LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
TPR repeat/Tetratricopeptide repeat - putative
Species:
Leishmania infantum
UniProt:
A4IDI0_LEIIN
TriTrypDb:
LINF_360027700
Length:
330

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4IDI0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDI0

Function

Biological processes
TermNameLevelCount
GO:0006457 protein folding 2 13
GO:0009987 cellular process 1 13
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 13
GO:0005515 protein binding 2 13
GO:0030544 Hsp70 protein binding 4 13
GO:0031072 heat shock protein binding 3 13
GO:0051879 Hsp90 protein binding 4 13
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 32 36 PF00656 0.581
CLV_NRD_NRD_1 126 128 PF00675 0.321
CLV_PCSK_KEX2_1 128 130 PF00082 0.473
CLV_PCSK_PC1ET2_1 128 130 PF00082 0.472
CLV_PCSK_SKI1_1 114 118 PF00082 0.534
CLV_PCSK_SKI1_1 13 17 PF00082 0.569
CLV_PCSK_SKI1_1 140 144 PF00082 0.448
CLV_PCSK_SKI1_1 255 259 PF00082 0.493
CLV_PCSK_SKI1_1 4 8 PF00082 0.648
DEG_SPOP_SBC_1 192 196 PF00917 0.703
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P7A6 Leptomonas seymouri 56% 100%
A0A0S4IZ49 Bodo saltans 38% 100%
A0A1X0NJW2 Trypanosomatidae 28% 77%
A0A1X0P800 Trypanosomatidae 39% 99%
A0A3Q8IKL8 Leishmania donovani 99% 100%
A0A422N1V8 Trypanosoma rangeli 40% 100%
A4HP75 Leishmania braziliensis 74% 94%
D0A371 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9ASY3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q1L5 Leishmania major 92% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS