Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function DUF72 - putative

Species:

Leishmania infantum

UniProt:

A4IDH9_LEIIN

TriTrypDb:

LINF_360027600

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IDH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.337
CLV_NRD_NRD_1	284	286	PF00675	0.424
CLV_NRD_NRD_1	287	289	PF00675	0.410
CLV_NRD_NRD_1	32	34	PF00675	0.444
CLV_NRD_NRD_1	99	101	PF00675	0.388
CLV_PCSK_FUR_1	285	289	PF00082	0.290
CLV_PCSK_KEX2_1	284	286	PF00082	0.424
CLV_PCSK_KEX2_1	287	289	PF00082	0.410
CLV_PCSK_KEX2_1	32	34	PF00082	0.554
CLV_PCSK_KEX2_1	487	489	PF00082	0.729
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.758
CLV_PCSK_SKI1_1	313	317	PF00082	0.349
CLV_PCSK_SKI1_1	390	394	PF00082	0.337
CLV_PCSK_SKI1_1	421	425	PF00082	0.470
CLV_PCSK_SKI1_1	93	97	PF00082	0.452
DEG_COP1_1	77	85	PF00400	0.526
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SPOP_SBC_1	15	19	PF00917	0.577
DEG_SPOP_SBC_1	266	270	PF00917	0.302
DEG_SPOP_SBC_1	277	281	PF00917	0.215
DOC_ANK_TNKS_1	372	379	PF00023	0.241
DOC_CYCLIN_RxL_1	418	428	PF00134	0.540
DOC_MAPK_gen_1	284	295	PF00069	0.295
DOC_MAPK_gen_1	310	318	PF00069	0.334
DOC_MAPK_MEF2A_6	284	293	PF00069	0.280
DOC_MAPK_MEF2A_6	444	453	PF00069	0.531
DOC_PP2B_PxIxI_1	69	75	PF00149	0.407
DOC_PP4_FxxP_1	220	223	PF00568	0.381
DOC_PP4_FxxP_1	58	61	PF00568	0.496
DOC_USP7_MATH_1	15	19	PF00917	0.524
DOC_USP7_MATH_1	266	270	PF00917	0.458
DOC_USP7_MATH_1	278	282	PF00917	0.278
DOC_USP7_MATH_1	443	447	PF00917	0.697
DOC_USP7_MATH_1	492	496	PF00917	0.746
DOC_WW_Pin1_4	164	169	PF00397	0.617
DOC_WW_Pin1_4	232	237	PF00397	0.217
DOC_WW_Pin1_4	260	265	PF00397	0.370
DOC_WW_Pin1_4	371	376	PF00397	0.465
DOC_WW_Pin1_4	39	44	PF00397	0.451
DOC_WW_Pin1_4	437	442	PF00397	0.767
DOC_WW_Pin1_4	457	462	PF00397	0.755
DOC_WW_Pin1_4	480	485	PF00397	0.638
LIG_14-3-3_CanoR_1	138	143	PF00244	0.621
LIG_14-3-3_CanoR_1	296	301	PF00244	0.300
LIG_14-3-3_CanoR_1	444	452	PF00244	0.551
LIG_14-3-3_CanoR_1	470	477	PF00244	0.648
LIG_14-3-3_CanoR_1	48	53	PF00244	0.490
LIG_14-3-3_CanoR_1	59	67	PF00244	0.397
LIG_14-3-3_CanoR_1	90	96	PF00244	0.428
LIG_deltaCOP1_diTrp_1	117	124	PF00928	0.356
LIG_EH_1	55	59	PF12763	0.382
LIG_FHA_1	257	263	PF00498	0.376
LIG_FHA_1	303	309	PF00498	0.356
LIG_FHA_1	379	385	PF00498	0.272
LIG_FHA_1	387	393	PF00498	0.462
LIG_FHA_1	405	411	PF00498	0.352
LIG_FHA_1	61	67	PF00498	0.467
LIG_FHA_2	121	127	PF00498	0.475
LIG_FHA_2	386	392	PF00498	0.423
LIG_FHA_2	496	502	PF00498	0.736
LIG_HCF-1_HBM_1	107	110	PF13415	0.297
LIG_LIR_Apic_2	218	223	PF02991	0.417
LIG_LIR_Apic_2	51	57	PF02991	0.408
LIG_LIR_Gen_1	123	128	PF02991	0.394
LIG_LIR_Gen_1	303	312	PF02991	0.306
LIG_LIR_Gen_1	324	335	PF02991	0.419
LIG_LIR_Gen_1	391	400	PF02991	0.417
LIG_LIR_Nem_3	303	309	PF02991	0.298
LIG_LIR_Nem_3	311	317	PF02991	0.302
LIG_LIR_Nem_3	324	330	PF02991	0.342
LIG_LIR_Nem_3	352	356	PF02991	0.376
LIG_LIR_Nem_3	391	396	PF02991	0.289
LIG_MYND_1	215	219	PF01753	0.417
LIG_NRBOX	244	250	PF00104	0.326
LIG_Pex14_1	54	58	PF04695	0.428
LIG_REV1ctd_RIR_1	207	214	PF16727	0.264
LIG_SH2_CRK	112	116	PF00017	0.455
LIG_SH2_CRK	327	331	PF00017	0.302
LIG_SH2_CRK	353	357	PF00017	0.289
LIG_SH2_PTP2	339	342	PF00017	0.334
LIG_SH2_STAP1	181	185	PF00017	0.334
LIG_SH2_STAP1	327	331	PF00017	0.350
LIG_SH2_STAT5	181	184	PF00017	0.338
LIG_SH2_STAT5	339	342	PF00017	0.274
LIG_SH2_STAT5	368	371	PF00017	0.334
LIG_SH3_2	43	48	PF14604	0.546
LIG_SH3_3	142	148	PF00018	0.582
LIG_SH3_3	165	171	PF00018	0.643
LIG_SH3_3	18	24	PF00018	0.626
LIG_SH3_3	223	229	PF00018	0.316
LIG_SH3_3	40	46	PF00018	0.459
LIG_SH3_3	54	60	PF00018	0.535
LIG_SH3_3	64	70	PF00018	0.509
LIG_SUMO_SIM_anti_2	252	259	PF11976	0.302
LIG_SUMO_SIM_par_1	252	259	PF11976	0.302
LIG_TRAF2_1	250	253	PF00917	0.441
LIG_WRC_WIRS_1	309	314	PF05994	0.417
MOD_CDK_SPK_2	260	265	PF00069	0.217
MOD_CDK_SPK_2	439	444	PF00069	0.528
MOD_CDK_SPxxK_3	437	444	PF00069	0.551
MOD_CDK_SPxxK_3	480	487	PF00069	0.644
MOD_CK1_1	14	20	PF00069	0.647
MOD_CK1_1	141	147	PF00069	0.605
MOD_CK1_1	269	275	PF00069	0.443
MOD_CK1_1	371	377	PF00069	0.445
MOD_CK1_1	379	385	PF00069	0.374
MOD_CK1_1	47	53	PF00069	0.578
MOD_CK1_1	495	501	PF00069	0.636
MOD_CK1_1	6	12	PF00069	0.556
MOD_CK1_1	88	94	PF00069	0.537
MOD_CK2_1	247	253	PF00069	0.440
MOD_CK2_1	371	377	PF00069	0.331
MOD_CK2_1	385	391	PF00069	0.442
MOD_CMANNOS	121	124	PF00535	0.364
MOD_DYRK1A_RPxSP_1	260	264	PF00069	0.217
MOD_GlcNHglycan	13	16	PF01048	0.606
MOD_GlcNHglycan	145	148	PF01048	0.682
MOD_GlcNHglycan	162	165	PF01048	0.695
MOD_GlcNHglycan	18	21	PF01048	0.571
MOD_GlcNHglycan	269	272	PF01048	0.412
MOD_GlcNHglycan	280	283	PF01048	0.259
MOD_GlcNHglycan	381	384	PF01048	0.438
MOD_GlcNHglycan	445	448	PF01048	0.776
MOD_GlcNHglycan	495	498	PF01048	0.694
MOD_GlcNHglycan	5	8	PF01048	0.610
MOD_GSK3_1	11	18	PF00069	0.664
MOD_GSK3_1	160	167	PF00069	0.697
MOD_GSK3_1	228	235	PF00069	0.422
MOD_GSK3_1	256	263	PF00069	0.438
MOD_GSK3_1	265	272	PF00069	0.431
MOD_GSK3_1	273	280	PF00069	0.445
MOD_GSK3_1	433	440	PF00069	0.628
MOD_GSK3_1	44	51	PF00069	0.436
MOD_GSK3_1	488	495	PF00069	0.757
MOD_GSK3_1	81	88	PF00069	0.546
MOD_N-GLC_1	396	401	PF02516	0.291
MOD_N-GLC_1	48	53	PF02516	0.573
MOD_NEK2_1	16	21	PF00069	0.524
MOD_NEK2_1	179	184	PF00069	0.277
MOD_NEK2_1	256	261	PF00069	0.429
MOD_NEK2_1	267	272	PF00069	0.395
MOD_NEK2_1	308	313	PF00069	0.395
MOD_NEK2_1	62	67	PF00069	0.533
MOD_PIKK_1	247	253	PF00454	0.473
MOD_PIKK_1	325	331	PF00454	0.302
MOD_PIKK_1	94	100	PF00454	0.396
MOD_PKA_2	128	134	PF00069	0.552
MOD_PKA_2	240	246	PF00069	0.406
MOD_PKA_2	443	449	PF00069	0.710
MOD_PKA_2	469	475	PF00069	0.644
MOD_PKA_2	47	53	PF00069	0.558
MOD_PKA_2	493	499	PF00069	0.651
MOD_Plk_1	302	308	PF00069	0.433
MOD_Plk_1	411	417	PF00069	0.354
MOD_Plk_1	48	54	PF00069	0.571
MOD_Plk_1	88	94	PF00069	0.574
MOD_Plk_4	34	40	PF00069	0.514
MOD_Plk_4	406	412	PF00069	0.363
MOD_Plk_4	6	12	PF00069	0.562
MOD_ProDKin_1	164	170	PF00069	0.615
MOD_ProDKin_1	232	238	PF00069	0.217
MOD_ProDKin_1	260	266	PF00069	0.370
MOD_ProDKin_1	371	377	PF00069	0.465
MOD_ProDKin_1	39	45	PF00069	0.452
MOD_ProDKin_1	437	443	PF00069	0.767
MOD_ProDKin_1	457	463	PF00069	0.754
MOD_ProDKin_1	480	486	PF00069	0.641
TRG_AP2beta_CARGO_1	303	313	PF09066	0.420
TRG_DiLeu_BaEn_1	252	257	PF01217	0.302
TRG_DiLeu_BaEn_1	304	309	PF01217	0.334
TRG_DiLeu_BaEn_2	390	396	PF01217	0.417
TRG_DiLeu_BaEn_4	252	258	PF01217	0.302
TRG_DiLeu_LyEn_5	212	217	PF01217	0.350
TRG_ENDOCYTIC_2	112	115	PF00928	0.424
TRG_ENDOCYTIC_2	327	330	PF00928	0.376
TRG_ENDOCYTIC_2	339	342	PF00928	0.197
TRG_ENDOCYTIC_2	353	356	PF00928	0.274
TRG_ER_diArg_1	283	285	PF00400	0.381
TRG_ER_diArg_1	287	290	PF00400	0.347
TRG_ER_diArg_1	295	298	PF00400	0.265
TRG_ER_diArg_1	32	34	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN3	Leptomonas seymouri	56%	100%
A0A0S4J806	Bodo saltans	35%	100%
A0A1X0P7Q2	Trypanosomatidae	43%	100%
A0A3Q8IG26	Leishmania donovani	100%	100%
A0A422N1S4	Trypanosoma rangeli	41%	100%
A4HP74	Leishmania braziliensis	73%	100%
D0A370	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q1L6	Leishmania major	90%	100%
V5BGE6	Trypanosoma cruzi	42%	100%