LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter - putative
Species:
Leishmania infantum
UniProt:
A4IDJ5_LEIIN
TriTrypDb:
LINF_360029200
Length:
511

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Annotations by Jardim et al.

Transporters, Plasma-membrane choline transporter

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0020016 ciliary pocket 2 1
GO:0110165 cellular anatomical entity 1 24
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Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IDJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDJ5

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 2
GO:0009987 cellular process 1 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0055085 transmembrane transport 2 2
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Molecular functions
TermNameLevelCount
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 30 34 PF00656 0.564
CLV_PCSK_KEX2_1 322 324 PF00082 0.386
CLV_PCSK_KEX2_1 399 401 PF00082 0.215
CLV_PCSK_PC1ET2_1 322 324 PF00082 0.391
CLV_PCSK_PC1ET2_1 399 401 PF00082 0.235
CLV_PCSK_SKI1_1 322 326 PF00082 0.403
CLV_PCSK_SKI1_1 381 385 PF00082 0.297
DEG_MDM2_SWIB_1 100 107 PF02201 0.338
DEG_MDM2_SWIB_1 201 209 PF02201 0.365
DEG_MDM2_SWIB_1 280 288 PF02201 0.316
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I9D8 Leptomonas seymouri 62% 100%
A0A0N1PA24 Leptomonas seymouri 33% 87%
A0A0S4IW21 Bodo saltans 37% 95%
A0A0S4KHP0 Bodo saltans 43% 100%
A0A1X0P8J3 Trypanosomatidae 47% 100%
A0A3Q8I9V7 Leishmania donovani 34% 84%
A0A3R7MAJ2 Trypanosoma rangeli 33% 100%
A0A3S5IRA1 Trypanosoma rangeli 46% 100%
A0A3S7XAV8 Leishmania donovani 100% 100%
A4H7J7 Leishmania braziliensis 36% 84%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS