Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDI3_LEIIN

TriTrypDb:

LINF_360028000

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016407	acetyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.609
CLV_NRD_NRD_1	197	199	PF00675	0.494
CLV_NRD_NRD_1	334	336	PF00675	0.721
CLV_PCSK_KEX2_1	126	128	PF00082	0.612
CLV_PCSK_KEX2_1	199	201	PF00082	0.445
CLV_PCSK_KEX2_1	333	335	PF00082	0.692
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.570
CLV_PCSK_SKI1_1	185	189	PF00082	0.430
CLV_PCSK_SKI1_1	288	292	PF00082	0.439
CLV_PCSK_SKI1_1	351	355	PF00082	0.442
CLV_PCSK_SKI1_1	58	62	PF00082	0.511
DEG_APCC_DBOX_1	350	358	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.488
DEG_SPOP_SBC_1	84	88	PF00917	0.498
DOC_ANK_TNKS_1	358	365	PF00023	0.384
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.499
DOC_MAPK_gen_1	162	170	PF00069	0.379
DOC_MAPK_gen_1	292	300	PF00069	0.446
DOC_PP1_RVXF_1	295	301	PF00149	0.370
DOC_PP1_RVXF_1	56	63	PF00149	0.519
DOC_PP4_FxxP_1	175	178	PF00568	0.395
DOC_PP4_FxxP_1	50	53	PF00568	0.542
DOC_SPAK_OSR1_1	359	363	PF12202	0.364
DOC_USP7_MATH_1	108	112	PF00917	0.740
DOC_USP7_MATH_1	336	340	PF00917	0.653
DOC_USP7_MATH_1	84	88	PF00917	0.624
DOC_WW_Pin1_4	75	80	PF00397	0.684
DOC_WW_Pin1_4	99	104	PF00397	0.708
LIG_14-3-3_CanoR_1	126	134	PF00244	0.572
LIG_14-3-3_CanoR_1	185	190	PF00244	0.536
LIG_14-3-3_CanoR_1	210	218	PF00244	0.384
LIG_14-3-3_CanoR_1	7	11	PF00244	0.546
LIG_BRCT_BRCA1_1	171	175	PF00533	0.389
LIG_BRCT_BRCA1_1	86	90	PF00533	0.501
LIG_FHA_1	14	20	PF00498	0.423
LIG_FHA_1	212	218	PF00498	0.387
LIG_FHA_1	220	226	PF00498	0.425
LIG_FHA_2	135	141	PF00498	0.574
LIG_FHA_2	20	26	PF00498	0.432
LIG_FHA_2	289	295	PF00498	0.541
LIG_FHA_2	33	39	PF00498	0.385
LIG_FHA_2	47	53	PF00498	0.367
LIG_LIR_Apic_2	172	178	PF02991	0.391
LIG_LIR_Apic_2	49	53	PF02991	0.534
LIG_LIR_Apic_2	64	68	PF02991	0.383
LIG_LIR_Gen_1	230	240	PF02991	0.345
LIG_LIR_Gen_1	268	276	PF02991	0.354
LIG_LIR_Nem_3	140	145	PF02991	0.454
LIG_LIR_Nem_3	202	208	PF02991	0.384
LIG_LIR_Nem_3	268	272	PF02991	0.317
LIG_SH2_CRK	14	18	PF00017	0.437
LIG_SH2_CRK	65	69	PF00017	0.404
LIG_SH2_STAP1	151	155	PF00017	0.482
LIG_SH2_STAP1	171	175	PF00017	0.275
LIG_SH2_STAP1	205	209	PF00017	0.300
LIG_SH2_STAP1	46	50	PF00017	0.416
LIG_SH2_STAT3	151	154	PF00017	0.473
LIG_SH2_STAT3	171	174	PF00017	0.295
LIG_SH2_STAT5	208	211	PF00017	0.303
LIG_SH2_STAT5	318	321	PF00017	0.382
LIG_SH3_3	175	181	PF00018	0.406
LIG_SH3_3	184	190	PF00018	0.384
LIG_SH3_3	359	365	PF00018	0.366
LIG_SUMO_SIM_par_1	165	173	PF11976	0.491
LIG_SUMO_SIM_par_1	185	192	PF11976	0.621
LIG_TRAF2_1	137	140	PF00917	0.570
LIG_TRAF2_1	213	216	PF00917	0.430
LIG_TRAF2_1	3	6	PF00917	0.566
LIG_TRAF2_1	35	38	PF00917	0.453
LIG_TYR_ITIM	316	321	PF00017	0.397
MOD_CK1_1	107	113	PF00069	0.684
MOD_CK1_1	116	122	PF00069	0.574
MOD_CK1_1	191	197	PF00069	0.537
MOD_CK1_1	339	345	PF00069	0.610
MOD_CK1_1	99	105	PF00069	0.723
MOD_CK2_1	134	140	PF00069	0.570
MOD_CK2_1	157	163	PF00069	0.409
MOD_CK2_1	288	294	PF00069	0.428
MOD_CK2_1	32	38	PF00069	0.495
MOD_CK2_1	92	98	PF00069	0.755
MOD_GlcNHglycan	201	204	PF01048	0.501
MOD_GlcNHglycan	272	275	PF01048	0.323
MOD_GlcNHglycan	328	331	PF01048	0.727
MOD_GlcNHglycan	338	341	PF01048	0.674
MOD_GlcNHglycan	94	97	PF01048	0.728
MOD_GlcNHglycan	98	101	PF01048	0.766
MOD_GSK3_1	104	111	PF00069	0.654
MOD_GSK3_1	115	122	PF00069	0.623
MOD_GSK3_1	185	192	PF00069	0.562
MOD_GSK3_1	199	206	PF00069	0.540
MOD_GSK3_1	92	99	PF00069	0.652
MOD_N-GLC_1	19	24	PF02516	0.346
MOD_N-GLC_1	324	329	PF02516	0.540
MOD_NEK2_1	113	118	PF00069	0.652
MOD_NEK2_1	133	138	PF00069	0.473
MOD_NEK2_1	170	175	PF00069	0.469
MOD_NEK2_1	19	24	PF00069	0.527
MOD_NEK2_1	238	243	PF00069	0.318
MOD_NEK2_1	346	351	PF00069	0.501
MOD_NEK2_2	13	18	PF00069	0.567
MOD_PIKK_1	113	119	PF00454	0.741
MOD_PIKK_1	170	176	PF00454	0.438
MOD_PIKK_1	19	25	PF00454	0.566
MOD_PIKK_1	211	217	PF00454	0.432
MOD_PKA_1	199	205	PF00069	0.525
MOD_PKA_1	334	340	PF00069	0.491
MOD_PKA_2	125	131	PF00069	0.572
MOD_PKA_2	134	140	PF00069	0.585
MOD_PKA_2	199	205	PF00069	0.527
MOD_PKA_2	334	340	PF00069	0.557
MOD_PKA_2	6	12	PF00069	0.570
MOD_Plk_1	19	25	PF00069	0.547
MOD_Plk_4	108	114	PF00069	0.645
MOD_Plk_4	203	209	PF00069	0.313
MOD_Plk_4	311	317	PF00069	0.493
MOD_Plk_4	46	52	PF00069	0.469
MOD_Plk_4	6	12	PF00069	0.559
MOD_ProDKin_1	75	81	PF00069	0.685
MOD_ProDKin_1	99	105	PF00069	0.707
TRG_DiLeu_BaEn_1	6	11	PF01217	0.443
TRG_DiLeu_BaEn_4	165	171	PF01217	0.498
TRG_DiLeu_BaLyEn_6	129	134	PF01217	0.550
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.337
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.456
TRG_ENDOCYTIC_2	14	17	PF00928	0.417
TRG_ENDOCYTIC_2	287	290	PF00928	0.355
TRG_ENDOCYTIC_2	318	321	PF00928	0.418
TRG_ER_diArg_1	125	127	PF00400	0.699
TRG_ER_diArg_1	198	201	PF00400	0.467
TRG_ER_diArg_1	333	335	PF00400	0.660
TRG_NLS_MonoExtN_4	196	202	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D4	Leptomonas seymouri	69%	99%
A0A0S4IZI8	Bodo saltans	39%	86%
A0A1X0P7V3	Trypanosomatidae	45%	100%
A0A3R7K298	Trypanosoma rangeli	46%	100%
A0A3S7XAU7	Leishmania donovani	100%	100%
A4HP78	Leishmania braziliensis	88%	100%
D0A374	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ASY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q1L2	Leishmania major	93%	100%
V5DCI4	Trypanosoma cruzi	45%	100%