Suppressor of disruption of TFIIS

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDI8_LEIIN

TriTrypDb:

LINF_360028500

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IDI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.359
CLV_C14_Caspase3-7	311	315	PF00656	0.497
CLV_NRD_NRD_1	218	220	PF00675	0.508
CLV_NRD_NRD_1	73	75	PF00675	0.516
CLV_PCSK_KEX2_1	218	220	PF00082	0.508
CLV_PCSK_KEX2_1	269	271	PF00082	0.554
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.528
CLV_PCSK_SKI1_1	156	160	PF00082	0.452
CLV_PCSK_SKI1_1	165	169	PF00082	0.472
CLV_PCSK_SKI1_1	334	338	PF00082	0.531
DEG_SPOP_SBC_1	136	140	PF00917	0.473
DEG_SPOP_SBC_1	239	243	PF00917	0.650
DOC_MAPK_gen_1	170	178	PF00069	0.643
DOC_MAPK_JIP1_4	172	178	PF00069	0.615
DOC_MAPK_MEF2A_6	114	123	PF00069	0.515
DOC_MAPK_MEF2A_6	170	178	PF00069	0.643
DOC_PP4_FxxP_1	168	171	PF00568	0.489
DOC_USP7_MATH_1	150	154	PF00917	0.494
DOC_USP7_MATH_1	250	254	PF00917	0.728
DOC_USP7_MATH_1	324	328	PF00917	0.468
DOC_WW_Pin1_4	10	15	PF00397	0.527
DOC_WW_Pin1_4	19	24	PF00397	0.412
DOC_WW_Pin1_4	4	9	PF00397	0.572
LIG_14-3-3_CanoR_1	137	145	PF00244	0.554
LIG_14-3-3_CanoR_1	206	210	PF00244	0.462
LIG_14-3-3_CterR_2	352	356	PF00244	0.706
LIG_Actin_WH2_2	326	342	PF00022	0.504
LIG_BIR_III_4	129	133	PF00653	0.515
LIG_BIR_III_4	160	164	PF00653	0.481
LIG_Clathr_ClatBox_1	285	289	PF01394	0.491
LIG_Clathr_ClatBox_1	31	35	PF01394	0.368
LIG_deltaCOP1_diTrp_1	195	199	PF00928	0.506
LIG_FHA_1	303	309	PF00498	0.397
LIG_FHA_2	137	143	PF00498	0.634
LIG_FHA_2	206	212	PF00498	0.482
LIG_FHA_2	35	41	PF00498	0.467
LIG_HCF-1_HBM_1	142	145	PF13415	0.490
LIG_LIR_Gen_1	106	115	PF02991	0.391
LIG_LIR_Gen_1	27	34	PF02991	0.497
LIG_LIR_Gen_1	276	286	PF02991	0.464
LIG_LIR_Gen_1	97	102	PF02991	0.478
LIG_LIR_Nem_3	106	110	PF02991	0.376
LIG_LIR_Nem_3	195	199	PF02991	0.544
LIG_LIR_Nem_3	222	228	PF02991	0.445
LIG_LIR_Nem_3	27	32	PF02991	0.498
LIG_LIR_Nem_3	276	281	PF02991	0.464
LIG_LIR_Nem_3	83	88	PF02991	0.402
LIG_LIR_Nem_3	97	101	PF02991	0.406
LIG_PCNA_yPIPBox_3	109	120	PF02747	0.506
LIG_PTB_Apo_2	33	40	PF02174	0.353
LIG_PTB_Phospho_1	33	39	PF10480	0.347
LIG_SH2_CRK	107	111	PF00017	0.523
LIG_SH2_CRK	112	116	PF00017	0.489
LIG_SH2_CRK	85	89	PF00017	0.469
LIG_SH2_NCK_1	221	225	PF00017	0.464
LIG_SH2_SRC	39	42	PF00017	0.503
LIG_SH2_STAP1	201	205	PF00017	0.393
LIG_SH2_STAP1	221	225	PF00017	0.218
LIG_SH2_STAP1	321	325	PF00017	0.501
LIG_SH2_STAP1	98	102	PF00017	0.495
LIG_SH2_STAT3	201	204	PF00017	0.392
LIG_SH2_STAT5	146	149	PF00017	0.384
LIG_SH2_STAT5	87	90	PF00017	0.501
LIG_SH3_3	171	177	PF00018	0.659
LIG_SH3_3	313	319	PF00018	0.440
LIG_SUMO_SIM_par_1	30	35	PF11976	0.376
LIG_TRAF2_1	262	265	PF00917	0.477
MOD_CK2_1	205	211	PF00069	0.508
MOD_CK2_1	259	265	PF00069	0.579
MOD_CK2_1	34	40	PF00069	0.418
MOD_GlcNHglycan	248	251	PF01048	0.708
MOD_GlcNHglycan	254	257	PF01048	0.711
MOD_GlcNHglycan	259	262	PF01048	0.640
MOD_GlcNHglycan	296	299	PF01048	0.369
MOD_GlcNHglycan	316	319	PF01048	0.337
MOD_GlcNHglycan	326	329	PF01048	0.410
MOD_GSK3_1	150	157	PF00069	0.333
MOD_GSK3_1	240	247	PF00069	0.636
MOD_GSK3_1	348	355	PF00069	0.611
MOD_N-GLC_1	150	155	PF02516	0.453
MOD_N-GLC_1	314	319	PF02516	0.578
MOD_NEK2_1	119	124	PF00069	0.493
MOD_NEK2_1	238	243	PF00069	0.645
MOD_NEK2_1	251	256	PF00069	0.743
MOD_NEK2_1	257	262	PF00069	0.643
MOD_NEK2_1	294	299	PF00069	0.380
MOD_NEK2_2	80	85	PF00069	0.476
MOD_PIKK_1	302	308	PF00454	0.389
MOD_PK_1	137	143	PF00069	0.458
MOD_PKA_2	136	142	PF00069	0.566
MOD_PKA_2	205	211	PF00069	0.511
MOD_PKA_2	257	263	PF00069	0.658
MOD_PKA_2	70	76	PF00069	0.496
MOD_Plk_1	281	287	PF00069	0.496
MOD_Plk_1	34	40	PF00069	0.354
MOD_Plk_4	24	30	PF00069	0.439
MOD_Plk_4	281	287	PF00069	0.466
MOD_Plk_4	34	40	PF00069	0.316
MOD_Plk_4	80	86	PF00069	0.441
MOD_ProDKin_1	19	25	PF00069	0.398
MOD_ProDKin_1	4	10	PF00069	0.572
TRG_DiLeu_BaEn_1	234	239	PF01217	0.556
TRG_DiLeu_BaEn_2	96	102	PF01217	0.547
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.463
TRG_ENDOCYTIC_2	107	110	PF00928	0.479
TRG_ENDOCYTIC_2	221	224	PF00928	0.406
TRG_ENDOCYTIC_2	225	228	PF00928	0.413
TRG_ENDOCYTIC_2	85	88	PF00928	0.460
TRG_ENDOCYTIC_2	98	101	PF00928	0.518
TRG_ER_diArg_1	170	173	PF00400	0.596
TRG_ER_diArg_1	217	219	PF00400	0.520
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I684	Leptomonas seymouri	67%	100%
A0A1X0P7P0	Trypanosomatidae	29%	100%
A0A3S7XB03	Leishmania donovani	99%	100%
A0A422N520	Trypanosoma rangeli	26%	100%
A4HP83	Leishmania braziliensis	79%	100%
E9ASZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1K7	Leishmania major	93%	100%
V5BKX8	Trypanosoma cruzi	29%	100%