Putative Bardet-Biedl syndrome 4 protein homolog (BBS4-like protein 4)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 4 protein - putative

Species:

Leishmania infantum

UniProt:

A4IDK2_LEIIN

TriTrypDb:

LINF_360029900

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0012506	vesicle membrane	4	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0032991	protein-containing complex	1	1
GO:0034464	BBSome	2	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4IDK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDK2

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006826	iron ion transport	8	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030001	metal ion transport	6	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0033572	transferrin transport	5	1
GO:0044782	cilium organization	5	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0060271	cilium assembly	6	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030276	clathrin binding	3	1
GO:0032050	clathrin heavy chain binding	4	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.461
CLV_NRD_NRD_1	183	185	PF00675	0.491
CLV_NRD_NRD_1	187	189	PF00675	0.468
CLV_NRD_NRD_1	328	330	PF00675	0.351
CLV_NRD_NRD_1	444	446	PF00675	0.558
CLV_NRD_NRD_1	64	66	PF00675	0.384
CLV_PCSK_FUR_1	62	66	PF00082	0.392
CLV_PCSK_KEX2_1	107	109	PF00082	0.342
CLV_PCSK_KEX2_1	183	185	PF00082	0.474
CLV_PCSK_KEX2_1	187	189	PF00082	0.417
CLV_PCSK_KEX2_1	444	446	PF00082	0.558
CLV_PCSK_KEX2_1	64	66	PF00082	0.384
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.385
CLV_PCSK_PC7_1	183	189	PF00082	0.405
CLV_PCSK_SKI1_1	103	107	PF00082	0.326
CLV_PCSK_SKI1_1	161	165	PF00082	0.452
CLV_PCSK_SKI1_1	211	215	PF00082	0.432
CLV_PCSK_SKI1_1	262	266	PF00082	0.360
CLV_PCSK_SKI1_1	318	322	PF00082	0.522
CLV_PCSK_SKI1_1	330	334	PF00082	0.391
DEG_APCC_DBOX_1	64	72	PF00400	0.485
DEG_MDM2_SWIB_1	432	439	PF02201	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.702
DEG_SPOP_SBC_1	469	473	PF00917	0.726
DOC_CKS1_1	438	443	PF01111	0.529
DOC_CYCLIN_RxL_1	100	110	PF00134	0.345
DOC_MAPK_gen_1	62	71	PF00069	0.500
DOC_PP2B_LxvP_1	462	465	PF13499	0.587
DOC_PP4_FxxP_1	333	336	PF00568	0.478
DOC_USP7_MATH_1	276	280	PF00917	0.330
DOC_USP7_MATH_1	302	306	PF00917	0.391
DOC_USP7_MATH_1	477	481	PF00917	0.687
DOC_USP7_UBL2_3	103	107	PF12436	0.359
DOC_WW_Pin1_4	124	129	PF00397	0.484
DOC_WW_Pin1_4	230	235	PF00397	0.295
DOC_WW_Pin1_4	31	36	PF00397	0.643
DOC_WW_Pin1_4	437	442	PF00397	0.526
LIG_14-3-3_CanoR_1	329	333	PF00244	0.387
LIG_14-3-3_CanoR_1	354	362	PF00244	0.440
LIG_14-3-3_CanoR_1	430	436	PF00244	0.462
LIG_Actin_WH2_2	313	331	PF00022	0.447
LIG_APCC_ABBA_1	223	228	PF00400	0.326
LIG_APCC_ABBA_1	366	371	PF00400	0.412
LIG_FHA_1	120	126	PF00498	0.440
LIG_FHA_2	233	239	PF00498	0.399
LIG_FHA_2	267	273	PF00498	0.466
LIG_LIR_Apic_2	331	336	PF02991	0.461
LIG_LIR_Gen_1	203	214	PF02991	0.452
LIG_LIR_Gen_1	305	316	PF02991	0.395
LIG_LIR_Gen_1	321	328	PF02991	0.480
LIG_LIR_Gen_1	424	432	PF02991	0.391
LIG_LIR_Gen_1	434	441	PF02991	0.383
LIG_LIR_Nem_3	173	178	PF02991	0.360
LIG_LIR_Nem_3	203	209	PF02991	0.454
LIG_LIR_Nem_3	292	297	PF02991	0.407
LIG_LIR_Nem_3	305	311	PF02991	0.407
LIG_LIR_Nem_3	321	325	PF02991	0.482
LIG_LIR_Nem_3	404	409	PF02991	0.458
LIG_LIR_Nem_3	424	429	PF02991	0.426
LIG_LIR_Nem_3	434	439	PF02991	0.448
LIG_LIR_Nem_3	95	101	PF02991	0.354
LIG_NRBOX	457	463	PF00104	0.482
LIG_NRBOX	67	73	PF00104	0.463
LIG_PCNA_TLS_4	187	194	PF02747	0.395
LIG_Pex14_1	170	174	PF04695	0.310
LIG_Pex14_1	339	343	PF04695	0.317
LIG_Pex14_2	432	436	PF04695	0.370
LIG_SH2_CRK	294	298	PF00017	0.407
LIG_SH2_CRK	322	326	PF00017	0.459
LIG_SH2_GRB2like	409	412	PF00017	0.439
LIG_SH2_GRB2like	78	81	PF00017	0.466
LIG_SH2_NCK_1	322	326	PF00017	0.459
LIG_SH2_PTP2	175	178	PF00017	0.442
LIG_SH2_SRC	226	229	PF00017	0.407
LIG_SH2_SRC	396	399	PF00017	0.464
LIG_SH2_STAP1	219	223	PF00017	0.328
LIG_SH2_STAP1	226	230	PF00017	0.326
LIG_SH2_STAP1	287	291	PF00017	0.407
LIG_SH2_STAP1	322	326	PF00017	0.459
LIG_SH2_STAP1	396	400	PF00017	0.379
LIG_SH2_STAP1	412	416	PF00017	0.391
LIG_SH2_STAP1	78	82	PF00017	0.362
LIG_SH2_STAP1	98	102	PF00017	0.164
LIG_SH2_STAT3	247	250	PF00017	0.399
LIG_SH2_STAT3	73	76	PF00017	0.360
LIG_SH2_STAT5	101	104	PF00017	0.353
LIG_SH2_STAT5	175	178	PF00017	0.378
LIG_SH2_STAT5	206	209	PF00017	0.417
LIG_SH2_STAT5	247	250	PF00017	0.313
LIG_SH2_STAT5	259	262	PF00017	0.291
LIG_SH2_STAT5	355	358	PF00017	0.368
LIG_SH2_STAT5	409	412	PF00017	0.373
LIG_SH2_STAT5	426	429	PF00017	0.400
LIG_SH2_STAT5	73	76	PF00017	0.374
LIG_SH3_3	231	237	PF00018	0.369
LIG_SH3_3	29	35	PF00018	0.610
LIG_SH3_3	462	468	PF00018	0.648
LIG_SUMO_SIM_anti_2	114	122	PF11976	0.473
LIG_SUMO_SIM_anti_2	238	244	PF11976	0.331
LIG_TRAF2_1	153	156	PF00917	0.391
LIG_TRAF2_1	421	424	PF00917	0.431
MOD_CDC14_SPxK_1	34	37	PF00782	0.616
MOD_CDK_SPxK_1	31	37	PF00069	0.624
MOD_CDK_SPxxK_3	437	444	PF00069	0.526
MOD_CK1_1	39	45	PF00069	0.586
MOD_CK2_1	109	115	PF00069	0.482
MOD_CK2_1	418	424	PF00069	0.431
MOD_Cter_Amidation	316	319	PF01082	0.473
MOD_GlcNHglycan	19	22	PF01048	0.662
MOD_GlcNHglycan	283	286	PF01048	0.391
MOD_GlcNHglycan	356	359	PF01048	0.347
MOD_GlcNHglycan	39	42	PF01048	0.610
MOD_GlcNHglycan	478	482	PF01048	0.763
MOD_GSK3_1	109	116	PF00069	0.430
MOD_GSK3_1	12	19	PF00069	0.547
MOD_GSK3_1	228	235	PF00069	0.413
MOD_GSK3_1	262	269	PF00069	0.372
MOD_GSK3_1	39	46	PF00069	0.585
MOD_N-GLC_2	391	393	PF02516	0.379
MOD_NEK2_1	109	114	PF00069	0.389
MOD_NEK2_1	119	124	PF00069	0.306
MOD_NEK2_1	17	22	PF00069	0.680
MOD_NEK2_1	193	198	PF00069	0.342
MOD_NEK2_1	28	33	PF00069	0.690
MOD_NEK2_1	328	333	PF00069	0.453
MOD_NEK2_1	89	94	PF00069	0.510
MOD_NEK2_2	412	417	PF00069	0.432
MOD_PIKK_1	132	138	PF00454	0.413
MOD_PIKK_1	302	308	PF00454	0.412
MOD_PK_1	418	424	PF00069	0.399
MOD_PKA_1	318	324	PF00069	0.463
MOD_PKA_2	328	334	PF00069	0.431
MOD_PKA_2	36	42	PF00069	0.712
MOD_PKA_2	89	95	PF00069	0.494
MOD_Plk_1	302	308	PF00069	0.372
MOD_Plk_1	445	451	PF00069	0.551
MOD_Plk_4	276	282	PF00069	0.331
MOD_Plk_4	328	334	PF00069	0.454
MOD_Plk_4	412	418	PF00069	0.448
MOD_Plk_4	446	452	PF00069	0.537
MOD_ProDKin_1	124	130	PF00069	0.477
MOD_ProDKin_1	230	236	PF00069	0.295
MOD_ProDKin_1	31	37	PF00069	0.642
MOD_ProDKin_1	437	443	PF00069	0.527
TRG_DiLeu_BaEn_1	115	120	PF01217	0.461
TRG_DiLeu_BaEn_1	446	451	PF01217	0.547
TRG_DiLeu_BaEn_4	227	233	PF01217	0.256
TRG_ENDOCYTIC_2	175	178	PF00928	0.323
TRG_ENDOCYTIC_2	206	209	PF00928	0.445
TRG_ENDOCYTIC_2	294	297	PF00928	0.407
TRG_ENDOCYTIC_2	322	325	PF00928	0.462
TRG_ENDOCYTIC_2	426	429	PF00928	0.365
TRG_ER_diArg_1	186	188	PF00400	0.486
TRG_NES_CRM1_1	115	129	PF08389	0.483
TRG_NES_CRM1_1	238	250	PF08389	0.301
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED7	Leptomonas seymouri	70%	100%
A0A1X0P7L4	Trypanosomatidae	47%	87%
A0A3Q8IH89	Leishmania donovani	100%	100%
A0A3R7MGH4	Trypanosoma rangeli	48%	100%
A1Z8E9	Drosophila melanogaster	31%	100%
A4HP97	Leishmania braziliensis	85%	100%
D0A3A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AT05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q1JQ97	Bos taurus	43%	95%
Q28G25	Xenopus tropicalis	42%	96%
Q4Q1J3	Leishmania major	98%	100%
Q5CZ52	Caenorhabditis elegans	27%	100%
Q8C1Z7	Mus musculus	43%	95%
Q96RK4	Homo sapiens	44%	95%
Q9STS3	Arabidopsis thaliana	20%	85%
V5DCK5	Trypanosoma cruzi	46%	100%