TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat - putative

Species:

Leishmania infantum

UniProt:

A4IDI0_LEIIN

TriTrypDb:

LINF_360027700

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDI0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0005515	protein binding	2	13
GO:0030544	Hsp70 protein binding	4	13
GO:0031072	heat shock protein binding	3	13
GO:0051879	Hsp90 protein binding	4	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.581
CLV_NRD_NRD_1	126	128	PF00675	0.321
CLV_PCSK_KEX2_1	128	130	PF00082	0.473
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.472
CLV_PCSK_SKI1_1	114	118	PF00082	0.534
CLV_PCSK_SKI1_1	13	17	PF00082	0.569
CLV_PCSK_SKI1_1	140	144	PF00082	0.448
CLV_PCSK_SKI1_1	255	259	PF00082	0.493
CLV_PCSK_SKI1_1	4	8	PF00082	0.648
DEG_SPOP_SBC_1	192	196	PF00917	0.703
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.540
DOC_MAPK_gen_1	114	122	PF00069	0.462
DOC_PP2B_LxvP_1	71	74	PF13499	0.552
DOC_USP7_MATH_1	192	196	PF00917	0.736
DOC_USP7_UBL2_3	103	107	PF12436	0.507
DOC_WW_Pin1_4	184	189	PF00397	0.695
DOC_WW_Pin1_4	89	94	PF00397	0.483
LIG_14-3-3_CanoR_1	239	244	PF00244	0.684
LIG_14-3-3_CanoR_1	299	309	PF00244	0.627
LIG_14-3-3_CanoR_1	82	90	PF00244	0.457
LIG_CtBP_PxDLS_1	97	103	PF00389	0.447
LIG_FHA_1	304	310	PF00498	0.493
LIG_FHA_1	320	326	PF00498	0.463
LIG_FHA_1	76	82	PF00498	0.473
LIG_FHA_2	23	29	PF00498	0.563
LIG_FHA_2	273	279	PF00498	0.521
LIG_IRF3_LxIS_1	309	314	PF10401	0.497
LIG_LIR_Gen_1	25	34	PF02991	0.491
LIG_LIR_Nem_3	25	30	PF02991	0.614
LIG_LIR_Nem_3	315	321	PF02991	0.506
LIG_LIR_Nem_3	46	50	PF02991	0.405
LIG_PTB_Apo_2	49	56	PF02174	0.391
LIG_PTB_Phospho_1	49	55	PF10480	0.467
LIG_SH2_CRK	67	71	PF00017	0.495
LIG_SH2_GRB2like	183	186	PF00017	0.691
LIG_SH2_NCK_1	302	306	PF00017	0.629
LIG_SH2_STAP1	67	71	PF00017	0.368
LIG_SH2_STAT5	321	324	PF00017	0.522
LIG_SH2_STAT5	59	62	PF00017	0.361
LIG_SH2_STAT5	89	92	PF00017	0.415
LIG_SH3_3	6	12	PF00018	0.523
LIG_TRAF2_1	207	210	PF00917	0.693
LIG_WW_2	9	12	PF00397	0.497
MOD_CDK_SPK_2	186	191	PF00069	0.656
MOD_CDK_SPxxK_3	184	191	PF00069	0.612
MOD_CK1_1	194	200	PF00069	0.662
MOD_CK1_1	303	309	PF00069	0.614
MOD_CK1_1	83	89	PF00069	0.388
MOD_CK2_1	225	231	PF00069	0.605
MOD_CK2_1	265	271	PF00069	0.547
MOD_GlcNHglycan	162	165	PF01048	0.557
MOD_GlcNHglycan	271	275	PF01048	0.605
MOD_GlcNHglycan	85	88	PF01048	0.390
MOD_GSK3_1	191	198	PF00069	0.651
MOD_GSK3_1	22	29	PF00069	0.532
MOD_N-GLC_1	184	189	PF02516	0.691
MOD_N-GLC_1	83	88	PF02516	0.416
MOD_N-GLC_2	52	54	PF02516	0.386
MOD_NEK2_1	22	27	PF00069	0.552
MOD_NEK2_1	272	277	PF00069	0.493
MOD_NEK2_1	298	303	PF00069	0.621
MOD_PIKK_1	212	218	PF00454	0.603
MOD_PIKK_1	241	247	PF00454	0.603
MOD_PIKK_1	38	44	PF00454	0.576
MOD_PK_1	26	32	PF00069	0.418
MOD_PKA_2	298	304	PF00069	0.599
MOD_PKB_1	237	245	PF00069	0.703
MOD_Plk_4	169	175	PF00069	0.396
MOD_ProDKin_1	184	190	PF00069	0.658
MOD_ProDKin_1	89	95	PF00069	0.494
MOD_SUMO_for_1	207	210	PF00179	0.751
MOD_SUMO_for_1	264	267	PF00179	0.508
MOD_SUMO_rev_2	106	116	PF00179	0.424
MOD_SUMO_rev_2	41	50	PF00179	0.485
MOD_SUMO_rev_2	8	17	PF00179	0.537
TRG_DiLeu_BaEn_4	209	215	PF01217	0.707
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.510
TRG_ENDOCYTIC_2	67	70	PF00928	0.492
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A6	Leptomonas seymouri	56%	100%
A0A0S4IZ49	Bodo saltans	38%	100%
A0A1X0NJW2	Trypanosomatidae	28%	77%
A0A1X0P800	Trypanosomatidae	39%	99%
A0A3Q8IKL8	Leishmania donovani	99%	100%
A0A422N1V8	Trypanosoma rangeli	40%	100%
A4HP75	Leishmania braziliensis	74%	94%
D0A371	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ASY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q1L5	Leishmania major	92%	100%
V5BKW9	Trypanosoma cruzi	40%	100%