Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IDI2_LEIIN

TriTrypDb:

LINF_360027900

Length:

938

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0055037	recycling endosome	8	1
GO:0097708	intracellular vesicle	5	1

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Expansion

Sequence features

A4IDI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDI2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	6
GO:0030234	enzyme regulator activity	2	6
GO:0030695	GTPase regulator activity	4	6
GO:0060589	nucleoside-triphosphatase regulator activity	3	6
GO:0098772	molecular function regulator activity	1	6
GO:0140677	molecular function activator activity	2	6
GO:0140678	molecular function inhibitor activity	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	589	593	PF00656	0.728
CLV_C14_Caspase3-7	684	688	PF00656	0.587
CLV_NRD_NRD_1	495	497	PF00675	0.526
CLV_NRD_NRD_1	535	537	PF00675	0.615
CLV_NRD_NRD_1	638	640	PF00675	0.554
CLV_NRD_NRD_1	647	649	PF00675	0.455
CLV_NRD_NRD_1	763	765	PF00675	0.390
CLV_PCSK_KEX2_1	535	537	PF00082	0.615
CLV_PCSK_KEX2_1	637	639	PF00082	0.536
CLV_PCSK_KEX2_1	678	680	PF00082	0.433

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK61	Leishmania donovani	100%	100%
A4HP77	Leishmania braziliensis	76%	100%
E9ASY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1L3	Leishmania major	92%	100%

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