Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDJ4_LEIIN

TriTrypDb:

LINF_360029100

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.432
CLV_C14_Caspase3-7	321	325	PF00656	0.682
CLV_C14_Caspase3-7	417	421	PF00656	0.603
CLV_C14_Caspase3-7	561	565	PF00656	0.616
CLV_NRD_NRD_1	100	102	PF00675	0.546
CLV_NRD_NRD_1	117	119	PF00675	0.408
CLV_NRD_NRD_1	141	143	PF00675	0.645
CLV_NRD_NRD_1	340	342	PF00675	0.723
CLV_NRD_NRD_1	402	404	PF00675	0.720
CLV_NRD_NRD_1	460	462	PF00675	0.488
CLV_NRD_NRD_1	521	523	PF00675	0.570
CLV_NRD_NRD_1	528	530	PF00675	0.537
CLV_NRD_NRD_1	589	591	PF00675	0.724
CLV_NRD_NRD_1	616	618	PF00675	0.784
CLV_PCSK_FUR_1	340	344	PF00082	0.678
CLV_PCSK_FUR_1	535	539	PF00082	0.676
CLV_PCSK_KEX2_1	100	102	PF00082	0.548
CLV_PCSK_KEX2_1	117	119	PF00082	0.398
CLV_PCSK_KEX2_1	340	342	PF00082	0.726
CLV_PCSK_KEX2_1	402	404	PF00082	0.561
CLV_PCSK_KEX2_1	459	461	PF00082	0.506
CLV_PCSK_KEX2_1	530	532	PF00082	0.588
CLV_PCSK_KEX2_1	534	536	PF00082	0.662
CLV_PCSK_KEX2_1	537	539	PF00082	0.698
CLV_PCSK_KEX2_1	550	552	PF00082	0.499
CLV_PCSK_KEX2_1	554	556	PF00082	0.514
CLV_PCSK_KEX2_1	588	590	PF00082	0.707
CLV_PCSK_KEX2_1	616	618	PF00082	0.784
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.681
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.604
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.682
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.722
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.499
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.514
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.700
CLV_PCSK_PC7_1	456	462	PF00082	0.486
CLV_PCSK_SKI1_1	154	158	PF00082	0.472
CLV_PCSK_SKI1_1	21	25	PF00082	0.526
CLV_PCSK_SKI1_1	279	283	PF00082	0.601
CLV_PCSK_SKI1_1	288	292	PF00082	0.456
CLV_PCSK_SKI1_1	368	372	PF00082	0.581
CLV_PCSK_SKI1_1	389	393	PF00082	0.457
CLV_PCSK_SKI1_1	551	555	PF00082	0.665
CLV_PCSK_SKI1_1	607	611	PF00082	0.769
DEG_APCC_DBOX_1	232	240	PF00400	0.435
DEG_APCC_DBOX_1	367	375	PF00400	0.579
DEG_Nend_UBRbox_2	1	3	PF02207	0.416
DEG_SPOP_SBC_1	9	13	PF00917	0.513
DOC_CYCLIN_RxL_1	285	296	PF00134	0.514
DOC_CYCLIN_RxL_1	365	373	PF00134	0.624
DOC_CYCLIN_RxL_1	518	528	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	609	612	PF00134	0.706
DOC_MAPK_gen_1	209	218	PF00069	0.348
DOC_MAPK_gen_1	425	432	PF00069	0.461
DOC_MAPK_MEF2A_6	154	163	PF00069	0.437
DOC_MAPK_MEF2A_6	209	218	PF00069	0.384
DOC_MAPK_MEF2A_6	384	392	PF00069	0.423
DOC_PP1_RVXF_1	105	111	PF00149	0.449
DOC_PP2B_LxvP_1	218	221	PF13499	0.406
DOC_PP2B_LxvP_1	239	242	PF13499	0.407
DOC_PP2B_LxvP_1	290	293	PF13499	0.559
DOC_PP2B_LxvP_1	609	612	PF13499	0.706
DOC_PP4_FxxP_1	163	166	PF00568	0.506
DOC_USP7_MATH_1	186	190	PF00917	0.662
DOC_USP7_MATH_1	194	198	PF00917	0.649
DOC_USP7_MATH_1	242	246	PF00917	0.383
DOC_USP7_MATH_1	255	259	PF00917	0.485
DOC_USP7_MATH_1	268	272	PF00917	0.402
DOC_USP7_MATH_1	32	36	PF00917	0.580
DOC_USP7_MATH_1	47	51	PF00917	0.318
DOC_USP7_MATH_1	476	480	PF00917	0.668
DOC_USP7_MATH_1	558	562	PF00917	0.627
DOC_USP7_MATH_1	59	63	PF00917	0.630
DOC_USP7_MATH_1	601	605	PF00917	0.617
DOC_USP7_MATH_1	9	13	PF00917	0.579
DOC_USP7_MATH_1	96	100	PF00917	0.696
DOC_USP7_UBL2_3	530	534	PF12436	0.705
DOC_USP7_UBL2_3	550	554	PF12436	0.503
DOC_USP7_UBL2_3	584	588	PF12436	0.672
DOC_WW_Pin1_4	203	208	PF00397	0.464
DOC_WW_Pin1_4	484	489	PF00397	0.783
DOC_WW_Pin1_4	579	584	PF00397	0.704
DOC_WW_Pin1_4	621	626	PF00397	0.738
DOC_WW_Pin1_4	89	94	PF00397	0.697
LIG_14-3-3_CanoR_1	150	154	PF00244	0.584
LIG_14-3-3_CanoR_1	272	278	PF00244	0.591
LIG_14-3-3_CanoR_1	343	349	PF00244	0.749
LIG_14-3-3_CanoR_1	389	395	PF00244	0.595
LIG_14-3-3_CanoR_1	425	430	PF00244	0.564
LIG_14-3-3_CanoR_1	600	610	PF00244	0.692
LIG_14-3-3_CanoR_1	616	623	PF00244	0.547
LIG_AP2alpha_1	153	157	PF02296	0.404
LIG_APCC_ABBA_1	445	450	PF00400	0.569
LIG_FHA_1	200	206	PF00498	0.553
LIG_FHA_1	383	389	PF00498	0.629
LIG_FHA_1	424	430	PF00498	0.490
LIG_FHA_1	442	448	PF00498	0.558
LIG_FHA_1	604	610	PF00498	0.764
LIG_FHA_2	166	172	PF00498	0.542
LIG_FHA_2	415	421	PF00498	0.614
LIG_FHA_2	493	499	PF00498	0.758
LIG_LIR_Apic_2	393	397	PF02991	0.634
LIG_LIR_Gen_1	304	312	PF02991	0.431
LIG_LIR_Gen_1	363	371	PF02991	0.539
LIG_LIR_Gen_1	385	394	PF02991	0.533
LIG_LIR_LC3C_4	170	174	PF02991	0.456
LIG_LIR_Nem_3	304	308	PF02991	0.428
LIG_LIR_Nem_3	363	367	PF02991	0.418
LIG_LIR_Nem_3	385	390	PF02991	0.535
LIG_NRBOX	235	241	PF00104	0.416
LIG_Pex14_2	153	157	PF04695	0.437
LIG_SH2_CRK	305	309	PF00017	0.433
LIG_SH2_CRK	364	368	PF00017	0.453
LIG_SH2_CRK	394	398	PF00017	0.640
LIG_SH2_NCK_1	448	452	PF00017	0.451
LIG_SH2_SRC	6	9	PF00017	0.454
LIG_SH2_STAP1	305	309	PF00017	0.433
LIG_SH2_STAP1	448	452	PF00017	0.451
LIG_SH2_STAP1	6	10	PF00017	0.590
LIG_SH3_2	95	100	PF14604	0.530
LIG_SH3_3	41	47	PF00018	0.399
LIG_SH3_3	90	96	PF00018	0.693
LIG_SUMO_SIM_par_1	212	217	PF11976	0.501
LIG_SUMO_SIM_par_1	245	251	PF11976	0.502
LIG_TYR_ITIM	303	308	PF00017	0.424
MOD_CDC14_SPxK_1	206	209	PF00782	0.380
MOD_CDK_SPK_2	579	584	PF00069	0.704
MOD_CDK_SPxK_1	203	209	PF00069	0.434
MOD_CK1_1	12	18	PF00069	0.591
MOD_CK1_1	199	205	PF00069	0.747
MOD_CK1_1	271	277	PF00069	0.473
MOD_CK1_1	304	310	PF00069	0.558
MOD_CK1_1	486	492	PF00069	0.633
MOD_CK1_1	582	588	PF00069	0.631
MOD_CK1_1	62	68	PF00069	0.675
MOD_CK1_1	89	95	PF00069	0.726
MOD_CK1_1	99	105	PF00069	0.517
MOD_CK2_1	223	229	PF00069	0.424
MOD_CK2_1	407	413	PF00069	0.594
MOD_CK2_1	492	498	PF00069	0.758
MOD_CK2_1	67	73	PF00069	0.671
MOD_CMANNOS	110	113	PF00535	0.561
MOD_Cter_Amidation	532	535	PF01082	0.719
MOD_GlcNHglycan	136	141	PF01048	0.640
MOD_GlcNHglycan	187	191	PF01048	0.584
MOD_GlcNHglycan	194	197	PF01048	0.615
MOD_GlcNHglycan	257	260	PF01048	0.601
MOD_GlcNHglycan	318	321	PF01048	0.578
MOD_GlcNHglycan	336	339	PF01048	0.666
MOD_GlcNHglycan	34	37	PF01048	0.571
MOD_GlcNHglycan	351	355	PF01048	0.593
MOD_GlcNHglycan	398	401	PF01048	0.582
MOD_GlcNHglycan	462	465	PF01048	0.510
MOD_GlcNHglycan	478	481	PF01048	0.430
MOD_GlcNHglycan	559	563	PF01048	0.626
MOD_GlcNHglycan	59	62	PF01048	0.735
MOD_GlcNHglycan	601	604	PF01048	0.625
MOD_GlcNHglycan	88	91	PF01048	0.608
MOD_GSK3_1	192	199	PF00069	0.605
MOD_GSK3_1	219	226	PF00069	0.541
MOD_GSK3_1	253	260	PF00069	0.553
MOD_GSK3_1	26	33	PF00069	0.339
MOD_GSK3_1	304	311	PF00069	0.558
MOD_GSK3_1	370	377	PF00069	0.595
MOD_GSK3_1	405	412	PF00069	0.651
MOD_GSK3_1	460	467	PF00069	0.509
MOD_GSK3_1	482	489	PF00069	0.626
MOD_GSK3_1	55	62	PF00069	0.617
MOD_GSK3_1	558	565	PF00069	0.621
MOD_GSK3_1	599	606	PF00069	0.639
MOD_GSK3_1	615	622	PF00069	0.604
MOD_GSK3_1	63	70	PF00069	0.654
MOD_GSK3_1	8	15	PF00069	0.538
MOD_N-GLC_1	374	379	PF02516	0.635
MOD_N-GLC_2	506	508	PF02516	0.670
MOD_NEK2_1	138	143	PF00069	0.687
MOD_NEK2_1	223	228	PF00069	0.415
MOD_NEK2_1	308	313	PF00069	0.451
MOD_NEK2_1	360	365	PF00069	0.466
MOD_NEK2_1	370	375	PF00069	0.451
MOD_NEK2_1	405	410	PF00069	0.735
MOD_NEK2_1	423	428	PF00069	0.506
MOD_NEK2_1	454	459	PF00069	0.451
MOD_PIKK_1	374	380	PF00454	0.565
MOD_PIKK_1	382	388	PF00454	0.513
MOD_PIKK_1	465	471	PF00454	0.559
MOD_PKA_1	460	466	PF00069	0.637
MOD_PKA_2	149	155	PF00069	0.556
MOD_PKA_2	199	205	PF00069	0.514
MOD_PKA_2	229	235	PF00069	0.510
MOD_PKA_2	271	277	PF00069	0.481
MOD_PKA_2	344	350	PF00069	0.724
MOD_PKA_2	441	447	PF00069	0.584
MOD_PKA_2	460	466	PF00069	0.480
MOD_PKA_2	544	550	PF00069	0.807
MOD_PKA_2	574	580	PF00069	0.690
MOD_PKA_2	599	605	PF00069	0.690
MOD_PKA_2	615	621	PF00069	0.611
MOD_PKA_2	62	68	PF00069	0.738
MOD_PKA_2	633	639	PF00069	0.493
MOD_PKA_2	99	105	PF00069	0.534
MOD_Plk_1	248	254	PF00069	0.396
MOD_Plk_2-3	326	332	PF00069	0.645
MOD_Plk_4	219	225	PF00069	0.456
MOD_Plk_4	235	241	PF00069	0.420
MOD_Plk_4	242	248	PF00069	0.390
MOD_Plk_4	273	279	PF00069	0.543
MOD_Plk_4	304	310	PF00069	0.558
MOD_Plk_4	47	53	PF00069	0.382
MOD_ProDKin_1	203	209	PF00069	0.457
MOD_ProDKin_1	484	490	PF00069	0.786
MOD_ProDKin_1	579	585	PF00069	0.703
MOD_ProDKin_1	621	627	PF00069	0.738
MOD_ProDKin_1	89	95	PF00069	0.694
TRG_DiLeu_BaEn_2	449	455	PF01217	0.572
TRG_ENDOCYTIC_2	305	308	PF00928	0.434
TRG_ENDOCYTIC_2	364	367	PF00928	0.439
TRG_ER_diArg_1	100	103	PF00400	0.541
TRG_ER_diArg_1	117	120	PF00400	0.548
TRG_ER_diArg_1	340	343	PF00400	0.713
TRG_ER_diArg_1	401	403	PF00400	0.676
TRG_ER_diArg_1	424	427	PF00400	0.508
TRG_ER_diArg_1	459	461	PF00400	0.490
TRG_ER_diArg_1	529	532	PF00400	0.573
TRG_ER_diArg_1	542	545	PF00400	0.728
TRG_NLS_Bipartite_1	522	538	PF00514	0.597
TRG_NLS_MonoExtC_3	340	345	PF00514	0.647
TRG_NLS_MonoExtC_3	533	538	PF00514	0.661
TRG_NLS_MonoExtN_4	340	346	PF00514	0.681
TRG_NLS_MonoExtN_4	531	538	PF00514	0.642
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ5	Leptomonas seymouri	43%	100%
A0A3Q8IJB7	Leishmania donovani	100%	100%
A4HP89	Leishmania braziliensis	74%	98%
E9ASZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	96%
Q4Q1K1	Leishmania major	91%	100%