Serine/threonine-protein phosphatase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4IDH8_LEIIN

TriTrypDb:

LINF_360027500

Length:

914

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote/Amastigote: 671

Expansion

Sequence features

A4IDH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDH8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.473
CLV_C14_Caspase3-7	23	27	PF00656	0.646
CLV_C14_Caspase3-7	688	692	PF00656	0.669
CLV_C14_Caspase3-7	782	786	PF00656	0.646
CLV_NRD_NRD_1	185	187	PF00675	0.379
CLV_NRD_NRD_1	499	501	PF00675	0.276
CLV_NRD_NRD_1	664	666	PF00675	0.724
CLV_NRD_NRD_1	8	10	PF00675	0.671
CLV_NRD_NRD_1	88	90	PF00675	0.640
CLV_PCSK_KEX2_1	403	405	PF00082	0.348
CLV_PCSK_KEX2_1	499	501	PF00082	0.276
CLV_PCSK_KEX2_1	664	666	PF00082	0.723
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.310
CLV_PCSK_SKI1_1	166	170	PF00082	0.510
CLV_PCSK_SKI1_1	186	190	PF00082	0.413
CLV_PCSK_SKI1_1	315	319	PF00082	0.362
CLV_PCSK_SKI1_1	365	369	PF00082	0.335
CLV_PCSK_SKI1_1	657	661	PF00082	0.652
CLV_PCSK_SKI1_1	857	861	PF00082	0.369
CLV_Separin_Metazoa	339	343	PF03568	0.537
DEG_APCC_DBOX_1	185	193	PF00400	0.406
DEG_APCC_DBOX_1	364	372	PF00400	0.335
DEG_SCF_TRCP1_1	547	552	PF00400	0.637
DEG_SPOP_SBC_1	106	110	PF00917	0.607
DOC_ANK_TNKS_1	270	277	PF00023	0.664
DOC_CKS1_1	137	142	PF01111	0.674
DOC_CKS1_1	67	72	PF01111	0.680
DOC_CYCLIN_RxL_1	312	322	PF00134	0.367
DOC_CYCLIN_yClb1_LxF_4	833	839	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.219
DOC_MAPK_gen_1	230	237	PF00069	0.412
DOC_MAPK_gen_1	301	310	PF00069	0.567
DOC_MAPK_gen_1	437	447	PF00069	0.278
DOC_MAPK_gen_1	722	732	PF00069	0.495
DOC_MAPK_gen_1	871	879	PF00069	0.398
DOC_MAPK_MEF2A_6	119	127	PF00069	0.652
DOC_MAPK_MEF2A_6	230	237	PF00069	0.404
DOC_MAPK_MEF2A_6	301	310	PF00069	0.567
DOC_MAPK_MEF2A_6	342	349	PF00069	0.406
DOC_MAPK_NFAT4_5	230	238	PF00069	0.541
DOC_PP2B_LxvP_1	102	105	PF13499	0.782
DOC_PP2B_LxvP_1	711	714	PF13499	0.693
DOC_PP4_FxxP_1	672	675	PF00568	0.623
DOC_PP4_FxxP_1	676	679	PF00568	0.619
DOC_PP4_FxxP_1	720	723	PF00568	0.625
DOC_PP4_FxxP_1	862	865	PF00568	0.372
DOC_USP7_MATH_1	106	110	PF00917	0.633
DOC_USP7_MATH_1	28	32	PF00917	0.647
DOC_USP7_MATH_1	393	397	PF00917	0.262
DOC_USP7_MATH_1	528	532	PF00917	0.623
DOC_USP7_MATH_1	538	542	PF00917	0.591
DOC_USP7_MATH_1	59	63	PF00917	0.734
DOC_USP7_MATH_1	598	602	PF00917	0.482
DOC_USP7_MATH_1	683	687	PF00917	0.577
DOC_USP7_MATH_1	696	700	PF00917	0.637
DOC_USP7_MATH_1	702	706	PF00917	0.786
DOC_USP7_MATH_1	714	718	PF00917	0.633
DOC_USP7_MATH_1	72	76	PF00917	0.535
DOC_USP7_MATH_1	772	776	PF00917	0.610
DOC_USP7_MATH_1	781	785	PF00917	0.618
DOC_USP7_MATH_1	788	792	PF00917	0.614
DOC_USP7_UBL2_3	11	15	PF12436	0.638
DOC_USP7_UBL2_3	415	419	PF12436	0.331
DOC_USP7_UBL2_3	657	661	PF12436	0.666
DOC_USP7_UBL2_3	898	902	PF12436	0.582
DOC_WW_Pin1_4	107	112	PF00397	0.657
DOC_WW_Pin1_4	136	141	PF00397	0.683
DOC_WW_Pin1_4	26	31	PF00397	0.715
DOC_WW_Pin1_4	285	290	PF00397	0.619
DOC_WW_Pin1_4	385	390	PF00397	0.439
DOC_WW_Pin1_4	468	473	PF00397	0.335
DOC_WW_Pin1_4	534	539	PF00397	0.670
DOC_WW_Pin1_4	575	580	PF00397	0.756
DOC_WW_Pin1_4	60	65	PF00397	0.662
DOC_WW_Pin1_4	66	71	PF00397	0.632
DOC_WW_Pin1_4	675	680	PF00397	0.592
DOC_WW_Pin1_4	706	711	PF00397	0.651
DOC_WW_Pin1_4	737	742	PF00397	0.393
DOC_WW_Pin1_4	79	84	PF00397	0.604
LIG_14-3-3_CanoR_1	119	127	PF00244	0.684
LIG_14-3-3_CanoR_1	453	459	PF00244	0.453
LIG_14-3-3_CanoR_1	787	793	PF00244	0.515
LIG_14-3-3_CanoR_1	857	862	PF00244	0.487
LIG_14-3-3_CanoR_1	89	95	PF00244	0.641
LIG_14-3-3_CterR_2	911	914	PF00244	0.691
LIG_Actin_WH2_2	256	273	PF00022	0.600
LIG_APCC_ABBA_1	739	744	PF00400	0.527
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.376
LIG_BIR_III_4	57	61	PF00653	0.686
LIG_BIR_III_4	73	77	PF00653	0.686
LIG_BRCT_BRCA1_1	685	689	PF00533	0.562
LIG_BRCT_BRCA1_1	716	720	PF00533	0.649
LIG_BRCT_BRCA1_2	716	722	PF00533	0.619
LIG_Clathr_ClatBox_1	340	344	PF01394	0.428
LIG_EVH1_1	102	106	PF00568	0.644
LIG_EVH1_2	909	913	PF00568	0.620
LIG_FHA_1	210	216	PF00498	0.561
LIG_FHA_1	27	33	PF00498	0.741
LIG_FHA_1	297	303	PF00498	0.570
LIG_FHA_1	464	470	PF00498	0.335
LIG_FHA_1	472	478	PF00498	0.335
LIG_FHA_1	816	822	PF00498	0.437
LIG_FHA_1	831	837	PF00498	0.390
LIG_FHA_2	129	135	PF00498	0.642
LIG_FHA_2	165	171	PF00498	0.564
LIG_FHA_2	19	25	PF00498	0.678
LIG_FHA_2	196	202	PF00498	0.396
LIG_FHA_2	31	37	PF00498	0.697
LIG_FHA_2	52	58	PF00498	0.677
LIG_FHA_2	561	567	PF00498	0.610
LIG_FHA_2	686	692	PF00498	0.667
LIG_FHA_2	702	708	PF00498	0.495
LIG_FHA_2	766	772	PF00498	0.396
LIG_FHA_2	780	786	PF00498	0.624
LIG_LIR_Apic_2	671	675	PF02991	0.628
LIG_LIR_Apic_2	717	723	PF02991	0.638
LIG_LIR_Apic_2	766	772	PF02991	0.396
LIG_LIR_Apic_2	860	865	PF02991	0.370
LIG_LIR_Gen_1	159	169	PF02991	0.441
LIG_LIR_Gen_1	332	341	PF02991	0.486
LIG_LIR_Gen_1	796	804	PF02991	0.387
LIG_LIR_Nem_3	159	165	PF02991	0.461
LIG_LIR_Nem_3	257	263	PF02991	0.662
LIG_LIR_Nem_3	3	7	PF02991	0.678
LIG_LIR_Nem_3	332	337	PF02991	0.481
LIG_LIR_Nem_3	487	493	PF02991	0.328
LIG_LIR_Nem_3	744	750	PF02991	0.530
LIG_LIR_Nem_3	796	801	PF02991	0.395
LIG_LYPXL_yS_3	501	504	PF13949	0.335
LIG_MYND_1	268	272	PF01753	0.673
LIG_MYND_1	83	87	PF01753	0.707
LIG_NRBOX	218	224	PF00104	0.412
LIG_Pex14_2	209	213	PF04695	0.441
LIG_Pex14_2	290	294	PF04695	0.667
LIG_Pex14_2	672	676	PF04695	0.640
LIG_PTB_Apo_2	666	673	PF02174	0.645
LIG_Rb_LxCxE_1	247	261	PF01857	0.520
LIG_SH2_CRK	314	318	PF00017	0.512
LIG_SH2_NCK_1	609	613	PF00017	0.506
LIG_SH2_SRC	323	326	PF00017	0.481
LIG_SH2_SRC	609	612	PF00017	0.494
LIG_SH2_STAP1	94	98	PF00017	0.639
LIG_SH2_STAT5	323	326	PF00017	0.413
LIG_SH2_STAT5	444	447	PF00017	0.335
LIG_SH2_STAT5	450	453	PF00017	0.335
LIG_SH2_STAT5	837	840	PF00017	0.474
LIG_SH2_STAT5	867	870	PF00017	0.427
LIG_SH3_2	84	89	PF14604	0.634
LIG_SH3_3	100	106	PF00018	0.556
LIG_SH3_3	134	140	PF00018	0.685
LIG_SH3_3	150	156	PF00018	0.410
LIG_SH3_3	347	353	PF00018	0.511
LIG_SH3_3	374	380	PF00018	0.241
LIG_SH3_3	435	441	PF00018	0.453
LIG_SH3_3	707	713	PF00018	0.695
LIG_SH3_3	80	86	PF00018	0.813
LIG_SH3_3	904	910	PF00018	0.629
LIG_SH3_4	898	905	PF00018	0.580
LIG_SUMO_SIM_par_1	856	863	PF11976	0.377
LIG_SUMO_SIM_par_1	875	880	PF11976	0.364
LIG_TRAF2_1	326	329	PF00917	0.403
LIG_TRAF2_1	518	521	PF00917	0.607
LIG_TRAF2_1	98	101	PF00917	0.720
LIG_WRC_WIRS_1	1	6	PF05994	0.620
LIG_WRC_WIRS_1	165	170	PF05994	0.524
LIG_WW_1	441	444	PF00397	0.389
LIG_WW_2	83	86	PF00397	0.625
LIG_WW_3	908	912	PF00397	0.672
MOD_CDK_SPK_2	385	390	PF00069	0.421
MOD_CDK_SPxxK_3	112	119	PF00069	0.686
MOD_CK1_1	110	116	PF00069	0.625
MOD_CK1_1	151	157	PF00069	0.610
MOD_CK1_1	200	206	PF00069	0.439
MOD_CK1_1	38	44	PF00069	0.666
MOD_CK1_1	388	394	PF00069	0.366
MOD_CK1_1	414	420	PF00069	0.389
MOD_CK1_1	436	442	PF00069	0.321
MOD_CK1_1	471	477	PF00069	0.314
MOD_CK1_1	52	58	PF00069	0.790
MOD_CK1_1	533	539	PF00069	0.604
MOD_CK1_1	66	72	PF00069	0.781
MOD_CK1_1	687	693	PF00069	0.607
MOD_CK1_1	698	704	PF00069	0.621
MOD_CK1_1	709	715	PF00069	0.623
MOD_CK1_1	770	776	PF00069	0.459
MOD_CK2_1	170	176	PF00069	0.485
MOD_CK2_1	18	24	PF00069	0.643
MOD_CK2_1	290	296	PF00069	0.654
MOD_CK2_1	30	36	PF00069	0.658
MOD_CK2_1	323	329	PF00069	0.397
MOD_CK2_1	514	520	PF00069	0.604
MOD_CK2_1	539	545	PF00069	0.592
MOD_CK2_1	555	561	PF00069	0.603
MOD_CK2_1	668	674	PF00069	0.740
MOD_CK2_1	701	707	PF00069	0.655
MOD_CK2_1	90	96	PF00069	0.700
MOD_Cter_Amidation	7	10	PF01082	0.766
MOD_GlcNHglycan	120	123	PF01048	0.637
MOD_GlcNHglycan	260	263	PF01048	0.576
MOD_GlcNHglycan	325	328	PF01048	0.483
MOD_GlcNHglycan	416	419	PF01048	0.362
MOD_GlcNHglycan	427	430	PF01048	0.246
MOD_GlcNHglycan	43	46	PF01048	0.772
MOD_GlcNHglycan	516	519	PF01048	0.657
MOD_GlcNHglycan	530	533	PF01048	0.615
MOD_GlcNHglycan	547	550	PF01048	0.500
MOD_GlcNHglycan	704	707	PF01048	0.607
MOD_GlcNHglycan	714	717	PF01048	0.722
MOD_GlcNHglycan	73	77	PF01048	0.790
MOD_GlcNHglycan	774	777	PF01048	0.545
MOD_GlcNHglycan	862	865	PF01048	0.372
MOD_GlcNHglycan	96	99	PF01048	0.777
MOD_GSK3_1	106	113	PF00069	0.553
MOD_GSK3_1	123	130	PF00069	0.571
MOD_GSK3_1	135	142	PF00069	0.548
MOD_GSK3_1	254	261	PF00069	0.581
MOD_GSK3_1	26	33	PF00069	0.751
MOD_GSK3_1	393	400	PF00069	0.333
MOD_GSK3_1	410	417	PF00069	0.308
MOD_GSK3_1	512	519	PF00069	0.604
MOD_GSK3_1	528	535	PF00069	0.668
MOD_GSK3_1	545	552	PF00069	0.620
MOD_GSK3_1	556	563	PF00069	0.590
MOD_GSK3_1	59	66	PF00069	0.725
MOD_GSK3_1	659	666	PF00069	0.651
MOD_GSK3_1	683	690	PF00069	0.567
MOD_GSK3_1	694	701	PF00069	0.652
MOD_GSK3_1	702	709	PF00069	0.656
MOD_GSK3_1	712	719	PF00069	0.771
MOD_GSK3_1	72	79	PF00069	0.797
MOD_GSK3_1	767	774	PF00069	0.413
MOD_GSK3_1	779	786	PF00069	0.626
MOD_GSK3_1	793	800	PF00069	0.502
MOD_GSK3_1	90	97	PF00069	0.568
MOD_LATS_1	48	54	PF00433	0.748
MOD_N-GLC_1	170	175	PF02516	0.481
MOD_N-GLC_1	296	301	PF02516	0.562
MOD_N-GLC_1	38	43	PF02516	0.805
MOD_N-GLC_1	528	533	PF02516	0.712
MOD_N-GLC_1	556	561	PF02516	0.663
MOD_N-GLC_1	668	673	PF02516	0.741
MOD_N-GLC_1	788	793	PF02516	0.614
MOD_N-GLC_2	866	868	PF02516	0.406
MOD_NEK2_1	118	123	PF00069	0.692
MOD_NEK2_1	127	132	PF00069	0.604
MOD_NEK2_1	290	295	PF00069	0.737
MOD_NEK2_1	463	468	PF00069	0.341
MOD_NEK2_1	689	694	PF00069	0.559
MOD_NEK2_1	830	835	PF00069	0.392
MOD_PIKK_1	398	404	PF00454	0.409
MOD_PIKK_1	788	794	PF00454	0.639
MOD_PK_1	178	184	PF00069	0.554
MOD_PK_1	403	409	PF00069	0.310
MOD_PK_1	797	803	PF00069	0.386
MOD_PKA_1	403	409	PF00069	0.310
MOD_PKA_1	651	657	PF00069	0.621
MOD_PKA_1	660	666	PF00069	0.627
MOD_PKA_2	118	124	PF00069	0.733
MOD_PKA_2	403	409	PF00069	0.349
MOD_PKA_2	436	442	PF00069	0.444
MOD_PKA_2	663	669	PF00069	0.734
MOD_PKA_2	694	700	PF00069	0.643
MOD_PKA_2	815	821	PF00069	0.453
MOD_Plk_1	151	157	PF00069	0.484
MOD_Plk_1	195	201	PF00069	0.474
MOD_Plk_1	556	562	PF00069	0.675
MOD_Plk_1	668	674	PF00069	0.709
MOD_Plk_1	743	749	PF00069	0.531
MOD_Plk_1	765	771	PF00069	0.395
MOD_Plk_1	824	830	PF00069	0.386
MOD_Plk_2-3	520	526	PF00069	0.579
MOD_Plk_4	313	319	PF00069	0.455
MOD_Plk_4	471	477	PF00069	0.314
MOD_Plk_4	857	863	PF00069	0.369
MOD_ProDKin_1	107	113	PF00069	0.657
MOD_ProDKin_1	136	142	PF00069	0.677
MOD_ProDKin_1	26	32	PF00069	0.715
MOD_ProDKin_1	285	291	PF00069	0.619
MOD_ProDKin_1	385	391	PF00069	0.439
MOD_ProDKin_1	468	474	PF00069	0.335
MOD_ProDKin_1	534	540	PF00069	0.670
MOD_ProDKin_1	575	581	PF00069	0.755
MOD_ProDKin_1	60	66	PF00069	0.663
MOD_ProDKin_1	675	681	PF00069	0.592
MOD_ProDKin_1	706	712	PF00069	0.651
MOD_ProDKin_1	737	743	PF00069	0.391
MOD_ProDKin_1	79	85	PF00069	0.735
MOD_SUMO_for_1	177	180	PF00179	0.420
MOD_SUMO_for_1	300	303	PF00179	0.589
MOD_SUMO_rev_2	36	44	PF00179	0.629
MOD_SUMO_rev_2	894	899	PF00179	0.643
TRG_DiLeu_BaLyEn_6	854	859	PF01217	0.392
TRG_ENDOCYTIC_2	314	317	PF00928	0.399
TRG_ENDOCYTIC_2	444	447	PF00928	0.335
TRG_ENDOCYTIC_2	491	494	PF00928	0.335
TRG_ENDOCYTIC_2	501	504	PF00928	0.335
TRG_ENDOCYTIC_2	609	612	PF00928	0.494
TRG_ENDOCYTIC_2	837	840	PF00928	0.474
TRG_ENDOCYTIC_2	867	870	PF00928	0.427
TRG_ENDOCYTIC_2	892	895	PF00928	0.451
TRG_ER_diArg_1	229	232	PF00400	0.402
TRG_ER_diArg_1	499	501	PF00400	0.279
TRG_NES_CRM1_1	332	344	PF08389	0.421
TRG_NLS_MonoExtN_4	722	728	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	48%	95%
A0A3S7XAZ4	Leishmania donovani	100%	100%
A4HP73	Leishmania braziliensis	65%	97%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q1L7	Leishmania major	88%	98%