WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4IDH6_LEIIN

TriTrypDb:

LINF_360027300

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4IDH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDH6

Function

Biological processes
Term	Name	Level	Count
GO:0009893	positive regulation of metabolic process	4	8
GO:0010604	positive regulation of macromolecule metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031396	regulation of protein ubiquitination	8	7
GO:0031398	positive regulation of protein ubiquitination	9	7
GO:0031399	regulation of protein modification process	6	7
GO:0031401	positive regulation of protein modification process	7	7
GO:0043085	positive regulation of catalytic activity	4	7
GO:0044093	positive regulation of molecular function	3	7
GO:0048518	positive regulation of biological process	3	8
GO:0050789	regulation of biological process	2	8
GO:0050790	regulation of catalytic activity	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051173	positive regulation of nitrogen compound metabolic process	5	8
GO:0051246	regulation of protein metabolic process	5	8
GO:0051247	positive regulation of protein metabolic process	6	8
GO:0051338	regulation of transferase activity	4	7
GO:0051347	positive regulation of transferase activity	5	7
GO:0051438	regulation of ubiquitin-protein transferase activity	5	7
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	7
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0065009	regulation of molecular function	2	7
GO:0080090	regulation of primary metabolic process	4	8
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	7
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	7
GO:1904666	regulation of ubiquitin protein ligase activity	6	7
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	7
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030162	regulation of proteolysis	6	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0045732	positive regulation of protein catabolic process	6	1
GO:0045862	positive regulation of proteolysis	7	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901800	positive regulation of proteasomal protein catabolic process	7	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	1
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	1
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	1
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	1
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008047	enzyme activator activity	3	8
GO:0010997	anaphase-promoting complex binding	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0044877	protein-containing complex binding	2	8
GO:0055106	ubiquitin-protein transferase regulator activity	3	8
GO:0097027	ubiquitin-protein transferase activator activity	4	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8
GO:1990757	ubiquitin ligase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.661
CLV_C14_Caspase3-7	652	656	PF00656	0.549
CLV_NRD_NRD_1	129	131	PF00675	0.534
CLV_NRD_NRD_1	294	296	PF00675	0.346
CLV_NRD_NRD_1	530	532	PF00675	0.589
CLV_NRD_NRD_1	546	548	PF00675	0.768
CLV_NRD_NRD_1	662	664	PF00675	0.643
CLV_PCSK_KEX2_1	129	131	PF00082	0.534
CLV_PCSK_KEX2_1	294	296	PF00082	0.254
CLV_PCSK_KEX2_1	529	531	PF00082	0.614
CLV_PCSK_KEX2_1	545	547	PF00082	0.753
CLV_PCSK_KEX2_1	662	664	PF00082	0.643
CLV_PCSK_PC7_1	525	531	PF00082	0.584
CLV_PCSK_PC7_1	542	548	PF00082	0.563
CLV_PCSK_SKI1_1	129	133	PF00082	0.518
CLV_PCSK_SKI1_1	536	540	PF00082	0.651
CLV_PCSK_SKI1_1	616	620	PF00082	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DEG_SPOP_SBC_1	220	224	PF00917	0.570
DEG_SPOP_SBC_1	411	415	PF00917	0.696
DOC_CKS1_1	104	109	PF01111	0.644
DOC_CKS1_1	679	684	PF01111	0.663
DOC_CYCLIN_RxL_1	202	213	PF00134	0.640
DOC_MAPK_MEF2A_6	245	253	PF00069	0.539
DOC_PP1_RVXF_1	164	171	PF00149	0.546
DOC_PP1_RVXF_1	342	349	PF00149	0.463
DOC_PP2B_LxvP_1	20	23	PF13499	0.675
DOC_PP2B_LxvP_1	32	35	PF13499	0.627
DOC_PP2B_LxvP_1	325	328	PF13499	0.520
DOC_PP4_FxxP_1	125	128	PF00568	0.606
DOC_PP4_FxxP_1	170	173	PF00568	0.498
DOC_PP4_MxPP_1	172	175	PF00568	0.565
DOC_USP7_MATH_1	10	14	PF00917	0.761
DOC_USP7_MATH_1	265	269	PF00917	0.640
DOC_USP7_MATH_1	273	277	PF00917	0.712
DOC_USP7_MATH_1	306	310	PF00917	0.531
DOC_USP7_MATH_1	312	316	PF00917	0.537
DOC_USP7_MATH_1	35	39	PF00917	0.765
DOC_USP7_MATH_1	411	415	PF00917	0.679
DOC_USP7_MATH_1	458	462	PF00917	0.762
DOC_USP7_MATH_1	501	505	PF00917	0.741
DOC_USP7_MATH_1	512	516	PF00917	0.595
DOC_WW_Pin1_4	103	108	PF00397	0.709
DOC_WW_Pin1_4	12	17	PF00397	0.750
DOC_WW_Pin1_4	192	197	PF00397	0.706
DOC_WW_Pin1_4	349	354	PF00397	0.570
DOC_WW_Pin1_4	407	412	PF00397	0.645
DOC_WW_Pin1_4	483	488	PF00397	0.806
DOC_WW_Pin1_4	624	629	PF00397	0.526
DOC_WW_Pin1_4	678	683	PF00397	0.654
LIG_14-3-3_CanoR_1	129	136	PF00244	0.504
LIG_14-3-3_CanoR_1	21	27	PF00244	0.792
LIG_14-3-3_CanoR_1	211	220	PF00244	0.500
LIG_14-3-3_CanoR_1	237	243	PF00244	0.517
LIG_14-3-3_CanoR_1	267	272	PF00244	0.684
LIG_14-3-3_CanoR_1	288	293	PF00244	0.584
LIG_14-3-3_CanoR_1	298	303	PF00244	0.517
LIG_14-3-3_CanoR_1	330	336	PF00244	0.518
LIG_14-3-3_CanoR_1	40	48	PF00244	0.405
LIG_14-3-3_CanoR_1	450	456	PF00244	0.752
LIG_14-3-3_CanoR_1	50	56	PF00244	0.493
LIG_14-3-3_CanoR_1	96	104	PF00244	0.585
LIG_BRCT_BRCA1_1	121	125	PF00533	0.657
LIG_Clathr_ClatBox_1	239	243	PF01394	0.429
LIG_eIF4E_1	534	540	PF01652	0.716
LIG_FHA_1	15	21	PF00498	0.731
LIG_FHA_1	175	181	PF00498	0.513
LIG_FHA_1	26	32	PF00498	0.692
LIG_FHA_1	305	311	PF00498	0.536
LIG_FHA_1	332	338	PF00498	0.581
LIG_FHA_1	367	373	PF00498	0.495
LIG_FHA_1	388	394	PF00498	0.452
LIG_FHA_1	67	73	PF00498	0.508
LIG_FHA_1	679	685	PF00498	0.670
LIG_FHA_1	99	105	PF00498	0.578
LIG_FHA_2	22	28	PF00498	0.701
LIG_FHA_2	253	259	PF00498	0.639
LIG_FHA_2	270	276	PF00498	0.471
LIG_FHA_2	650	656	PF00498	0.530
LIG_FHA_2	670	676	PF00498	0.460
LIG_HP1_1	353	357	PF01393	0.508
LIG_Integrin_RGD_1	159	161	PF01839	0.582
LIG_LIR_Apic_2	122	128	PF02991	0.638
LIG_LIR_Apic_2	167	173	PF02991	0.501
LIG_LIR_Gen_1	352	362	PF02991	0.432
LIG_LIR_Gen_1	476	485	PF02991	0.682
LIG_LIR_Gen_1	52	63	PF02991	0.476
LIG_LIR_Nem_3	352	357	PF02991	0.429
LIG_LIR_Nem_3	52	58	PF02991	0.480
LIG_LIR_Nem_3	643	649	PF02991	0.554
LIG_LYPXL_yS_3	421	424	PF13949	0.693
LIG_OCRL_FandH_1	291	303	PF00620	0.424
LIG_PCNA_PIPBox_1	329	338	PF02747	0.497
LIG_Pex14_1	604	608	PF04695	0.615
LIG_Pex14_2	646	650	PF04695	0.439
LIG_SH2_CRK	55	59	PF00017	0.475
LIG_SH2_CRK	608	612	PF00017	0.605
LIG_SH2_CRK	633	637	PF00017	0.489
LIG_SH2_NCK_1	608	612	PF00017	0.605
LIG_SH2_NCK_1	633	637	PF00017	0.560
LIG_SH2_PTP2	354	357	PF00017	0.506
LIG_SH2_STAP1	633	637	PF00017	0.489
LIG_SH2_STAP1	68	72	PF00017	0.451
LIG_SH2_STAT5	179	182	PF00017	0.559
LIG_SH2_STAT5	354	357	PF00017	0.506
LIG_SH2_STAT5	534	537	PF00017	0.710
LIG_SH2_STAT5	55	58	PF00017	0.439
LIG_SH2_STAT5	68	71	PF00017	0.441
LIG_SH3_3	16	22	PF00018	0.742
LIG_SH3_3	170	176	PF00018	0.562
LIG_SH3_3	193	199	PF00018	0.556
LIG_SH3_3	325	331	PF00018	0.501
LIG_SH3_3	347	353	PF00018	0.413
LIG_SH3_3	405	411	PF00018	0.666
LIG_SH3_3	416	422	PF00018	0.694
LIG_SH3_3	481	487	PF00018	0.732
LIG_SH3_3	622	628	PF00018	0.474
LIG_SH3_3	89	95	PF00018	0.533
LIG_SUMO_SIM_par_1	238	243	PF11976	0.491
LIG_TRAF2_1	671	674	PF00917	0.637
LIG_TRAF2_1	82	85	PF00917	0.596
LIG_WRC_WIRS_1	332	337	PF05994	0.508
MOD_CDK_SPxxK_3	195	202	PF00069	0.605
MOD_CDK_SPxxK_3	678	685	PF00069	0.663
MOD_CK1_1	195	201	PF00069	0.703
MOD_CK1_1	212	218	PF00069	0.307
MOD_CK1_1	231	237	PF00069	0.399
MOD_CK1_1	25	31	PF00069	0.780
MOD_CK1_1	269	275	PF00069	0.688
MOD_CK1_1	277	283	PF00069	0.692
MOD_CK1_1	39	45	PF00069	0.498
MOD_CK1_1	410	416	PF00069	0.632
MOD_CK1_1	451	457	PF00069	0.744
MOD_CK1_1	460	466	PF00069	0.739
MOD_CK1_1	486	492	PF00069	0.740
MOD_CK1_1	506	512	PF00069	0.589
MOD_CK1_1	654	660	PF00069	0.576
MOD_CK1_1	669	675	PF00069	0.515
MOD_CK1_1	70	76	PF00069	0.429
MOD_CK2_1	21	27	PF00069	0.682
MOD_CK2_1	252	258	PF00069	0.511
MOD_CK2_1	370	376	PF00069	0.532
MOD_CK2_1	474	480	PF00069	0.811
MOD_GlcNHglycan	121	124	PF01048	0.768
MOD_GlcNHglycan	125	128	PF01048	0.671
MOD_GlcNHglycan	230	233	PF01048	0.557
MOD_GlcNHglycan	275	279	PF01048	0.767
MOD_GlcNHglycan	314	317	PF01048	0.351
MOD_GlcNHglycan	325	328	PF01048	0.262
MOD_GlcNHglycan	360	363	PF01048	0.487
MOD_GlcNHglycan	371	375	PF01048	0.436
MOD_GlcNHglycan	438	441	PF01048	0.730
MOD_GlcNHglycan	456	459	PF01048	0.585
MOD_GlcNHglycan	462	465	PF01048	0.741
MOD_GlcNHglycan	467	470	PF01048	0.689
MOD_GlcNHglycan	488	491	PF01048	0.758
MOD_GlcNHglycan	509	512	PF01048	0.700
MOD_GlcNHglycan	514	517	PF01048	0.614
MOD_GlcNHglycan	548	551	PF01048	0.699
MOD_GlcNHglycan	58	61	PF01048	0.524
MOD_GlcNHglycan	668	671	PF01048	0.635
MOD_GSK3_1	10	17	PF00069	0.739
MOD_GSK3_1	112	119	PF00069	0.474
MOD_GSK3_1	160	167	PF00069	0.495
MOD_GSK3_1	174	181	PF00069	0.423
MOD_GSK3_1	2	9	PF00069	0.782
MOD_GSK3_1	209	216	PF00069	0.451
MOD_GSK3_1	21	28	PF00069	0.716
MOD_GSK3_1	265	272	PF00069	0.662
MOD_GSK3_1	273	280	PF00069	0.714
MOD_GSK3_1	300	307	PF00069	0.546
MOD_GSK3_1	310	317	PF00069	0.517
MOD_GSK3_1	35	42	PF00069	0.680
MOD_GSK3_1	366	373	PF00069	0.493
MOD_GSK3_1	378	385	PF00069	0.474
MOD_GSK3_1	407	414	PF00069	0.642
MOD_GSK3_1	450	457	PF00069	0.748
MOD_GSK3_1	46	53	PF00069	0.428
MOD_GSK3_1	465	472	PF00069	0.743
MOD_GSK3_1	503	510	PF00069	0.692
MOD_GSK3_1	561	568	PF00069	0.796
MOD_GSK3_1	650	657	PF00069	0.619
MOD_GSK3_1	66	73	PF00069	0.252
MOD_GSK3_1	98	105	PF00069	0.543
MOD_LATS_1	296	302	PF00433	0.607
MOD_LATS_1	94	100	PF00433	0.585
MOD_N-GLC_1	304	309	PF02516	0.317
MOD_N-GLC_1	506	511	PF02516	0.663
MOD_NEK2_1	139	144	PF00069	0.466
MOD_NEK2_1	146	151	PF00069	0.409
MOD_NEK2_1	164	169	PF00069	0.350
MOD_NEK2_1	209	214	PF00069	0.514
MOD_NEK2_1	266	271	PF00069	0.690
MOD_NEK2_1	30	35	PF00069	0.781
MOD_NEK2_1	310	315	PF00069	0.532
MOD_NEK2_1	379	384	PF00069	0.509
MOD_NEK2_1	430	435	PF00069	0.765
MOD_NEK2_1	51	56	PF00069	0.514
MOD_NEK2_1	582	587	PF00069	0.792
MOD_NEK2_1	649	654	PF00069	0.513
MOD_NEK2_1	67	72	PF00069	0.365
MOD_PIKK_1	10	16	PF00454	0.728
MOD_PIKK_1	387	393	PF00454	0.454
MOD_PIKK_1	414	420	PF00454	0.574
MOD_PIKK_1	669	675	PF00454	0.636
MOD_PK_1	267	273	PF00069	0.675
MOD_PK_1	298	304	PF00069	0.556
MOD_PKA_1	129	135	PF00069	0.508
MOD_PKA_1	546	552	PF00069	0.767
MOD_PKA_2	102	108	PF00069	0.643
MOD_PKA_2	129	135	PF00069	0.508
MOD_PKA_2	210	216	PF00069	0.472
MOD_PKA_2	266	272	PF00069	0.656
MOD_PKA_2	39	45	PF00069	0.623
MOD_PKA_2	449	455	PF00069	0.748
MOD_PKA_2	49	55	PF00069	0.454
MOD_PKA_2	546	552	PF00069	0.767
MOD_PKA_2	582	588	PF00069	0.719
MOD_Plk_1	140	146	PF00069	0.493
MOD_Plk_1	339	345	PF00069	0.493
MOD_Plk_1	583	589	PF00069	0.795
MOD_Plk_1	654	660	PF00069	0.630
MOD_Plk_2-3	561	567	PF00069	0.786
MOD_Plk_4	179	185	PF00069	0.564
MOD_Plk_4	25	31	PF00069	0.737
MOD_Plk_4	288	294	PF00069	0.623
MOD_Plk_4	306	312	PF00069	0.402
MOD_Plk_4	331	337	PF00069	0.506
MOD_Plk_4	42	48	PF00069	0.456
MOD_Plk_4	469	475	PF00069	0.812
MOD_Plk_4	583	589	PF00069	0.678
MOD_ProDKin_1	103	109	PF00069	0.721
MOD_ProDKin_1	12	18	PF00069	0.751
MOD_ProDKin_1	192	198	PF00069	0.699
MOD_ProDKin_1	349	355	PF00069	0.566
MOD_ProDKin_1	407	413	PF00069	0.655
MOD_ProDKin_1	483	489	PF00069	0.806
MOD_ProDKin_1	624	630	PF00069	0.524
MOD_ProDKin_1	678	684	PF00069	0.659
TRG_DiLeu_BaEn_1	27	32	PF01217	0.589
TRG_DiLeu_BaEn_1	674	679	PF01217	0.637
TRG_DiLeu_BaEn_2	140	146	PF01217	0.493
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.522
TRG_ENDOCYTIC_2	354	357	PF00928	0.419
TRG_ENDOCYTIC_2	421	424	PF00928	0.693
TRG_ENDOCYTIC_2	55	58	PF00928	0.468
TRG_ENDOCYTIC_2	633	636	PF00928	0.490
TRG_ER_diArg_1	128	130	PF00400	0.567
TRG_ER_diArg_1	293	295	PF00400	0.346
TRG_ER_diArg_1	529	531	PF00400	0.612
TRG_ER_diArg_1	545	547	PF00400	0.752
TRG_ER_diArg_1	614	617	PF00400	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD9	Leptomonas seymouri	57%	89%
A0A3S7XAS2	Leishmania donovani	100%	100%
A4HP71	Leishmania braziliensis	78%	100%
D0A364	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q1L9	Leishmania major	94%	100%