Uncharacterized protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDK1_LEIIN

TriTrypDb:

LINF_360029800

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 212

Expansion

Sequence features

A4IDK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.770
CLV_MEL_PAP_1	78	84	PF00089	0.407
CLV_NRD_NRD_1	33	35	PF00675	0.626
CLV_NRD_NRD_1	338	340	PF00675	0.768
CLV_PCSK_KEX2_1	33	35	PF00082	0.626
CLV_PCSK_KEX2_1	338	340	PF00082	0.739
CLV_PCSK_SKI1_1	206	210	PF00082	0.614
CLV_PCSK_SKI1_1	333	337	PF00082	0.611
CLV_PCSK_SKI1_1	5	9	PF00082	0.619
CLV_PCSK_SKI1_1	72	76	PF00082	0.513
CLV_Separin_Metazoa	69	73	PF03568	0.532
DEG_APCC_DBOX_1	71	79	PF00400	0.432
DEG_COP1_1	229	237	PF00400	0.684
DOC_CKS1_1	214	219	PF01111	0.731
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.710
DOC_MAPK_MEF2A_6	59	66	PF00069	0.530
DOC_PP2B_LxvP_1	207	210	PF13499	0.575
DOC_USP7_MATH_1	101	105	PF00917	0.653
DOC_USP7_MATH_1	208	212	PF00917	0.749
DOC_USP7_MATH_1	228	232	PF00917	0.508
DOC_USP7_MATH_1	312	316	PF00917	0.865
DOC_WW_Pin1_4	209	214	PF00397	0.746
DOC_WW_Pin1_4	226	231	PF00397	0.582
DOC_WW_Pin1_4	257	262	PF00397	0.760
DOC_WW_Pin1_4	263	268	PF00397	0.665
LIG_14-3-3_CanoR_1	126	131	PF00244	0.643
LIG_14-3-3_CanoR_1	181	188	PF00244	0.651
LIG_14-3-3_CanoR_1	304	312	PF00244	0.730
LIG_14-3-3_CanoR_1	394	398	PF00244	0.637
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BIR_III_3	1	5	PF00653	0.649
LIG_deltaCOP1_diTrp_1	350	356	PF00928	0.652
LIG_FHA_1	125	131	PF00498	0.645
LIG_FHA_1	18	24	PF00498	0.485
LIG_FHA_1	263	269	PF00498	0.714
LIG_FHA_1	394	400	PF00498	0.708
LIG_FHA_1	53	59	PF00498	0.523
LIG_FHA_1	89	95	PF00498	0.729
LIG_FHA_2	214	220	PF00498	0.733
LIG_FHA_2	251	257	PF00498	0.663
LIG_FHA_2	335	341	PF00498	0.764
LIG_FHA_2	41	47	PF00498	0.553
LIG_FHA_2	436	442	PF00498	0.552
LIG_GBD_Chelix_1	66	74	PF00786	0.434
LIG_LIR_Gen_1	125	136	PF02991	0.604
LIG_LIR_Gen_1	198	207	PF02991	0.691
LIG_LIR_Gen_1	350	360	PF02991	0.660
LIG_LIR_Gen_1	386	393	PF02991	0.614
LIG_LIR_Gen_1	437	447	PF02991	0.727
LIG_LIR_Gen_1	60	67	PF02991	0.621
LIG_LIR_Gen_1	73	84	PF02991	0.399
LIG_LIR_Nem_3	198	202	PF02991	0.670
LIG_LIR_Nem_3	350	356	PF02991	0.652
LIG_LIR_Nem_3	386	392	PF02991	0.616
LIG_LIR_Nem_3	437	442	PF02991	0.728
LIG_LIR_Nem_3	60	64	PF02991	0.625
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.616
LIG_Pex14_1	274	278	PF04695	0.541
LIG_RPA_C_Fungi	29	41	PF08784	0.632
LIG_SH2_NCK_1	439	443	PF00017	0.718
LIG_SH2_PTP2	389	392	PF00017	0.526
LIG_SH2_PTP2	458	461	PF00017	0.542
LIG_SH2_SRC	439	442	PF00017	0.641
LIG_SH2_STAP1	199	203	PF00017	0.677
LIG_SH2_STAP1	439	443	PF00017	0.542
LIG_SH2_STAT5	128	131	PF00017	0.649
LIG_SH2_STAT5	292	295	PF00017	0.751
LIG_SH2_STAT5	35	38	PF00017	0.626
LIG_SH2_STAT5	389	392	PF00017	0.526
LIG_SH2_STAT5	458	461	PF00017	0.756
LIG_SH2_STAT5	61	64	PF00017	0.618
LIG_SH3_3	207	213	PF00018	0.584
LIG_SH3_3	227	233	PF00018	0.716
LIG_SUMO_SIM_par_1	134	139	PF11976	0.759
LIG_SUMO_SIM_par_1	50	55	PF11976	0.368
LIG_TRAF2_1	329	332	PF00917	0.718
LIG_TYR_ITIM	197	202	PF00017	0.675
MOD_CK1_1	122	128	PF00069	0.634
MOD_CK1_1	212	218	PF00069	0.827
MOD_CK1_1	22	28	PF00069	0.615
MOD_CK1_1	245	251	PF00069	0.728
MOD_CK1_1	257	263	PF00069	0.700
MOD_CK1_1	305	311	PF00069	0.686
MOD_CK1_1	364	370	PF00069	0.778
MOD_CK2_1	158	164	PF00069	0.559
MOD_CK2_1	250	256	PF00069	0.745
MOD_CK2_1	334	340	PF00069	0.767
MOD_CK2_1	370	376	PF00069	0.795
MOD_GlcNHglycan	121	124	PF01048	0.625
MOD_GlcNHglycan	145	148	PF01048	0.625
MOD_GlcNHglycan	183	186	PF01048	0.665
MOD_GlcNHglycan	261	264	PF01048	0.711
MOD_GlcNHglycan	314	317	PF01048	0.678
MOD_GlcNHglycan	36	39	PF01048	0.481
MOD_GlcNHglycan	364	367	PF01048	0.588
MOD_GlcNHglycan	376	380	PF01048	0.554
MOD_GlcNHglycan	408	411	PF01048	0.771
MOD_GlcNHglycan	412	415	PF01048	0.683
MOD_GlcNHglycan	82	85	PF01048	0.595
MOD_GSK3_1	122	129	PF00069	0.636
MOD_GSK3_1	19	26	PF00069	0.573
MOD_GSK3_1	208	215	PF00069	0.779
MOD_GSK3_1	222	229	PF00069	0.622
MOD_GSK3_1	250	257	PF00069	0.790
MOD_GSK3_1	259	266	PF00069	0.796
MOD_GSK3_1	303	310	PF00069	0.672
MOD_GSK3_1	360	367	PF00069	0.760
MOD_GSK3_1	398	405	PF00069	0.676
MOD_GSK3_1	406	413	PF00069	0.702
MOD_NEK2_1	121	126	PF00069	0.609
MOD_NEK2_1	242	247	PF00069	0.765
MOD_NEK2_1	360	365	PF00069	0.757
MOD_NEK2_1	370	375	PF00069	0.653
MOD_NEK2_1	398	403	PF00069	0.696
MOD_NEK2_1	406	411	PF00069	0.619
MOD_NEK2_1	435	440	PF00069	0.621
MOD_NEK2_1	50	55	PF00069	0.582
MOD_PIKK_1	176	182	PF00454	0.670
MOD_PIKK_1	52	58	PF00454	0.379
MOD_PKA_2	242	248	PF00069	0.690
MOD_PKA_2	303	309	PF00069	0.718
MOD_PKA_2	393	399	PF00069	0.638
MOD_PKA_2	80	86	PF00069	0.423
MOD_Plk_1	17	23	PF00069	0.442
MOD_Plk_4	116	122	PF00069	0.540
MOD_Plk_4	126	132	PF00069	0.443
MOD_Plk_4	19	25	PF00069	0.480
MOD_Plk_4	242	248	PF00069	0.592
MOD_ProDKin_1	209	215	PF00069	0.754
MOD_ProDKin_1	226	232	PF00069	0.578
MOD_ProDKin_1	257	263	PF00069	0.752
MOD_SUMO_rev_2	215	223	PF00179	0.743
TRG_DiLeu_BaEn_4	331	337	PF01217	0.703
TRG_DiLeu_BaLyEn_6	366	371	PF01217	0.503
TRG_ENDOCYTIC_2	128	131	PF00928	0.571
TRG_ENDOCYTIC_2	199	202	PF00928	0.675
TRG_ENDOCYTIC_2	292	295	PF00928	0.622
TRG_ENDOCYTIC_2	389	392	PF00928	0.603
TRG_ENDOCYTIC_2	439	442	PF00928	0.719
TRG_ENDOCYTIC_2	61	64	PF00928	0.618
TRG_ER_diArg_1	33	35	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAU2	Leishmania donovani	100%	100%
A4HP96	Leishmania braziliensis	71%	100%
E9AT04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1J4	Leishmania major	90%	100%