LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter - putative
Species:
Leishmania infantum
UniProt:
A4IDJ5_LEIIN
TriTrypDb:
LINF_360029200
Length:
511

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Annotations by Jardim et al.

Transporters, Plasma-membrane choline transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0110165 cellular anatomical entity 1 24
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDJ5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 30 34 PF00656 0.564
CLV_PCSK_KEX2_1 322 324 PF00082 0.386
CLV_PCSK_KEX2_1 399 401 PF00082 0.215
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.391
CLV_PCSK_PC1ET2_1 399 401 PF00082 0.235
CLV_PCSK_SKI1_1 322 326 PF00082 0.403
CLV_PCSK_SKI1_1 381 385 PF00082 0.297
DEG_MDM2_SWIB_1 100 107 PF02201 0.338
DEG_MDM2_SWIB_1 201 209 PF02201 0.365
DEG_MDM2_SWIB_1 280 288 PF02201 0.316
DEG_MDM2_SWIB_1 85 93 PF02201 0.536
DEG_SPOP_SBC_1 324 328 PF00917 0.305
DOC_ANK_TNKS_1 442 449 PF00023 0.166
DOC_CKS1_1 287 292 PF01111 0.387
DOC_MAPK_MEF2A_6 186 195 PF00069 0.288
DOC_MAPK_MEF2A_6 231 240 PF00069 0.481
DOC_MAPK_MEF2A_6 381 389 PF00069 0.513
DOC_PP4_FxxP_1 462 465 PF00568 0.421
DOC_SPAK_OSR1_1 79 83 PF12202 0.504
DOC_USP7_MATH_1 143 147 PF00917 0.302
DOC_USP7_MATH_1 26 30 PF00917 0.698
DOC_USP7_MATH_1 465 469 PF00917 0.321
DOC_WW_Pin1_4 119 124 PF00397 0.447
DOC_WW_Pin1_4 286 291 PF00397 0.387
DOC_WW_Pin1_4 417 422 PF00397 0.223
LIG_14-3-3_CanoR_1 221 227 PF00244 0.476
LIG_14-3-3_CanoR_1 323 332 PF00244 0.227
LIG_Actin_WH2_2 206 223 PF00022 0.280
LIG_Actin_WH2_2 357 372 PF00022 0.352
LIG_APCC_ABBA_1 61 66 PF00400 0.564
LIG_BIR_II_1 1 5 PF00653 0.648
LIG_BIR_III_4 33 37 PF00653 0.570
LIG_BIR_III_4 499 503 PF00653 0.603
LIG_BRCT_BRCA1_1 1 5 PF00533 0.551
LIG_BRCT_BRCA1_1 330 334 PF00533 0.228
LIG_BRCT_BRCA1_1 430 434 PF00533 0.379
LIG_BRCT_BRCA1_1 459 463 PF00533 0.418
LIG_deltaCOP1_diTrp_1 87 94 PF00928 0.430
LIG_EH1_1 187 195 PF00400 0.248
LIG_EH1_1 272 280 PF00400 0.400
LIG_EH1_1 451 459 PF00400 0.317
LIG_eIF4E_1 413 419 PF01652 0.439
LIG_FHA_1 170 176 PF00498 0.227
LIG_FHA_1 227 233 PF00498 0.467
LIG_FHA_1 287 293 PF00498 0.419
LIG_FHA_1 295 301 PF00498 0.239
LIG_FHA_1 399 405 PF00498 0.430
LIG_FHA_1 425 431 PF00498 0.278
LIG_FHA_1 470 476 PF00498 0.443
LIG_GBD_Chelix_1 453 461 PF00786 0.235
LIG_LIR_Apic_2 460 465 PF02991 0.444
LIG_LIR_Gen_1 101 112 PF02991 0.263
LIG_LIR_Gen_1 244 255 PF02991 0.326
LIG_LIR_Gen_1 431 441 PF02991 0.419
LIG_LIR_Gen_1 471 481 PF02991 0.471
LIG_LIR_Gen_1 87 97 PF02991 0.425
LIG_LIR_LC3C_4 336 339 PF02991 0.262
LIG_LIR_Nem_3 101 107 PF02991 0.266
LIG_LIR_Nem_3 242 248 PF02991 0.322
LIG_LIR_Nem_3 326 332 PF02991 0.283
LIG_LIR_Nem_3 377 382 PF02991 0.379
LIG_LIR_Nem_3 431 437 PF02991 0.357
LIG_LIR_Nem_3 460 466 PF02991 0.330
LIG_LIR_Nem_3 47 53 PF02991 0.673
LIG_LIR_Nem_3 471 477 PF02991 0.385
LIG_LIR_Nem_3 87 92 PF02991 0.422
LIG_MLH1_MIPbox_1 459 463 PF16413 0.262
LIG_Pex14_2 100 104 PF04695 0.250
LIG_Pex14_2 201 205 PF04695 0.324
LIG_Pex14_2 280 284 PF04695 0.296
LIG_Pex14_2 410 414 PF04695 0.444
LIG_Pex14_2 85 89 PF04695 0.574
LIG_Rb_LxCxE_1 366 377 PF01857 0.407
LIG_SH2_CRK 382 386 PF00017 0.439
LIG_SH2_CRK 492 496 PF00017 0.492
LIG_SH2_CRK 50 54 PF00017 0.660
LIG_SH2_GRB2like 356 359 PF00017 0.414
LIG_SH2_GRB2like 378 381 PF00017 0.433
LIG_SH2_GRB2like 413 416 PF00017 0.439
LIG_SH2_PTP2 134 137 PF00017 0.310
LIG_SH2_PTP2 247 250 PF00017 0.400
LIG_SH2_PTP2 271 274 PF00017 0.174
LIG_SH2_SRC 356 359 PF00017 0.414
LIG_SH2_SRC 394 397 PF00017 0.453
LIG_SH2_STAT3 263 266 PF00017 0.187
LIG_SH2_STAT5 134 137 PF00017 0.248
LIG_SH2_STAT5 166 169 PF00017 0.350
LIG_SH2_STAT5 247 250 PF00017 0.321
LIG_SH2_STAT5 271 274 PF00017 0.320
LIG_SH2_STAT5 305 308 PF00017 0.280
LIG_SH2_STAT5 378 381 PF00017 0.422
LIG_SH2_STAT5 394 397 PF00017 0.422
LIG_SH2_STAT5 413 416 PF00017 0.439
LIG_SH3_3 252 258 PF00018 0.367
LIG_SH3_3 310 316 PF00018 0.222
LIG_SH3_3 50 56 PF00018 0.646
LIG_SH3_3 59 65 PF00018 0.527
LIG_SUMO_SIM_par_1 426 431 PF11976 0.350
LIG_TYR_ITIM 132 137 PF00017 0.261
LIG_TYR_ITIM 48 53 PF00017 0.669
LIG_WRC_WIRS_1 318 323 PF05994 0.209
MOD_CK1_1 122 128 PF00069 0.446
MOD_CK1_1 146 152 PF00069 0.349
MOD_CK1_1 286 292 PF00069 0.442
MOD_CK1_1 328 334 PF00069 0.285
MOD_CK1_1 351 357 PF00069 0.498
MOD_CK1_1 468 474 PF00069 0.438
MOD_CK2_1 351 357 PF00069 0.414
MOD_CK2_1 390 396 PF00069 0.502
MOD_GlcNHglycan 124 127 PF01048 0.629
MOD_GlcNHglycan 141 144 PF01048 0.167
MOD_GlcNHglycan 178 181 PF01048 0.327
MOD_GlcNHglycan 222 225 PF01048 0.222
MOD_GlcNHglycan 29 32 PF01048 0.499
MOD_GlcNHglycan 297 300 PF01048 0.313
MOD_GlcNHglycan 350 354 PF01048 0.252
MOD_GlcNHglycan 467 470 PF01048 0.210
MOD_GlcNHglycan 50 53 PF01048 0.475
MOD_GSK3_1 113 120 PF00069 0.290
MOD_GSK3_1 139 146 PF00069 0.399
MOD_GSK3_1 226 233 PF00069 0.465
MOD_GSK3_1 324 331 PF00069 0.273
MOD_GSK3_1 424 431 PF00069 0.258
MOD_GSK3_1 465 472 PF00069 0.271
MOD_GSK3_1 98 105 PF00069 0.301
MOD_N-GLC_1 10 15 PF02516 0.498
MOD_N-GLC_1 500 505 PF02516 0.323
MOD_N-GLC_2 415 417 PF02516 0.313
MOD_NEK2_1 176 181 PF00069 0.342
MOD_NEK2_1 219 224 PF00069 0.449
MOD_NEK2_1 226 231 PF00069 0.435
MOD_NEK2_1 239 244 PF00069 0.342
MOD_NEK2_1 278 283 PF00069 0.245
MOD_NEK2_1 293 298 PF00069 0.201
MOD_NEK2_1 300 305 PF00069 0.351
MOD_NEK2_1 348 353 PF00069 0.471
MOD_NEK2_1 428 433 PF00069 0.269
MOD_NEK2_1 441 446 PF00069 0.218
MOD_NEK2_1 48 53 PF00069 0.699
MOD_NEK2_1 491 496 PF00069 0.479
MOD_NEK2_2 469 474 PF00069 0.441
MOD_PIKK_1 117 123 PF00454 0.389
MOD_PIKK_1 283 289 PF00454 0.255
MOD_PIKK_1 38 44 PF00454 0.684
MOD_PKA_1 322 328 PF00069 0.200
MOD_PKA_2 220 226 PF00069 0.502
MOD_PKA_2 27 33 PF00069 0.691
MOD_PKA_2 322 328 PF00069 0.252
MOD_PKA_2 484 490 PF00069 0.575
MOD_PKA_2 75 81 PF00069 0.607
MOD_Plk_4 143 149 PF00069 0.330
MOD_Plk_4 169 175 PF00069 0.393
MOD_Plk_4 230 236 PF00069 0.431
MOD_Plk_4 300 306 PF00069 0.287
MOD_Plk_4 333 339 PF00069 0.274
MOD_Plk_4 390 396 PF00069 0.495
MOD_Plk_4 428 434 PF00069 0.348
MOD_Plk_4 457 463 PF00069 0.312
MOD_Plk_4 469 475 PF00069 0.386
MOD_Plk_4 88 94 PF00069 0.294
MOD_ProDKin_1 119 125 PF00069 0.446
MOD_ProDKin_1 286 292 PF00069 0.387
MOD_ProDKin_1 417 423 PF00069 0.223
TRG_DiLeu_BaLyEn_6 222 227 PF01217 0.522
TRG_ENDOCYTIC_2 134 137 PF00928 0.286
TRG_ENDOCYTIC_2 247 250 PF00928 0.380
TRG_ENDOCYTIC_2 271 274 PF00928 0.384
TRG_ENDOCYTIC_2 382 385 PF00928 0.424
TRG_ENDOCYTIC_2 492 495 PF00928 0.486
TRG_ENDOCYTIC_2 50 53 PF00928 0.666
TRG_ER_diArg_1 209 212 PF00400 0.369
TRG_Pf-PMV_PEXEL_1 346 350 PF00026 0.288

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 62% 100%
A0A0N1PA24 Leptomonas seymouri 33% 87%
A0A0S4IW21 Bodo saltans 37% 95%
A0A0S4KHP0 Bodo saltans 43% 100%
A0A1X0P8J3 Trypanosomatidae 47% 100%
A0A3Q8I9V7 Leishmania donovani 34% 84%
A0A3R7MAJ2 Trypanosoma rangeli 33% 100%
A0A3S5IRA1 Trypanosoma rangeli 46% 100%
A0A3S7XAV8 Leishmania donovani 100% 100%
A4H7J7 Leishmania braziliensis 36% 84%
A4HP90 Leishmania braziliensis 75% 99%
A4HVY0 Leishmania infantum 34% 84%
A5PMW0 Danio rerio 24% 73%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
D0A392 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A393 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 99%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 84%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
P0CM92 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 30% 93%
P0CM93 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 30% 93%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 95%
Q20026 Caenorhabditis elegans 24% 66%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 28% 95%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 28% 97%
Q4Q1K0 Leishmania major 92% 100%
Q4QFU7 Leishmania major 36% 84%
Q4WYG7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 95%
Q53GD3 Homo sapiens 23% 72%
Q54IJ2 Dictyostelium discoideum 25% 93%
Q5AB93 Candida albicans (strain SC5314 / ATCC MYA-2876) 28% 99%
Q6BIV4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 29% 100%
Q6C938 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 89%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 92%
Q6FLC9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 92%
Q6GN42 Xenopus laevis 23% 72%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 28% 92%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 92%
V5AWF7 Trypanosoma cruzi 46% 100%
V5BMB4 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS