LeishMANIAdb
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Guanylate kinase-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanylate kinase-like protein
Gene product:
guanylate kinase-like protein
Species:
Leishmania infantum
UniProt:
A4IDK0_LEIIN
TriTrypDb:
LINF_360029700
Length:
329

Annotations

Annotations by Jardim et al.

Purine metabolism, Guanylate kinase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005777 peroxisome 6 1
GO:0005829 cytosol 2 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDK0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDK0

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0044237 cellular metabolic process 2 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0004385 guanylate kinase activity 6 3
GO:0016776 phosphotransferase activity, phosphate group as acceptor 4 3
GO:0019205 nucleobase-containing compound kinase activity 5 3
GO:0050145 nucleoside monophosphate kinase activity 5 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 164 166 PF00675 0.369
CLV_NRD_NRD_1 268 270 PF00675 0.324
CLV_NRD_NRD_1 39 41 PF00675 0.404
CLV_NRD_NRD_1 60 62 PF00675 0.424
CLV_NRD_NRD_1 82 84 PF00675 0.274
CLV_PCSK_KEX2_1 164 166 PF00082 0.315
CLV_PCSK_KEX2_1 39 41 PF00082 0.464
CLV_PCSK_KEX2_1 60 62 PF00082 0.388
CLV_PCSK_KEX2_1 82 84 PF00082 0.364
CLV_PCSK_SKI1_1 138 142 PF00082 0.369
CLV_PCSK_SKI1_1 149 153 PF00082 0.309
CLV_PCSK_SKI1_1 175 179 PF00082 0.314
CLV_Separin_Metazoa 316 320 PF03568 0.354
DEG_APCC_KENBOX_2 291 295 PF00400 0.257
DEG_SPOP_SBC_1 117 121 PF00917 0.398
DOC_CKS1_1 203 208 PF01111 0.566
DOC_MAPK_gen_1 245 254 PF00069 0.315
DOC_MAPK_gen_1 39 47 PF00069 0.426
DOC_MAPK_HePTP_8 242 254 PF00069 0.257
DOC_MAPK_HePTP_8 36 48 PF00069 0.434
DOC_MAPK_MEF2A_6 245 254 PF00069 0.294
DOC_MAPK_MEF2A_6 39 48 PF00069 0.397
DOC_PP2B_LxvP_1 114 117 PF13499 0.393
DOC_PP4_FxxP_1 253 256 PF00568 0.390
DOC_PP4_FxxP_1 47 50 PF00568 0.291
DOC_USP7_MATH_1 11 15 PF00917 0.707
DOC_USP7_MATH_1 117 121 PF00917 0.378
DOC_USP7_MATH_1 16 20 PF00917 0.667
DOC_USP7_MATH_1 182 186 PF00917 0.415
DOC_USP7_MATH_1 209 213 PF00917 0.725
DOC_USP7_MATH_1 224 228 PF00917 0.733
DOC_USP7_MATH_1 50 54 PF00917 0.320
DOC_WW_Pin1_4 120 125 PF00397 0.418
DOC_WW_Pin1_4 202 207 PF00397 0.623
DOC_WW_Pin1_4 232 237 PF00397 0.693
LIG_14-3-3_CanoR_1 175 180 PF00244 0.405
LIG_14-3-3_CanoR_1 207 212 PF00244 0.555
LIG_14-3-3_CanoR_1 269 277 PF00244 0.369
LIG_BIR_II_1 1 5 PF00653 0.656
LIG_BIR_III_2 192 196 PF00653 0.218
LIG_BRCT_BRCA1_1 233 237 PF00533 0.479
LIG_deltaCOP1_diTrp_1 65 72 PF00928 0.390
LIG_FHA_1 121 127 PF00498 0.405
LIG_FHA_1 153 159 PF00498 0.336
LIG_FHA_1 172 178 PF00498 0.177
LIG_FHA_1 242 248 PF00498 0.347
LIG_FHA_1 33 39 PF00498 0.540
LIG_FHA_2 269 275 PF00498 0.416
LIG_FHA_2 66 72 PF00498 0.358
LIG_FHA_2 93 99 PF00498 0.432
LIG_LIR_Apic_2 235 241 PF02991 0.549
LIG_LIR_Gen_1 110 117 PF02991 0.165
LIG_LIR_Gen_1 308 318 PF02991 0.380
LIG_LIR_Gen_1 97 105 PF02991 0.343
LIG_LIR_Nem_3 110 114 PF02991 0.200
LIG_LIR_Nem_3 296 301 PF02991 0.321
LIG_LIR_Nem_3 308 314 PF02991 0.308
LIG_LIR_Nem_3 65 69 PF02991 0.362
LIG_LIR_Nem_3 97 102 PF02991 0.315
LIG_PDZ_Class_1 324 329 PF00595 0.475
LIG_Pex14_1 66 70 PF04695 0.291
LIG_SH2_CRK 111 115 PF00017 0.315
LIG_SH2_CRK 238 242 PF00017 0.508
LIG_SH2_CRK 311 315 PF00017 0.412
LIG_SH2_STAT5 166 169 PF00017 0.291
LIG_SH2_STAT5 301 304 PF00017 0.376
LIG_SH2_STAT5 92 95 PF00017 0.354
LIG_SH3_3 2 8 PF00018 0.578
LIG_SH3_3 230 236 PF00018 0.620
LIG_SUMO_SIM_par_1 173 180 PF11976 0.385
LIG_SUMO_SIM_par_1 199 205 PF11976 0.687
LIG_SUMO_SIM_par_1 321 328 PF11976 0.504
LIG_TRAF2_1 95 98 PF00917 0.390
LIG_TYR_ITIM 109 114 PF00017 0.315
LIG_TYR_ITIM 309 314 PF00017 0.375
MOD_CDK_SPK_2 202 207 PF00069 0.568
MOD_CK1_1 120 126 PF00069 0.369
MOD_CK1_1 227 233 PF00069 0.731
MOD_CK1_1 53 59 PF00069 0.283
MOD_CK1_1 75 81 PF00069 0.285
MOD_CK2_1 268 274 PF00069 0.371
MOD_CK2_1 65 71 PF00069 0.384
MOD_CK2_1 92 98 PF00069 0.390
MOD_CMANNOS 287 290 PF00535 0.292
MOD_GlcNHglycan 18 21 PF01048 0.649
MOD_GlcNHglycan 50 53 PF01048 0.291
MOD_GSK3_1 116 123 PF00069 0.339
MOD_GSK3_1 171 178 PF00069 0.332
MOD_GSK3_1 220 227 PF00069 0.753
MOD_GSK3_1 50 57 PF00069 0.231
MOD_GSK3_1 70 77 PF00069 0.297
MOD_N-GLC_1 293 298 PF02516 0.378
MOD_NEK2_1 133 138 PF00069 0.367
MOD_NEK2_1 201 206 PF00069 0.642
MOD_NEK2_1 32 37 PF00069 0.589
MOD_NEK2_1 324 329 PF00069 0.568
MOD_NEK2_1 70 75 PF00069 0.288
MOD_PIKK_1 177 183 PF00454 0.312
MOD_PK_1 207 213 PF00069 0.558
MOD_PKA_2 268 274 PF00069 0.291
MOD_Plk_1 109 115 PF00069 0.390
MOD_Plk_1 273 279 PF00069 0.342
MOD_Plk_1 293 299 PF00069 0.378
MOD_Plk_1 70 76 PF00069 0.395
MOD_Plk_2-3 268 274 PF00069 0.347
MOD_Plk_2-3 293 299 PF00069 0.432
MOD_Plk_2-3 65 71 PF00069 0.354
MOD_Plk_4 140 146 PF00069 0.398
MOD_Plk_4 196 202 PF00069 0.521
MOD_Plk_4 227 233 PF00069 0.666
MOD_Plk_4 293 299 PF00069 0.403
MOD_Plk_4 54 60 PF00069 0.291
MOD_Plk_4 65 71 PF00069 0.291
MOD_ProDKin_1 120 126 PF00069 0.418
MOD_ProDKin_1 202 208 PF00069 0.623
MOD_ProDKin_1 232 238 PF00069 0.689
MOD_SUMO_rev_2 263 271 PF00179 0.390
TRG_DiLeu_BaEn_1 98 103 PF01217 0.390
TRG_ENDOCYTIC_2 111 114 PF00928 0.315
TRG_ENDOCYTIC_2 311 314 PF00928 0.380
TRG_ENDOCYTIC_2 91 94 PF00928 0.315
TRG_ER_diArg_1 147 150 PF00400 0.334
TRG_ER_diArg_1 163 165 PF00400 0.390
TRG_ER_diArg_1 38 40 PF00400 0.403
TRG_ER_diArg_1 59 61 PF00400 0.354
TRG_ER_diArg_1 81 83 PF00400 0.370
TRG_Pf-PMV_PEXEL_1 184 188 PF00026 0.276
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.383
TRG_Pf-PMV_PEXEL_1 60 65 PF00026 0.354

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I117 Leptomonas seymouri 51% 100%
A0A1X0P7T4 Trypanosomatidae 31% 100%
A0A3R7LXR6 Trypanosoma rangeli 30% 100%
A0A3S7XAW4 Leishmania donovani 99% 100%
A4HP95 Leishmania braziliensis 73% 100%
D0A398 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AT03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
Q4Q1J5 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS