MOD_PKA_2	113	119	PF00069	0.541
MOD_PKA_2	257	263	PF00069	0.597
MOD_PKA_2	36	42	PF00069	0.494
MOD_PKA_2	70	76	PF00069	0.543
MOD_Plk_1	157	163	PF00069	0.486
MOD_Plk_1	245	251	PF00069	0.479
MOD_Plk_1	294	300	PF00069	0.462
MOD_Plk_4	102	108	PF00069	0.360
MOD_Plk_4	157	163	PF00069	0.511
MOD_Plk_4	16	22	PF00069	0.542
MOD_Plk_4	234	240	PF00069	0.701
MOD_Plk_4	245	251	PF00069	0.410
MOD_Plk_4	272	278	PF00069	0.308
MOD_Plk_4	65	71	PF00069	0.543
MOD_Plk_4	79	85	PF00069	0.612
MOD_ProDKin_1	215	221	PF00069	0.546
MOD_ProDKin_1	349	355	PF00069	0.573
MOD_ProDKin_1	422	428	PF00069	0.584
MOD_ProDKin_1	454	460	PF00069	0.650
MOD_ProDKin_1	476	482	PF00069	0.677
TRG_DiLeu_BaEn_2	367	373	PF01217	0.504
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.500
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.415
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.369
TRG_DiLeu_LyEn_5	303	308	PF01217	0.542
TRG_ENDOCYTIC_2	17	20	PF00928	0.507
TRG_ENDOCYTIC_2	359	362	PF00928	0.547
TRG_ENDOCYTIC_2	62	65	PF00928	0.585
TRG_ER_diArg_1	119	122	PF00400	0.514
TRG_ER_diArg_1	256	258	PF00400	0.527
TRG_ER_diArg_1	353	356	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I690	Leptomonas seymouri	26%	100%
A0A3S7XAV6	Leishmania donovani	98%	100%
A4HP98	Leishmania braziliensis	63%	100%
E9AT07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q1J1	Leishmania major	88%	99%