Chaperonin HSP60, mitochondrial

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperonin HSP60 - mitochondrial precursor

Species:

Leishmania infantum

UniProt:

A4IDH4_LEIIN

TriTrypDb:

LINF_360027100

Length:

566

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Chaperonin HSP60, mitochondrial

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IDH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IDH4

Function

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Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	15
GO:0009987	cellular process	1	15
GO:0042026	protein refolding	3	15

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.263
CLV_NRD_NRD_1	20	22	PF00675	0.470
CLV_PCSK_KEX2_1	124	126	PF00082	0.279
CLV_PCSK_KEX2_1	20	22	PF00082	0.470
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.263
CLV_PCSK_SKI1_1	143	147	PF00082	0.283
CLV_PCSK_SKI1_1	153	157	PF00082	0.305
CLV_PCSK_SKI1_1	204	208	PF00082	0.406
CLV_PCSK_SKI1_1	25	29	PF00082	0.479
CLV_PCSK_SKI1_1	252	256	PF00082	0.288

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUI9	Leptomonas seymouri	47%	100%
A0A0N1I104	Leptomonas seymouri	23%	99%
A0A0N1PDS3	Leptomonas seymouri	58%	95%
A0A0S4IN05	Bodo saltans	57%	96%
A0A0S4ITK5	Bodo saltans	46%	82%
A0A0S4J048	Bodo saltans	22%	99%
A0A0S4J2A3	Bodo saltans	22%	98%
A0A0S4J618	Bodo saltans	76%	100%
A0A1X0NUX8	Trypanosomatidae	57%	95%
A0A1X0P1I2	Trypanosomatidae	45%	100%

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